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  1. Article ; Online: Comment on: Combination therapy with long-acting bronchodilators and the risk of major adverse cardiovascular events in patients with COPD: a systematic review and meta-analysis.

    Almagro, Pere / Martinez-Camblor, Pablo

    The European respiratory journal

    2023  Volume 61, Issue 3

    MeSH term(s) Humans ; Bronchodilator Agents/adverse effects ; Cardiovascular System ; Lung ; Cardiovascular Diseases ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/chemically induced
    Chemical Substances Bronchodilator Agents
    Language English
    Publishing date 2023-03-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02208-2022
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
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  2. Article ; Online: Regarding: Dual versus single long-acting bronchodilator use could raise acute coronary syndrome risk by over 50.

    Almagro, Pere / Malik, Komal / Martínez-Camblor, Pablo

    Journal of internal medicine

    2022  Volume 291, Issue 5, Page(s) 705–706

    MeSH term(s) Acute Coronary Syndrome/drug therapy ; Administration, Inhalation ; Adrenal Cortex Hormones ; Adrenergic beta-2 Receptor Agonists/therapeutic use ; Bronchodilator Agents/adverse effects ; Humans ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Treatment Outcome
    Chemical Substances Adrenal Cortex Hormones ; Adrenergic beta-2 Receptor Agonists ; Bronchodilator Agents
    Language English
    Publishing date 2022-01-18
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.13438
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  3. Article ; Online: Impact of comorbidities in COPD clinical control criteria. The CLAVE study.

    Almagro, Pere / Soler-Cataluña, Juan José / Huerta, Arturo / González-Segura, Diego / Cosío, Borja G

    BMC pulmonary medicine

    2024  Volume 24, Issue 1, Page(s) 6

    Abstract: Background: Chronic obstructive pulmonary disease (COPD) frequently coexists with other chronic diseases, namely comorbidities. They negatively impact prognosis, exacerbations and quality of life in COPD patients. However, no studies have been performed ...

    Abstract Background: Chronic obstructive pulmonary disease (COPD) frequently coexists with other chronic diseases, namely comorbidities. They negatively impact prognosis, exacerbations and quality of life in COPD patients. However, no studies have been performed to explore the impact of these comorbidities on COPD clinical control criteria.
    Research question: Determine the relationship between individualized comorbidities and COPD clinical control criteria.
    Study design and methods: Observational, multicenter, cross-sectional study performed in Spain involving 4801 patients with severe COPD (< 50 predicted forced expiratory volume in the first second [FEV
    Results: Most frequent comorbidities were arterial hypertension (51.2%), dyslipidemia (36.0%), diabetes (24.9%), obstructive sleep apnea-hypopnea syndrome (14.9%), anxiety (14.1%), heart failure (11.6%), depression (11.8%), atrial fibrillation (11.5%), peripheral arterial vascular disease (10.4%) and ischemic heart disease (10.1%). After age and FEV
    Interpretation: Comorbidities are frequent in patients with severe COPD, negatively impacting COPD clinical control criteria. They are related to health-related quality of life measured by the COPD assessment test. Our results suggest that comorbidities should be investigated and treated in these patients to improve their clinical control.
    Take-home points: Study question: What is the impact of comorbidities on COPD clinical control criteria?
    Results: Among 4801 patients with severe COPD (27.5% controlled and 72.5% uncontrolled), after adjustment by age and FEV
    Interpretation: Comorbidities are related to health-related quality of life measured by the COPD assessment test scores and history of exacerbations in the previous three months.
    MeSH term(s) Humans ; Atrial Fibrillation ; Cross-Sectional Studies ; Diabetes Mellitus ; Forced Expiratory Volume ; Gastroesophageal Reflux/epidemiology ; Gastroesophageal Reflux/complications ; Heart Failure ; Hypertension/complications ; Obesity, Abdominal/complications ; Peripheral Vascular Diseases/complications ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Quality of Life ; Sleep Apnea, Obstructive/complications
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-023-02758-0
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  4. Article ; Online: Lack of Clinical Control in COPD Patients Depending on the Target and the Therapeutic Option.

    Soler-Cataluña, Juan José / Huerta, Arturo / Almagro, Pere / González-Segura, Diego / Cosío, Borja G

    International journal of chronic obstructive pulmonary disease

    2023  Volume 18, Page(s) 1367–1376

    Abstract: Introduction: According to the Global Initiative for chronic obstructive lung disease (GOLD), when a treatment is not achieving an appropriate response it should be switched taking into account the predominant treatable trait to target (dyspnea or ... ...

