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  1. Article ; Online: Pancreatic involvement in SARS-CoV-2: case report and living review.

    Pinte, Larisa / Baicus, Cristian

    Journal of gastrointestinal and liver diseases : JGLD

    2020  Volume 29, Issue 2, Page(s) 275–276

    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Humans ; Male ; Middle Aged ; Pancreatitis/diagnosis ; Pancreatitis/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country Romania
    Document type Case Reports ; Letter ; Review
    ZDB-ID 2427021-0
    ISSN 1842-1121 ; 1841-8724
    ISSN (online) 1842-1121
    ISSN 1841-8724
    DOI 10.15403/jgld-2618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hyper-inflammation after COVID-19 mARN vaccination: at the crossroads of multisystem inflammatory disease and adult-onset Still's disease. Does terminology matter?

    Baicus, Cristian / Delcea, Caterina / Pinte, Larisa / Dan, Gheorghe Andrei

    Romanian journal of internal medicine = Revue roumaine de medecine interne

    2022  Volume 60, Issue 1, Page(s) 3–5

    MeSH term(s) Adult ; COVID-19/prevention & control ; Humans ; Inflammation/etiology ; Still's Disease, Adult-Onset ; Vaccination
    Language English
    Publishing date 2022-03-17
    Publishing country Germany
    Document type Letter
    ZDB-ID 2015966-3
    ISSN 2501-062X ; 0035-3973 ; 1582-3296
    ISSN (online) 2501-062X
    ISSN 0035-3973 ; 1582-3296
    DOI 10.2478/rjim-2021-0035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Causes of eosinophilic ascites - A systematic review.

    Pinte, Larisa / Baicuş, Cristian

    Romanian journal of internal medicine = Revue roumaine de medecine interne

    2019  Volume 57, Issue 2, Page(s) 110–124

    Abstract: Background: In the last years an uprising interest for a relatively unknown entity, eosinophilic ascites (EA), has been recorded. Our aim is to investigate the potential causes of EA development, as well as clinical, laboratory, endoscopic and ... ...

    Abstract Background: In the last years an uprising interest for a relatively unknown entity, eosinophilic ascites (EA), has been recorded. Our aim is to investigate the potential causes of EA development, as well as clinical, laboratory, endoscopic and radiologic features, management and outcome in these patients.
    Methods: The following research was performed on PubMed (MEDLINE) database using the medical subject headings [Mesh] terms "Ascites" AND "Eosinophils".
    Results: A total of 284 results, dating from 1962 onwards, were found and abstracts were examined. 131 papers were excluded and the remaining 153 publications, consisting in case reports and series of cases, were analyzed. From 171 patients with EA, 127 subjects (74%) had EGE, 17 (10%) parasitic and fungal infections, 11(7%) Hypereosinophilic syndrome and 16 patients (9%) less common diseases (eosinophilic pancreatitis, chronic eosinophilic leukemia, myelofibrosis, T-cell lymphoma, Churg Strauss Syndrome, Systemic lupus erythematosus, Familial paroxysmal polyserositis and Ménétrier's disease). High eosinophil blood count and IgE levels as well as gastrointestinal symptoms are frequent. The diagnosis is based on ascitic fluid analysis, imaging and endoscopic biopsies. Therapy with corticosteroids results in resolution of eosinophilic ascites in almost all patients.
    Conclusion: In most cases, in the absence of allergy, parasitic infections, malignancy, hematological disorders, peritoneal tuberculosis, inflammatory bowel disease or autoimmune disease, EA develops as a manifestation of eosinophilic gastroenteritis.
    MeSH term(s) Ascites/etiology ; Ascites/pathology ; Eosinophilia/etiology ; Eosinophilia/pathology ; Humans
    Language English
    Publishing date 2019-03-12
    Publishing country Germany
    Document type Journal Article ; Systematic Review
    ZDB-ID 2015966-3
    ISSN 2501-062X ; 0035-3973 ; 1582-3296
    ISSN (online) 2501-062X
    ISSN 0035-3973 ; 1582-3296
    DOI 10.2478/rjim-2018-0041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Eosinophilic pancreatitis versus pancreatitis associated with eosinophilic gastroenteritis - a systematic review regarding clinical features and diagnosis.

    Pinte, Larisa / Băicuș, Cristian

    Romanian journal of internal medicine = Revue roumaine de medecine interne

    2019  Volume 57, Issue 4, Page(s) 284–295

    Abstract: Background: Over the past years, eosinophil infiltration involving the gastrointestinal tract and pancreas leading to eosinophilic pancreatitis, eosinophilic gastroenteritis and hypereosinophilic syndrome has been reported in the literature. We aimed to ...

