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  1. Article: Structure Prediction and Potential Inhibitors Docking of Enterovirus 2C Proteins.

    Li, Daoqun / Zhang, Leiliang

    Frontiers in microbiology

    2022  Volume 13, Page(s) 856574

    Abstract: Human enterovirus infections are mostly asymptomatic and occasionally could be severe and life-threatening. The conserved non-structural 2C from enteroviruses protein is a promising target in antiviral therapies against human enteroviruses. Understanding ...

    Abstract Human enterovirus infections are mostly asymptomatic and occasionally could be severe and life-threatening. The conserved non-structural 2C from enteroviruses protein is a promising target in antiviral therapies against human enteroviruses. Understanding of 2C-drug interactions is crucial for developing the potential antiviral agents. While functions of enterovirus 2C proteins have been widely studied, three-dimensional structure information of 2C is limited. In this study, the structures of 2C proteins from 20 enteroviruses were simulated and reconstructed using
    Language English
    Publishing date 2022-04-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.856574
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nurse Life-and-Death Education From the Perspective of Chinese Traditional Culture.

    Zhang, Huilin / Lv, Tingting / Li, Lezhi / Chen, Fengzhi / He, Shijia / Ding, Daoqun

    Omega

    2024  , Page(s) 302228241236981

    Abstract: This quasi-experimental study investigated the impact of traditional Chinese culture-based life-and-death education on 38 ICU nurses. Participants underwent 14 hours of training, and data were collected before and after the intervention using various ... ...

    Abstract This quasi-experimental study investigated the impact of traditional Chinese culture-based life-and-death education on 38 ICU nurses. Participants underwent 14 hours of training, and data were collected before and after the intervention using various questionnaires. Frequency and percentage were used for categorical data; mean and standard deviation for measurement data; and paired-sample
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207363-8
    ISSN 1541-3764 ; 0030-2228
    ISSN (online) 1541-3764
    ISSN 0030-2228
    DOI 10.1177/00302228241236981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Targeting F13 from monkeypox virus and variola virus by tecovirimat: Molecular simulation analysis.

    Li, Daoqun / Liu, Yuwen / Li, Kangxin / Zhang, Leiliang

    The Journal of infection

    2022  Volume 85, Issue 4, Page(s) e99–e101

    MeSH term(s) Benzamides ; Humans ; Isoindoles ; Monkeypox virus ; Variola virus
    Chemical Substances Benzamides ; Isoindoles
    Language English
    Publishing date 2022-07-08
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2022.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Picornavirus 2C proteins: structure-function relationships and interactions with host factors.

    Yin, Chunhui / Zhao, Haomiao / Xia, Xiaoyi / Pan, Zhengyang / Li, Daoqun / Zhang, Leiliang

    Frontiers in cellular and infection microbiology

    2024  Volume 14, Page(s) 1347615

    Abstract: Picornaviruses, which are positive-stranded, non-enveloped RNA viruses, are known to infect people and animals with a broad spectrum of diseases. Among the nonstructural proteins in picornaviruses, 2C proteins are highly conserved and exhibit multiple ... ...

    Abstract Picornaviruses, which are positive-stranded, non-enveloped RNA viruses, are known to infect people and animals with a broad spectrum of diseases. Among the nonstructural proteins in picornaviruses, 2C proteins are highly conserved and exhibit multiple structural domains, including amphipathic α-helices, an ATPase structural domain, and a zinc finger structural domain. This review offers a comprehensive overview of the functional structures of picornaviruses' 2C protein. We summarize the mechanisms by which the 2C protein enhances viral replication. 2C protein interacts with various host factors to form the replication complex, ultimately promoting viral replication. We review the mechanisms through which picornaviruses' 2C proteins interact with the NF-κB, RIG-I, MDA5, NOD2, and IFN pathways, contributing to the evasion of the antiviral innate immune response. Additionally, we provide an overview of broad-spectrum antiviral drugs for treating various enterovirus infections, such as guanidine hydrochloride, fluoxetine, and dibucaine derivatives. These drugs may exert their inhibitory effects on viral infections by targeting interactions with 2C proteins. The review underscores the need for further research to elucidate the precise mechanisms of action of 2C proteins and to identify additional host factors for potential therapeutic intervention. Overall, this review contributes to a deeper understanding of picornaviruses and offers insights into the antiviral strategies against these significant viral pathogens.
    MeSH term(s) Humans ; Animals ; Picornaviridae ; NF-kappa B/metabolism ; RNA ; Virus Replication ; Antiviral Agents/pharmacology ; Structure-Activity Relationship
    Chemical Substances NF-kappa B ; RNA (63231-63-0) ; Antiviral Agents
    Language English
    Publishing date 2024-02-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2024.1347615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: High-Performance Waveguide-Integrated Ge/Si Avalanche Photodetector with Lateral Multiplication Region.

