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  1. Book ; Thesis: Die Interaktion Dephosphorylierungs-imitierender Substitutionen im Kalium Chlorid Cotransporter 2 (KCC2) mit Furosemid und VU0463271

    Lyu, Su Ir / Draguhn, Andreas

    2020  

    Institution Universität Heidelberg
    Author's details vorgelegt von Su Ir Lyu ; Doktorvater: Prof. Dr. med. Andreas Draguhn
    Language German
    Size 56 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2020
    HBZ-ID HT020696639
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 E 107 order for loan Magazin

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  2. Article: Progress and challenges in research of the mechanisms of anhedonia in major depressive disorder.

    Su, Yun-Ai / Si, Tianmei

    General psychiatry

    2022  Volume 35, Issue 1, Page(s) e100724

    Abstract: There is an increasing heavy disease burden of major depressive disorder (MDD) globally. Both high diagnostic heterogeneity and complicated pathological mechanisms of MDD pose significant challenges. There is much evidence to support anhedonia as a core ... ...

    Abstract There is an increasing heavy disease burden of major depressive disorder (MDD) globally. Both high diagnostic heterogeneity and complicated pathological mechanisms of MDD pose significant challenges. There is much evidence to support anhedonia as a core feature of MDD. In the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, anhedonia is further emphasised as a key item in the diagnosis of major depression with melancholic features. Anhedonia is a multifaceted symptom that includes deficits in various aspects of reward processing, such as anticipatory anhedonia, consummatory anhedonia, and decision-making anhedonia. Anhedonia is expected to become an important clinicopathological sign for predicting the treatment outcome of MDD and assisting clinical decision making. However, the precise neurobiological mechanisms of anhedonia in MDD are not clearly understood. In this paper, we reviewed (1) the current understanding of the link between anhedonia and MDD; (2) the biological basis of the pathological mechanism of anhedonia in MDD; and (3) challenges in research on the pathological mechanisms of anhedonia in MDD. A more in-depth understanding of anhedonia associated with MDD will improve the diagnosis, prediction, and treatment of patients with MDD in the future.
    Language English
    Publishing date 2022-02-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2941976-1
    ISSN 2517-729X ; 2517-729X ; 2096-5923
    ISSN (online) 2517-729X
    ISSN 2517-729X ; 2096-5923
    DOI 10.1136/gpsych-2021-100724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The clinical potential of counterfactual AI models.

    Lee, Su-In / Topol, Eric J

    Lancet (London, England)

    2024  Volume 403, Issue 10428, Page(s) 717

    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(24)00313-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article: Effects of Cheliped Amputation on the Personality of Crayfish.

    Lu, Leiyu / Su, Li / Si, Mengdi / Wang, Guangyao / Li, Chunlin

    Animals : an open access journal from MDPI

    2024  Volume 14, Issue 7

    Abstract: Animal personality, which describes inter-individual differences and intra-individual consistency in behaviors across time and contexts, has been widely observed and has significance for both ecology and evolution. Morphological modifications, ... ...

    Abstract Animal personality, which describes inter-individual differences and intra-individual consistency in behaviors across time and contexts, has been widely observed and has significance for both ecology and evolution. Morphological modifications, particularly during early life stages, may highly influence animal behavior in adulthood; thus, exploring this relationship can elucidate personality development throughout ontogeny. In this study, we reared juvenile crayfish (
    Language English
    Publishing date 2024-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani14071132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Machine learning-based prediction of diagnostic markers for Graves' orbitopathy.

    Cai, Yunying / Su, Heng / Si, Yongting / Ni, Ninghua

    Endocrine

    2023  Volume 81, Issue 2, Page(s) 277–289

    Abstract: Purpose: The pathogenesis of Graves' orbitopathy/thyroid-associated orbitopathy (TAO) is still unclear, and abnormal DNA methylation in TAO has been reported. Thus, selecting and exploring TAO biomarkers associated with DNA methylation may provide a ... ...

