LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 87

Search options

  1. Article ; Online: How do we address treating the negative symptoms of schizophrenia pharmacologically?

    Kantrowitz, Joshua T

    Expert opinion on pharmacotherapy

    2021  Volume 22, Issue 14, Page(s) 1811–1813

    MeSH term(s) Antipsychotic Agents/therapeutic use ; Humans ; Schizophrenia/drug therapy ; Schizophrenic Psychology
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2021-06-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2021.1939677
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5130: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Additional perspective on cariprazine and negative symptoms.

    Kantrowitz, Joshua T

    Expert opinion on pharmacotherapy

    2021  Volume 23, Issue 12, Page(s) 1469–1470

    MeSH term(s) Antipsychotic Agents ; Humans ; Piperazines ; Risperidone
    Chemical Substances Antipsychotic Agents ; Piperazines ; cariprazine (F6RJL8B278) ; Risperidone (L6UH7ZF8HC)
    Language English
    Publishing date 2021-08-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2021.1968828
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5130: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Trace Amine-Associated Receptor 1 as a Target for the Development of New Antipsychotics: Current Status of Research and Future Directions.

    Kantrowitz, Joshua T

    CNS drugs

    2021  Volume 35, Issue 11, Page(s) 1153–1161

    Abstract: Schizophrenia is a mental illness associated with an array of symptoms that often result in disability. The primary treatments for schizophrenia are termed antipsychotics. Although antipsychotics modulate a number of different receptor types and subtypes, ...

    Abstract Schizophrenia is a mental illness associated with an array of symptoms that often result in disability. The primary treatments for schizophrenia are termed antipsychotics. Although antipsychotics modulate a number of different receptor types and subtypes, all currently regulatory agency-approved antipsychotics share in common direct or functional antagonism at the dopamine type 2 receptor (D
    MeSH term(s) Animals ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/metabolism ; Biomedical Research/methods ; Biomedical Research/trends ; Clinical Trials, Phase II as Topic/methods ; Drug Delivery Systems/methods ; Drug Delivery Systems/trends ; Drug Development/methods ; Drug Development/trends ; Forecasting ; Humans ; Receptors, G-Protein-Coupled/metabolism ; Schizophrenia/drug therapy ; Schizophrenia/metabolism
    Chemical Substances Antipsychotic Agents ; Receptors, G-Protein-Coupled ; Trace amine-associated receptor 1 (XMC8VP6RI2)
    Language English
    Publishing date 2021-10-15
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1203800-3
    ISSN 1179-1934 ; 1172-7047
    ISSN (online) 1179-1934
    ISSN 1172-7047
    DOI 10.1007/s40263-021-00864-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4083: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: The Potential Role of Lumateperone-Something Borrowed? Something New?

    Kantrowitz, Joshua T

    JAMA psychiatry

    2020  Volume 77, Issue 4, Page(s) 343–344

    MeSH term(s) Heterocyclic Compounds, 4 or More Rings ; Humans ; Schizophrenia
    Chemical Substances Heterocyclic Compounds, 4 or More Rings ; lumateperone (70BSQ12069)
    Language English
    Publishing date 2020-01-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2019.4265
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.235: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Targeting Serotonin 5-HT

    Kantrowitz, Joshua T

    CNS drugs

    2020  Volume 34, Issue 9, Page(s) 947–959

    Abstract: Schizophrenia is a major mental illness associated with profound disability. Current treatments for schizophrenia (antipsychotics) all have a similar mechanism of action and are primarily dopamine type 2 receptor ( ... ...

