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Article ; Online: Detection and localization of S

Nath, Madhwendra / Srivastava, Subodh / Kulshrestha, Niharika / Singh, Dilbag

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

2021 Volume 235, Issue 6, Page(s) 615–624

Abstract: ... made to detect and localize the major heart sounds, that is, S ...

Abstract	Adults born after 1970s are more prone to cardiovascular diseases. Death rate percentage is quite high due to heart related diseases. Therefore, there is necessity to enquire the problem or detection of heart diseases earlier for their proper treatment. As, Valvular heart disease, that is, stenosis and regurgitation of heart valve, are also a major cause of heart failure; which can be diagnosed at early-stage by detection and analysis of heart sound signal, that is, HS signal. In this proposed work, an attempt has been made to detect and localize the major heart sounds, that is, S
MeSH term(s)	Algorithms ; Heart ; Heart Auscultation ; Heart Sounds ; Humans ; Phonocardiography ; Signal Processing, Computer-Assisted
Language	English
Publishing date	2021-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1065942-0
ISSN	2041-3033 ; 0046-2039 ; 0954-4119
ISSN (online)	2041-3033
ISSN	0046-2039 ; 0954-4119
DOI	10.1177/0954411921998108
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Article ; Online: Visible-light-induced C-S bond formation in the synthesis of 2,4-disubstituted thiazoles through cascade difunctionalization of acetophenone: a greener approach.

Rajput, Khushbu / Singh, Vishal / Mahaur, Priya / Singh, Sundaram / Srivastava, Vandana

Organic & biomolecular chemistry

2024 Volume 22, Issue 14, Page(s) 2774–2779

Abstract: A groundbreaking approach has been developed for synthesizing 2,4-disubstituted thiazoles using an eco-friendly and metal-free approach. This novel method utilizes methyl aryl ketones, ...

Abstract	A groundbreaking approach has been developed for synthesizing 2,4-disubstituted thiazoles using an eco-friendly and metal-free approach. This novel method utilizes methyl aryl ketones,
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d4ob00096j
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Article ; Online: Bioinspired enantioselective total syntheses of antibacterial callistrilones enabled by double S

Dethe, Dattatraya H / Dherange, Balu D / Das, Saikat / Srivastava, Aparna

Chemical communications (Cambridge, England)

2022 Volume 58, Issue 36, Page(s) 5474–5477

Abstract: A bioinspired, catalytic approach to the enantioselective total syntheses of antibacterial callistrilones A, C-E and 13- ...

Abstract	A bioinspired, catalytic approach to the enantioselective total syntheses of antibacterial callistrilones A, C-E and 13-
MeSH term(s)	Alkenes ; Anti-Bacterial Agents/pharmacology ; Catalysis ; Lewis Acids ; Stereoisomerism
Chemical Substances	Alkenes ; Anti-Bacterial Agents ; Lewis Acids
Language	English
Publishing date	2022-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d2cc01398c
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Article ; Online: TORC1 mediated regulation of mitochondrial integrity and calcium ion homeostasis by Wat1/mLst8 in S. pombe.

Anjum, Simmi / Srivastava, Swati / Panigrahi, Lalita / Ansari, Uzair Ahmad / Trivedi, Arun Kumar / Ahmed, Shakil

International journal of biological macromolecules

2023 Volume 253, Issue Pt 3, Page(s) 126907

Abstract: The mTOR complexes play a fundamental role in mitochondrial biogenesis and cellular homeostasis. Wat1, an ortholog of mammalian Lst8 is an important component of TOR complex and is essential for the regulation of downstream signaling. Earlier we reported ...

Abstract	The mTOR complexes play a fundamental role in mitochondrial biogenesis and cellular homeostasis. Wat1, an ortholog of mammalian Lst8 is an important component of TOR complex and is essential for the regulation of downstream signaling. Earlier we reported the role of Wat1 in oxidative stress response. Here, we have shown that the abrogation of wat1 causes respiratory defects and mitochondrial depolarization that leads to a decrease in ATP production. The confocal and electron microscopy in wat1Δ cells revealed the fragmented mitochondrial morphology implying its role in mitochondrial fission. Furthermore, we also showed its role in autophagy and the maintenance of calcium ion homeostasis. Additionally, tor2-287 mutant cells also exhibit defects in mitochondrial integrity indicating the TORC1-dependent involvement of Wat1 in the maintenance of mitochondrial homeostasis. The interaction studies of Wat1 and Tor2 with Por1 and Mmm1 proteins revealed a plausible cross-talk between mitochondria and endoplasmic reticulum through the Mitochondria-associated membranes (MAM) and endoplasmic reticulum-mitochondria encounter structure (ERMES) complex, involving TORC1. Taken together, this study demonstrates the involvement of Wat1/mLst8 in harmonizing various mitochondrial functions, redox status, and Ca
MeSH term(s)	Animals ; Schizosaccharomyces ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Calcium/metabolism ; Mitochondria/metabolism ; Homeostasis ; Mammals
Chemical Substances	Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2023-09-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.126907
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Article ; Online: Genetic instability from a single S phase after whole-genome duplication.

