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Article ; Online: Neurobiological basis of emergence from anesthesia.

Song, Xue-Jun / Hu, Jiang-Jian

2024

Abstract: The suppression of consciousness by anesthetics and the emergence of the brain from anesthesia are complex and elusive processes. Anesthetics may exert their inhibitory effects by binding to specific protein targets or through membrane-mediated targets, ... ...

Abstract	The suppression of consciousness by anesthetics and the emergence of the brain from anesthesia are complex and elusive processes. Anesthetics may exert their inhibitory effects by binding to specific protein targets or through membrane-mediated targets, disrupting neural activity and the integrity and function of neural circuits responsible for signal transmission and conscious perception/subjective experience. Emergence from anesthesia was generally thought to depend on the elimination of the anesthetic from the body. Recently, studies have suggested that emergence from anesthesia is a dynamic and active process that can be partially controlled and is independent of the specific molecular targets of anesthetics. This article summarizes the fundamentals of anesthetics' actions in the brain and the mechanisms of emergence from anesthesia that have been recently revealed in animal studies.
Language	English
Publishing date	2024-03-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	282488-7
ISSN	1878-108X ; 0378-5912 ; 0166-2236
ISSN (online)	1878-108X
ISSN	0378-5912 ; 0166-2236
DOI	10.1016/j.tins.2024.02.006
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Zs.A 1442: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Diabetic Neuropathic Pain: Directions for Exploring Treatments.

Chen, Yuchen / Song, Xue-Jun

Biomedicines

2024 Volume 12, Issue 3

Abstract: Diabetic neuropathic pain (DNP) is one of the common and severe late-stage complications of diabetes mellitus, which could greatly influence the patients' quality of life. Patients with DNP often experience spontaneous pain and evoked pain such as ... ...

Abstract	Diabetic neuropathic pain (DNP) is one of the common and severe late-stage complications of diabetes mellitus, which could greatly influence the patients' quality of life. Patients with DNP often experience spontaneous pain and evoked pain such as mechanical allodynia and thermal hyperalgesia, meaning that their physical and psychological health are severely impaired. Unfortunately, the mechanisms of DNP remain highly elusive, so substantial breakthrough in effective DNP targeted treatments is still clinically challenging. This article will hence summarise the main mechanisms currently known to underlie DNP pathogenesis, along with describing some of the current and potential treatment methods against diabetic neuropathic pain.
Language	English
Publishing date	2024-03-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12030589
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Article ; Online: Vitamins in neuropathy: pathophysiological and therapeutic roles.

Chen, Peng / Song, Xue-Jun

Current opinion in neurology

2023 Volume 36, Issue 5, Page(s) 388–393

Abstract: Purpose of review: Vitamin deficiency is a risk factor in the development of peripheral neuropathy, which leads to complex and severe diseases. This review provides an update overview of the literature on the roles of vitamins in peripheral neuropathy, ... ...

Abstract	Purpose of review: Vitamin deficiency is a risk factor in the development of peripheral neuropathy, which leads to complex and severe diseases. This review provides an update overview of the literature on the roles of vitamins in peripheral neuropathy, highlighting their pathophysiological and therapeutic roles. Recent findings: The importance and clinical manifestations and implications of the vitamins and vitamin deficiencies are further demonstrated in peripheral neuropathy and the associated diseases. Vitamin deficiency is common in various severe and complex diseases such as diabetes, chemotherapy, acute nutritional axonal neuropathy, dermatitis, complex regional pain syndrome, postherpetic neuralgia, carpal tunnel syndrome, and so forth and some rare clinical case reports. There is evidence that deficiencies of almost all vitamins are associated with diabetic neuropathy. Vitamin supplementation may serve as an effective therapeutic strategy. Summary: The vitamins play critical roles in maintaining physiological functions, and vitamin deficiencies cause peripheral neuropathy with various severe and complex diseases. The therapeutic benefits of vitamins and further understanding of the mechanisms for vitamin treatment effects should be emphasized and highlighted. More clinical trials are needed to establish optimal treatment strategies for vitamins in the various neuropathies. A large range of people/patients screening for vitamin deficiencies may be considered in order to provide early diagnosis and timely medical assistance.
MeSH term(s)	Humans ; Vitamins/therapeutic use ; Vitamin A ; Vitamin K ; Diabetic Neuropathies ; Risk Factors
Chemical Substances	Vitamins ; Vitamin A (11103-57-4) ; Vitamin K (12001-79-5)
Language	English
Publishing date	2023-07-31
Publishing country	England
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1182686-1
ISSN	1473-6551 ; 1350-7540
ISSN (online)	1473-6551
ISSN	1350-7540
DOI	10.1097/WCO.0000000000001194
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Zs.A 2524: Show issues

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Article: [Heavy metal exposure and reproductive toxicity: Advances in studies].