    Liu, Daoqun / Zhang, Peng / Tang, Bo / Wang, Wenwu / Li, Zhihua

    Micromachines

    2022  Volume 13, Issue 5

    Abstract: High-performance waveguide-integrated Ge/Si APDs in separate absorption, charge, and multiplication (SACM) schemes have been exploited to facilitate energy-efficient optical communication and interconnects. However, the charge layer design is complex and ...

    Abstract High-performance waveguide-integrated Ge/Si APDs in separate absorption, charge, and multiplication (SACM) schemes have been exploited to facilitate energy-efficient optical communication and interconnects. However, the charge layer design is complex and time-consuming. A waveguide-integrated Ge/Si avalanche photodetector (APD) is proposed in a separate absorption and multiplication (SAM) configuration. The device can work at low voltage and high speed with a lateral multiplication region without complexity of the charge layer. The proposed device is implemented by the complementary metal-oxide-semiconductor (CMOS) process in the 8-inch Si photonics platform. The device has a low breakdown voltage of 12 V and shows high responsivity of 15.1 A/W at 1550 nm wavelength under optical power of -22.49 dBm, corresponding to a multiplication gain of 18.1. Moreover, an opto-electrical bandwidth of 20.7 GHz is measured at 10.6 V. The high-speed performance at low voltage shows a great potential to implement high-energy-efficient Si optical communications and interconnections.
    Language English
    Publishing date 2022-04-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi13050649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: When the going gets tough: Power affects the process of making tough decisions.

    Li, Xiaoming / Chen, Chuansheng / Zhou, Xin / Ding, Daoqun

    The Journal of social psychology

    2021  Volume 162, Issue 2, Page(s) 231–244

    Abstract: Powerful roles often require individuals to cope with impactful, complicated decisions. The present article reports two experiments investigating the effect of manipulated power mindset on the process of decision-making under different conditions: high ... ...

    Abstract Powerful roles often require individuals to cope with impactful, complicated decisions. The present article reports two experiments investigating the effect of manipulated power mindset on the process of decision-making under different conditions: high vs. low choice conflict (Exp. 1) or high vs. no cognitive load (Exp. 2). Results showed that under the high-choice conflict and high-cognitive load conditions, high-power participants were more likely than low-power participants to take less time, adopt an alternative-based (rather than attribute-based) strategy, rate the tasks as easier, and report higher confidence in and satisfaction with their decisions. Power had no effect on the decision-making process under the low-choice conflict and no-cognitive load conditions. These results suggest that power interacts with choice difficulty to affect the decision-making process.
    MeSH term(s) Decision Making ; Humans ; Personal Satisfaction
    Language English
    Publishing date 2021-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2066653-6
    ISSN 1940-1183 ; 0022-4545
    ISSN (online) 1940-1183
    ISSN 0022-4545
    DOI 10.1080/00224545.2021.1874258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Can Sexual Appeal, Beauty, or Virtue Increase the Opportunity for a Woman to Be Selected as a Spouse? The Mediating Role of Human Uniqueness.

    Lai, Ji / Ding, Daoqun / Chen, Xinling / Li, Shenglan

    Frontiers in psychology

    2021  Volume 12, Page(s) 698712

    Abstract: High mating value is believed to correspond with high mating opportunities. On that premise, this study explores three cues that are linked to women of high long-term mating value, namely a "beautiful" facial appearance, "sexually attractive" body shape, ...

    Abstract High mating value is believed to correspond with high mating opportunities. On that premise, this study explores three cues that are linked to women of high long-term mating value, namely a "beautiful" facial appearance, "sexually attractive" body shape, and "virtuous" behavior. With exclusive attention focused on the above cues, this study examines what kind of human attributes would make a contribution to women's mating opportunities. The results reveal that both "beautiful" women and "virtuous" women were assessed (in this study) as having greater mating opportunities than "sexually attractive" women. In regard to the human attributes, only the "beautiful" woman was assessed as having high levels of human uniqueness and human nature. Meanwhile, "virtuous" women were assessed as having higher levels of human uniqueness but lower levels of human nature. In contrast, "sexually attractive" women were assessed as having lower levels of human uniqueness but higher levels of human nature. In addition, the results of a mediation analysis show that the trait of human uniqueness, and not human nature, was the mediator between the three types of women and women's mating opportunities. This finding means that, when women have higher levels of human uniqueness, they can acquire more mating opportunities. These findings contribute an improved understanding to why and how "beauty" or "virtue" increases the opportunity for woman to be selected as a spouse.
    Language English
    Publishing date 2021-09-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.698712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Do High Psychopaths Care More about Moral Consequences than Low Psychopaths in Chinese Culture? An Exploration Using the CNI Model.

