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  1. Book: Back pain

    Chong, Sam / Cregg, Roman / Souter, Andrew

    (Oxford pain management library)

    2012  

    Author's details ed. by Andrew Souter ; RomasCregg ; Sam Chong
    Series title Oxford pain management library
    Keywords Backache ; Backache--Treatment
    Language English
    Size XII, 159 S. : Ill., graph. Darst., 18 cm
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT017401565
    ISBN 978-0-19-960977-2 ; 0-19-960977-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 3887 order for loan Magazin

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  2. Article ; Online: Is gabapentin effective for women with unexplained chronic pelvic pain?

    Horne, Andrew W / Vincent, Katy / Cregg, Roman / Daniels, Jane

    BMJ (Clinical research ed.)

    2017  Volume 358, Page(s) j3520

    MeSH term(s) Amines/therapeutic use ; Analgesics/therapeutic use ; Chronic Pain/drug therapy ; Cyclohexanecarboxylic Acids/therapeutic use ; Female ; Gabapentin ; Humans ; Pelvic Pain/drug therapy ; Randomized Controlled Trials as Topic ; gamma-Aminobutyric Acid/therapeutic use
    Chemical Substances Amines ; Analgesics ; Cyclohexanecarboxylic Acids ; gamma-Aminobutyric Acid (56-12-2) ; Gabapentin (6CW7F3G59X)
    Language English
    Publishing date 2017-09-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.j3520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Postoperative pain management.

    Stasiowska, Maria K / Ng, Su Cheen / Gubbay, Anthony N / Cregg, Roman

    British journal of hospital medicine (London, England : 2005)

    2015  Volume 76, Issue 10, Page(s) 570–575

    Abstract: This article provides an overview of current methods used in acute pain management and explains why effective analgesia is crucial in the early postoperative period. It describes the pharmacology of both common and specialist analgesics, as well as ... ...

    Abstract This article provides an overview of current methods used in acute pain management and explains why effective analgesia is crucial in the early postoperative period. It describes the pharmacology of both common and specialist analgesics, as well as explaining the role and uses of regional and neuraxial analgesia, for the non-anaesthetist.
    MeSH term(s) Acetaminophen/therapeutic use ; Amines/therapeutic use ; Analgesics/therapeutic use ; Analgesics, Non-Narcotic/therapeutic use ; Analgesics, Opioid/therapeutic use ; Anesthesia, Conduction/methods ; Anesthetics, Local/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Cyclohexanecarboxylic Acids/therapeutic use ; Humans ; Pain Management ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control ; Pregabalin/therapeutic use ; gamma-Aminobutyric Acid/therapeutic use
    Chemical Substances Amines ; Analgesics ; Analgesics, Non-Narcotic ; Analgesics, Opioid ; Anesthetics, Local ; Anti-Inflammatory Agents, Non-Steroidal ; Cyclohexanecarboxylic Acids ; Acetaminophen (362O9ITL9D) ; Pregabalin (55JG375S6M) ; gamma-Aminobutyric Acid (56-12-2) ; gabapentin (6CW7F3G59X)
    Language English
    Publishing date 2015-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2015.76.10.570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Pharmacogenetics of analgesic drugs.

    Cregg, Roman / Russo, Giovanna / Gubbay, Anthony / Branford, Ruth / Sato, Hiroe

    British journal of pain

    2015  Volume 7, Issue 4, Page(s) 189–208

    Abstract: Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined. • Analgesics act in various ways on the peripheral and central pain pathways and are regarded ... ...

    Abstract • Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined. • Analgesics act in various ways on the peripheral and central pain pathways and are regarded as one of the most valuable but equally dangerous groups of medications. • While pharmacokinetic properties of drugs, metabolism in particular, have been scrutinised by genotype-phenotype correlation studies, the clinical significance of inherited variants in genes governing pharmacodynamics of analgesics remains largely unexplored (apart from the µ-opioid receptor). • Lack of replication of the findings from one study to another makes meaningful personalised analgesic regime still a distant future. • This narrative review will focus on findings related to pharmacogenetics of commonly used analgesic medications and highlight authors' views on future clinical implications of pharmacogenetics in the context of pharmacological treatment of chronic pain.
    Language English
    Publishing date 2015-10-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2670872-3
    ISSN 2049-4645 ; 2049-4637
    ISSN (online) 2049-4645
    ISSN 2049-4637
    DOI 10.1177/2049463713507439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Persistent postsurgical pain.

    Cregg, Roman / Anwar, Sibtain / Farquhar-Smith, Paul

    Current opinion in supportive and palliative care

    2013  Volume 7, Issue 2, Page(s) 144–152

    Abstract: Purpose of review: Persistent postsurgical pain (PPP) is an important cause of pain morbidity following surgery for almost any cause, but there is a greater evidence base for pain after cancer surgery. Historically, both patients and practitioners have ... ...

