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  1. Article ; Online: A tale of Science - The Nobel Prize in Physiology or Medicine 2023.

    Häfner, Sophia Julia

    Biomedical journal

    2024  Volume 47, Issue 2, Page(s) 100716

    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2024.100716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A matter of timing - At what age should multilevel surgery be performed in cerebral palsy patients?

    Häfner, Sophia Julia

    Biomedical journal

    2021  Volume 43, Issue 6, Page(s) 465–468

    Abstract: A rather eventful decade draws to a close, but before the year concludes, we learn in this issue of the Biomedical Journal about the correlation of age with the improvement of motor functions in cerebral palsy patients after myofascial release surgery, ... ...

    Abstract A rather eventful decade draws to a close, but before the year concludes, we learn in this issue of the Biomedical Journal about the correlation of age with the improvement of motor functions in cerebral palsy patients after myofascial release surgery, and the impact on health and life quality of excessive weight during pregnancy. Moreover, we learn about differences in dexterity test norms between populations, and gain some insight into the latest improvements to the challenging medical study program in Taiwan. Finally, we attend an interesting discussion between experts of the field regarding the use of melatonin to protect the brains of preterm infants.
    MeSH term(s) Brain ; Cerebral Palsy ; Female ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Pregnancy ; Quality of Life ; Taiwan
    Language English
    Publishing date 2021-01-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2020.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Guards! Guards! How innate lymphoid cells ensure local law and order.

    Häfner, Sophia Julia

    Biomedical journal

    2021  Volume 44, Issue 2, Page(s) 105–111

    Abstract: This special issue of the Biomedical Journal is dedicated to the latest official recruits in the field of immunology: innate lymphoid cells, the tissue-resident sentinels and first responders to damage or invasion. Subsequently, we consider extracellular ...

    Abstract This special issue of the Biomedical Journal is dedicated to the latest official recruits in the field of immunology: innate lymphoid cells, the tissue-resident sentinels and first responders to damage or invasion. Subsequently, we consider extracellular vesicle release during bacterial infection, how immunomodulation can avoid compromising Mycobacterium tuberculosis clearance, and how innate immunity jeopardises the organism during rheumatoid arthritis. Moreover, we ponder over the predictive value of cardiac troponin in influenza, the virtues of cashew nuts and bilirubin, as well as holes in the heart. Finally, we learn that mandibular movement during swallowing increases with the vertical dimension of occlusion, and that early controlled relaxation incisions restore the blood supply to the extremities in harlequin ichthyosis neonates.
    MeSH term(s) Arthritis, Rheumatoid ; Humans ; Immunity, Innate ; Immunomodulation ; Infant, Newborn ; Lymphocytes
    Language English
    Publishing date 2021-04-27
    Publishing country United States
    Document type Editorial
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2021.04.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Level up for culture models - How 3D cell culture models benefit SARS-CoV-2 research.

    Häfner, Sophia Julia

    Biomedical journal

    2021  Volume 44, Issue 1, Page(s) 1–6

    Abstract: Welcome to a new decade and a new issue of the Biomedical Journal - casting a sorrowful look onto a year that will go down in history as a tombstone etched by the COVID-19 pandemic, but also a hopeful glance into the future, now that multiple vaccination ...

    Abstract Welcome to a new decade and a new issue of the Biomedical Journal - casting a sorrowful look onto a year that will go down in history as a tombstone etched by the COVID-19 pandemic, but also a hopeful glance into the future, now that multiple vaccination programs against the SARS-CoV-2 virus have started. This issue is dedicated to the continuous effort by researchers all around the globe to understand and counter the pathogen, as well as to be better prepared for future threats. Therefore, we learn about the advantages of complex 3D cell culture models for studying host-virus interactions, and the disease course of COVID-19 in children. Moreover, we discover how neutralising monoclonal antibodies and peptide-based vaccines against SARS-CoV-2 are developed, and the therapeutic potentials of lopinavir/ritonavir, mesenchymal stem cells, as well as plant and algae extracts. Finally, we ponder over the lessons to be learnt from SARS-CoV and MERS, and hear about differences between nucleotide-based SARS-CoV-2 detection methods.
    MeSH term(s) Antiviral Agents ; Bioprinting ; COVID-19 ; COVID-19 Vaccines ; Cell Culture Techniques ; Child ; Humans ; Pandemics ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; COVID-19 Vaccines
    Language English
    Publishing date 2021-02-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2021.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: This is not a pipe - But how harmful is electronic cigarette smoke.