    Abstract Introduction: According to the Global Initiative for chronic obstructive lung disease (GOLD), when a treatment is not achieving an appropriate response it should be switched taking into account the predominant treatable trait to target (dyspnea or exacerbations). The objective of the present study was to investigate the lack of clinical control according to the target and medication groups.
    Materials and methods: This was a post-hoc analysis of the CLAVE study, an observational, cross-sectional, multicenter study which evaluated the clinical control, and related-factors, in a cohort of 4801 patients with severe chronic obstructive pulmonary disease (COPD). The primary endpoint was the percentage of uncontrolled patients defined as COPD Assessment Test (CAT) >16 or presence of exacerbations in the last 3 months despite receiving long-acting beta
    Results: In the dyspnea pathway, lack of clinical control was of 25.0% of patients receiving LABA or LAMA in monotherapy, 29.5% by those with LABA + LAMA, 38.3% with LABA + ICS and 37.0% with triple therapy (LABA + LAMA + ICS). In the exacerbation pathway, percentages were 87.1%, 76.7%, 83.3%, and 84.1%, respectively. Low physical activity and high Charlson comorbidity index were independent factor of non-control in all therapeutic groups. Additional factors were lower post-bronchodilator FEV1 and poor adherence to inhalers.
    Conclusion: There are still room for improvement in COPD control. From the pharmacological perspective, every step in treatment have a pool of uncontrolled patients in which a step-up could be considered according to a trait to target strategy.
    MeSH term(s) Humans ; Cross-Sectional Studies ; Dyspnea ; Exercise ; Muscarinic Antagonists ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/drug therapy
    Chemical Substances Muscarinic Antagonists
    Language English
    Publishing date 2023-07-06
    Publishing country New Zealand
    Document type Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 2212419-6
    ISSN 1178-2005 ; 1176-9106
    ISSN (online) 1178-2005
    ISSN 1176-9106
    DOI 10.2147/COPD.S414910
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  5. Article ; Online: Risk Factors for Mortality in Hospitalized Coronavirus Disease 2019 Patients.

    Dietl, Beatriz / Martínez-Camblor, Pablo / Almagro, Pere

    Chest

    2020  Volume 158, Issue 6, Page(s) 2699–2700

    MeSH term(s) COVID-19 ; China ; Fatal Outcome ; Humans ; Pandemics ; Pneumonia, Viral ; Risk Factors ; SARS-CoV-2
    Language English
    Publishing date 2020-09-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.07.097
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    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  6. Article ; Online: Underdiagnosis in COPD: a battle worth fighting.

    Almagro, Pere / Soriano, Joan B

    The Lancet. Respiratory medicine

    2017  Volume 5, Issue 5, Page(s) 367–368

    Language English
    Publishing date 2017-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(17)30133-9
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    Zs.A 7041: Show issues Location:
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  7. Article ; Online: Inhaled corticosteroids and pneumonia mortality in COPD patients.

    Almagro, Pere / Martinez-Camblor, Pablo / Soriano, Joan B

    The European respiratory journal

    2019  Volume 54, Issue 3

    MeSH term(s) Adrenal Cortex Hormones ; Humans ; Pneumonia ; Pulmonary Disease, Chronic Obstructive ; Selection Bias
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2019-09-05
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01035-2019
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    Zs.A 2322: Show issues Location:
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  8. Article ; Online: Letter to the editor regarding: "Development of the ProPal-COPD tool to identify patients with COPD for proactive palliative care".

    Almagro, Pere / Martinez Camblor, Pablo

    International journal of chronic obstructive pulmonary disease

    2017  Volume 12, Page(s) 2731–2734

    MeSH term(s) Humans ; Palliative Care ; Patient Comfort ; Pulmonary Disease, Chronic Obstructive
    Language English
    Publishing date 2017
    Publishing country New Zealand
    Document type Journal Article ; Comment
    ISSN 1178-2005
    ISSN (online) 1178-2005
    DOI 10.2147/COPD.S148601
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  9. Article ; Online: Medium and long-term prognosis in hospitalised older adults with multimorbidity. A prospective cohort study.