    Abstract Purpose of review: Persistent postsurgical pain (PPP) is an important cause of pain morbidity following surgery for almost any cause, but there is a greater evidence base for pain after cancer surgery. Historically, both patients and practitioners have struggled to recognize and accept this growing problem. This review will seek to highlight the awareness of this increasing epidemic and will discuss evidence base for diagnosis, risk factors and current strategies for prevention and treatment, especially after cancer surgery.
    Recent findings: Given the potential size of the problems of PPP, there is a relative paucity of recent data, especially as regards effective treatments. The review will synthesize current and existing evidence to give a balanced up-to-date view. There is a clear need for more high-quality randomized trials.
    Summary: An estimated 40,000 patients in the UK will develop PPP, of whom at least 5-10% will have severe pain. Lack of clear definition and lack of awareness have been barriers to diagnosis and access to treatment. Several risk factors associated with PPP have been identified and reduction of these factors may prevent its development. At present, there are large gaps in the evidence base and more large controlled trials are warranted.
    MeSH term(s) Breast Neoplasms/surgery ; Chemoradiotherapy/adverse effects ; Chronic Disease ; Female ; Head and Neck Neoplasms/surgery ; Humans ; Inflammation/complications ; Neoplasms/complications ; Neoplasms/surgery ; Neuralgia/etiology ; Pain, Postoperative/etiology ; Pain, Postoperative/physiopathology ; Pain, Postoperative/prevention & control ; Risk Factors ; Thoracic Surgical Procedures/adverse effects
    Language English
    Publishing date 2013-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2633726-5
    ISSN 1751-4266 ; 1751-4258
    ISSN (online) 1751-4266
    ISSN 1751-4258
    DOI 10.1097/SPC.0b013e328360b09e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Book: Back pain

    Souter, Andrew / Cregg, Roman / Chong, Sam

    (Oxford pain management library)

    2012  

    Author's details edited by Andrew Souter, Roman Cregg, Sam Chong
    Series title Oxford pain management library
    MeSH term(s) Back Pain/therapy ; Pain Management/methods
    Language English
    Size xii, 159 p. :, ill. ;, 20 cm.
    Publisher Oxford University Press
    Publishing place Oxford
    Document type Book
    ISBN 9780199609772 ; 0199609772
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Article: Endotracheal tube cuff pressure monitoring: a review of the evidence.

    Sultan, Pervez / Carvalho, Brendan / Rose, Bernd Oliver / Cregg, Roman

    Journal of perioperative practice

    2011  Volume 21, Issue 11, Page(s) 379–386

    Abstract: Tracheal intubation constitutes a routine part of anaesthetic practice both in the operating theatre as well as in the care of critically ill patients. The procedure is estimated to be performed 13-20 million times annually in the United States alone. ... ...

    Abstract Tracheal intubation constitutes a routine part of anaesthetic practice both in the operating theatre as well as in the care of critically ill patients. The procedure is estimated to be performed 13-20 million times annually in the United States alone. There has been a recent renewal of interest in the morbidity associated with endotracheal tube cuff overinflation, particularly regarding the rationale and requirement for endotracheal tube cuff monitoring intra-operatively.
    MeSH term(s) Anesthesia ; Emergency Medical Services ; Intensive Care Units ; Intubation, Intratracheal/methods ; Pressure ; United States
    Language English
    Publishing date 2011-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2226186-2
    ISSN 1750-4589
    ISSN 1750-4589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4006: Show issues Location:
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  8. Article: Thyroid surgery: what are the options for anaesthesia?

    Cregg, Roman / Raghuraman, Thippa / Green, David / Windsor, Jeremy

    British journal of hospital medicine (London, England : 2005)

    2008  Volume 69, Issue 7, Page(s) 424

    MeSH term(s) Adult ; Anesthesia/adverse effects ; Anesthesia/methods ; Anesthetics, Intravenous/therapeutic use ; Anesthetics, Local/therapeutic use ; Bupivacaine/therapeutic use ; Female ; Humans ; Piperidines/therapeutic use ; Risk Factors ; Thyroidectomy/methods ; Thyrotoxicosis/surgery ; Treatment Outcome
    Chemical Substances Anesthetics, Intravenous ; Anesthetics, Local ; Piperidines ; remifentanil (P10582JYYK) ; Bupivacaine (Y8335394RO)
    Language English
    Publishing date 2008-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2008.69.7.30428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: GaPP2, a multicentre randomised controlled trial of the efficacy of gabapentin for the management of chronic pelvic pain in women: study protocol.

    Vincent, Katy / Baranowski, Andrew / Bhattacharya, Siladitya / Birch, Judy / Cheong, Ying / Cregg, Roman / Daniels, Jane / Hewitt, Catherine A / Macfarlane, Gary J / Middleton, Lee / Szubert, Wojciech / Tracey, Irene / Williams, Amanda C de C / Horne, Andrew W

    BMJ open

    2018  Volume 8, Issue 1, Page(s) e014924

    Abstract: Introduction: Chronic pelvic pain (CPP) affects more than 1 million UK women with associated healthcare costs of £158 million annually. Current evidence supporting interventions when no underlying pathology is identified is very limited and treatment is ...

