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  1. Article ; Online: Patients assisted at the Department of Medicine of a pediatric hospital at the beginning of the COVID-19 pandemic in Buenos Aires, Argentina.

    Cairoli, Héctor / Raiden, Silvina / Chiolo, María J / Di Lalla, Sandra / Ferrero, Fernando

    Archivos argentinos de pediatria

    2020  Volume 118, Issue 6, Page(s) 418–426

    Abstract: Introduction: Despite the magnitude of the COVID-19 pandemic, the information about its development in pediatrics is still limited. This report describes the characteristics of patients admitted to a children's hospital due to COVID-19 during the first ... ...

    Title translation Pacientes asistidos en el Departamento de Medicina de un hospital pediátrico en el inicio de la pandemia COVID-19 en Buenos Aires, Argentina.
    Abstract Introduction: Despite the magnitude of the COVID-19 pandemic, the information about its development in pediatrics is still limited. This report describes the characteristics of patients admitted to a children's hospital due to COVID-19 during the first three months of the pandemic.
    Method: Descriptive study including all patients hospitalized due to COVID-19 between 4/1/2020 and 6/30/2020.
    Results: A total of 191 patients were hospitalized due to COVID-19; their median age was 7.7 years; 89% had a history of close contact. Of them, 35.6 % were considered asymptomatic; 61.2 %, mild cases; and 3.2 %, moderate cases (no severe cases). None of them received a specific treatment for the disease. The most common symptoms were fever, sore throat, and cough. The median length of stay was 6 days.
    Conclusion: A total of 191 cases of children and adolescents admitted due to COVID-19 are reported. Most were asymptomatic or presented with a mild disease.
    MeSH term(s) Adolescent ; Argentina ; COVID-19/epidemiology ; COVID-19/therapy ; Child ; Child, Preschool ; Cough/epidemiology ; Cough/virology ; Female ; Fever/epidemiology ; Fever/virology ; Hospitalization/statistics & numerical data ; Hospitals, Pediatric ; Humans ; Infant ; Length of Stay ; Male ; Pharyngitis/epidemiology ; Pharyngitis/virology ; Severity of Illness Index
    Language Spanish
    Publishing date 2020-11-23
    Publishing country Argentina
    Document type Journal Article
    ZDB-ID 424449-7
    ISSN 1668-3501 ; 0325-0075 ; 0004-0487
    ISSN (online) 1668-3501
    ISSN 0325-0075 ; 0004-0487
    DOI 10.5546/aap.2020.eng.423
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  2. Article ; Online: Children hospitalized for COVID-19 during the first winter of the pandemic in Buenos Aires, Argentina.

    Raiden, Silvina / Cairoli, Héctor / Potasnik, Javier / Di Lalla, Sandra / Chiolo, María J / Torres, Fernando / Domínguez, Paula / Ferrero, Fernando

    Boletin medico del Hospital Infantil de Mexico

    2021  Volume 78, Issue 6, Page(s) 501–505

    Abstract: Background: Although there are reports on COVID-19 in pediatrics, the characteristics of the population of each country, its health systems, and how the pandemic was addressed could give the disease distinctive features worldwide. We aimed to describe ... ...

    Abstract Background: Although there are reports on COVID-19 in pediatrics, the characteristics of the population of each country, its health systems, and how the pandemic was addressed could give the disease distinctive features worldwide. We aimed to describe the characteristics of patients hospitalized for COVID-19 in a tertiary pediatric hospital in the City of Buenos Aires, Argentina.
    Methods: We conducted a descriptive study, including all patients hospitalized for COVID-19 from 04/26/2020 to 10/31/2020 in a tertiary pediatric hospital. We described the demographic, clinical, and epidemiological characteristics of the patients.
    Results: During the period studied, 578 patients were hospitalized with COVID-19. The median age was 4.2 years, and 83% reported close contact with a confirmed COVID-19 case. Regarding severity, 30.8% were asymptomatic, and 60.4% showed mild, 7.4% moderate, and 1.4% severe symptoms. Among symptomatic patients, fever was the most frequent symptom, followed by sore throat and cough.
    Conclusions: We reported 578 cases of children and adolescents hospitalized with COVID-19, of which the majority showed mild or asymptomatic disease.
    MeSH term(s) Adolescent ; Argentina/epidemiology ; COVID-19 ; Child ; Child, Preschool ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-12-15
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 730519-9
    ISSN 1665-1146 ; 1665-1146 ; 0539-6115 ; 0539-6123
    ISSN (online) 1665-1146
    ISSN 1665-1146 ; 0539-6115 ; 0539-6123
    DOI 10.24875/BMHIM.21000039
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  3. Article ; Online: Children hospitalized for COVID-19 during the first winter of the pandemic in Buenos Aires, Argentina