    Molina, Siena / Martinez-Urrea, Ana / Malik, Komal / Libori, Ginebra / Monzon, Helena / Martínez-Camblor, Pablo / Almagro, Pere

    PloS one

    2023  Volume 18, Issue 6, Page(s) e0285923

    Abstract: Background: Data about long-term prognosis after hospitalisation of elderly multimorbid patients remains scarce.: Objectives: Evaluate medium and long-term prognosis in hospitalised patients older than 75 years of age with multimorbidity. Explore the ...

    Abstract Background: Data about long-term prognosis after hospitalisation of elderly multimorbid patients remains scarce.
    Objectives: Evaluate medium and long-term prognosis in hospitalised patients older than 75 years of age with multimorbidity. Explore the impact of gender, age, frailty, physical dependence, and chronic diseases on mortality over a seven-year period.
    Methods: We included prospectively all patients hospitalised for medical reasons over 75 years of age with two or more chronic illnesses in a specialised ward. Data on chronic diseases were collected using the Charlson comorbidity index and a questionnaire for disorders not included in this index. Demographic characteristics, Clinical Frailty Scale, Barthel index, and complications during hospitalisation were collected.
    Results: 514 patients (46% males) with a mean age of 85 (± 5) years were included. The median follow-up was 755 days (interquartile range 25-75%: 76-1,342). Mortality ranged from 44% to 68%, 82% and 91% at one, three, five, and seven years. At inclusion, men were slightly younger and with lower levels of physical impairment. Nevertheless, in the multivariate analysis, men had higher mortality (p<0.001; H.R.:1.43; 95% C.I.95%:1.16-1.75). Age, Clinical Frailty Scale, Barthel, and Charlson indexes were significant predictors in the univariate and multivariate analysis (all p<0.001). Dementia and neoplastic diseases were statistically significant in the unadjusted but not the adjusted model. In a cluster analysis, three patterns of patients were identified, with increasing significant mortality differences between them (p<0.001; H.R.:1.67; 95% CI: 1.49-1.88).
    Conclusions: In our cohort, individual diseases had a limited predictive prognostic capacity, while the combination of chronic illness, frailty, and physical dependence were independent predictors of survival.
    MeSH term(s) Male ; Humans ; Aged ; Aged, 80 and over ; Female ; Multimorbidity ; Frailty ; Prospective Studies ; Prognosis ; Chronic Disease ; Frail Elderly
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0285923
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  10. Article ; Online: Medium and long-term prognosis in hospitalised older adults with multimorbidity. A prospective cohort study.

    Siena Molina / Ana Martinez-Urrea / Komal Malik / Ginebra Libori / Helena Monzon / Pablo Martínez-Camblor / Pere Almagro

    PLoS ONE, Vol 18, Iss 6, p e

    2023  Volume 0285923

    Abstract: Background Data about long-term prognosis after hospitalisation of elderly multimorbid patients remains scarce. Objectives Evaluate medium and long-term prognosis in hospitalised patients older than 75 years of age with multimorbidity. Explore the impact ...

    Abstract Background Data about long-term prognosis after hospitalisation of elderly multimorbid patients remains scarce. Objectives Evaluate medium and long-term prognosis in hospitalised patients older than 75 years of age with multimorbidity. Explore the impact of gender, age, frailty, physical dependence, and chronic diseases on mortality over a seven-year period. Methods We included prospectively all patients hospitalised for medical reasons over 75 years of age with two or more chronic illnesses in a specialised ward. Data on chronic diseases were collected using the Charlson comorbidity index and a questionnaire for disorders not included in this index. Demographic characteristics, Clinical Frailty Scale, Barthel index, and complications during hospitalisation were collected. Results 514 patients (46% males) with a mean age of 85 (± 5) years were included. The median follow-up was 755 days (interquartile range 25-75%: 76-1,342). Mortality ranged from 44% to 68%, 82% and 91% at one, three, five, and seven years. At inclusion, men were slightly younger and with lower levels of physical impairment. Nevertheless, in the multivariate analysis, men had higher mortality (p<0.001; H.R.:1.43; 95% C.I.95%:1.16-1.75). Age, Clinical Frailty Scale, Barthel, and Charlson indexes were significant predictors in the univariate and multivariate analysis (all p<0.001). Dementia and neoplastic diseases were statistically significant in the unadjusted but not the adjusted model. In a cluster analysis, three patterns of patients were identified, with increasing significant mortality differences between them (p<0.001; H.R.:1.67; 95% CI: 1.49-1.88). Conclusions In our cohort, individual diseases had a limited predictive prognostic capacity, while the combination of chronic illness, frailty, and physical dependence were independent predictors of survival.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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