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  1. Book: Phenotyping for plant breeding

    Panguluri, Siva Kumar

    applications of phenotyping methods for crop improvement

    2013  

    Author's details Siva Kumar Panguluri ..., eds
    Language English
    Size XI, 211 S.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017898912
    ISBN 978-1-4614-8319-9 ; 1-4614-8319-0
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    138/187 available for loan (reading room) Freihandmagazin (U1)

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  2. Article ; Online: Influence of Age on Hyperoxia-Induced Cardiac Pathophysiology in Type 1 Diabetes Mellitus (T1DM) Mouse Model.

    Saleem, Faizan / Mansour, Hussein / Vichare, Riddhi / Ayalasomayajula, Yashwant / Yassine, Jenna / Hesaraghatta, Anagha / Panguluri, Siva Kumar

    Cells

    2023  Volume 12, Issue 11

    Abstract: Mechanical ventilation often results in hyperoxia, a condition characterized by excess ... ...

    Abstract Mechanical ventilation often results in hyperoxia, a condition characterized by excess SpO
    MeSH term(s) Female ; Mice ; Male ; Animals ; Diabetes Mellitus, Type 1/complications ; Disease Models, Animal ; Hyperoxia/complications ; Ventricular Remodeling ; Cardiomegaly
    Language English
    Publishing date 2023-05-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12111457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Influence of age and sex on physical, cardiac electrical and functional alterations in progressive hyperoxia treatment: A time course study in a murine model.

    Ayalasomayajula, Yashwant / Hesaraghatta, Anagha / Dantuluri, Neha / Yassine, Jenna / Saleem, Faizan / Mansour, Hussein / Chayawatto, Chayapatou / Rangarajan, Nishank / Rangarajan, Sashank / Krishnan, Smrithi / Panguluri, Siva Kumar

    Experimental gerontology

    2024  Volume 191, Page(s) 112435

    Abstract: Oxygen supplementation is a widely used treatment for ICU patients. However, it can lead to hyperoxia, which in turn can result in oxidative stress, cardiac remodeling, and even mortality. This paper expands upon previous research conducted by our lab to ...

    Abstract Oxygen supplementation is a widely used treatment for ICU patients. However, it can lead to hyperoxia, which in turn can result in oxidative stress, cardiac remodeling, and even mortality. This paper expands upon previous research conducted by our lab to establish time-dependent cardiac changes under hyperoxia. In this study, both young and aged mice (male and female) underwent 72 h of hyperoxia exposure and were monitored at 24-hour intervals for cardiac electrophysiological and functional parameters using ECG and electrocardiogram data. Our analysis showed that young male mice experienced significant weight loss as well as significant lung edema by 48 h. Although young male mice were highly susceptible to physical changes, they were resistant to early cardiac functional and electrophysiological changes compared to the other groups. Both young and aged female and aged males developed functional impairments by 24 h of hyperoxia exposure. Furthermore, sex and age differences were noted in the onset of electrophysiological changes. While some groups could resist early cardiac remodeling, our data suggests that 72 h of hyperoxia exposure is sufficient to induce significant cardiac remodeling across all age and sex groups. Our data establishes that time-dependent cardiac changes due to oxygen supplementation can have devastating consequences even with short exposure periods. These findings can aid in developing clinical practices for individuals admitted to the ICU by elucidating the impact of aging, sex, and length of stay under mechanical ventilation to limit hyperoxia-induced cardiac remodeling.
    Language English
    Publishing date 2024-04-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 390992-x
    ISSN 1873-6815 ; 0531-5565
    ISSN (online) 1873-6815
    ISSN 0531-5565
    DOI 10.1016/j.exger.2024.112435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 579: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Influence of Age on Hyperoxia-Induced Cardiac Pathophysiology in Type 1 Diabetes Mellitus (T1DM) Mouse Model

    Faizan Saleem / Hussein Mansour / Riddhi Vichare / Yashwant Ayalasomayajula / Jenna Yassine / Anagha Hesaraghatta / Siva Kumar Panguluri

    Cells, Vol 12, Iss 1457, p

    2023  Volume 1457

    Abstract: Mechanical ventilation often results in hyperoxia, a condition characterized by excess SpO 2 levels (>96%). Hyperoxia results in changes in the physiological parameters, severe cardiac remodeling, arrhythmia development, and alteration of cardiac ion ... ...