    Abstract Introduction: Chronic pelvic pain (CPP) affects more than 1 million UK women with associated healthcare costs of £158 million annually. Current evidence supporting interventions when no underlying pathology is identified is very limited and treatment is frequently inadequate. Gabapentin (a GABA analogue) is efficacious and often well tolerated in other chronic pain conditions. We have completed a successful pilot randomised controlled trial Gabapentin for Pelvic Pain 1 (GaPP1) and here describe the protocol for our definitive multicentre trial to assess the efficacy of gabapentin in the management of CPP in women Gabapentin for Pelvic Pain 2 (GaPP2).
    Methods and analysis: We plan to perform a double-blind placebo-controlled randomised multicentre clinical trial, recruiting 300 women with CPP from up to 40 National Health Service hospitals within the UK. After randomisation, women will titrate their medication (gabapentin or placebo) over a 4-week period to a maximum of 2700 mg or placebo equivalent and will then maintain a stable dose for a 12-week period. Response to treatment will be monitored with validated questionnaires and coprimary outcome measures of average and worst pain scores will be employed. The primary objective is to test the hypothesis that treatment with gabapentin has the potential to provide an effective oral treatment to alleviate pain in women with CPP in the absence of any obvious pelvic pathology.
    Ethics and dissemination: Ethical approval has been obtained from the Coventry and Warwick Research Ethics Committee (REC 15/WM/0036). Data will be presented at international conferences and published in peer-reviewed journals. We will make the information obtained from the study available to the public through national bodies and charities.
    Trial registration number: ISRCTN77451762; Pre-results.
    MeSH term(s) Adolescent ; Adult ; Amines/therapeutic use ; Analgesics/therapeutic use ; Chronic Disease ; Chronic Pain/drug therapy ; Cyclohexanecarboxylic Acids/therapeutic use ; Double-Blind Method ; Female ; Gabapentin ; Humans ; Middle Aged ; Pain Management/methods ; Pain Measurement ; Pelvic Pain/drug therapy ; Pilot Projects ; Research Design ; Surveys and Questionnaires ; Treatment Outcome ; Young Adult ; gamma-Aminobutyric Acid/therapeutic use
    Chemical Substances Amines ; Analgesics ; Cyclohexanecarboxylic Acids ; gamma-Aminobutyric Acid (56-12-2) ; Gabapentin (6CW7F3G59X)
    Language English
    Publishing date 2018-01-31
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2016-014924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pain channelopathies.

    Cregg, Roman / Momin, Aliakmal / Rugiero, Francois / Wood, John N / Zhao, Jing

    The Journal of physiology

    2010  Volume 588, Issue Pt 11, Page(s) 1897–1904

    Abstract: Pain remains a major clinical challenge, severely afflicting around 6% of the population at any one time. Channelopathies that underlie monogenic human pain syndromes are of great clinical relevance, as cell surface ion channels are tractable drug ... ...

    Abstract Pain remains a major clinical challenge, severely afflicting around 6% of the population at any one time. Channelopathies that underlie monogenic human pain syndromes are of great clinical relevance, as cell surface ion channels are tractable drug targets. The recent discovery that loss-of-function mutations in the sodium channel Nav1.7 underlie a recessive pain-free state in otherwise normal people is particularly significant. Deletion of channel-encoding genes in mice has also provided insights into mammalian pain mechanisms. Ion channels expressed by immune system cells (e.g. P2X7) have been shown to play a pivotal role in changing pain thresholds, whilst channels involved in sensory transduction (e.g. TRPV1), the regulation of neuronal excitability (potassium channels), action potential propagation (sodium channels) and neurotransmitter release (calcium channels) have all been shown to be potentially selective analgesic drug targets in some animal pain models. Migraine and visceral pain have also been associated with voltage-gated ion channel mutations. Insights into such channelopathies thus provide us with a number of potential targets to control pain.
    MeSH term(s) Animals ; Channelopathies/genetics ; Channelopathies/physiopathology ; Electrophysiology ; Humans ; Ion Channels/genetics ; Ion Channels/physiology ; Mice ; Migraine Disorders/genetics ; Migraine Disorders/physiopathology ; Muscular Diseases/genetics ; Muscular Diseases/physiopathology ; NAV1.7 Voltage-Gated Sodium Channel ; Neurotransmitter Agents/metabolism ; Neurotransmitter Agents/physiology ; Pain/genetics ; Pain/physiopathology ; Signal Transduction/genetics ; Signal Transduction/physiology ; Sodium Channels/genetics ; Sodium Channels/physiology
    Chemical Substances Ion Channels ; NAV1.7 Voltage-Gated Sodium Channel ; Neurotransmitter Agents ; Scn9a protein, mouse ; Sodium Channels
    Language English
    Publishing date 2010-02-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/jphysiol.2010.187807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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