    Abstract Background: Over the past years, eosinophil infiltration involving the gastrointestinal tract and pancreas leading to eosinophilic pancreatitis, eosinophilic gastroenteritis and hypereosinophilic syndrome has been reported in the literature. We aimed to analyze and compare the features involving patients with eosinophilic pancreatitis and pancreatitis associated with eosinophilic gastroenteritis and to determine if there is a connection between the two disorders or if they in fact meet the diagnostic criteria for hypereosinophilic syndrome.
    Material and methods: The following search was performed in March 2019 on PubMed (MEDLINE) database using the medical terms "pancreatitis", "eosinophilic pancreatitis", "eosinophilic gastroenteritis" and "hypereosinophilic syndrome".
    Results: The search revealed 119 publications from 1970 onwards. A total of 83 papers were excluded, and the remaining 36 publications, consisting in case reports and case series, were analyzed. From 45 patients, 20 subjects with eosinophilic gastroenteritis developed pancreatitis, 20/45 had eosinophilic pancreatitis, and 5/45 hypereosinophilic syndrome involving the pancreas. There was no significant difference regarding clinical, laboratory and imaging features between the three groups, despite the multiple theories that explain the association of pancreatic and gastrointestinal eosinophilic infiltration. Although there was a strong resemblance between the three groups, histological evidence of eosinophilic gastrointestinal infiltration guided the treatment towards a less invasive way, while subjects with eosinophilic pancreatitis underwent pancreatic surgery to exclude potentially malignant lesions.
    Conclusion: Although there are various theories that explain pancreatitis development in patients with eosinophilic gastroenteritis, hypereosinophilia diagnostic work-up should be taken into account in all patients with high number of blood eosinophils, even in those with eosinophilic pancreatitis in order to establish the diagnosis using a minimally invasive approach and to apply an adequate treatment.
    MeSH term(s) Enteritis/complications ; Enteritis/diagnosis ; Eosinophilia/complications ; Eosinophilia/diagnosis ; Gastritis/complications ; Gastritis/diagnosis ; Humans ; Hypereosinophilic Syndrome/complications ; Hypereosinophilic Syndrome/diagnosis ; Pancreatitis/diagnosis ; Pancreatitis/immunology
    Language English
    Publishing date 2019-05-23
    Publishing country Germany
    Document type Comparative Study ; Journal Article ; Systematic Review
    ZDB-ID 2015966-3
    ISSN 2501-062X ; 0035-3973 ; 1582-3296
    ISSN (online) 2501-062X
    ISSN 0035-3973 ; 1582-3296
    DOI 10.2478/rjim-2019-0012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hyper-inflammation after COVID-19 mARN vaccination

    Baicus Cristian / Delcea Caterina / Pinte Larisa / Dan Gheorghe Andrei

    Romanian Journal of Internal Medicine, Vol 60, Iss 1, Pp 3-

    at the crossroads of multisystem inflammatory disease and adult-onset Still’s disease. Does terminology matter?

    2022  Volume 5

    Keywords covid-19 vaccine ; multisystemic inflammatory syndrome ; adult-onset still’s disease ; cytokine storm ; anakinra ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Causes of eosinophilic ascites – A systematic review

    Pinte Larisa / Baicuş Cristian

    Romanian Journal of Internal Medicine, Vol 57, Iss 2, Pp 110-

    2019  Volume 124

    Abstract: Background. In the last years an uprising interest for a relatively unknown entity, eosinophilic ascites (EA), has been recorded. ...

    Abstract Background. In the last years an uprising interest for a relatively unknown entity, eosinophilic ascites (EA), has been recorded.
    Keywords ascites ; hypereosinophilia ; eosinophilic ascites ; eosinophilic gastroenteritis ; hypereosinophilic syndrome ; parasitic infection ; systematic review ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2019-06-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Eosinophilic pancreatitis versus pancreatitis associated with eosinophilic gastroenteritis – a systematic review regarding clinical features and diagnosis

    Pinte Larisa / Băicuș Cristian

    Romanian Journal of Internal Medicine, Vol 57, Iss 4, Pp 284-

    2019  Volume 295

    Abstract: Background. Over the past years, eosinophil infiltration involving the gastrointestinal tract and pancreas leading to eosinophilic pancreatitis, eosinophilic gastroenteritis and hypereosinophilic syndrome has been reported in the literature. ...

    Abstract Background. Over the past years, eosinophil infiltration involving the gastrointestinal tract and pancreas leading to eosinophilic pancreatitis, eosinophilic gastroenteritis and hypereosinophilic syndrome has been reported in the literature.
    Keywords pancreatitis ; eosinophils ; esoninophilic pancreatitis ; eosinophilic gastroenteritis ; hypereosinophilic syndrome ; systematic review ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: COVID-19: a trigger for severe thrombotic microangiopathy in a patient with complement gene variant.