    Abstract Purpose: The pathogenesis of Graves' orbitopathy/thyroid-associated orbitopathy (TAO) is still unclear, and abnormal DNA methylation in TAO has been reported. Thus, selecting and exploring TAO biomarkers associated with DNA methylation may provide a reference for new therapeutic targets.
    Methods: The TAO-associated expression data and methylation data were downloaded from The Gene Expression Omnibus database. Firstly, weighted gene co-expression network analysis was used to obtain the TAO-related genes, which were intersected with differentially methylated genes (DMGs), and differentially expressed genes between TAO samples and normal samples to obtain TAO-associated DMGs (TA-DMGs). Thereafter, the functions of the TA-DMGs were analyzed, and diagnostic markers were screened by least absolute shrinkage and selection operator (Lasso) regression analysis and support vector machine (SVM) analysis. The expression levels and diagnostic values of the diagnostic markers were also analyzed. Furthermore, single gene pathway enrichment analysis was performed for each diagnostic marker separately using gene set enrichment analysis (GSEA) software. Next, we also performed immune infiltration analysis for each sample in the GSE58331 dataset using the single-sample GSEA algorithm, and the correlation between diagnostic markers and differential immune cells was explored. Lastly, the expressions of diagnostic markers were explored by quantitative real-time polymerase chain reaction (qRT-PCR).
    Results: A total of 125 TA-DMGs were obtained. The enrichment analysis results indicated that these TA-DMGs were mainly involved in immune-related pathways, such as Th1 and Th2 cell differentiation and the regulation of innate immune response. Moreover, two diagnostic markers, including S100A11 and NKD2, were obtained by Lasso regression analysis and SVM analysis. Single gene pathway enrichment analysis showed that S100A11 was involved in protein polyufmylation, pancreatic-mediated proteolysis, and NKD2 was involved in innate immune response in mucosa, Wnt signaling pathway, etc. Meanwhile, immune cell infiltration analysis screened 12 immune cells, including CD56 dim natural killer cells and Neutrophil cells that significantly differed between TAO and normal samples, with the strongest positive correlation between NKD2 and CD56 dim natural killer cells. Finally, the qRT-PCR illustrated the expressions of NKD2 and S100A11 between normal and TAO.
    Conclusion: NKD2 and S100A11 were screened as biomarkers of TAO and might be regulated by DNA methylation in TAO, providing a new reference for the diagnosis and treatment of TAO patients.
    MeSH term(s) Humans ; Graves Ophthalmopathy/diagnosis ; Graves Ophthalmopathy/genetics ; Algorithms ; Cell Differentiation ; Machine Learning ; Calcium-Binding Proteins ; Adaptor Proteins, Signal Transducing
    Chemical Substances NKD2 protein, human ; Calcium-Binding Proteins ; Adaptor Proteins, Signal Transducing
    Language English
    Publishing date 2023-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-023-03349-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3884: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Efficient composite chlorinated ethenes removal using gallic acid to enhance Fe/Ni nanoparticles activated persulfate.

    Che, Mingda / Su, Hongjian / Si, Huimin / Guo, Bin / Huang, Renliang / Zhao, Jing / Su, Rongxin

    Environmental science and pollution research international

    2024  Volume 31, Issue 6, Page(s) 9421–9432

    Abstract: As the representative volatile chlorinated hydrocarbons detected in wastewater, the removal of composite chlorinated ethenes is a major challenge in wastewater treatment. In the present study, an efficient removal system for composite chlorinated ethenes ...