Sheng, Zheng-Cheng / Xu, Song / Shang, Xue-Jun

Zhonghua nan ke xue = National journal of andrology

2023 Volume 29, Issue 2, Page(s) 181–185

Abstract: Heavy metals are among the major pollutants affecting the environment, with a higher density of metal element than that of water and an extensive presence in the natural environment. Trace elements such as zinc, copper, nickel and chromium mediate ... ...

Abstract	Heavy metals are among the major pollutants affecting the environment, with a higher density of metal element than that of water and an extensive presence in the natural environment. Trace elements such as zinc, copper, nickel and chromium mediate important physiological functions and metabolic regulation at normal levels, and insufficient intake of them will lead to related diseases. Heavy metals such as cadmium, lead and mercury do not participate in the normal metabolism of the human body and will cause damage to the body even at an extremely low dose. Heavy metal pollution mainly comes from industrial wastewater, fossil fuel combustion, wastewater, smelting, mining, vehicle exhaust, hazardous waste dumping, and fertilizer abuse. Unable to be biodegraded, heavy metals have a long biological half-life in nature, which in turn leads to bio-accumulation and -amplification. Eating contaminated vegetables is one way of being exposed to heavy metals. Heavy metals produce adverse effects not only on the human reproductive system, but also on the fetus by penetrating the placental barrier, and on the hypothalamic-pituitary-gonadal axis as well, consequently affecting sexual maturation and reproductive function. With the sharp increase of heavy metals in the environment, researches on their reproductive toxicity and antagonistic drugs have an important clinical significance.
MeSH term(s)	Female ; Pregnancy ; Humans ; Wastewater ; Placenta/chemistry ; Placenta/metabolism ; Metals, Heavy/toxicity ; Metals, Heavy/analysis ; Mercury/toxicity ; Cadmium
Chemical Substances	Wastewater ; Metals, Heavy ; Mercury (FXS1BY2PGL) ; Cadmium (00BH33GNGH)
Language	Chinese
Publishing date	2023-10-17
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
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Article ; Online: The evolution of ephemeral flora in Xinjiang, China: insights from plastid phylogenomic analyses of Brassicaceae.

Xiao, Tian-Wen / Song, Feng / Vu, Duc Quy / Feng, Ying / Ge, Xue-Jun

BMC plant biology

2024 Volume 24, Issue 1, Page(s) 111

Abstract: Background: The ephemeral flora of northern Xinjiang, China, plays an important role in the desert ecosystems. However, the evolutionary history of this flora remains unclear. To gain new insights into its origin and evolutionary dynamics, we ... ...

Abstract	Background: The ephemeral flora of northern Xinjiang, China, plays an important role in the desert ecosystems. However, the evolutionary history of this flora remains unclear. To gain new insights into its origin and evolutionary dynamics, we comprehensively sampled ephemeral plants of Brassicaceae, one of the essential plant groups of the ephemeral flora. Results: We reconstructed a phylogenetic tree using plastid genomes and estimated their divergence times. Our results indicate that ephemeral species began to colonize the arid areas in north Xinjiang during the Early Miocene and there was a greater dispersal of ephemeral species from the surrounding areas into the ephemeral community of north Xinjiang during the Middle and Late Miocene, in contrast to the Early Miocene or Pliocene periods. Conclusions: Our findings, together with previous studies, suggest that the ephemeral flora originated in the Early Miocene, and species assembly became rapid from the Middle Miocene onwards, possibly attributable to global climate changes and regional geological events.
MeSH term(s)	Phylogeny ; Ecosystem ; Brassicaceae/genetics ; China ; Plastids/genetics
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2059868-3
ISSN	1471-2229 ; 1471-2229
ISSN (online)	1471-2229
ISSN	1471-2229
DOI	10.1186/s12870-024-04796-0
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Article ; Online: B vitamins as a treatment for diabetic pain and neuropathy.

Karaganis, Stephen / Song, Xue-Jun

Journal of clinical pharmacy and therapeutics

2021 Volume 46, Issue 5, Page(s) 1199–1212

Abstract: What is known and objective: B vitamin therapy is a common treatment for diabetic pain and neuropathy, yet its use remains controversial in patients lacking B vitamin deficiencies. The aim of this review was to summarize the current evidence for the ... ...