    Abstract Mechanical ventilation often results in hyperoxia, a condition characterized by excess SpO 2 levels (>96%). Hyperoxia results in changes in the physiological parameters, severe cardiac remodeling, arrhythmia development, and alteration of cardiac ion channels, all of which can point toward a gradual increase in the risk of developing cardiovascular disease (CVD). This study extends the analysis of our prior work in young Akita mice, which demonstrated that exposure to hyperoxia worsens cardiac outcomes in a type 1 diabetic murine model as compared to wild-type (WT) mice. Age is an independent risk factor, and when present with a major comorbidity, such as type 1 diabetes (T1D), it can further exacerbate cardiac outcomes. Thus, this research subjected aged T1D Akita mice to clinical hyperoxia and analyzed the cardiac outcomes. Overall, aged Akita mice (60 to 68 weeks) had preexisting cardiac challenges compared to young Akita mice. Aged mice were overweight, had an increased cardiac cross-sectional area, and showed prolonged QTc and JT intervals, which are proposed as major risk factors for CVD like intraventricular arrhythmias. Additionally, exposure to hyperoxia resulted in severe cardiac remodeling and a decrease in Kv 4.2 and KChIP2 cardiac potassium channels in these rodents. Based on sex-specific differences, aged male Akita mice had a higher risk of poor cardiac outcomes than aged females. Aged male Akita mice had prolonged RR, QTc, and JT intervals even at baseline normoxic exposure. Moreover, they were not protected against hyperoxic stress through adaptive cardiac hypertrophy, which, at least to some extent, is due to reduced cardiac androgen receptors. This study in aged Akita mice aims to draw attention to the clinically important yet understudied subject of the effect of hyperoxia on cardiac parameters in the presence of preexisting comorbidities. The findings would help revise the provision of care for older T1D patients admitted to ICUs.
    Keywords type 1 diabetes ; hyperoxia ; potassium channels ; cardiovascular disease (CVD) ; aging ; mechanical ventilation ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Impact of age and sex on hyperoxia-induced cardiovascular pathophysiology.

    Vichare, Riddhi / Saleem, Faizan / Mansour, Hussein / Bojkovic, Katarina / Cheng, Feng / Biswal, Manas / Panguluri, Siva Kumar

    Mechanisms of ageing and development

    2022  Volume 208, Page(s) 111727

    Abstract: Hyperoxia is characterized by pronounced inflammatory responses, pulmonary cell apoptosis, and adverse cardiac remodeling due to an excess supply of oxygen. Hyperoxic episodes are frequent in mechanically ventilated patients and are associated with in- ... ...

