LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 339

Search options

  1. Book ; Online: A contribution to discern the true impact of covid-19 on human mortality

    Barone, Stefano

    2024  

    Abstract: The years 2020 and 2021 were characterized by the covid-19 pandemic. The true impact of the pandemic on populations health and life has still to be completely discerned. Objective difficulties to account deaths due to covid-19, determined the risk of ... ...

    Abstract The years 2020 and 2021 were characterized by the covid-19 pandemic. The true impact of the pandemic on populations health and life has still to be completely discerned. Objective difficulties to account deaths due to covid-19, determined the risk of underestimating such impact, hence official mortality data started to be examined. The main objective of this work is to discern the true impact of covid-19 in EU during the crucial years 2020 and 2021. The mortality trends, already increasing in EU in pre-pandemic years, are modelled. The excess mortality attributable to covid-19, on yearly basis, is estimated via a novel strategy combining datasets from different official sources. Considering demographic and geographic factors, new indexes are formulated, which allow rankings of EU countries, and socio-political and economic reflections. The new indexes here formulated provide a different perspective to see the relative impact of the pandemic in EU. This work, also in line with the conclusions of previously published authoritative papers on demographic studies of excess mortality, represents an original methodology, which timely implemented, can be at the service of public decision makers for future emerging needs.

    Comment: 30 pages, 5 figures, 3 tables
    Keywords Statistics - Applications ; Quantitative Biology - Populations and Evolution
    Subject code 310
    Publishing date 2024-01-08
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: Lasciarsi Merton alle spalle, ma per andare in quale direzione?

    Barone-Adesi, Francesco / Canali, Stefano

    Epidemiologia e prevenzione

    2023  Volume 47, Issue 1-2, Page(s) 14–16

    Title translation Leaving Merton behind, but to go in which direction?
    Language Italian
    Publishing date 2023-03-21
    Publishing country Italy
    Document type News
    ZDB-ID 1038112-0
    ISSN 1120-9763
    ISSN 1120-9763
    DOI 10.19191/EP23.1-2.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2748: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 265: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Can AI deliver advice that is judgement-free for science policy?

    Canali, Stefano / Barone-Adesi, Francesco

    Nature

    2023  Volume 624, Issue 7991, Page(s) 252

    MeSH term(s) Artificial Intelligence/ethics ; Machine Learning/ethics ; Policy ; Bias ; Science
    Language English
    Publishing date 2023-12-12
    Publishing country England
    Document type Letter
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-023-03949-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Pandemetrics: systematically assessing, monitoring, and controlling the evolution of a pandemic.

    Barone, Stefano / Chakhunashvili, Alexander

    Quality & quantity

    2022  Volume 57, Issue 2, Page(s) 1701–1723

    Abstract: The still ongoing pandemic of SARS-CoV-2 virus and COVID-19 disease, affecting the population worldwide, has demonstrated the need of more accurate methodologies for assessing, monitoring, and controlling an outbreak of such devastating proportions. ... ...

    Abstract The still ongoing pandemic of SARS-CoV-2 virus and COVID-19 disease, affecting the population worldwide, has demonstrated the need of more accurate methodologies for assessing, monitoring, and controlling an outbreak of such devastating proportions. Authoritative attempts have been made in traditional fields of medicine (epidemiology, virology, infectiology) to address these shortcomings, mainly by relying on mathematical and statistical modeling. However, here, we propose approaching the methodological work from a different, and to some extent alternative, standpoint. Applied systematically, the concepts and tools of statistical engineering and quality management, developed not only in healthcare settings, but also in other scientific contexts, can be very useful in assessing, monitoring, and controlling pandemic events. We propose a methodology based on a set of tools and techniques, formulas, graphs, and tables to support the decision-making concerning the management of a pandemic like COVID-19. This methodological body is hereby named Pandemetrics. This name intends to emphasize the peculiarity of our approach to measuring, and graphically presenting the unique context of the COVID-19 pandemic.
    Language English
    Publishing date 2022-06-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2003280-8
    ISSN 1573-7845 ; 0033-5177
    ISSN (online) 1573-7845
    ISSN 0033-5177
    DOI 10.1007/s11135-022-01424-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: LEADER local action groups and inner areas. An Italian case study.

    Barone, Vincenzo / Gaeta, Giuseppe Lucio / Ghinoi, Stefano / Silvestri, Francesco

    Evaluation and program planning

    2023  Volume 101, Page(s) 102357

    Abstract: In this study we investigate marginality in European rural areas to understand how EU policies for local development can stimulate novel approaches to social innovation and economic growth. The method applied is a Social Network Analysis (SNA) on the ... ...