    Silvina Raiden / Héctor Cairoli / Javier Potasnik / Sandra Di Lalla / María J. Chiolo / Fernando Torres / Paula Domínguez / Fernando Ferrero

    Boletín Médico del Hospital Infantil de México, Vol 78, Iss

    2021  Volume 6

    Abstract: Background: Although there are reports on COVID-19 in pediatrics, the characteristics of the population of each country, its health systems, and how the pandemic was addressed could give the disease distinctive features worldwide. We aimed to describe ... ...

    Abstract Background: Although there are reports on COVID-19 in pediatrics, the characteristics of the population of each country, its health systems, and how the pandemic was addressed could give the disease distinctive features worldwide. We aimed to describe the characteristics of patients hospitalized for COVID-19 in a tertiary pediatric hospital in the City of Buenos Aires, Argentina. Methods: We conducted a descriptive study, including all patients hospitalized for COVID-19 from 04/26/2020 to 10/31/2020 in a tertiary pediatric hospital. We described the demographic, clinical, and epidemiological characteristics of the patients. Results: During the period studied, 578 patients were hospitalized with COVID-19. The median age was 4.2 years, and 83% reported close contact with a confirmed COVID-19 case. Regarding severity, 30.8% were asymptomatic, and 60.4% showed mild, 7.4% moderate, and 1.4% severe symptoms. Among symptomatic patients, fever was the most frequent symptom, followed by sore throat and cough. Conclusions: We reported 578 cases of children and adolescents hospitalized with COVID-19, of which the majority showed mild or asymptomatic disease.
    Keywords Coronavirus infection. COVID-19. Pneumonia. Hospitalization. Children ; Pediatrics ; RJ1-570 ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Permanyer
    Document type Article ; Online
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  4. Article ; Online: Children hospitalized for COVID-19 during the first winter of the pandemic in Buenos Aires, Argentina

    Raiden, Silvina / Cairoli, Hector / Potasnik, Javier / Di Lalla, Sandra / Chiolo, Maria Jose / Torres, Fernando Adrian / Dominguez, Paula / Ferrero, Fernando

    medRxiv

    Abstract: Background: Although there are reports on COVID-19 in pediatrics, it is possible that the characteristics of each population, their health systems and how they faced the pandemic made the disease show distinctive features in different countries. We aimed ...

    Abstract Background: Although there are reports on COVID-19 in pediatrics, it is possible that the characteristics of each population, their health systems and how they faced the pandemic made the disease show distinctive features in different countries. We aimed to describe the characteristics of patients hospitalized for COVID-19 in a tertiary pediatric hospital in the City of Buenos Aires, Argentina. Methods: Descriptive study, including all patients hospitalized for COVID-19 in a tertiary pediatric hospital, from 04/26/2020 to 10/31/2020. Demographic, clinical and epidemiological characteristics of the patients are described. Results: In the studied period 578 children and adolescents were hospitalized for COVID-19. The median age was 4.2 years and 83% had a history of close contact with a confirmed COVID-19 case. Regarding severity, 30.8% were asymptomatic, 60.4% mild, 7.4% moderate, and 1.4% severe. Among those with symptoms, the most frequent was fever, followed by sore throat and cough. Conclusion: We reported 578 cases of children and adolescents hospitalized for COVID-19, most of them showed a mild or asymptomatic condition.
    Keywords covid19
    Language English
    Publishing date 2020-11-06
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.11.05.20225300
    Database COVID19

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  5. Article ; Online: Adenosine triphosphate-dependent calcium signaling during ventilator-induced lung injury is amplified by hypercapnia.