    Abstract Schizophrenia is a major mental illness associated with profound disability. Current treatments for schizophrenia (antipsychotics) all have a similar mechanism of action and are primarily dopamine type 2 receptor (D
    MeSH term(s) Animals ; Antipsychotic Agents/pharmacology ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Humans ; Indoles/pharmacology ; Lysergic Acid Diethylamide/pharmacology ; Piperidines/pharmacology ; Receptor, Serotonin, 5-HT2A/drug effects ; Receptor, Serotonin, 5-HT2A/metabolism ; Schizophrenia/drug therapy ; Schizophrenia/physiopathology ; Serotonin 5-HT2 Receptor Antagonists/pharmacology ; Urea/analogs & derivatives ; Urea/pharmacology
    Chemical Substances Antipsychotic Agents ; Heterocyclic Compounds, 4 or More Rings ; Indoles ; Piperidines ; Receptor, Serotonin, 5-HT2A ; Serotonin 5-HT2 Receptor Antagonists ; roluperidone (4P31I0M3BF) ; lumateperone (70BSQ12069) ; Lysergic Acid Diethylamide (8NA5SWF92O) ; Urea (8W8T17847W) ; pimavanserin (JZ963P0DIK)
    Language English
    Publishing date 2020-08-11
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1203800-3
    ISSN 1179-1934 ; 1172-7047
    ISSN (online) 1179-1934
    ISSN 1172-7047
    DOI 10.1007/s40263-020-00752-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4083: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: The glutamate/N-methyl-d-aspartate receptor (NMDAR) model of schizophrenia at 35: On the path from syndrome to disease.

    Javitt, Daniel C / Kantrowitz, Joshua T

    Schizophrenia research

    2022  Volume 242, Page(s) 56–61

    MeSH term(s) Aspartic Acid ; Glutamic Acid ; Humans ; Receptors, Glutamate ; Receptors, N-Methyl-D-Aspartate ; Schizophrenia
    Chemical Substances Receptors, Glutamate ; Receptors, N-Methyl-D-Aspartate ; Aspartic Acid (30KYC7MIAI) ; Glutamic Acid (3KX376GY7L)
    Language English
    Publishing date 2022-02-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2022.01.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2351: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 543: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Tardive Dyskinesia Suppressed With Ginkgo Biloba.

    Petridis, Petros D / Jaffe, Ari B / Kantrowitz, Joshua T / Grinband, Jack

    Journal of clinical psychopharmacology

    2023  Volume 43, Issue 6, Page(s) 549–551

    MeSH term(s) Humans ; Tardive Dyskinesia/chemically induced ; Tardive Dyskinesia/drug therapy ; Ginkgo biloba ; Plant Extracts/adverse effects ; Antipsychotic Agents/adverse effects
    Chemical Substances Plant Extracts ; Antipsychotic Agents
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Letter
    ZDB-ID 604631-9
    ISSN 1533-712X ; 0271-0749
    ISSN (online) 1533-712X
    ISSN 0271-0749
    DOI 10.1097/JCP.0000000000001764
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1664: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: N-methyl-d-aspartate-type glutamate receptor modulators and related medications for the enhancement of auditory system plasticity in schizophrenia.

    Kantrowitz, Joshua T

    Schizophrenia research

    2018  Volume 207, Page(s) 70–79

    Abstract: Deficits in N-methyl-d-aspartate-type (NMDAR) function contribute to cognitive deficits in schizophrenia, particularly dysfunction in neuroplasticity, defined as reduced learning during training on exercises that place implicit, increasing demands on ... ...

    Abstract Deficits in N-methyl-d-aspartate-type (NMDAR) function contribute to cognitive deficits in schizophrenia, particularly dysfunction in neuroplasticity, defined as reduced learning during training on exercises that place implicit, increasing demands on early sensory (auditory and visual) information processing. Auditory mismatch negativity (MMN) can be both a target engagement biomarker for the NMDAR and a proxy measure of neurophysiological plasticity. This review covers the evidence for using NMDAR modulator and related compounds for enhancement of cognition, with a particular focus on early auditory processing/plasticity. Compounds covered include glycine site agonists, glycine and system A-type transporter inhibitors, d-amino acid oxidase inhibitors, memantine and nicotinic alpha-7 acetylcholine receptor agonists. As opposed to daily treatment studies focusing on schizophrenia in general, intermittent, non-daily treatment combining NMDAR modulators with neuroplasticity-based paradigms, using MMN as target-engagement biomarkers show promise as treatments to both remediate plasticity deficits and overall functional deficits.
    MeSH term(s) Auditory Perception/drug effects ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/etiology ; Excitatory Amino Acid Agents/pharmacology ; Humans ; Neuronal Plasticity/drug effects ; Receptors, N-Methyl-D-Aspartate/drug effects ; Schizophrenia/complications ; Schizophrenia/drug therapy
    Chemical Substances Excitatory Amino Acid Agents ; Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2018-02-17
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2018.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2351: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 543: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Improving the reproducibility of proton magnetic resonance spectroscopy brain thermometry: Theoretical and empirical approaches.