    Abstract As the representative volatile chlorinated hydrocarbons detected in wastewater, the removal of composite chlorinated ethenes is a major challenge in wastewater treatment. In the present study, an efficient removal system for composite chlorinated ethenes was reported, in which gallic acid was used to enhance the activation of persulfate by Fe/Ni nanoparticles. The influences of gallic acid-Fe/Ni and persulfate concentrations, initial pH value, reaction temperature, inorganic anions, and natural organic matters were evaluated in the composite chlorinated ethenes removal. Our results showed that the gallic acid-Fe/Ni-persulfate system with 9.0 mM of gallic acid-Fe/Ni and 30.0 mM of persulfate yielded about 100% trichloroethylene removal and 97.3%-98.6% perchloroethylene removal in the pH range of 3.0-12.0. Electron paramagnetic resonance analysis and radical quenching experiments indicated that SO
    MeSH term(s) Wastewater ; Hydrocarbons, Chlorinated/chemistry ; Trichloroethylene/chemistry ; Nanoparticles/chemistry ; Water Pollutants, Chemical/chemistry ; Oxidation-Reduction ; Ethylenes
    Chemical Substances ethylene (91GW059KN7) ; Wastewater ; Hydrocarbons, Chlorinated ; Trichloroethylene (290YE8AR51) ; Water Pollutants, Chemical ; Ethylenes
    Language English
    Publishing date 2024-01-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-31823-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  7. Article ; Online: Doctor-Patient Cancer Screening Communications among Church-based Chinese Adults - The Role of Caregiver Experience and Family History.

    Hou, Su-I

    Asian Pacific journal of cancer prevention : APJCP

    2021  Volume 22, Issue 1, Page(s) 241–247

    Abstract: Objective: Significant gap exists in the literature examining cancer screening communication related factors among Chinese immigrants.  This study examined the role of cancer caregiver experience and family history on doctor-patient cancer screening ... ...

    Abstract Objective: Significant gap exists in the literature examining cancer screening communication related factors among Chinese immigrants.  This study examined the role of cancer caregiver experience and family history on doctor-patient cancer screening communication among church-based Chinese adults.
    Methods: A self-administered survey was conducted among adults from 9 Chinese churches (n=372). Cancer Communication was measured by "Dr. recommended screenings" and "Talked to doctors about cancer screenings". The survey was developed in English and translated in Chinese.
    Results: Mean age was 44.31 (SD=14.74), 60% were males, 72% were married, majority had college education (85%), and 17% reported had been a primary cancer caregiver and 54% reported having family cancer history. Cancer caregivers scored higher on doctor-patient cancer communication, as well as cancer knowledge and screening norms.  Participants with family cancer history were also more likely to talk to doctor about screening, as well as perceived higher cancer risk, lower health status, and screening barriers. Multiple regression analyses showed that primary caregiver experience was still a significant predictor on talking to doctors about cancer screenings (OR=2.1; 95%CI=[1.10, 4.01]; p=0.025), yet doctors more like to recommend screening among caregivers became non-significant.  The significant influence of family cancer history on talking with doctors on cancer screenings also disappeared.  Older age (OR=2.52; p=0.006) and being married (OR=2.45; p=0.022) were significant on predicting communication of cancer screenings with doctors. Data also showed that doctors were more likely to recommend cancer screenings to older (OR=2.75, p <.001), married (OR=2.57; p=0.006) adults.
    Conclusion: Current study calls attentions to primary cancer caregiver experience, family history, age, and marital factors when designing tailored doctor-patient cancer screening communication programs among church-based Chinese to address cancer disparities.
    Language English
    Publishing date 2021-01-01
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2021.22.1.241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Advances in functional MRI research in bipolar disorder: from the perspective of mood states.

    Wu, Yankun / Su, Yun-Ai / Zhu, Linlin / Li, Jitao / Si, Tianmei

    General psychiatry

    2024  Volume 37, Issue 1, Page(s) e101398

    Abstract: Bipolar disorder is characterised by recurrent and alternating episodes of mania/hypomania and depression. Current breakthroughs in functional MRI techniques have uncovered the functional neuroanatomy of bipolar disorder. However, the pathophysiology ... ...