    Briva, Arturo / Santos, Cristina / Malacrida, Leonel / Rocchiccioli, Fabiana / Soto, Juan / Angulo, Martin / Batthyany, Carlos / Cairoli, Ernesto / Piriz, Hector

    Experimental lung research

    2011  Volume 37, Issue 8, Page(s) 471–481

    Abstract: Adenosine triphosphate (ATP) is released by alveolar epithelial cells during ventilator-induced lung injury (VILI) and regulates fluid transport across epithelia. High CO(2) levels are observed in patients with "permissive hypercapnia," which inhibits ... ...

    Abstract Adenosine triphosphate (ATP) is released by alveolar epithelial cells during ventilator-induced lung injury (VILI) and regulates fluid transport across epithelia. High CO(2) levels are observed in patients with "permissive hypercapnia," which inhibits alveolar fluid reabsorption (AFR) in alveolar epithelial cells. The authors set out to determine whether VILI affects AFR and whether the purinergic pathway is modulated in cells exposed to hypercapnia. Control group was compared against VILI (tidal volume [Vt] = 35 mL/kg, zero positive end-expiratory pressure [PEEP]) and protective ventilation (Vt = 6 mL/kg, PEEP = 10 cm H(2)O) groups. Lung mechanics, histology, and AFR were evaluated. Alveolar epithelial cells (AECs) were loaded with Fura 2-AM to measure intracellular calcium in the presence ATP (10 μM) at 5% or 10% CO(2) as compared with baseline. High tidal volume ventilation impairs lung mechanics and AFR. Hypercapnia (HC) increases intracellular calcium levels in response to ATP stimulation. HC + ATP is the most detrimental combination decreasing AFR. Purinergic signaling in AECs is modulated by high CO(2) levels via increased cytosolic calcium. The authors reason that this modulation may play a role in the impairment of alveolar epithelial functions induced by hypercapnia.
    MeSH term(s) Acute Lung Injury/etiology ; Acute Lung Injury/pathology ; Acute Lung Injury/physiopathology ; Adenosine Triphosphate/metabolism ; Adenosine Triphosphate/pharmacology ; Animals ; Calcium Signaling/drug effects ; Hypercapnia/physiopathology ; Male ; Pulmonary Gas Exchange ; Rats ; Rats, Inbred WKY ; Respiration, Artificial/adverse effects ; Respiratory Mechanics ; Tidal Volume
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2011-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 603791-4
    ISSN 1521-0499 ; 0190-2148
    ISSN (online) 1521-0499
    ISSN 0190-2148
    DOI 10.3109/01902148.2011.598217
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  6. Article ; Online: Blood neutrophils from children with COVID-19 exhibit both inflammatory and anti-inflammatory markers.

    Seery, Vanesa / Raiden, Silvina C / Algieri, Silvia C / Grisolía, Nicolás A / Filippo, Daniela / De Carli, Norberto / Di Lalla, Sandra / Cairoli, Héctor / Chiolo, María J / Meregalli, Claudia N / Gimenez, Lorena I / Gregorio, Gabriela / Sarli, Mariam / Alcalde, Ana L / Davenport, Carolina / Bruera, María J / Simaz, Nancy / Pérez, Mariela F / Nivela, Valeria /
    Bayle, Carola / Tuccillo, Patricia / Agosta, María T / Pérez, Hernán / Villa Nova, Susana / Suárez, Patricia / Takata, Eugenia M / García, Mariela / Lattner, Jorge / Rolón, María J / Coll, Patricia / Sananez, Inés / Holgado, María P / Ferrero, Fernando / Geffner, Jorge / Arruvito, Lourdes

    EBioMedicine

    2021  Volume 67, Page(s) 103357

    Abstract: Background: Perhaps reflecting that children with COVID-19 rarely exhibit severe respiratory symptoms and often remain asymptomatic, little attention has been paid to explore the immune response in pediatric COVID-19. Here, we analyzed the phenotype and ...