    Abstract Hyperoxia is characterized by pronounced inflammatory responses, pulmonary cell apoptosis, and adverse cardiac remodeling due to an excess supply of oxygen. Hyperoxic episodes are frequent in mechanically ventilated patients and are associated with in-hospital mortality. This study extends the analysis of prior published research by our group as it investigates the influence of age in male and female rodents exposed to hyperoxic conditions. Age is an independent cardiovascular risk factor, often compounded by variables like obesity, diabetes, and a decline in sex hormones and their receptors. This study simulates clinical hyperoxia by subjecting rodents to > 90 % of oxygen for 72 h and compares the changes in cardiac structural and functional parameters with those exposed to normal air. While in both sexes conduction abnormalities with ageing were discernible, aged females owing to their inherent higher baseline QTc, were at a higher risk of developing arrhythmias as compared to age-matched males. Quantitative real-time RT-PCR and western blot analysis reflected altered expression of cardiac potassium channels, resulting in conduction abnormalities in aged female rodents. Unaffected by age and sex, hyperoxia-treated mice had altered body composition, as evidenced by a considerable reduction in body weight. Interestingly, compensatory hypertrophy observed as a protective mechanism in young males was absent in aged males, whereas protection of hearts from hyperoxia-induced cardiac hypertrophy was absent in aged female mice, both of which may be at least in part due to a reduction in sex steroid receptors and the systemic steroid levels. Finally, statistical analysis revealed that hyperoxia had the greatest impact on most of the cardiac parameters, followed by age and then sex. This data established an imperative finding that can change the provision of care for aged individuals admitted to ICU by elucidating the impact of intrinsic aging on hyperoxia-induced cardiac remodeling.
    MeSH term(s) Mice ; Male ; Female ; Animals ; Hyperoxia/complications ; Hyperoxia/metabolism ; Ventricular Remodeling ; Heart ; Arrhythmias, Cardiac ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-09-06
    Publishing country Ireland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 183915-9
    ISSN 1872-6216 ; 0047-6374
    ISSN (online) 1872-6216
    ISSN 0047-6374
    DOI 10.1016/j.mad.2022.111727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1012: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book: Phenotyping for plant breeding

    Panguluri, Siva Kumar

    applications of phenotyping methods for crop improvement

    2013  

    Author's details Siva Kumar Panguluri ... [ed.]
    Keywords Phenotype ; Plant breeding ; Plant genetics
    Language English
    Size XI, 211 S., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book
    ISBN 1461483190 ; 9781461483199 ; 9781461483205 ; 1461483204
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Book: Phenotyping for plant breeding

    Panguluri, Siva Kumar / Kumar, Are Ashok

    applications of phenotyping methods for crop improvement

    2013  

    Author's details Siva Kumar Panguluri, Are Ashok Kumar, editors
    Keywords Plant breeding. ; Plant genetics. ; Phenotype.
    Language English
    Dates of publication 2013-2013
    Size xi, 211 pages :, illustrations (some color) ;, 24 cm
    Document type Book
    ISBN 1461483190 ; 9781461483199
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Hyperoxia-induced cardiotoxicity and ventricular remodeling in type-II diabetes mice.

    Rodgers, Jennifer Leigh / Samal, Eva / Mohapatra, Subhra / Panguluri, Siva Kumar

    Heart and vessels

    2017  Volume 33, Issue 5, Page(s) 561–572

    Abstract: Hyperoxia, or supplemental oxygen, is regularly used in the clinical setting for critically ill patients in ICU. However, several recent studies have demonstrated the negative impact of this treatment in patients in critical care, including increased ... ...

    Abstract Hyperoxia, or supplemental oxygen, is regularly used in the clinical setting for critically ill patients in ICU. However, several recent studies have demonstrated the negative impact of this treatment in patients in critical care, including increased rates of lung and cardiac injury, as well as increased mortality. The purpose of this study was to determine the predisposition for arrhythmias and electrical remodeling in a type 2 diabetic mouse model (db/db), as a result of hyperoxia treatment. For this, db/db and their heterozygous controls were treated with hyperoxia (> 90% oxygen) or normoxia (normal air) for 72-h. Immediately following hyperoxia or normoxia treatments, mice underwent surface ECG. Excised left ventricles were used to assess ion channel expression, including for Kv1.4, Kv1.5, Kv4.2, and KChIP2. Serum cardiac markers were also measured, including cardiac troponin I and lactate dehydrogenase. Our results showed that db/db mice have increased sensitivity to arrhythmia. Normoxia-treated db/db mice displayed features of arrhythmia, including QTc and JT prolongation, as well as QRS prolongation. A significant increase in QRS prolongation was also observed in hyperoxia-treated db/db mice, when compared to hyperoxia-treated heterozygous control mice. Db/db mice were also shown to exhibit ion channel dysregulation, as demonstrated by down-regulation in Kv1.5, Kv4.2, and KChIP2 under hyperoxia conditions. From these results, we conclude that: (1) diabetic mice showed distinct pathophysiology, when compared to heterozygous controls, both in normoxia and hyperoxia conditions. (2) Diabetic mice were more susceptible to arrhythmia at normal air conditions; this effect was exacerbated at hyperoxia conditions. (3) Unlike in heterozygous controls, diabetic mice did not demonstrate cardiac hypertrophy as a result of hyperoxia. (4) Ion channel remodeling was also observed in db/db mice under hyperoxia condition similar to its heterozygous controls.
    MeSH term(s) Animals ; Cardiotoxicity ; Diabetes Mellitus, Experimental ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/physiopathology ; Disease Models, Animal ; Electrocardiography ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/physiopathology ; Hyperoxia/complications ; Hyperoxia/physiopathology ; Long QT Syndrome/diagnosis ; Long QT Syndrome/etiology ; Long QT Syndrome/physiopathology ; Male ; Mice ; Ventricular Remodeling/physiology
    Language English
    Publishing date 2017-12-05
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 89678-0
    ISSN 1615-2573 ; 0910-8327 ; 0935-736X
    ISSN (online) 1615-2573
    ISSN 0910-8327 ; 0935-736X
    DOI 10.1007/s00380-017-1100-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2049: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Using quantitative real-time reverse transcriptase polymerase chain reaction to validate gene regulation by PTTG.