Abstract	What is known and objective: B vitamin therapy is a common treatment for diabetic pain and neuropathy, yet its use remains controversial in patients lacking B vitamin deficiencies. The aim of this review was to summarize the current evidence for the efficacy of B vitamin therapy in diabetic patients with neuropathy. Comment: We screened the English literature for clinical studies evaluating B vitamins as a therapy for pain and neuropathy in diabetic patients. We selected 43 relevant studies for qualitative analysis based on our selection criteria. Our survey of the literature revealed substantive heterogeneity with respect to efficacies of reported outcomes, as well as study design. Most beneficial outcomes were reported against baseline measures, with few positive comparisons against placebo. This highlights the need for larger, placebo-controlled studies. What is new and conclusion: B vitamins should be considered a plausible therapy for diabetic neuropathy, but its overall efficacy remains uncertain and requires further study.
MeSH term(s)	Chronic Pain/drug therapy ; Diabetic Neuropathies/drug therapy ; Drug Combinations ; Humans ; Vitamin B Complex/therapeutic use
Chemical Substances	Drug Combinations ; Vitamin B Complex (12001-76-2)
Language	English
Publishing date	2021-02-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639006-7
ISSN	1365-2710 ; 0269-4727
ISSN (online)	1365-2710
ISSN	0269-4727
DOI	10.1111/jcpt.13375
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Article: Characterization of Inflammatory Signals in BV-2 Microglia in Response to Wnt3a.

Li, Cheng / Wu, Ying / Huang, Ming-Yue / Song, Xue-Jun

Biomedicines

2023 Volume 11, Issue 4

Abstract: Activation of microglia is one of the pathological bases of neuroinflammation, which involves various diseases of the central nervous system. Inhibiting the inflammatory activation of microglia is a therapeutic approach to neuroinflammation. In this ... ...

Abstract	Activation of microglia is one of the pathological bases of neuroinflammation, which involves various diseases of the central nervous system. Inhibiting the inflammatory activation of microglia is a therapeutic approach to neuroinflammation. In this study, we report that activation of the Wnt/β-catenin signaling pathway in a model of neuroinflammation in Lipopolysaccharide (LPS)/IFN-γ-stimulated BV-2 cells can result in inhibition of production of nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). Activation of the Wnt/β-catenin signaling pathway also results in inhibition of the phosphorylation of nuclear factor-κB (NF-κB) and extracellular signal-regulated kinase (ERK) in the LPS/IFN-γ-stimulated BV-2 cells. These findings indicate that activation of the Wnt/β-catenin signaling pathway can inhibit neuroinflammation through downregulating the pro-inflammatory cytokines including iNOS, TNF-α, and IL-6, and suppress NF-κB/ERK-related signaling pathways. In conclusion, this study indicates that the Wnt/β-catenin signaling activation may play an important role in neuroprotection in certain neuroinflammatory diseases.
Language	English
Publishing date	2023-04-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11041121
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Article: Comparison of pediatric pelvic fractures and associated injuries caused by different types of road traffic accidents.

Song, Bao-Jian / Wang, Qiang / Feng, Wei / Zhu, Dan-Jiang / Zhang, Xue-Jun

Chinese journal of traumatology = Zhonghua chuang shang za zhi

2024

Abstract: Purpose: To explore the clinical characteristics of pediatric pelvic fracturs caused by traffic accidents and to analyze the accompanying injuries and complications.: Methods: A total of 222 cases involved traffic accidents was enrolled in this case- ... ...

