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Article: Measurement of Calprotectin and PTH in the Amniotic Fluid of Early Second Trimester Pregnancies and Their Impact on Fetuses with Growth Disorders: Are Their Levels Related to Oxidative Stress?

Maroudias, George / Vrachnis, Dionysios / Fotiou, Alexandros / Loukas, Nikolaos / Mantzou, Aimilia / Pergialiotis, Vasileiοs / Valsamakis, George / Machairiotis, Nikolaos / Stavros, Sofoklis / Panagopoulos, Periklis / Vakas, Panagiotis / Kanaka-Gantenbein, Christina / Drakakis, Petros / Vrachnis, Nikolaos

Journal of clinical medicine

2024 Volume 13, Issue 3

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2024-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13030855
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Article ; Online: Intraoperative radio-guided localization of parathyroid adenomas using 3D freehand SPECT technology.

Anesidis, Stathis / Akrida, Ioanna / Michalaki, Marina / Apostololpoulos, Dimitrios / Papathanasiou, Nikolaos / Benetatos, Nikolaos / Kalogeropoulou, Christina / Panagopoulos, Konstantinos / Maroulis, Ioannis

Updates in surgery

2024

Abstract: Parathyroidectomy for primary hyperparathyroidism (PHPT) could have poor outcomes, even with accurate preoperative localization of the adenomas, because their intraoperative localization can be challenging. Freehand single photon emission computed ... ...

Abstract	Parathyroidectomy for primary hyperparathyroidism (PHPT) could have poor outcomes, even with accurate preoperative localization of the adenomas, because their intraoperative localization can be challenging. Freehand single photon emission computed tomography (fhSPECT) is a new technique for radio-guided intraoperative navigation. Its use during parathyroidectomy could be useful and such data are limited. We herein present our experience on the feasibility of fhSPECT for intraoperative detection of abnormal parathyroid glands. We retrospectively reviewed the clinical data of 55 patients (30-77 years old) with PHPT due to parathyroid adenomas, that were subjected to parathyroidectomy from 12/2017 to 7/2022. In average, 111 ± 74 MBq of Tc-99 m Sestamibi were injected intravenously, approximately 2 h before the operation and fhSPECT was used to generate 3D images during parathyroidectomy. Measurements of PTH and calcium levels were performed preoperatively, postoperatively and 4-6 months after the procedure. FhSPECT successfully identified the parathyroid adenoma in all the patients. It took 3 min (median time) for fhSPECT to detect at least one radioactive spot in all patients. The mean duration of the operation was 66.6 ± 7.3 min. Forty-nine patients out of 55 had solitary and 6/55 had multiple adenomas, whereas 6/55 had ectopic abnormal parathyroid glands. None of the patients had persistent hyperparathyroidism during follow-up. To the best of our knowledge, this is the largest series of patients with PHPT that underwent fhSPECT assisted parathyroidectomy. Our data suggest that this navigation system is helpful in identifying parathyroid adenomas intraoperatively.
Language	English
Publishing date	2024-03-22
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2572692-4
ISSN	2038-3312 ; 2038-131X
ISSN (online)	2038-3312
ISSN	2038-131X
DOI	10.1007/s13304-024-01819-1
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Article ; Online: Are Extensive Open Lung Resections for Elderly Patients with Lung Cancer Justified?

Panagopoulos, Nikolaos / Grapatsas, Konstantinos / Leivaditis, Vasileios / Galanis, Michail / Dougenis, Dimitrios

Current oncology (Toronto, Ont.)

2023 Volume 30, Issue 6, Page(s) 5470–5484

Abstract: Background: Older patients with malignancies are more comorbid than younger ones and are usually undertreated only because of their age. The aim of this study is to investigate the safety of open anatomical lung resections for lung cancer in elderly ... ...

