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  1. Article: Werner Döring 75 Jahre alt

    Schmidt, Hartwig / Döring, Werner

    Uni HH : Berichte und Meinungen aus der Universität Hamburg Vol. 17, No. 5 , p. 80-81

    1986  Volume 17, Issue 5, Page(s) 80–81

    Author's details Hartwig Schmidt
    Publishing place Hamburg
    Document type Article
    ZDB-ID 221155-5
    Database Former special subject collection: coastal and deep sea fishing

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  2. Book: Schädel-Hirn-Trauma

    Wallesch, Claus-Werner / Kulke, Hartwig

    neurologische Rehabilitation und Neuropsychologie : eine Einführung für Ärzte, Psychologen, Therapeuten und Pflegende

    2017  

    Author's details Claus-W. Wallesch, Hartwig Kulke
    Keywords Schädel-Hirn-Trauma ; Anschlussheilbehandlung
    Subject Anschlussheilverfahren ; Rehabilitation ; Nachbehandlung ; Heilverfahren ; Schädel-Hirn-Verletzung ; Schädelhirntrauma ; Schädeltrauma ; Schädelverletzung ; Hirntrauma ; Gehirntrauma ; Hirnverletzung ; Gehirnverletzung
    Language German
    Size 141 Seiten, Illustrationen, Diagramme
    Edition 1. Auflage
    Publisher Verlag W. Kohlhammer
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT019388092
    ISBN 978-3-17-032023-9 ; 978317032026 ; 9783170320253 ; 9783170320260 ; 3-17-032023-8 ; 3170320262 ; 3170320254
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2017 A 1652 available for loan (reading room) Lesesaal EG

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  3. Book ; Online ; Thesis: Die Therapie der postoperativen Lymphfistel nach Pankreaslinksresektionen

    Bidlingmaier, Elisabeth Carolin [Verfasser] / Hartwig, Werner [Akademischer Betreuer]

    2023  

    Author's details Elisabeth Carolin Bidlingmaier ; Betreuer: Werner Hartwig
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Book ; Thesis: Adaptation und Ermüdung

    Hartwig, Werner

    Einflüsse auf die Biomechanik des Laufens im Hinblick auf die Prävention von Verletzungen des Kniegelenks

    1996  

    Author's details vorgelegt von Werner Hartwig
    Language German
    Size 127 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Univ., Diss., 1996
    HBZ-ID HT007826024
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    97 D 3020 order for loan Magazin

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  5. Book ; Online ; Thesis: Die Rolle von LGR6 in der Genese des humanen duktalen Pankreaskarzinoms (PDAC)

    Härtwig, Daniel [Verfasser] / Werner, Jens [Akademischer Betreuer]

    2019  

    Author's details Daniel Härtwig ; Betreuer: Jens Werner
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article: 5‐Fluorouracil – Determination of α‐fluoro‐β‐alanine in urine by GC‐MS/MS : Biomonitoring Methods, 2019

    Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe / Schierl, Rudolf / Fischer, Elke / Scherer, Gerhard / Hagedorn, Heinz Werner / Göen, Thomas / Hartwig, Andrea / MAK Commission

    The MAK collection for occupational health and safety, 4(1):303-316

    2019  

    Abstract: The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the presented biomonitoring method. The method described hereinafter permits ... ...

    Institution Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe
    Abstract The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the presented biomonitoring method. The method described hereinafter permits the determination of α‐fluoro‐β‐alanine (FBAL), the main metabolite of 5‐fluorouracil, at low concentration levels and can be used for the biomonitoring of exposed individuals (manufacture, pharmacy, medicine). To this end, urine samples are spiked with 13C‐FBAL as internal standard (IS) and acidified with 0.1 M hydrochloric acid. The samples are then extracted and purified using a strong cation exchanger. After resuspension and derivatisation, FBAL is analysed using GC‐MS/MS in the MRM (Multiple Reaction Monitoring) mode and quantified with reference to the internal standard. Calibration standards are prepared in pooled urine and processed in the same way as the samples to be analysed.
    Keywords 5-fluorouracil ; Analyses in Biological Materials ; Biomonitoring-Methoden ; Biomonitoring Methods ; GC-MS/MS ; biomonitoring ; gas chromatography mass spectrometry ; urine ; α-fluoro-β-alanine
    Language English
    Document type Article
    DOI 10.4126/FRL01-006455590
    Database Repository for Life Sciences

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  7. Article: 5‐Fluoruracil – Bestimmung von α‐Fluor‐β‐alanin in Urin mittels GC‐MS/MS : Biomonitoring Methods in German language, 2019

    Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe / Schierl, Rudolf / Fischer, Elke / Scherer, Gerhard / Hagedorn, Heinz Werner / Göen, Thomas / Hartwig, Andrea / MAK Commission

    The MAK collection for occupational health and safety, 4(1):337-352

    2019  

    Abstract: The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the presented biomonitoring method. The method described hereinafter permits ... ...