    Dong, Zhengchao / Kantrowitz, Joshua T / Mann, J John

    NMR in biomedicine

    2022  Volume 35, Issue 9, Page(s) e4749

    Abstract: In proton magnetic resonance spectroscopy ( ...

    Abstract In proton magnetic resonance spectroscopy (
    MeSH term(s) Brain/diagnostic imaging ; Brain/pathology ; Magnetic Resonance Imaging ; Phantoms, Imaging ; Proton Magnetic Resonance Spectroscopy ; Reproducibility of Results ; Thermometry/methods
    Language English
    Publishing date 2022-05-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1000976-0
    ISSN 1099-1492 ; 0952-3480
    ISSN (online) 1099-1492
    ISSN 0952-3480
    DOI 10.1002/nbm.4749
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2869: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: New Developments in the Treatment of Schizophrenia: An Expert Roundtable.

    Kantrowitz, Joshua T / Correll, Christoph U / Jain, Rakesh / Cutler, Andrew J

    The international journal of neuropsychopharmacology

    2023  Volume 26, Issue 5, Page(s) 322–330

    Abstract: Background: Schizophrenia is a disabling disorder that profoundly affects functioning and quality of life. While available antipsychotics have improved outcomes for patients with schizophrenia, they are relatively ineffective for negative and cognitive ... ...

    Abstract Background: Schizophrenia is a disabling disorder that profoundly affects functioning and quality of life. While available antipsychotics have improved outcomes for patients with schizophrenia, they are relatively ineffective for negative and cognitive symptoms and are associated with a range of troublesome side effects. A significant unmet medical need for more effective and better-tolerated therapies remains.
    Methods: A roundtable consisting of 4 experts in the treatment of patients with schizophrenia convened to discuss the current treatment landscape, unmet needs from patient and societal perspectives, and the potential of emerging therapies with novel mechanisms of action (MOAs).
    Results: Key areas of unmet need include optimal implementation of available treatments, effective treatment of negative and cognitive symptoms, improvements in medication adherence, novel MOAs, avoidance of postsynaptic dopamine blockade-related adverse effects, and individualized approaches to treatment. With the possible exception of clozapine, all currently available antipsychotics primarily act by blocking dopamine D2 receptors. Agents with novel MOAs are urgently needed to effectively target the full range of symptoms in schizophrenia and facilitate an individualized treatment approach. Discussion focused on promising novel MOAs that have demonstrated potential in phase 2 and 3 trials include muscarinic receptor agonism, trace amine-associated receptor 1 agonism, serotonin receptor antagonism/inverse agonism, and glutamatergic modulation.
    Conclusions: Results from early clinical trials of agents with novel MOAs are encouraging, particularly for muscarinic and trace amine-associated receptor 1 agonists. These agents offer renewed hope for meaningful improvement in the management of patients with schizophrenia.
    MeSH term(s) Humans ; Antipsychotic Agents/therapeutic use ; Antipsychotic Agents/pharmacology ; Schizophrenia/drug therapy ; Drug Inverse Agonism ; Quality of Life ; Clozapine/therapeutic use
    Chemical Substances Antipsychotic Agents ; Clozapine (J60AR2IKIC)
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440129-0
    ISSN 1469-5111 ; 1461-1457
    ISSN (online) 1469-5111
    ISSN 1461-1457
    DOI 10.1093/ijnp/pyad011
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5187: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top