    Panguluri, Siva Kumar / Kakar, Sham S

    Methods in molecular biology (Clifton, N.J.)

    2012  Volume 815, Page(s) 131–145

    Abstract: Pituitary tumor transforming gene is an important gene which is involved in many cellular functions including cell division, DNA repair, organ development, expression, and secretion of various angiogenic and metastatic factors. Overexpression of this ... ...

    Abstract Pituitary tumor transforming gene is an important gene which is involved in many cellular functions including cell division, DNA repair, organ development, expression, and secretion of various angiogenic and metastatic factors. Overexpression of this gene has also been reported in many cancers. Understanding the molecular pathways induced by this oncogene is therefore important not only to understand the development of the disease but also for proper diagnosis and treatment. Gene profiling is an excellent tool to identify the genetic mechanisms, networks, and pathways associated with a particular disease. Oligo-nucleotide microarrays can be everybody's choice as a first step to identify the global expression of genes involved in the study of interest. Each technique has its own limitation. Therefore, further confirmation of the results with a different technique is always necessary. Quantitative real-time reverse-transcriptase polymerase chain reaction (qRT-PCR) is one of the widely used and best described techniques to confirm the microarray data. Here, we describe the qRT-PCR techniques for gene profiling studies and the methods used for the analysis of the output data for further studies.
    MeSH term(s) Adenoviridae/genetics ; Cells, Cultured ; DNA Primers ; DNA, Complementary/chemical synthesis ; Data Interpretation, Statistical ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Genetic Vectors ; Humans ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; RNA/genetics ; RNA/isolation & purification ; RNA Interference ; Real-Time Polymerase Chain Reaction/methods ; Reverse Transcriptase Polymerase Chain Reaction/methods ; Securin
    Chemical Substances DNA Primers ; DNA, Complementary ; Neoplasm Proteins ; Securin ; pituitary tumor-transforming protein 1, human ; RNA (63231-63-0)
    Language English
    Publishing date 2012
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-61779-424-7_11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Editorial: current topics in pharmacogenomics.

    Panguluri, Siva Kumar / Sneed, Kevin B / Pathak, Yashwant / Zhou, Shufeng

    Recent patents on biotechnology

    2014  Volume 8, Issue 2, Page(s) 109

    MeSH term(s) Biomarkers/metabolism ; Humans ; Pharmacogenetics ; Precision Medicine
    Chemical Substances Biomarkers
    Language English
    Publishing date 2014-08-29
    Publishing country United Arab Emirates
    Document type Editorial ; Introductory Journal Article
    ISSN 2212-4012
    ISSN (online) 2212-4012
    DOI 10.2174/1872208309666140904124649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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