    Abstract Background: Perhaps reflecting that children with COVID-19 rarely exhibit severe respiratory symptoms and often remain asymptomatic, little attention has been paid to explore the immune response in pediatric COVID-19. Here, we analyzed the phenotype and function of circulating neutrophils from children with COVID-19.
    Methods: An observational study including 182 children with COVID-19, 21 children with multisystem inflammatory syndrome (MIS-C), and 40 healthy children was performed in Buenos Aires, Argentina. Neutrophil phenotype was analyzed by flow cytometry in blood samples. Cytokine production, plasma levels of IgG antibodies directed to the spike protein of SARS-CoV-2 and citrullinated histone H3 were measured by ELISA. Cell-free DNA was quantified by fluorometry.
    Findings: Compared with healthy controls, neutrophils from children with COVID-19 showed a lower expression of CD11b, CD66b, and L-selectin but a higher expression of the activation markers HLA-DR, CD64 and PECAM-1 and the inhibitory receptors LAIR-1 and PD-L1. No differences in the production of cytokines and NETs were observed. Interestingly, the expression of CD64 in neutrophils and the serum concentration of IgG antibodies directed to the spike protein of SARS-CoV-2 distinguished asymptomatic from mild and moderate COVID-19.
    Interpretation: Acute lung injury is a prominent feature of severe COVID-19 in adults. A low expression of adhesion molecules together with a high expression of inhibitory receptors in neutrophils from children with COVID-19 might prevent tissue infiltration by neutrophils preserving lung function.
    Funding: This study was supported by the Ministry of Science and Technology (National Agency for Scientific and Technological Promotion, IP-COVID-19-0277 and PMO BID PICT 2018-2548), and University of Buenos Aires from Argentina (20020170100573BA).
    MeSH term(s) Antibodies, Viral/blood ; Argentina ; Biomarkers/blood ; COVID-19/blood ; COVID-19/immunology ; Case-Control Studies ; Child ; Child, Preschool ; Cytokines/blood ; Female ; Flow Cytometry ; Humans ; Immunoglobulin G/blood ; Infant ; Male ; Neutrophils/immunology ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/immunology ; Systemic Inflammatory Response Syndrome/blood ; Systemic Inflammatory Response Syndrome/immunology
    Chemical Substances Antibodies, Viral ; Biomarkers ; Cytokines ; Immunoglobulin G ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-05-09
    Publishing country Netherlands
    Document type Journal Article ; Observational Study
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2021.103357
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  7. Article ; Online: Nefromegalia: forma de presentación infrecuente de leucemia linfoblástica aguda en un lactante.

    Martins, Andrea / Cairoli, Héctor / Domínguez, Paula / Martin, Sandra / Ortiz, Corina / Potasznik, Javier / Schenone, Norma

    Archivos argentinos de pediatria

    2008  Volume 106, Issue 3, Page(s) 263–265

    Abstract: Nephromegaly in infancy may be due to several causes, being the most relevant: renal polycystic autosomic recessive disease, venous renal thrombosis, deposit diseases, kidney tumors, nephrotic congenital syndrome and neoplastic infiltration. Although ... ...

    Title translation Nephromegaly: as unusual presentation of acute lymphoblastic leukemia in an infant.
    Abstract Nephromegaly in infancy may be due to several causes, being the most relevant: renal polycystic autosomic recessive disease, venous renal thrombosis, deposit diseases, kidney tumors, nephrotic congenital syndrome and neoplastic infiltration. Although renal infiltration is relatively frequent in acute lymphoblastic leukemia, nephromegaly is an unusual form of presentation in this pathology. The case of a four-year-old patient, who presents bilateral nephromegaly and pancytopenia, is presented. Acute Lymphoblastic Leukemia is diagnosed, initiating the corresponding chemotherapic treatment.
    MeSH term(s) Female ; Humans ; Hypertrophy/etiology ; Infant ; Kidney/pathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis
    Language Spanish
    Publishing date 2008-06
    Publishing country Argentina
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 424449-7
    ISSN 1668-3501 ; 0325-0075 ; 0004-0487
    ISSN (online) 1668-3501
    ISSN 0325-0075 ; 0004-0487
    DOI 10.1590/S0325-00752008000300013
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  8. Article ; Online: Neoplasia endocrina múltiple en perro

    Víctor Castillo / Víctor Cairoli / María Rodríguez / Héctor López Vale / Alberto Vartabedian

    Revista Científica, Vol 11, Iss

    asociación de insulinoma, adenoma corticoadrenal y tumor hipopisario. reporte de un casos

    2010  Volume 6

    Abstract: El presente reporte es referido a un canino, Shih-tzu, hembra, de 8 años de edad, que presentó tres tumores endocrinos primarios asociados (insulinoma. adenoma corticoadrenal y tumor de hipófisis), catalogándose como Neoplasia Endocrina Múltiple (NEM). ... ...

