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Article ; Online: Anomalous electrons in a metallic kagome ferromagnet.

Ekahana, Sandy Adhitia / Soh, Y / Tamai, Anna / Gosálbez-Martínez, Daniel / Yao, Mengyu / Hunter, Andrew / Fan, Wenhui / Wang, Yihao / Li, Junbo / Kleibert, Armin / Vaz, C A F / Ma, Junzhang / Lee, Hyungjun / Xiong, Yimin / Yazyev, Oleg V / Baumberger, Felix / Shi, Ming / Aeppli, G

Nature

2024 Volume 627, Issue 8002, Page(s) 67–72

Abstract: Ordinary metals contain electron liquids within well-defined 'Fermi' surfaces at which the electrons behave as if they were non-interacting. In the absence of transitions to entirely new phases such as insulators or superconductors, interactions between ... ...

Abstract	Ordinary metals contain electron liquids within well-defined 'Fermi' surfaces at which the electrons behave as if they were non-interacting. In the absence of transitions to entirely new phases such as insulators or superconductors, interactions between electrons induce scattering that is quadratic in the deviation of the binding energy from the Fermi level. A long-standing puzzle is that certain materials do not fit this 'Fermi liquid' description. A common feature is strong interactions between electrons relative to their kinetic energies. One route to this regime is special lattices to reduce the electron kinetic energies. Twisted bilayer graphene
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-024-07085-w
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Article ; Online: Corrigendum: Co-stimulation with TLR7 agonist imiquimod and inactivated Influenza virus particles promotes mouse B cell activation, differentiation, and accelerated antigen specific antibody production.

Li, Can / To, Kelvin K W / Zhang, Anna J X / Lee, Andrew C Y / Zhu, Houshun / Mak, Winger W N / Hung, Ivan F N / Yuen, Kwok-Yung

Frontiers in immunology

2022 Volume 13, Page(s) 1053779

Abstract: This corrects the article DOI: 10.3389/fimmu.2018.02370.]. ...

Abstract	[This corrects the article DOI: 10.3389/fimmu.2018.02370.].
Language	English
Publishing date	2022-10-21
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1053779
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Article: COVID-19 Associated Vasculitis Confirmed by the Tissues RT-PCR: A Case Series Report.

Biomedicines

2023 Volume 11, Issue 3

Abstract: Background: Several cases of skin and central nervous system vasculopathy associated with COVID-19 in children have been published, but the information is rather limited. Our study aimed to describe these cases of vasculitis associated with COVID-19 in ... ...

Abstract	Background: Several cases of skin and central nervous system vasculopathy associated with COVID-19 in children have been published, but the information is rather limited. Our study aimed to describe these cases of vasculitis associated with COVID-19 in children. Methods: In the retrospective-prospective case series study we included information regarding four children with COVID-19-associated vasculitis. In every case, we had a morphological description and the etiology was confirmed via real-time polymerase chain reaction during a tissue biopsy. Results: The most involved systems were skin (4/4), respiratory (3/4), cardiovascular (2/4), nervous (1/4), eye (1/4), kidney (1/4), and inner year (1/4). All patients had increased inflammatory markers and thrombotic parameters (D-dimer). No patient met the criteria for multisystem inflammatory syndrome in children. Two patients met polyarteritis nodosa criteria, one met Henoch-Schonlein purpura criteria, and one met unclassified vasculitis criteria. All patients were treated with systemic glucocorticosteroids (two-pulse therapy). Non-biologic DMARDs were prescribed in all cases; 1/4 patients (25%) was treated with intravenous immunoglobuline, and 3/4 (75%) were treated with biologics (etanercept, tocilizumab, and adalimumab). Conclusions: Vasculitis associated with COVID-19 could be a life-threatening condition; SARS-CoV-2 might be a new trigger or etiological agent for vasculitis and other immune-mediated diseases. Further research and collection of similar cases are required.
Language	English
Publishing date	2023-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11030870
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Article ; Online: Rational design of three-in-one Pt/MnO

Yi, Zhihao / Ren, Yashuang / Li, Yang / Li, Yanna / Long, Feng / Zhu, Anna

Talanta

2023 Volume 265, Page(s) 124839

Abstract: In this work, a novel three-in-one Pt/ ... ...