    Institution Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe
    Abstract The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the presented biomonitoring method. The method described hereinafter permits the determination of α‐fluoro‐β‐alanine (FBAL), the main metabolite of 5‐fluorouracil, at low concentration levels and can be used for the biomonitoring of exposed individuals (manufacture, pharmacy, medicine). To this end, urine samples are spiked with 13C‐FBAL as internal standard (IS) and acidified with 0.1 M hydrochloric acid. The samples are then extracted and purified using a strong cation exchanger. After resuspension and derivatisation, FBAL is analysed using GC‐MS/MS in the MRM (Multiple Reaction Monitoring) mode and quantified with reference to the internal standard. Calibration standards are prepared in pooled urine and processed in the same way as the samples to be analysed.
    Keywords 5-Fluoruracil ; Analysen in biologischem Material ; Biomonitoring ; Biomonitoring-Methoden ; Biomonitoring Methods ; GC-MS/MS ; Gaschromatographie-Massenspektrometrie ; Urin ; α-Fluor-β-alanin
    Language German
    Document type Article
    DOI 10.4126/FRL01-006455588
    Database Repository for Life Sciences

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  8. Article: Bitumen (Dampf und Aerosol bei der Heißverarbeitung) : MAK value documentation in German language, 2019 MAK value documentation in German language, 2019

    Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe / Nies, Eberhard / Brüning, Thomas / Steinhausen, M. / Welge, P. / Werner, S.C.M. / Pallapies, Dirk / Bartsch, Rüdiger / Brinkmann, Britta / Schriever‐Schwemmer, Gerlinde / Hartwig, Andrea / MAK Commission

    The MAK collection for occupational health and safety, 4(3):1253-1371

    2019  

    Abstract: The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the classification of bitumen [8052‐42‐4; 64741‐56‐6; 64742‐93‐4] in Carcinogen Category 2 considering all toxicological endpoints. New ... ...

    Institution Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe
    Abstract The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the classification of bitumen [8052‐42‐4; 64741‐56‐6; 64742‐93‐4] in Carcinogen Category 2 considering all toxicological endpoints. New data allowed a separate assessment of the harmful properties of vapours and aerosols from high‐temperature processing of two bitumen groups. Straight‐Run and Air‐Rectified Bitumen For the derivation of a maximum concentration at the workplace (MAK value), a 2‐year inhalation study in rats exposed to vapours and aerosols from a mixture of straight‐run and air‐rectified bitumen is used. Due to an increased incidence of bronchioalveolar hyperplasia in the lungs and of inflammatory cells in the nasal epithelium, the study resulted in a NOAEC of 6 mg/m3. Taking into account the extrapolation from an animal study and the increased respiratory volume at the workplace compared with the exposure of the animals at rest, a MAK value of 1.5 mg/m3 (sum of vapour and inhalable fraction) is derived for straight‐run and air‐rectified bitumen based on bitumen condensate standard. The MAK value is one‐third of the mean concentration at which three out of 12 inflammation markers are elevated in the sputum of exposed workers. However, the clinical relevance of this finding is unclear and the margin to the MAK value is considered sufficient. The effects on the lung is the most sensitive endpoint, so vapours and aerosols of bitumen are assigned to Peak Limitation Category II with an excursion factor of 2. All in all, the investigated straight‐run and air‐rectified bitumens did not exhibit distinct genotoxic or carcinogenic properties. However, due to the wide range in the chemical composition, harmful emissions of carcinogenic and mutagenic substances during high‐temperature processing cannot be completely excluded. Therefore, vapours and aerosols of straight‐run and air‐rectified bitumens, as commonly used in road paving, are regarded as suspicious carcinogens and classified in Carcinogen Category 3 B. As no data are available for developmental toxicity they are assigned to Pregnancy Risk Group D. Skin contact may contribute significantly to systemic toxicity and the “H” notation is confirmed. Sensitization is not expected from the available data. Oxidized Bitumen There are no inhalation studies available for evaluation of the carcinogenicity of oxidized bitumen (“Roofing Bitumen”). The new animal studies published since 2001 and most of the previous studies show the carcinogenicity of condensates of vapours and aerosols of oxidized bitumens in skin painting studies in mice, so that a significant number of tested oxidized bitumens must be considered carcinogenic. The positive animal experiments on the carcinogenicity are consistent with the results of a genotoxicity study in roofing workers with increased DNA strand break rates. Vapours and aerosols of oxidized bitumen are classified in Carcinogen Category 2. A MAK value could not be derived. Mutations in bacteria and higher levels of benzo[a]pyrene in oxidized bitumen condensates compared to those of straight‐run and air‐rectified bitumen and the systemic availability of inhaled vapours and aerosols of oxidized bitumen support suspicion of germ cell mutagenicity. Therefore, vapours and aerosols of oxidized bitumen are classified in Category 3 B for germ cell mutagens. Skin contact may contribute significantly to systemic toxicity and the “H” notation is confirmed. Sensitization is not expected from the available data.
    Keywords (sub)akute Toxizität ; (sub)chronische Toxizität ; Arbeitsstoff ; Bitumen ; Gefahrstoff ; Genotoxizität ; Destillationsbitumen ; Kanzerogenität ; Hautresorption ; Oxidationsbitumen ; MAK Value Documentations ; MAK-Begründungen ; MAK-Wert ; Metabolismus ; Spitzenbegrenzung ; Reizwirkung ; Reproduktionstoxizität ; Wirkungsmechanismus ; Toxikokinetik ; Toxizität ; fruchtschädigende Wirkung ; keimzellmutagene Wirkung ; krebserzeugende Wirkung ; maximale Arbeitsplatzkonzentration ; sensibilisierende Wirkung
    Language German
    Document type Article
    DOI 10.4126/FRL01-006461022
    Database Repository for Life Sciences