Gemble, Simon / Wardenaar, René / Keuper, Kristina / Srivastava, Nishit / Nano, Maddalena / Macé, Anne-Sophie / Tijhuis, Andréa E / Bernhard, Sara Vanessa / Spierings, Diana C J / Simon, Anthony / Goundiam, Oumou / Hochegger, Helfrid / Piel, Matthieu / Foijer, Floris / Storchová, Zuzana / Basto, Renata

Nature

2022 Volume 604, Issue 7904, Page(s) 146–151

Abstract: Diploid and stable karyotypes are associated with health and fitness in animals. By contrast, whole-genome duplications-doublings of the entire complement of chromosomes-are linked to genetic instability and frequently found in human ... ...

Abstract	Diploid and stable karyotypes are associated with health and fitness in animals. By contrast, whole-genome duplications-doublings of the entire complement of chromosomes-are linked to genetic instability and frequently found in human cancers
MeSH term(s)	Chromosomal Instability/genetics ; DNA Damage ; DNA Replication ; Gene Duplication ; Humans ; Karyotype ; Mitosis ; S Phase/genetics ; Tetraploidy
Language	English
Publishing date	2022-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-04578-4
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Article ; Online: Impact of Environmental Pollutants on Alzheimer’s Disease

Yogyata Srivastava, Abhishek Chauhan, S. B. Singh and Tanu Jindal

Nature Environment and Pollution Technology, Vol 21, Iss 4, Pp 1689-

A Review

2022 Volume 1695

Abstract: ... that exposure to many environmental pollutants increases the risk of Alzheimer’s disease (AD). Pollutants like PM 10, PM2.5, and ... Alzheimer’s disease, The different sources of pollution and their effect on various stages of human life ...

Abstract	Environmental pollution is one of the major concerns as it affects public health and is responsible for various neurological disorders too. Neurological disorders are governed by many different factors - they can be genetic, based on lifestyle, or environmental. In many recent studies, it has been observed that exposure to many environmental pollutants increases the risk of Alzheimer’s disease (AD). Pollutants like PM 10, PM2.5, and some other ultrafine nanoparticles, lipophilic vaporized toxicant (acrolein) can easily reach the brain by crossing the blood-brain barrier after it they can activate the innate immune responses inside the target site like neurons, astrocytes, and microglia by this way they can be neurotoxic. Human epidemiological evidence proves that there is a correlation between environmental pollutants and neurological disorders like dysfunction of mitochondrial, oxidative stress, disruption in the myelin sheath, the blood-brain barrier anatomy alterations, and endoplasmic reticulum stress which direct towards cognitive impairment with lower quality of lifestyle. The review article aims to culminate the correlation between the environmental factors and Alzheimer’s disease, The different sources of pollution and their effect on various stages of human life, developmental neurotoxicity, and neurological disorders also have been discussed.
Keywords	alzheimer’s disease ; pm10 ; pm2.5 ; nanoparticles ; lipophilic vaporized toxicants ; Environmental effects of industries and plants ; TD194-195 ; Science (General) ; Q1-390
Subject code	333
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Technoscience Publications
Document type	Article ; Online
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Article ; Online: Unraveling the terpene synthase family and characterization of BsTPS2 contributing to (S)-( +)-linalool biosynthesis in Boswellia.

Bhargav, Pravesh / Chaurasia, Seema / Kumar, Aashish / Srivastava, Gaurav / Pant, Yatish / Chanotiya, Chandan Singh / Ghosh, Sumit

Plant molecular biology

2023 Volume 113, Issue 4-5, Page(s) 219–236

Abstract: ... FPP into (S)-( +)-linalool and (E)-(-)-nerolidol, respectively, in vitro assays. However, BsTPS2 ... BsTPS2, which is involved in wound-induced biosynthesis of (S)-( +)-linalool, a monoterpene resin ...