Abstract	Background: Older patients with malignancies are more comorbid than younger ones and are usually undertreated only because of their age. The aim of this study is to investigate the safety of open anatomical lung resections for lung cancer in elderly patients. Methods: We retrospectively analyzed all patients who underwent lung resection for lung cancer in our institution and categorized them into two groups: the elderly group (≥70 years old) and the control (<70). Results: In total, 135 patients were included in the elderly group and 375 in the control. Elderly patients were more frequently diagnosed with squamous cell carcinoma (59.3% vs. 51.5%, Conclusions: Elderly patients should not be excluded from open major lung resections as the survival benefit is not reduced in selected patients.
MeSH term(s)	Humans ; Aged ; Carcinoma, Non-Small-Cell Lung/pathology ; Retrospective Studies ; Pneumonectomy ; Neoplasm Staging ; Lung Neoplasms/pathology ; Lung/pathology
Language	English
Publishing date	2023-06-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol30060414
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Article ; Online: Fasting Plasma Glucose Increase and Neutrophil-to-Lymphocyte Ratio as Risk Predictors of Clinical Outcome of COVID-19 Pneumonia in Type 2 Diabetes Mellitus.

Petrakis, Vasilios / Panagopoulos, Periklis / Trypsianis, Grigorios / Papazoglou, Dimitrios / Papanas, Nikolaos

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

2023 Volume 131, Issue 4, Page(s) 194–197

Abstract: Aim of the study: To evaluate fasting plasma glucose (FPG) increase and neutrophil-to-lymphocyte ratio (NLR) as risk predictors of severe clinical outcome of COVID-19 pneumonia in type 2 diabetes mellitus (T2DM) hospitalised patients.: Patients and ... ...

Abstract	Aim of the study: To evaluate fasting plasma glucose (FPG) increase and neutrophil-to-lymphocyte ratio (NLR) as risk predictors of severe clinical outcome of COVID-19 pneumonia in type 2 diabetes mellitus (T2DM) hospitalised patients. Patients and methods: Type 2 diabetes mellitus (T2DM) patients hospitalised between March 2020 and February 2021 were studied retrospectively. The NLR ratio at admission and FPG increase (day 7, day with maximal FPG) were evaluated in association with the clinical progression of SARS-CoV-2 infection. Results: Three hundred patients (165 men, 135 women) were included in the study. The mean age was 67.17±8.65 years. Severe COVID-19 pneumonia was diagnosed in 170 patients (56.7%). Fifty-four patients (18%) were intubated and 49 (16.3%) died. Greater increase in FPG (79.5 vs. 44.5 mg/dL for day 1-7, p<0.001; and 113.5 vs. 75 mg/dL for day 1-day with maximum glucose value, p<0.001) and higher NLR at admission (10.65 vs. 6.85) were seen in patients with need of high-flow oxygen compared to those without need, and they were associated with a higher probability of intubation and death. Conclusion: FPG increase and NLR could be significant risk predictors of severe COVID-19 pneumonia in T2DM hospitalised patients.
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Aged ; COVID-19/complications ; Diabetes Mellitus, Type 2/complications ; Blood Glucose ; Retrospective Studies ; Neutrophils ; SARS-CoV-2 ; Fasting ; Lymphocytes
Chemical Substances	Blood Glucose
Language	English
Publishing date	2023-01-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1225416-2
ISSN	1439-3646 ; 0947-7349
ISSN (online)	1439-3646
ISSN	0947-7349
DOI	10.1055/a-2009-6937
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Article: Tracing Time Trends of Births in Greece.

Vlachadis, Nikolaos / Siori, Maria / Petrakos, Georgios / Panagopoulos, Periklis / Kornarou, Eleni / Barbouni, Anastasia / Antonakopoulos, Nikolaos / Tigka, Maria / Lykeridou, Aikaterini / Vrachnis, Nikolaos

Cureus

2023 Volume 15, Issue 1, Page(s) e34040

Abstract: Introduction The aim of this study was to comprehensively investigate and present time trends in births in Greece over the last seven decades. Methods Data on live births were derived from the Hellenic Statistical Authority, covering a 72-year period ... ...