    Pinte, Larisa / Sorohan, Bogdan Marian / Prohászka, Zoltán / Gherghiceanu, Mihaela / Băicuş, Cristian

    Romanian journal of internal medicine = Revue roumaine de medecine interne

    2022  Volume 60, Issue 2, Page(s) 138–142

    Abstract: The evidence regarding thrombotic microangiopathy (TMA) related to Coronavirus Infectious Disease 2019 (COVID-19) in patients with complement gene mutations as a cause of acute kidney injury (AKI) are limited. We presented the case of a 23-year-old male ... ...

    Abstract The evidence regarding thrombotic microangiopathy (TMA) related to Coronavirus Infectious Disease 2019 (COVID-19) in patients with complement gene mutations as a cause of acute kidney injury (AKI) are limited. We presented the case of a 23-year-old male patient admitted with an asymptomatic form of COVID-19, but with uncontrolled hypertension and AKI. Kidney biopsy showed severe lesions of TMA. In evolution patient had persistent microangiopathic hemolytic anemia, decreased level of haptoglobin and increased LDH level. Decreased complement C3 level and the presence of schistocytes were found for the first time after biopsy. Kidney function progressively decreased and the patient remained hemodialysis dependent. Complement work-up showed a heterozygous variant with unknown significance in complement factor I (CFI) c.-13G>A, affecting the 5' UTR region of the gene. In addition, the patient was found to be heterozygous for the complement factor H (CFH) H3 haplotype (involving the rare alleles of c.-331C>T, Q672Q and E936D polymorphisms) reported as a risk factor of atypical hemolytic uremic syndrome. This case of AKI associated with severe TMA and secondary hemolytic uremic syndrome highlights the importance of genetic risk modifiers in the alternative pathway dysregulation of the complement in the setting of COVID-19, even in asymptomatic forms.
    MeSH term(s) Acute Kidney Injury/complications ; Adult ; Atypical Hemolytic Uremic Syndrome/complications ; Atypical Hemolytic Uremic Syndrome/genetics ; COVID-19/complications ; Communicable Diseases/complications ; Humans ; Male ; Thrombotic Microangiopathies/genetics ; Young Adult
    Language English
    Publishing date 2022-06-14
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 2015966-3
    ISSN 2501-062X ; 0035-3973 ; 1582-3296
    ISSN (online) 2501-062X
    ISSN 0035-3973 ; 1582-3296
    DOI 10.2478/rjim-2021-0040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Impact of Antibiotic Use on Mortality in Patients Hospitalized in a COVID-19 Centre from Romania: A Retrospective Study.

    Iosub, Maria-Ilinca / Balan, Elena-Sabina / Pinte, Larisa / Draghici, Ana-Maria / Baicus, Cristian / Badea, Camelia

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 11

    Abstract: Background and Objectives: Considering the significant number of patients worldwide that received empirical antibiotic therapy for COVID-19 infection due to their critical condition and the lack of therapeutical guidelines, we wanted to find out the ... ...

    Abstract Background and Objectives: Considering the significant number of patients worldwide that received empirical antibiotic therapy for COVID-19 infection due to their critical condition and the lack of therapeutical guidelines, we wanted to find out the consequences of antibiotic use in our study population. Materials and Methods: We conducted a retrospective cohort study including symptomatic patients older than 18 years, hospitalized for SARS-CoV-2 between March and December 2020 in the Internal Medicine and Pneumology Departments of Colentina Clinical Hospital. The elected outcome was death, while independent variables were antibiotic therapy and literature-cited parameters associated with mortality in this disease. Results: Out of 198 included patients, 96 (48.48%) patients received antibiotic therapy during hospitalization. Female gender (OR = 2.61, p = 0.04), history of neoplasm (OR = 7.147, p = 0.01), heart failure (OR = 8.62, p = 0.002), and diabetes mellitus (OR = 3.05, p = 0.02) were significantly associated with death in multivariate analysis. Antibiotic treatment showed a higher probability of death both in bivariate (OR = 5.333, p < 0.001) and multivariate analysis adjusted for the aforementioned prognostic factors (OR = 3.55, p = 0.01). Conclusions: After adjusting for confounders, in-hospital antibiotic administration did not improve survival in COVID-19 patients.
    MeSH term(s) Humans ; Female ; Retrospective Studies ; Anti-Bacterial Agents/therapeutic use ; Romania/epidemiology ; SARS-CoV-2 ; Hospitalization ; COVID-19 Drug Treatment
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58111628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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