Abstract	Boswellia tree bark exudes oleo-gum resin in response to wounding, which is rich in terpene volatiles. But, the molecular and biochemical basis of wound-induced formation of resin volatiles remains poorly understood. Here, we combined RNA-sequencing (RNA-seq) and metabolite analysis to unravel the terpene synthase (TPS) family contributing to wound-induced biosynthesis of resin volatiles in B. serrata, an economically-important Boswellia species. The analysis of large-scale RNA-seq data of bark and leaf samples representing more than 600 million sequencing reads led to the identification of 32 TPSs, which were classified based on phylogenetic relationship into various TPSs families found in angiosperm species such as TPS-a, b, c, e/f, and g. Moreover, RNA-seq analysis of bark samples collected at 0-24 h post-wounding shortlisted 14 BsTPSs that showed wound-induced transcriptional upregulation in bark, suggesting their important role in wound-induced biosynthesis of resin volatiles. Biochemical characterization of a bark preferentially-expressed and wound-inducible TPS (BsTPS2) in vitro and in planta assays revealed its involvement in resin terpene biosynthesis. Bacterially-expressed recombinant BsTPS2 catalyzed the conversion of GPP and FPP into (S)-( +)-linalool and (E)-(-)-nerolidol, respectively, in vitro assays. However, BsTPS2 expression in Nicotiana benthamiana found that BsTPS2 is a plastidial linalool synthase. In contrast, cytosolic expression of BsTPS2 did not form any product. Overall, the present work unraveled a suite of TPSs that potentially contributed to the biosynthesis of resin volatiles in Boswellia and biochemically characterized BsTPS2, which is involved in wound-induced biosynthesis of (S)-( +)-linalool, a monoterpene resin volatile with a known role in plant defense.
MeSH term(s)	Humans ; Boswellia/genetics ; Boswellia/metabolism ; Phylogeny ; Terpenes/metabolism ; Alkyl and Aryl Transferases/genetics
Chemical Substances	linalool (D81QY6I88E) ; terpene synthase (EC 2.5.1.-) ; Terpenes ; Alkyl and Aryl Transferases (EC 2.5.-)
Language	English
Publishing date	2023-10-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	778032-1
ISSN	1573-5028 ; 0167-4412
ISSN (online)	1573-5028
ISSN	0167-4412
DOI	10.1007/s11103-023-01384-y
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Article ; Online: Author Correction: Stripe rust resistance gene(s) postulation in wheat germplasm with the help of differentials and tagged molecular markers.

Haider, Mohammad Waris / Kaur, Jaspal / Bala, Ritu / Singh, Sandeep / Srivastava, Puja / Sharma, Achla / Singh, Rohtas / Kumari, Jyoti

Scientific reports

2023 Volume 13, Issue 1, Page(s) 10176

Language	English
Publishing date	2023-06-22
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-37367-8
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Article ; Online: Stripe rust resistance gene(s) postulation in wheat germplasm with the help of differentials and tagged molecular markers.

Haider, Mohammad Waris / Kaur, Jaspal / Bala, Ritu / Singh, Sandeep / Srivastava, Puja / Sharma, Achla / Singh, Rohtas / Kumari, Jyoti

Scientific reports

2023 Volume 13, Issue 1, Page(s) 9007

Abstract: Thirteen known Yr gene-associated markers pertaining to genes (Yr5, Yr10, Yr15, Yr24/Yr26) were used to identify the genes in selected wheat germplasm which were found resistant under field conditions at two locations in Punjab, India against stripe rust. ...

Abstract	Thirteen known Yr gene-associated markers pertaining to genes (Yr5, Yr10, Yr15, Yr24/Yr26) were used to identify the genes in selected wheat germplasm which were found resistant under field conditions at two locations in Punjab, India against stripe rust. In field evaluation, 38 genotypes exhibited highly resistant response, with a final rust severity (FRS) ranging from 0 to TR. Seven genotypes expressed a resistant to moderately resistant response with FRS ranging from 5MR-10S. In race-specific phenotying against most prevalent pathotypes of Puccinia striiformis tritici (46S119,110S119 &238S119) by seedling reaction test (SRT) 14 genotypes (29.2%) were found to be immune (IT = 0), 28 genotypes (58.3%) were resistant (IT = 1), and 3 genotypes (6.3%) were moderately resistant (IT = 2). Yr5 was detected in sixteen lines with the help of two markers Xwmc175 and Xgwm120 linked with Yr5. Yr10 was detected in ten lines with the marker Xpsp3000 and Yr15 was detected in fourteen lines with two linked markers; Xgwm413 and Xgwm273. Likewise, Yr24/26 was detected in 15 lines with two linked markers, namely Xbarc181 and Xbarc187. Based on the race specific phenotyping data and marker data, fourteen lines were found to carry a single gene, 16 showed the presence of two gene combinations, and seven genotypes were found to have a combination of three genes. Frequencies of Yr5, Yr15 and Yr26/Yr24 was high among test wheat germplasm in comparison to Yr10.
MeSH term(s)	Triticum/genetics ; Plant Diseases/genetics ; Genetic Markers ; Genotype ; Basidiomycota/genetics ; Disease Resistance/genetics
Chemical Substances	Genetic Markers
Language	English
Publishing date	2023-06-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-36197-y
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Article ; Online: Observation of D_{s}^{±}/D^{0} Enhancement in Au+Au Collisions at sqrt[s_{NN}]=200 GeV.