Abstract	Introduction The aim of this study was to comprehensively investigate and present time trends in births in Greece over the last seven decades. Methods Data on live births were derived from the Hellenic Statistical Authority, covering a 72-year period from 1950 to 2021. Trends in the number of births were assessed using joinpoint regression analysis. The annual percentage change (APC) and the average annual percent change (AAPC) were calculated with a 95% confidence interval (95% CI) and level of statistical significance p<0.05. Results The overall trend during 1950-2021 was clearly downward (AAPC = -0.9, 95% CI: -1.2 to -0.7). Over the first three decades, births fluctuated to a record high of 162,839 in 1967, with an overall slight downward trend (1950-1981: APC = -0.2, 95% CI: -0.4 to -0.1, p<0.001). During the 1980 decade, the trend was sharply downward (1981-1988: APC = -4.7, 95% CI: -6.2 to -3.2, p<0.001), followed by a stabilization in the 1990s (1988-2001: APC = -0.1, 95% CI: -0.7 to 0.4, p=0.586). The first decade of the 21st century was the only period during the last seven decades with an increasing trend in births in the Greek population (2001-2008: APC = 1.9, 95% CI: 0.3 to 3.5, p = 0.021), but it was followed by plummeting trends during the recent years (2008-2021: APC = -2.7, 95% CI: -3.2 to -2.3, p<0.001), leading to the historic low of 83,756 births in 2019. Conclusion The time trend analysis of births in Greece indicated a dramatic plummet in natality in Greece, predominantly attributed to the large decline in births in the 1980s, which could not be reversed in the 1990s and 2000s. The recent decrease in births was associated with the financial recession and has put the Greek population in a disastrous low-fertility spiral.
Language	English
Publishing date	2023-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.34040
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Article: Investigating the Association of Assisted Reproduction Techniques and Adverse Perinatal Outcomes.

Potiris, Anastasios / Perros, Paraskevas / Drakaki, Eirini / Mavrogianni, Despoina / Machairiotis, Nikolaos / Sfakianakis, Antonios / Karampitsakos, Theodoros / Vrachnis, Dionysios / Antonakopoulos, Nikolaos / Panagopoulos, Periklis / Drakakis, Peter / Stavros, Sofoklis

Journal of clinical medicine

2024 Volume 13, Issue 2

Abstract: Background: Infertility affects about 80 million individuals worldwide and 10-15% of couples at reproductive age will seek medical assistance. There is increasing evidence that pregnancies after Assisted Reproduction Techniques (ART) are associated with ...

Abstract	Background: Infertility affects about 80 million individuals worldwide and 10-15% of couples at reproductive age will seek medical assistance. There is increasing evidence that pregnancies after Assisted Reproduction Techniques (ART) are associated with pre-term birth, low birthweight, congenital defects, and increased mortality rates. The aim of this review is to assess all the published literature and provide an updated review on the effect of assisted conception and perinatal and neonatal outcomes. Methods: Comprehensive research on Pubmed/Medline, Scopus, and Google scholar electronic databases was conducted from July 2023 up to September 2023, using the terms assisted reproductive techniques, ART, in vitro fertilization, IVF, intracytoplasmic sperm injection, ICSI, preterm birth, PTB, low birth weight, LBW, chromosomal defects, congenital defects, and hypospadias. In total, 87 full text articles were retrieved and after a careful evaluation, 31 studies were selected for data extraction. Results: Our review demonstrated a higher risk of congenital and chromosomal defects, and a higher incidence of male genital tract defects and heart defects in ART pregnancies. Regarding pre-term birth, our results were contradictory. Conclusions: Although assisted reproduction techniques are associated with increased risks, they are safe regarding perinatal outcomes and couples should not be discouraged from utilizing them. Our results aim to alert clinicians to these specific outcomes and offer more personalized care and counseling to infertile couples and their children.
Language	English
Publishing date	2024-01-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13020328
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Article: Is There a Correlation between Apelin and Insulin Concentrations in Early Second Trimester Amniotic Fluid with Fetal Growth Disorders?

Vrachnis, Dionysios / Antonakopoulos, Nikolaos / Fotiou, Alexandros / Pergialiotis, Vasilios / Loukas, Nikolaos / Valsamakis, Georgios / Iavazzo, Christos / Stavros, Sofoklis / Maroudias, Georgios / Panagopoulos, Periklis / Vlahos, Nikolaos / Peppa, Melpomeni / Stefos, Theodoros / Mastorakos, George

Journal of clinical medicine

2023 Volume 12, Issue 9

Abstract: Introduction: Fetal growth disturbances place fetuses at increased risk for perinatal morbidity and mortality. As yet, little is known about the basic pathogenetic mechanisms underlying deranged fetal growth. Apelin is an adipokine with several ... ...