    Abstract Bipolar disorder is characterised by recurrent and alternating episodes of mania/hypomania and depression. Current breakthroughs in functional MRI techniques have uncovered the functional neuroanatomy of bipolar disorder. However, the pathophysiology underlying mood instability, mood switching and the development of extreme mood states is less well understood. This review presents a comprehensive overview of current evidence from functional MRI studies from the perspective of mood states. We first summarise the disrupted brain activation patterns and functional connectivity that have been reported in bipolar disorder, irrespective of the mood state. We next focus on research that solely included patients in a single mood state for a better understanding of the pathophysiology of bipolar disorder and research comparing patients with different mood states to dissect mood state-related effects. Finally, we briefly summarise current theoretical models and conclude this review by proposing potential avenues for future research. A comprehensive understanding of the pathophysiology with consideration of mood states could not only deepen our understanding of how acute mood episodes develop at a neurophysiological level but could also facilitate the identification of biological targets for personalised treatment and the development of new interventions for bipolar disorder.
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2941976-1
    ISSN 2517-729X ; 2517-729X ; 2096-5923
    ISSN (online) 2517-729X
    ISSN 2517-729X ; 2096-5923
    DOI 10.1136/gpsych-2023-101398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Multifunctional molecularly imprinted nanozymes with improved enrichment and specificity for organic and inorganic trace compounds.

    Ge, Zhanyi / Zhao, Yilin / Li, Jiayi / Si, Zhaobo / Du, Wenbo / Su, Haijia

    Nanoscale

    2024  Volume 16, Issue 5, Page(s) 2608–2620

    Abstract: Although nanozymes exhibit properties superior to those of natural enzymes and conventional engineered enzymes, the development of highly specific nanozymes remains a challenge. New yolk-shell ... ...

    Abstract Although nanozymes exhibit properties superior to those of natural enzymes and conventional engineered enzymes, the development of highly specific nanozymes remains a challenge. New yolk-shell Fe
    MeSH term(s) Spectroscopy, Fourier Transform Infrared ; Lead ; Molecular Imprinting/methods ; Ferrosoferric Oxide/chemistry ; Magnetics ; Inorganic Chemicals ; Adsorption
    Chemical Substances Lead (2P299V784P) ; Ferrosoferric Oxide (XM0M87F357) ; Inorganic Chemicals
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr03968d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Endoscopic resection

    Chen, Han / Hu, Die / Su, Wei / Li, Shuo / Zhang, Guoxin / Si, Xinmin / Zhou, Xiaoying

    Translational cancer research

    2024  Volume 13, Issue 2, Page(s) 989–998

    Abstract: Background: Early-stage colorectal cancer (CRC) patients treated with either endoscopic resection (ER) alone or combined ER with chemoradiotherapy (CRT) have unknown survival rates. A national descriptive epidemiological study was conducted to compare ... ...

    Abstract Background: Early-stage colorectal cancer (CRC) patients treated with either endoscopic resection (ER) alone or combined ER with chemoradiotherapy (CRT) have unknown survival rates. A national descriptive epidemiological study was conducted to compare the long-term survival of patients with T1 stage CRC with or without the two different treatment options.
    Methods: Our study identified the records of patients with T1-stage CRC between 2010 and 2018 by searching the Surveillance, Epidemiology, and End Results (SEER) database. Long-term survival was compared using Kaplan-Meier methods and Cox proportional hazard models based on patient demographic and cancer parameters.
    Results: After propensity score matching (PSM), 825 T1-stage CRC patients were finally enrolled in this study, with 718 patients treated with ER and 107 patients treated with ER + CRT. The overall survival (OS) and cancer specific survival (CSS) rates were similar between the two treatment options (OS: P=0.47; CSS: P=0.28). According to subgroup analysis, older patients and patients with rectal tumor locations exhibited significantly higher OS and CSS rates in the ER + CRT group than in the ER group (OS: P<0.0001; CSS: P<0.0001).
    Conclusions: The findings from the SEER database showed that OS and CSS rates were similar between the ER and ER + CRT treated groups. Older patients and patients with rectal cancer benefited the most from ER + CRT treatment.
    Language English
    Publishing date 2024-01-24
    Publishing country China
    Document type Journal Article
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr-23-1411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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