    Abstract El presente reporte es referido a un canino, Shih-tzu, hembra, de 8 años de edad, que presentó tres tumores endocrinos primarios asociados (insulinoma. adenoma corticoadrenal y tumor de hipófisis), catalogándose como Neoplasia Endocrina Múltiple (NEM). El diagnóstico clínico presuntivo inicial fue de sulinoma, debido a la presencia de hipoglicemias reiteradas. La relación insulina: glucosa corregida confirmó el diagnóstico clínico. Al realizar la exploración ecográfica de abdomen para detectar posibles metástasis, se evidenció un tumor en la glándula adrenal izquierda. La tomografía computarizada (abdomen y región selar), confirmó esta neoplasia y permitió encontrar otro en hipófisis. La relación cortisol: creatinina urinaria detectada fue de 60 (normal entre 8 -24). La estimulación con ACTH resultó correspondiente y la medición de ACTH endógena disminuida (menor de 6,5 pmol/L), sospechándose de hiperfunción de la adrenal pero sin receptor a la ACTH en las células neoplásicas adrenales. El resto de las hormonas hipofisarias evaluadas estaban dentro del rango normal. El insulinoma y el tumor adrenal fueron extirpados quirúrgicamente, enviándose para el diagnóstico histopatológico correspondiente, tratándose de un carcinoma de células ï¢ y adenoma corticoadrenal no metastático de zona fascicular, respectivamente. El tumor hipofisario fue tratado con radioterapia. Por presentar tumores primarios en tres diferentes glándulas de secreción endocrina el caso reportado se puede clasificar dentro de los síndromes NEM. Se concluye que ante un tumor funcional endocrino, como el caso reportado, es necesario evaluar la posibilidad de existencia de neoplasia en otras glándulas y está indicado el estudio bioquímico e imagenológico de ellas.
    Keywords neoplasia endocrina múltiple ; adenoma adrenal ; hipófisis ; insulinoma ; caninos ; Cattle ; SF191-275 ; Veterinary medicine ; SF600-1100
    Language English
    Publishing date 2010-06-01T00:00:00Z
    Publisher Universidad del Zulia
    Document type Article ; Online
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  9. Article ; Online: Síndrome de Gradenigo: comunicación de un caso.

    Guedes, Verónica / Gallegos, Paulina / Ferrero, Alexis / García Minúzzi, Mariana / Casanovas, Alejandra / Georgetti, Belén / Potaznik, Javier / Cairoli, Héctor / Schenone, Norma

    Archivos argentinos de pediatria

    2010  Volume 108, Issue 3, Page(s) e74–5

    Abstract: Acute otitis media is the most common bacterial infection in children. Despite efficient antibiotic therapy, there are still reports of both intratemporal and intracranial complications with potential risk of high morbidity and mortality. Mastoiditis, ... ...

    Title translation Gradenigo's syndrome: a case-report.
    Abstract Acute otitis media is the most common bacterial infection in children. Despite efficient antibiotic therapy, there are still reports of both intratemporal and intracranial complications with potential risk of high morbidity and mortality. Mastoiditis, apical petrositis and labyrinthitis are caused by the extension of purulent middle ear infection into nearby structures. Giuseppe Gradenigo first described the clinical triad of acute otitis media, unilateral pain in the region innervated by the 1 masculine and 2 masculine branches of the trigeminal nerve and ipsilateral abducens nerve paralysis. This is a serious but rare complication of middle ear infection that should be suspected in every patient with unilateral headache and abducens nerve palsy. We report a case of Gradenigo's syndrome in a 6-year-old boy.
    MeSH term(s) Abducens Nerve Diseases/diagnosis ; Child ; Humans ; Male ; Otitis Media/diagnosis ; Syndrome ; Trigeminal Neuralgia/diagnosis
    Language Spanish
    Publishing date 2010-06
    Publishing country Argentina
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 424449-7
    ISSN 1668-3501 ; 0325-0075 ; 0004-0487
    ISSN (online) 1668-3501
    ISSN 0325-0075 ; 0004-0487
    DOI 10.1590/S0325-00752010000300012
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  10. Article ; Online: A poor and delayed anti-SARS-CoV2 IgG response is associated to severe COVID-19 in children.