Abstract	In this work, a novel three-in-one Pt/MnO
MeSH term(s)	Humans ; Oxides/chemistry ; Cysteine ; Ascorbic Acid/chemistry ; Colorimetry/methods ; Manganese Compounds/chemistry ; Hydrogen Peroxide/chemistry
Chemical Substances	Oxides ; Cysteine (K848JZ4886) ; Ascorbic Acid (PQ6CK8PD0R) ; Manganese Compounds ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2023-06-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2023.124839
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Article: Respiratory function after 30+ years following sulfur mustard exposure in survivors in Sweden.

Moradi, Faraidoun / Kjellberg, Sanna / Li, Ying / Daka, Bledar / Olin, Anna-Carin

Frontiers in medicine

2024 Volume 11, Page(s) 1251500

Abstract: Background: Sulfur mustard (SM) exposure causes acute and chronic respiratory diseases. The extent of small airway dysfunction (SAD) in individuals exposed to SM is unclear. This study evaluated and compared SAD in SM-exposed and SM-unexposed ... ...

Abstract	Background: Sulfur mustard (SM) exposure causes acute and chronic respiratory diseases. The extent of small airway dysfunction (SAD) in individuals exposed to SM is unclear. This study evaluated and compared SAD in SM-exposed and SM-unexposed participants using noninvasive lung function tests assessing small airway function. Methods: This retrospective cohort study involved SM-exposed ( Results: No statistically significant differences in age, height, or body mass index were observed between the two groups. IOS showed significantly increased small airway resistance, while N Conclusion: Exposure to SM was positively associated with long-term impairment of respiratory tract function in the small airways in the majority of the previously SM-exposed individuals in the present study. Furthermore, both IOS and N
Language	English
Publishing date	2024-03-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1251500
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Article ; Online: Disulfide-constrained peptide scaffolds enable a robust peptide-therapeutic discovery platform.

Zhou, Lijuan / Cai, Fei / Li, Yanjie / Gao, Xinxin / Wei, Yuehua / Fedorova, Anna / Kirchhofer, Daniel / Hannoush, Rami N / Zhang, Yingnan

PloS one

2024 Volume 19, Issue 3, Page(s) e0300135

Abstract: Peptides present an alternative modality to immunoglobulin domains or small molecules for developing therapeutics to either agonize or antagonize cellular pathways associated with diseases. However, peptides often suffer from poor chemical and physical ... ...

Abstract	Peptides present an alternative modality to immunoglobulin domains or small molecules for developing therapeutics to either agonize or antagonize cellular pathways associated with diseases. However, peptides often suffer from poor chemical and physical stability, limiting their therapeutic potential. Disulfide-constrained peptides (DCP) are naturally occurring and possess numerous desirable properties, such as high stability, that qualify them as drug-like scaffolds for peptide therapeutics. DCPs contain loop regions protruding from the core of the molecule that are amenable to peptide engineering via direct evolution by use of phage display technology. In this study, we have established a robust platform for the discovery of peptide therapeutics using various DCPs as scaffolds. We created diverse libraries comprising seven different DCP scaffolds, resulting in an overall diversity of 2 x 1011. The effectiveness of this platform for functional hit discovery has been extensively evaluated, demonstrating a hit rate comparable to that of synthetic antibody libraries. By utilizing chemically synthesized and in vitro folded peptides derived from selections of phage displayed DCP libraries, we have successfully generated functional inhibitors targeting the HtrA1 protease. Through affinity maturation strategies, we have transformed initially weak binders against Notch2 with micromolar Kd values to high-affinity ligands in the nanomolar range. This process highlights a viable hit-to-lead progression. Overall, our platform holds significant potential to greatly enhance the discovery of peptide therapeutics.
MeSH term(s)	Disulfides ; Peptides/pharmacology ; Peptides/chemistry ; Peptide Library ; Peptide Hydrolases
Chemical Substances	Disulfides ; Peptides ; Peptide Library ; Peptide Hydrolases (EC 3.4.-)
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0300135
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Article ; Online: Characterization of Androgen Receptor Complex Associated Protein (ARCAP) in hepatocellular carcinoma and liver.