Abstract	Purpose: To explore the clinical characteristics of pediatric pelvic fracturs caused by traffic accidents and to analyze the accompanying injuries and complications. Methods: A total of 222 cases involved traffic accidents was enrolled in this case-control study. The data of children with pelvic fractures caused by traffic accidents who were admitted to our hospital from January 2006 to December 2021 were analyzed retrospectively. Sex, age, Tile classification, abbreviated injury scale score, injury severity score, mortality, and accompanying injuries were studied. The ANOVA was used for measurement data, and the non-parametric rank sum test was used for non-normally distributed data. The Fisher's exact probability method was used for the count data. Results: Of all enrolled cases, 140 are boys and 82 are girls, including 144 aged < 6 years, 65 aged between 6 and 12 years, and 13 aged > 12 years. Depending on the injury mechanism, there are 15 cases involving pedestrians vs. motorcycles (PVM), 91 cases involving pedestrians vs. passenger cars (PVC), 78 cases involving pedestrians vs. commercial vehicles (PVV), and 38 cases involving motor vehicles vs. motor vehicles (MVM). Associated injuries are reported in 198 cases (89.2%), primarily involving the abdomen injury in 144 cases (64.9%), and lower limb injury in 99 cases (44.6%). PVV injury involves longer hospital stay (p = 0.004). Intensive care unit admission rate is significantly higher in the MVM group than in other groups (p = 0.004). Head injury (p = 0.001) and face injury (p = 0.037) are more common in the MVM group, whereas abdominal injury (p = 0.048) and lower limb injury (p = 0.037) are more common in the PVV group. In the MVM group, the brain injury (p = 0.004) and femoral neck injury (p = 0.044) are more common. In the PVM group, the mediastinum (p = 0.004), ear (p = 0.009), lumbar vertebrae (p = 0.008), and spinal cord (p = 0.011) are the most vulnerable regions, while in the PVV group, the perineum (p < 0.001), urethra (p = 0.001), rectum (p = 0.006), anus (p = 0.004), and lower limb soft tissues (p = 0.024) are the most vulnerable regions. Children aged > 12 years have higher pelvic abbreviated injury scale scores (p = 0.019). There are significant differences in the classification of pelvic fractures among children < 6, 6 - 12, and > 12 years of age, with Tile C being more likely to occur in children > 12 years of age (p = 0.033). Children aged > 12 years are more likely to sustain injuries to the spleen (p = 0.022), kidneys (p = 0.019), pancreas (p < 0.001), lumbar vertebrae (p = 0.013), and sacrum (p = 0.024). The MVM group has the highest complication rate (p = 0.003). Conclusion: PVC is the leading cause of the abdomen and lower extremities injury and has the most concomitant injuries. Different traffic injuries often lead to different associated injuries. Older children are more likely to sustain more severe pelvic fractures and peripelvic organs injuries. The MVM group has the highest extent of injury and complication rates.
Language	English
Publishing date	2024-01-26
Publishing country	China
Document type	Journal Article
ZDB-ID	2276839-7
ISSN	1008-1275
ISSN	1008-1275
DOI	10.1016/j.cjtee.2024.01.005
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Article: [Trace elements and sperm quality: An update].

Zhao, Xiao-Dong / Wang, Zu-Heng / Shang, Xue-Jun / Xu, Song

Zhonghua nan ke xue = National journal of andrology

2023 Volume 28, Issue 10, Page(s) 935–940

Abstract: With changes in the modes of life and work, infertility is becoming a serious international problem. The incidence of infertility is 10－15% of the couples of childbearing age in China and is increasing year by year, and 30－50% of the cases are related to ...

Abstract	With changes in the modes of life and work, infertility is becoming a serious international problem. The incidence of infertility is 10－15% of the couples of childbearing age in China and is increasing year by year, and 30－50% of the cases are related to male factors. Trace elements refer to the chemical elements that account for less than 1/10,000 of the total weight of the human body, of which less than 100 mg is required per person per day. They are important biochemical components in the semen. Trace elements are essential for normal spermatogenesis, sperm maturation and capacitation, and maintenance of normal sperm function, though sperm quality can be affected by genetic, epigenetic, environmental and lifestyle-related factors. This focuses on the latest progress in the studies of the effects of trace elements on sperm quality.
MeSH term(s)	Male ; Humans ; Trace Elements ; Semen ; Spermatozoa ; Semen Analysis ; Infertility ; Infertility, Male/epidemiology ; Sperm Motility
Chemical Substances	Trace Elements
Language	Chinese
Publishing date	2023-10-15
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
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Article ; Online: Seroprevalence of SARS-CoV-2 neutralising antibodies and cross-reactivity to JN.1 one year after the BA.5/BF.7 wave in China.

Song, Xue-Dong / Yang, Guo-Jian / Jiang, Xiao-Lin / Wang, Xue-Jun / Zhang, Yu-Wei / Wu, Jie / Wang, Ming-Ming / Chen, Rui-Rui / He, Xue-Juan / Dong, Gang / Ma, Mai-Juan

The Lancet regional health. Western Pacific

2024 Volume 44, Page(s) 101040

Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Journal Article
ISSN	2666-6065
ISSN (online)	2666-6065
DOI	10.1016/j.lanwpc.2024.101040
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