Adam, J / Adamczyk, L / Adams, J R / Adkins, J K / Agakishiev, G / Aggarwal, M M / Ahammed, Z / Alekseev, I / Anderson, D M / Aparin, A / Aschenauer, E C / Ashraf, M U / Atetalla, F G / Attri, A / Averichev, G S / Bairathi, V / Barish, K / Behera, A / Bellwied, R /

Bhasin, A / Bielcik, J / Bielcikova, J / Bland, L C / Bordyuzhin, I G / Brandenburg, J D / Brandin, A V / Butterworth, J / Caines, H / Calderón de la Barca Sánchez, M / Cebra, D / Chakaberia, I / Chaloupka, P / Chan, B K / Chang, F-H / Chang, Z / Chankova-Bunzarova, N / Chatterjee, A / Chen, D / Chen, J / Chen, J H / Chen, X / Chen, Z / Cheng, J / Cherney, M / Chevalier, M / Choudhury, S / Christie, W / Chu, X / Crawford, H J / Csanád, M / Daugherity, M / Dedovich, T G / Deppner, I M / Derevschikov, A A / Didenko, L / Dong, X / Drachenberg, J L / Dunlop, J C / Edmonds, T / Elsey, N / Engelage, J / Eppley, G / Esumi, S / Evdokimov, O / Ewigleben, A / Eyser, O / Fatemi, R / Fazio, S / Federic, P / Fedorisin, J / Feng, C J / Feng, Y / Filip, P / Finch, E / Fisyak, Y / Francisco, A / Fu, C / Fulek, L / Gagliardi, C A / Galatyuk, T / Geurts, F / Ghimire, N / Gibson, A / Gopal, K / Gou, X / Grosnick, D / Guryn, W / Hamad, A I / Hamed, A / Harabasz, S / Harris, J W / He, S / He, W / He, X / He, Y / Heppelmann, S / Herrmann, N / Hoffman, E / Holub, L / Hong, Y / Horvat, S / Hu, Y / Huang, H Z / Huang, S L / Huang, T / Huang, X / Humanic, T J / Huo, P / Igo, G / Isenhower, D / Jacobs, W W / Jena, C / Jentsch, A / Ji, Y / Jia, J / Jiang, K / Jowzaee, S / Ju, X / Judd, E G / Kabana, S / Kabir, M L / Kagamaster, S / Kalinkin, D / Kang, K / Kapukchyan, D / Kauder, K / Ke, H W / Keane, D / Kechechyan, A / Kelsey, M / Khyzhniak, Y V / Kikoła, D P / Kim, C / Kimelman, B / Kincses, D / Kinghorn, T A / Kisel, I / Kiselev, A / Kocan, M / Kochenda, L / Kosarzewski, L K / Kramarik, L / Kravtsov, P / Krueger, K / Kulathunga Mudiyanselage, N / Kumar, L / Kumar, S / Kunnawalkam Elayavalli, R / Kwasizur, J H / Lacey, R / Lan, S / Landgraf, J M / Lauret, J / Lebedev, A / Lednicky, R / Lee, J H / Leung, Y H / Li, C / Li, W / Li, X / Li, Y / Liang, Y / Licenik, R / Lin, T / Lin, Y / Lisa, M A / Liu, F / Liu, H / Liu, P / Liu, T / Liu, X / Liu, Y / Liu, Z / Ljubicic, T / Llope, W J / Longacre, R S / Lukow, N S / Luo, S / Luo, X / Ma, G L / Ma, L / Ma, R / Ma, Y G / Magdy, N / Majka, R / Mallick, D / Margetis, S / Markert, C / Matis, H S / Mazer, J A / Minaev, N G / Mioduszewski, S / Mohanty, B / Mooney, I / Moravcova, Z / Morozov, D A / Nagy, M / Nam, J D / Nasim, Md / Nayak, K / Neff, D / Nelson, J M / Nemes, D B / Nie, M / Nigmatkulov, G / Niida, T / Nogach, L V / Nonaka, T / Nunes, A S / Odyniec, G / Ogawa, A / Oh, S / Okorokov, V A / Page, B S / Pak, R / Pandav, A / Panebratsev, Y / Pawlik, B / Pawlowska, D / Pei, H / Perkins, C / Pinsky, L / Pintér, R L / Pluta, J / Pokhrel, B R / Porter, J / Posik, M / Pruthi, N K / Przybycien, M / Putschke, J / Qiu, H / Quintero, A / Radhakrishnan, S K / Ramachandran, S / Ray, R L / Reed, R / Ritter, H G / Rogachevskiy, O V / Romero, J L / Ruan, L / Rusnak, J / Sahoo, N R / Sako, H / Salur, S / Sandweiss, J / Sato, S / Schmidke, W B / Schmitz, N / Schweid, B R / Seck, F / Seger, J / Sergeeva, M / Seto, R / Seyboth, P / Shah, N / Shahaliev, E / Shanmuganathan, P V / Shao, M / Sheikh, A I / Shen, W Q / Shi, S S / Shi, Y / Shou, Q Y / Sichtermann, E P / Sikora, R / Simko, M / Singh, J / Singha, S / Smirnov, N / Solyst, W / Sorensen, P / Spinka, H M / Srivastava, B / Stanislaus, T D S / Stefaniak, M / Stewart, D J / Strikhanov, M / Stringfellow, B / Suaide, A A P / Sumbera, M / Summa, B / Sun, X M / Sun, X / Sun, Y / Surrow, B / Svirida, D N / Szymanski, P / Tang, A H / Tang, Z / Taranenko, A / Tarnowsky, T / Thomas, J H / Timmins, A R / Tlusty, D / Tokarev, M / Tomkiel, C A / Trentalange, S / Tribble, R E / Tribedy, P / Tripathy, S K / Tsai, O D / Tu, Z / Ullrich, T / Underwood, D G / Upsal, I / Van Buren, G / Vanek, J / Vasiliev, A N / Vassiliev, I / Videbæk, F / Vokal, S / Voloshin, S A / Wang, F / Wang, G / Wang, J S / Wang, P / Wang, Y / Wang, Z / Webb, J C / Weidenkaff, P C / Wen, L / Westfall, G D / Wieman, H / Wissink, S W / Witt, R / Wu, Y / Xiao, Z G / Xie, G / Xie, W / Xu, H / Xu, N / Xu, Q H / Xu, Y F / Xu, Y / Xu, Z / Yang, C / Yang, Q / Yang, S / Yang, Y / Yang, Z / Ye, Z / Yi, L / Yip, K / Yu, Y / Zbroszczyk, H / Zha, W / Zhang, C / Zhang, D / Zhang, S / Zhang, X P / Zhang, Y / Zhang, Z J / Zhang, Z / Zhao, J / Zhong, C / Zhou, C / Zhu, X / Zhu, Z / Zurek, M / Zyzak, M