Chang, Tai-Jay / Hsia, Cheng-Yuan / Chau, Gar-Yang / Hsiao, Liang-Tsai / Huang, Kuang-Tzu / King, Kung-Liang / Lui, Wing-Yiu / Li, Anna F-Y / Wang, Chia-Lin / Tsai, Pin-Hsing / Chien, Yueh / Lin, Ta-Hsien

Journal of the Chinese Medical Association : JCMA

2021 Volume 84, Issue 12, Page(s) 1100–1108

Abstract: Background: Hepatocellular carcinoma (HCC) ranks many tasks in clinical oncology due to possibly developing a general tumor in men and, usually lead to malignant to death within years. Researches had reported about major factors for being HCC was male ... ...

Abstract	Background: Hepatocellular carcinoma (HCC) ranks many tasks in clinical oncology due to possibly developing a general tumor in men and, usually lead to malignant to death within years. Researches had reported about major factors for being HCC was male sex and HCC associated with cirrhosis in childhood was found more common in males than females. In certain mouse strains as studied, breeding with testosterone significantly increases the development of HCC. Furthermore, castration of male mice diminished the frequency of the development of liver tumors. Meanwhile male hepatitis B virus transgenic mice have a greater occurrence of HCC than females. Methods: We apply degenerate priming PCR to observe the expression of various steroid receptors in livers. Yeast-two hybrid screening to search a novel RNA fragment helps to find a new full-length gene by RACE experiment. RT-PCR is applied to detect various expressions in tissues and cell lines. In situ hybridization detects DNA in Chromosome mapping. GFP-constructs transfection proves the gene localization in cells. Immunoprecipitation pulldown assay verifies protein interaction. Gene transfection followed with luciferase assay demonstrates the interaction of genes within cellular signaling. Genomic alignment analysis for observing sequences data perform from NCBI database website (http://www.ncbi.nim.nih.gov/genebank/). Results: The androgen receptor (AR) expression level is found at the highest level among the steroid receptors families detected in liver tumors. By yeast-two hybrid screening, we cloned an Androgen Receptor Complex Associated Protein (ARCAP), of 95 Kd in molecular weight and its cDNA. ARCAP locates at Chromosome 1. Our findings indicate ARCAP is highly expressed in hepatoma cell lines and liver tumors and their adjacent tumors as observed. Yeast two-hybrid assay and in vitro immunoprecipitation assays demonstrated an interaction between AR and ARCAP. Conclusion: We aim to search for different types and levels of steroid receptors expressed within human HCCs and in the adjacent liver tissues. To verify possible molecular mechanisms by which AR might affect hepatoma cells, we had characterized a novel protein ARCAP which functions as a coregulator to interact with AR within liver. The ligand-dependent AR with its cofactor, ARCAP, can induce a signal cascade by transactivation.
MeSH term(s)	Animals ; Carcinoma, Hepatocellular/physiopathology ; Hepatitis B virus ; Liver/metabolism ; Liver/physiopathology ; Liver Neoplasms ; Male ; Mice ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism
Chemical Substances	Receptors, Androgen
Language	English
Publishing date	2021-09-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2107283-8
ISSN	1728-7731 ; 1726-4901
ISSN (online)	1728-7731
ISSN	1726-4901
DOI	10.1097/JCMA.0000000000000628
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Article ; Online: Pandemic aspect of dexamethasone: Molecular mechanisms and clinical application.

Li, Anna F Y / Wang, Chia-Lin / Tai, Hsiao-Yun / Fu, Yun-Ju / Tsai, Fu-Ting / Tsai, Yi-Ching / Ko, Yu-Ling / Li, Mei-Jane / Lin, Chiou-Chyn / Chang, Tai-Jay

Journal of the Chinese Medical Association : JCMA

2020 Volume 84, Issue 3, Page(s) 245–247

Abstract: The rapid spread of coronavirus disease (COVID-19) in many countries has caused inconvenience in conducting daily life activities, and even deaths. Dexamethasone is a corticosteroid applied in clinical medicine since 1957, especially in immune therapy ... ...