    Abstract In this study we investigate marginality in European rural areas to understand how EU policies for local development can stimulate novel approaches to social innovation and economic growth. The method applied is a Social Network Analysis (SNA) on the call tenders of an Italian Local Action Group managing the LEADER programme in the Piacentino and Parmense Apennine (Emilia-Romagna). The implementation of the Inner Area Strategy in a part of the LEADER territory (11 out of the 59 municipalities of the LEADER area) allows to verify complementarities, interrelations and overlays between the two development policies.
    MeSH term(s) Humans ; Program Evaluation ; Economic Development ; Policy
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2013444-7
    ISSN 1873-7870 ; 0149-7189
    ISSN (online) 1873-7870
    ISSN 0149-7189
    DOI 10.1016/j.evalprogplan.2023.102357
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Possible role of glucose-6-phosphatase 3 in the pathogenesis of uterine leiomyomas

    Paola Marcolongo / Virginia Barone / Stefano Luisi

    AboutOpen, Vol 10, Iss

    2023  Volume 1

    Abstract: Background and aim: Glucose-6-phosphatase catalytic subunit 3 (G6PC3) has been recently described as a metabolite repair enzyme involved in the disposal of the phosphorylated glucose analog 1,5-anhydroglucitol-6-phosphate (1,5AG6P). This function is ... ...

    Abstract Background and aim: Glucose-6-phosphatase catalytic subunit 3 (G6PC3) has been recently described as a metabolite repair enzyme involved in the disposal of the phosphorylated glucose analog 1,5-anhydroglucitol-6-phosphate (1,5AG6P). This function is especially relevant in neutrophils; indeed, G6PC3 deficiency leads to neutropenia as the accumulated metabolite 1,5AG6P inhibits the first step of glycolysis. Like neutrophils, tumoral metabolism also mainly relies on glycolysis, and we wondered if G6PC3 is expressed in uterine leiomyoma samples and if it can eventually have a role in the pathogenesis of these tumors. Understanding the complex pathophysiology of leiomyomas is a prerequisite to develop new therapeutic strategies. Methods: We used human uterine leiomyoma and matched myometrial samples. Immunohistochemistry and quantitative polymerase chain reaction (qPCR) were performed. Results: Immunohistochemical analysis has not evidenced appreciable differences between pathologic versus normal tissue samples. Indeed, qPCR analysis suggests a higher expression of G6PC3 in human uterine leiomyoma than in matched myometrial samples. Conclusion: A targeted therapeutic inhibition of G6PC3 in uterine leiomyoma samples is a potential strategy to slow down tumor growth.
    Keywords G6PC3 ; G6PT ; 1,5-Anhydroglucitol-6-phosphate ; Glycolysis ; Uterine leiomyomas ; Medicine ; R
    Subject code 500
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher AboutScience Srl
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: On-Line Thermally Induced Evolved Gas Analysis: An Update-Part 2: EGA-FTIR.

    Gullifa, Giuseppina / Barone, Laura / Papa, Elena / Materazzi, Stefano / Risoluti, Roberta

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 24

    Abstract: The on-line thermally induced evolved gas analysis (OLTI-EGA) is widely applied in many different fields. Aimed to update the applications, our group has systematically collected and published examples of EGA characterizations. Following the recently ... ...

    Abstract The on-line thermally induced evolved gas analysis (OLTI-EGA) is widely applied in many different fields. Aimed to update the applications, our group has systematically collected and published examples of EGA characterizations. Following the recently published review on EGA-MS applications, this second part reviews the latest applications of Evolved Gas Analysis performed by on-line coupling heating devices to infrared spectrometers (EGA-FTIR). The selected 2019, 2020, 2021 and early 2022 references are collected and briefly described in this review; these are useful to help researchers to easily find applications that are sometimes difficult to locate.
    Language English
    Publishing date 2022-12-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27248926
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: A Longitudinal RCT on the Effectiveness of a Psychological Intervention for Hospital Healthcare Workers During the COVID-19 Pandemic: What We Learned to Date.

    Rizzi, Damiano / Monaci, Michela / Gambini, Giulia / Benzi, Ilaria Maria Antonietta / Perlini, Stefano / De Silvestri, Annalisa / Klersy, Catherine / Barone, Lavinia

    Journal of clinical psychology in medical settings

    2024  

    Abstract: The COVID-19 pandemic has led to significant psychological distress among frontline healthcare workers (HCWs), with a particular increase in trauma-related symptoms. This study investigated the longitudinal course of trauma-associated symptoms and ... ...