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  9. Article ; Online: WNT enhancing signals in pancreatic cancer are transmitted by LGR6.

    Wang, Jing / Koch, Dominik T / Hofmann, Felix O / Härtwig, Daniel / Beirith, Iris / Janssen, Klaus Peter / Bazhin, Alexandr V / Niess, Hanno / Werner, Jens / Renz, Bernhard W / Ilmer, Matthias

    Aging

    2023  Volume 15, Issue 20, Page(s) 10897–10914

    Abstract: The G-protein-coupled receptor LGR6 associates with ligands of the R-Spondin (RSPO) family to potentiate preexisting signals of the canonical WNT pathway. However, its importance in pancreatic ductal adenocarcinoma (PDAC) remains unclear. Here, we show ... ...

    Abstract The G-protein-coupled receptor LGR6 associates with ligands of the R-Spondin (RSPO) family to potentiate preexisting signals of the canonical WNT pathway. However, its importance in pancreatic ductal adenocarcinoma (PDAC) remains unclear. Here, we show that LGR6 is differentially expressed in various PDAC cell lines of mesenchymal and epithelial phenotype, respectively, siding with the latter subsets. LGR6 expression is altered based upon the cells' WNT activation status. Furthermore, extrinsic enhancement of WNT pathway signaling increased LGR6 expression suggestive of a reinforcing self-regulatory loop in highly WNT susceptible cells. Downregulation of LGR6 on the other hand, seemed to tamper those effects. Last, downregulation of LGR6 reduced cancer stemness as determined by functional
    MeSH term(s) Humans ; Pancreatic Neoplasms/pathology ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Wnt Signaling Pathway/genetics ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Pancreatic Neoplasms
    Chemical Substances Receptors, G-Protein-Coupled ; LGR6 protein, human
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Chronische Pankreatitis - Update Leitlinie: Eine Frage der richtigen Therapie zum richtigen Zeitpunkt.

    D'Haese, Jan G / Hartwig, Werner / Werner, Jens

    Zentralblatt fur Chirurgie

    2016  Volume 141, Issue 2, Page(s) 125–128

    MeSH term(s) Diagnosis, Differential ; Drainage ; Early Diagnosis ; Early Medical Intervention ; Guideline Adherence ; Humans ; Islets of Langerhans Transplantation ; Pain Measurement ; Pancreatectomy ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/surgery ; Pancreatic Pseudocyst/diagnosis ; Pancreatic Pseudocyst/surgery ; Pancreaticojejunostomy ; Pancreatitis, Chronic/complications ; Pancreatitis, Chronic/diagnosis ; Pancreatitis, Chronic/etiology ; Pancreatitis, Chronic/surgery ; Splenectomy
    Language German
    Publishing date 2016-04
    Publishing country Germany
    Document type Comparative Study ; Journal Article
    ZDB-ID 200935-3
    ISSN 1438-9592 ; 0044-409X
    ISSN (online) 1438-9592
    ISSN 0044-409X
    DOI 10.1055/s-0036-1583222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 95: Show issues

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