Abstract	The rapid spread of coronavirus disease (COVID-19) in many countries has caused inconvenience in conducting daily life activities, and even deaths. Dexamethasone is a corticosteroid applied in clinical medicine since 1957, especially in immune therapy fields. Herein, we present the characteristics of Dexamethasone, from molecular mechanisms such as genomic and nongenomic pathways by cellular signal regulations, to clinical applications in various phases of the disease. During COVID-19 pandemic, Dexamethasone given to patients who required oxygen or ventilation therapy showed improved life efficacy.
MeSH term(s)	Dexamethasone/pharmacology ; Dexamethasone/therapeutic use ; Humans ; Receptors, Glucocorticoid/physiology ; SARS-CoV-2 ; Signal Transduction/physiology ; COVID-19 Drug Treatment
Chemical Substances	Receptors, Glucocorticoid ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2020-12-21
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2107283-8
ISSN	1728-7731 ; 1726-4901
ISSN (online)	1728-7731
ISSN	1726-4901
DOI	10.1097/JCMA.0000000000000485
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ab Jg. 2022: Lesesaal (EG)

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Article: Detection of SARS-CoV-2 S protein based on FRET between carbon quantum dots and gold nanoparticles.

Li, Yang / Ren, Yashuang / Yi, Zhihao / Han, Shitong / Liu, Shilei / Long, Feng / Zhu, Anna

Heliyon

2023 Volume 9, Issue 11, Page(s) e22674

Abstract: The COVID-19 pandemic caused by SARS-CoV-2 virus brings nasty crisis for public health in the world. Until now, the virus has caused multiple infections in many people. Detecting antigen to SARS-CoV-2 is a powerful method for the diagnosis of COVID-19 ... ...

Abstract	The COVID-19 pandemic caused by SARS-CoV-2 virus brings nasty crisis for public health in the world. Until now, the virus has caused multiple infections in many people. Detecting antigen to SARS-CoV-2 is a powerful method for the diagnosis of COVID-19 and is helpful for controlling and stopping the pandemic. Herein, a rapid and quantitative detection method of SARS-CoV-2 spike(S) protein was built based on the fluorescence resonance energy transfer (FRET) phenomenon without complicated steps. In the process of detecting, the carbon quantum dots (CQDs) and gold nanoparticles (AuNPs) act as donor and acceptor. By modifying the SARS-CoV-2 antibodies on the surface of CQDs and AuNPs, we achieved S protein specific detection using the distance-based FRET phenomenon. Through the electric charge regulation, the limit of detection (LOD) is 0.05 ng/mL, the linear range is 0.1-100 ng/mL, and the detection process only takes 12 min. The proposed method exhibits several advantages such as be available for variants (B.1.1.529 and B.1.617.2) and be suitable for human serum, which is of significance for detecting viral in time and prevention the viral transmission.
Language	English
Publishing date	2023-11-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e22674
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Article ; Online: Microencapsulation of luteinizing hormone-releasing hormone agonist in poly (lactic-co-glycolic acid) microspheres by spray-drying.

Shi, Nian-Qiu / Zhou, Jia / Walker, Jennifer / Li, Li / Hong, Justin K Y / Olsen, Karl F / Tang, Jie / Ackermann, Rose / Wang, Yan / Qin, Bin / Schwendeman, Anna / Schwendeman, Steven P

Journal of controlled release : official journal of the Controlled Release Society

2020 Volume 321, Page(s) 756–772

Abstract: A spray drying technique was developed to prepare injectable and biodegradable poly(lactic-co-glycolic acid) (PLGA) microspheres encapsulating a model luteinizing hormone-releasing hormone agonist (LHRHa)-based peptide, leuprolide. Various spray drying ... ...

Abstract	A spray drying technique was developed to prepare injectable and biodegradable poly(lactic-co-glycolic acid) (PLGA) microspheres encapsulating a model luteinizing hormone-releasing hormone agonist (LHRHa)-based peptide, leuprolide. Various spray drying parameters were evaluated to prepare 1-month controlled release formulations with a similar composition to the commercial Lupron Depot® (LD). A single water-in-oil emulsion of aqueous leuprolide/gelatin solution in PLGA 75/25 acid capped (13 kDa Mw) dissolved in methylene chloride (DCM) was spray-dried before washing the microspheres in cold ddH
MeSH term(s)	Glycolates ; Glycols ; Gonadotropin-Releasing Hormone/agonists ; Lactic Acid ; Microspheres ; Particle Size ; Polyglycolic Acid ; Polylactic Acid-Polyglycolic Acid Copolymer
Chemical Substances	Glycolates ; Glycols ; glycolic acid (0WT12SX38S) ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Polyglycolic Acid (26009-03-0) ; Gonadotropin-Releasing Hormone (33515-09-2) ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2020-01-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2020.01.023
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