Abstract	Introduction: Fetal growth disturbances place fetuses at increased risk for perinatal morbidity and mortality. As yet, little is known about the basic pathogenetic mechanisms underlying deranged fetal growth. Apelin is an adipokine with several biological activities. Over the past decade, it has been investigated for its possible role in fetal growth restriction. Most studies have examined apelin concentrations in maternal serum and amniotic fluid in the third trimester or during neonatal life. In this study, apelin concentrations were examined for the first time in early second-trimester fetuses. Another major regulator of tissue growth and metabolism is insulin. Materials and methods: This was a prospective observational cohort study. We measured apelin and insulin concentrations in the amniotic fluid of 80 pregnant women who underwent amniocentesis in the early second trimester. Amniotic fluid samples were stored in appropriate conditions until delivery. The study groups were then defined, i.e., gestations with different fetal growth patterns (SGA, AGA, and LGA). Measurements were made using ELISA kits. Results: Apelin and insulin levels were measured in all 80 samples. The analysis revealed statistically significant differences in apelin concentrations among groups ( Conclusions: A clear trend towards decreasing apelin concentrations as birthweight progressively increased was identified. Amniotic fluid apelin concentrations in the early second trimester may be useful as a predictive factor for determining the risk of a fetus being born LGA. Future studies are expected/needed to corroborate the present findings and should ideally focus on the potential interplay of apelin with other known intrauterine metabolic factors.
Language	English
Publishing date	2023-04-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12093166
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Article ; Online: Diabetes Mellitus and Hypertension as Major Risk Factors of Mortality From Covid-19 Pneumonia.

Petrakis, Vasileios / Panagopoulos, Periklis / Papazoglou, Dimitrios / Papanas, Nikolaos

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

2020 Volume 130, Issue 3, Page(s) 205–206

MeSH term(s)	COVID-19 ; Diabetes Mellitus/etiology ; Humans ; Hypertension/complications ; Hypertension/epidemiology ; Risk Factors
Language	English
Publishing date	2020-12-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1225416-2
ISSN	1439-3646 ; 0947-7349
ISSN (online)	1439-3646
ISSN	0947-7349
DOI	10.1055/a-1325-0381
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Article ; Online: Diabetes Mellitus as the Major Factor of Prolonged Hospitalisation in Mild or Moderate COVID-19 Pneumonia.

Petrakis, Vasileios / Trypsianis, Grigorios / Panagopoulos, Periklis / Papazoglou, Dimitrios / Papanas, Nikolaos

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

2021 Volume 130, Issue 5, Page(s) 351–352

MeSH term(s)	COVID-19 ; Diabetes Mellitus/epidemiology ; Hospitalization ; Humans
Language	English
Publishing date	2021-06-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1225416-2
ISSN	1439-3646 ; 0947-7349
ISSN (online)	1439-3646
ISSN	0947-7349
DOI	10.1055/a-1468-4296
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Article ; Online: Dalbavancin for the Treatment of Complicated Gram-Positive Skin and Soft Tissue Infections.

Petrakis, Vasilios / Panagopoulos, Periklis / Papanas, Nikolaos

The international journal of lower extremity wounds

2020 Volume 19, Issue 3, Page(s) 236–241

Abstract: New antimicrobial agents have been developed to treat infections caused by methicillin- ... ...

Abstract	New antimicrobial agents have been developed to treat infections caused by methicillin-resistant
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Gram-Positive Bacterial Infections/drug therapy ; Humans ; Skin Diseases, Infectious/drug therapy ; Skin Diseases, Infectious/microbiology ; Soft Tissue Infections/drug therapy ; Soft Tissue Infections/microbiology ; Teicoplanin/analogs & derivatives ; Teicoplanin/pharmacology ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Teicoplanin (61036-62-2) ; dalbavancin (808UI9MS5K)
Language	English
Publishing date	2020-06-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2171119-7
ISSN	1552-6941 ; 1534-7346
ISSN (online)	1552-6941
ISSN	1534-7346
DOI	10.1177/1534734620921677
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