    Abstract The COVID-19 pandemic has led to significant psychological distress among frontline healthcare workers (HCWs), with a particular increase in trauma-related symptoms. This study investigated the longitudinal course of trauma-associated symptoms and behaviors in HCWs and the effectiveness of a brief dialectical behavior therapy (DBT)-informed intervention in mitigating these symptoms over 12 months. The trial included 225 HCWs randomly assigned to one of three groups: no intervention (control), in-person DBT-informed intervention, or online DBT-informed intervention. Over time, a natural decrease in PTSD symptoms was observed in all groups. Contrary to expectations, no difference was found between the control and intervention groups. However, for participants with severe PTSD symptoms, the intervention significantly mitigated their distress. No differences emerged between in-person and online interventions, suggesting equal effectiveness. Females reported higher trauma-related symptoms, while no differences emerged among different professional roles. These findings underscore the importance of targeted interventions for HCWs experiencing severe symptoms and highlight the potential of online modalities. Further research is needed to optimize the deployment of mental health resources within the healthcare setting, particularly during crises.
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1235893-9
    ISSN 1573-3572 ; 1068-9583
    ISSN (online) 1573-3572
    ISSN 1068-9583
    DOI 10.1007/s10880-023-09988-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4286: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Indicaxanthin prevents eryptosis induced by cigarette smoke extract by interfering with active Fas-mediated signaling.

    Restivo, Ignazio / Giardina, Ilenia Concetta / Barone, Rosario / Cilla, Antonio / Burgio, Stefano / Allegra, Mario / Tesoriere, Luisa / Attanzio, Alessandro

    BioFactors (Oxford, England)

    2024  

    Abstract: A physiological mechanism of programmed cell death called eryptosis occurs in aged or damaged red blood cells (RBCs). Dysregulated eryptosis contributes to abnormal microcirculation and prothrombotic risk. Cigarette smoke extract (CSE) induces a p38 MAPK- ...

    Abstract A physiological mechanism of programmed cell death called eryptosis occurs in aged or damaged red blood cells (RBCs). Dysregulated eryptosis contributes to abnormal microcirculation and prothrombotic risk. Cigarette smoke extract (CSE) induces a p38 MAPK-initiated, Fas-mediated eryptosis, activating the death-inducing signaling complex (DISC). Indicaxanthin (Ind) from cactus pear fruits, is a bioavailable dietary phytochemical in humans and it is able to incorporate into RBCs enhancing their defense against numerous stimuli. This in vitro work shows that Ind, at concentrations that mimic plasma concentrations after a fruit meal, protects erythrocytes from CSE-induced eryptosis. CSE from commercial cigarettes was prepared in aqueous solution using an impinger air sampler and nicotine content was determined. RBCs were treated with CSE for 3 h in the absence or presence of increasing concentrations of Ind (from 1 to 5 μM). Cytofluorimetric measurements indicated that Ind reduced CSE-induced phosphatidylserine externalization and ceramide formation in a concentration-dependent manner. Confocal microscopy visualization and coimmunoprecipitation experiments revealed that Ind prevented both CSE-triggered Fas aggregation and FasL/FADD/caspase 8 recruitment in the membrane, indicating inhibition of DISC assembly. Ind inhibited the phosphorylation of p38 MAPK, caspase-8/caspase-3 cleavage, and caspase-3 activity induced by CSE. Finally, Ind reduced CSE-induced ATP depletion and restored aminophospholipid translocase activity impaired by CSE treatment. In conclusion, Ind concentrations comparable to nutritionally relevant plasma concentrations, can prevent Fas-mediated RBC death signaling induced by CSE, which suggests that dietary intake of cactus pear fruits may limit the deleterious effects of cigarette smoking.
    Language English
    Publishing date 2024-03-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 59230-4
    ISSN 1872-8081 ; 0951-6433
    ISSN (online) 1872-8081
    ISSN 0951-6433
    DOI 10.1002/biof.2051
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Book ; Online: Il farmaco : ricerca, sviluppo e applicazione in terapia

    Capone, Giacomo / Tomasi, Francesco De / Fuccella, Luciano Maria / Orlando, Valentina / Menditto, Enrica / Putignano, Daria / Bocchi, Ilenia / Piscitelli, Antonella / Barone, Domenico / Bonato, Stefano / Colonna, Roberto / Iadevaia, Vincenzo / Russo, Veronica / Romano, Silvia / Vinci, Paolo / Cammarata, Silvia / Guerriero, Francesca / Calderazzo, Valentina / Novellino, Ettore

    2019  

    Keywords xxxx
    Size 1 electronic resource (266 pages)
    Publisher FedOA - Federico II University Press
    Document type Book ; Online
    Note Italian ; Open Access
    HBZ-ID HT021047014
    ISBN 9788868870652 ; 8868870657
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top