Physical review letters

2021 Volume 127, Issue 9, Page(s) 92301

Abstract: We report on the first measurement of charm-strange meson D_{s}^{±} production at midrapidity ... in Au+Au collisions at sqrt[s_{NN}]=200 GeV from the STAR experiment. The yield ratio between strange (D ... _{s}^{±}) and nonstrange (D^{0}) open-charm mesons is presented and compared to model calculations ...

Abstract	We report on the first measurement of charm-strange meson D_{s}^{±} production at midrapidity in Au+Au collisions at sqrt[s_{NN}]=200 GeV from the STAR experiment. The yield ratio between strange (D_{s}^{±}) and nonstrange (D^{0}) open-charm mesons is presented and compared to model calculations. A significant enhancement, relative to a pythia simulation of p+p collisions, is observed in the D_{s}^{±}/D^{0} yield ratio in Au+Au collisions over a large range of collision centralities. Model calculations incorporating abundant strange-quark production in the quark-gluon plasma and coalescence hadronization qualitatively reproduce the data. The transverse-momentum integrated yield ratio of D_{s}^{±}/D^{0} at midrapidity is consistent with a prediction from a statistical hadronization model with the parameters constrained by the yields of light and strange hadrons measured at the same collision energy. These results suggest that the coalescence of charm quarks with strange quarks in the quark-gluon plasma plays an important role in D_{s}^{±}-meson production in heavy-ion collisions.
Language	English
Publishing date	2021-09-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.127.092301
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