    Li, Shenglan / Ding, Daoqun / Wu, Zhihui / Yi, Liangliang / Lai, Ji / Dang, Le

    Healthcare (Basel, Switzerland)

    2020  Volume 8, Issue 4

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2020-11-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare8040505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Effects of Primary and Secondary Psychopathy on Deontological and Utilitarian Response Tendencies: The Mediator Role of Alexithymia.

    Wu, Zhihui / Chen, Xiyou / Ding, Daoqun / Zou, Shengqi / Li, Shenglan / Zhang, Xiangyi

    Healthcare (Basel, Switzerland)

    2022  Volume 10, Issue 9

    Abstract: 1) Background: The purpose of this study is to provide more nuanced insights into the effects of sub-dimensional levels of psychopathy on moral dilemma judgments. To this end, this study examined the effects of primary and secondary psychopathy on ... ...

    Abstract (1) Background: The purpose of this study is to provide more nuanced insights into the effects of sub-dimensional levels of psychopathy on moral dilemma judgments. To this end, this study examined the effects of primary and secondary psychopathy on utilitarian and deontological response tendencies. Moreover, this study also explored the mediating role of alexithymia as well as the moderating role of gender in these effects. (2) Methods: A total of 1227 participants were recruited through the online questionnaire service wjx.cn. After deleting unfinished questionnaires, the remaining 1170 participants were included in the final data analysis. Each participant completed a demographic information questionnaire, the Levenson Self-Report Psychopathy Scale, the Toronto Alexithymia Scale-20, and six pairs of moral dilemmas. Descriptive and correlational analyses of study variables were conducted in SPSS 22.0. Mediation and gender difference analyses were conducted in AMOS 23.0. (3) Results: Primary psychopathy was negatively correlated with deontological response tendencies and uncorrelated with utilitarian response tendencies. By contrast, secondary psychopathy also correlated negatively with deontological response tendencies, but it correlated positively with utilitarian response tendencies. Mediation analysis revealed that alexithymia only mediated the relationship between secondary psychopathy and deontological response tendencies. Multi-group analysis revealed that there was no difference between females and males in the indirect effect model. (4) Conclusions: People with high primary psychopathy are less likely to reject harm in moral dilemmas. By contrast, people with high secondary psychopathy have high alexithymia, which causes them to be less concerned about avoiding harm, and they are more likely to maximize outcomes in moral dilemmas. These findings shed new light on the moral dilemma judgments of individuals with primary and secondary psychopathy.
    Language English
    Publishing date 2022-08-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare10091650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Palmitoylation of SARS-CoV-2 S protein is critical for S-mediated syncytia formation and virus entry.

    Li, Daoqun / Liu, Yihan / Lu, Yue / Gao, Shan / Zhang, Leiliang

    Journal of medical virology

    2021  Volume 94, Issue 1, Page(s) 342–348

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing coronavirus disease 2019 (COVID-19) pandemic. The S protein is the key viral protein for associating with ACE2, the receptor for SARS-CoV-2. There are many kinds of ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing coronavirus disease 2019 (COVID-19) pandemic. The S protein is the key viral protein for associating with ACE2, the receptor for SARS-CoV-2. There are many kinds of posttranslational modifications in S protein. However, the detailed mechanism of palmitoylation of SARS-CoV-2 S remains to be elucidated. In our current study, we characterized the palmitoylation of SARS-CoV-2 S. Both the C15 and cytoplasmic tail of SARS-CoV-2 S were palmitoylated. Fatty acid synthase inhibitor C75 and zinc finger DHHC domain-containing palmitoyltransferase (ZDHHC) inhibitor 2-BP reduced the palmitoylation of S. Interestingly, palmitoylation of SARS-CoV-2 S was not required for plasma membrane targeting of S but was critical for S-mediated syncytia formation and SARS-CoV-2 pseudovirus particle entry. Overexpression of ZDHHC2, ZDHHC3, ZDHHC4, ZDHHC5, ZDHHC8, ZDHHC9, ZDHHC11, ZDHHC14, ZDHHC16, ZDHHC19, and ZDHHC20 promoted the palmitoylation of S. Furthermore, those ZDHHCs were identified to associate with SARS-CoV-2 S. Our study not only reveals the mechanism of S palmitoylation but also will shed important light into the role of S palmitoylation in syncytia formation and virus entry.
    MeSH term(s) 4-Butyrolactone/analogs & derivatives ; 4-Butyrolactone/pharmacology ; Acyltransferases/antagonists & inhibitors ; COVID-19/pathology ; Cell Line ; Cell Membrane/metabolism ; Giant Cells/metabolism ; HEK293 Cells ; Humans ; Lipoylation/physiology ; Protein Processing, Post-Translational/physiology ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Internalization
    Chemical Substances 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Acyltransferases (EC 2.3.-) ; ZDHHC1 protein, human (EC 2.3.1.-) ; 4-Butyrolactone (OL659KIY4X)
    Language English
    Publishing date 2021-09-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.27339
    Database MEDical Literature Analysis and Retrieval System OnLINE

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