    Sananez, Inés / Raiden, Silvina C / Algieri, Silvia C / Uranga, Macarena / Grisolía, Nicolás A / Filippo, Daniela / De Carli, Norberto / Lalla, Sandra Di / Cairoli, Héctor / Chiolo, María J / Meregalli, Claudia N / Cohen, Emilia / Mosquera, Graciela / Marcó Del Pont, María / Giménez, Lorena I / Gregorio, Gabriela / Sarli, Mariam / Alcalde, Ana L / Davenport, Carolina /
    Bruera, María J / Simaz, Nancy / Pérez, Mariela F / Nivela, Valeria / Bayle, Carola / Alvarez, Laura / Revetria, María / Tuccillo, Patricia / Agosta, María T / Pérez, Hernán / Nova, Susana Villa / Suárez, Patricia / Takata, Eugenia M / García, Mariela / Lattner, Jorge / Rolón, María J / Coll, Patricia / Salvatori, Melina / Piccardo, Claudio / Russo, Constanza / Varese, Augusto / Seery, Vanesa / Holgado, María P / Polo, María L / Ceballos, Ana / Nuñez, Myriam / Penedo, Juan Martín Gómez / Ferrero, Fernando / Geffner, Jorge / Arruvito, Lourdes

    EBioMedicine

    2021  Volume 72, Page(s) 103615

    Abstract: Background: Most children and youth develop mild or asymptomatic disease during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, a very small number of patients suffer severe Coronavirus induced disease 2019 (COVID-19). ... ...

    Abstract Background: Most children and youth develop mild or asymptomatic disease during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, a very small number of patients suffer severe Coronavirus induced disease 2019 (COVID-19). The reasons underlying these different outcomes remain unknown.
    Methods: We analyzed three different cohorts: children with acute infection (n=550), convalescent children (n=138), and MIS-C (multisystem inflammatory syndrome in children, n=42). IgG and IgM antibodies to the spike protein of SARS-CoV-2, serum-neutralizing activity, plasma cytokine levels, and the frequency of circulating Follicular T helper cells (cTfh) and plasmablasts were analyzed by conventional methods.
    Findings: Fifty-eight percent of the children in the acute phase of infection had no detectable antibodies at the time of sampling while a seronegative status was found in 25% and 12% of convalescent and MIS-C children, respectively. When children in the acute phase of the infection were stratified according disease severity, we found that contrasting with the response of children with asymptomatic, mild and moderate disease, children with severe COVID-19 did not develop any detectable response. A defective antibody response was also observed in the convalescent cohort for children with severe disease at the time of admission. This poor antibody response was associated to both, a low frequency of cTfh and a high plasma concentration of inflammatory cytokines.
    Interpretation: A weak and delayed kinetic of antibody response to SARS-CoV-2 together with a systemic pro-inflammatory profile characterize pediatric severe COVID-19. Because comorbidities are highly prevalent in children with severe COVID-19, further studies are needed to clarify their contribution in the weak antibody response observed in severe disease.
    Funding: National Agency for Scientific and Technological Promotion from Argentina (IP-COVID-19-0277 and PMO-BID-PICT2018-2548).
    MeSH term(s) Antibodies, Viral/blood ; Antibody Formation ; Argentina ; COVID-19/blood ; COVID-19/complications ; COVID-19/immunology ; Child ; Child, Preschool ; Cytokines/blood ; Female ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Infant ; Male ; SARS-CoV-2/immunology ; Systemic Inflammatory Response Syndrome/blood ; Systemic Inflammatory Response Syndrome/immunology
    Chemical Substances Antibodies, Viral ; Cytokines ; Immunoglobulin G ; Immunoglobulin M
    Language English
    Publishing date 2021-10-11
    Publishing country Netherlands
    Document type Journal Article ; Observational Study
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2021.103615
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