    Häfner, Sophia Julia

    Biomedical journal

    2021  Volume 44, Issue 3, Page(s) 227–234

    Abstract: This issue of the Biomedical Journal tells us about the risks of electronic cigarette smoking, variations of SARS-CoV-2 and ACE2, and how COVID-19 affects the gastrointestinal system. Moreover, we learn that cancer immunotherapy seems to work well in ... ...

    Abstract This issue of the Biomedical Journal tells us about the risks of electronic cigarette smoking, variations of SARS-CoV-2 and ACE2, and how COVID-19 affects the gastrointestinal system. Moreover, we learn that cancer immunotherapy seems to work well in elderly patients, how thyroid hormones regulate noncoding RNAs in a liver tumour context, and that G6PD is a double-edged sword of redox signalling. We also discover that Perilla leaf extract could inhibit SARS-CoV-2, that artificial neural networks can diagnose COVID-19 patients and predict vaccine epitopes on the Epstein-Barr Virus, and that men and women have differential inflammatory responses to physical effort. Finally, the surgical strategies for drug-resistant epilepsy, computer-supervised double-jaw surgery, dental pulp stem cell motility, and the restitution of the brain blood supply after atherosclerotic stroke are discussed.
    MeSH term(s) Aged ; COVID-19/diagnosis ; Electronic Nicotine Delivery Systems ; Epstein-Barr Virus Infections ; Exercise ; Female ; Herpesvirus 4, Human/immunology ; Humans ; Male ; Neural Networks, Computer ; Plant Extracts/pharmacology ; SARS-CoV-2/drug effects ; Smoke
    Chemical Substances Plant Extracts ; Smoke
    Language English
    Publishing date 2021-06-04
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2021.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Protecting the blossoming brain - Neurocritical care in children.

    Häfner, Sophia Julia

    Biomedical journal

    2020  Volume 43, Issue 3, Page(s) 195–202

    Abstract: This special issue of the Biomedical Journal is entirely dedicated to the latest updates regarding the medical efforts to preserve the fragile young brain after injury. Thereby, we learn about symptoms and diseases such as different forms of epilepsy, ... ...

    Abstract This special issue of the Biomedical Journal is entirely dedicated to the latest updates regarding the medical efforts to preserve the fragile young brain after injury. Thereby, we learn about symptoms and diseases such as different forms of epilepsy, acute encephalopathy, increased intracranial pressure, and posthaemorrhagic hydrocephalus, as well as about their origins, such as infection, autoimmune diseases, preterm birth, or abusive head trauma. Moreover, diagnosis and surveillance techniques are discussed, including ultrasound of the optic nerve sheath diameter and multimodal monitoring. Finally, we discover various established and emerging therapeutic approaches, comprising target temperature management, ketogenic diet, and immunomodulation.
    MeSH term(s) Brain ; Child ; Female ; Humans ; Infant, Newborn ; Intracranial Pressure ; Optic Nerve ; Point-of-Care Systems ; Pregnancy ; Premature Birth
    Language English
    Publishing date 2020-06-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2020.06.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Bargain with the tooth fairy - The savings accounts for dental stem cells.

    Häfner, Sophia Julia

    Biomedical journal

    2020  Volume 43, Issue 2, Page(s) 99–106

    Abstract: Despite the hard times COVID-19 has imposed on us, the Biomedical Journal strives to provide fresh and compelling reading material - to be enjoyed safely from home. In this issue, we glance behind the scenes of dental stem cell preservation for potential ...

    Abstract Despite the hard times COVID-19 has imposed on us, the Biomedical Journal strives to provide fresh and compelling reading material - to be enjoyed safely from home. In this issue, we glance behind the scenes of dental stem cell preservation for potential therapeutic use, and discover that cancer cells hijack podoplanin expression to induce thrombosis. Moreover, we learn how the helicase DDX17 promotes tumour stemness, how genetic defects in meiosis and DNA repair cause premature ovarian insufficiency, and that the brain-derived neurotrophic factor is associated with several psychiatric diseases. Further accounts relate the role of miR-95-3p in colorectal cancer, the protective power of eggplants against mercury poisoning, and the predictive value of inhibin A for premature delivery. Finally, the very rare case of adenoid cystic carcinoma in the external auditory canal receives some attention, and we get to read up on how 3D imaging and modelling combines functional and aesthetic repair of cleft lip and palate cases.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Cell Differentiation/physiology ; Coronavirus Infections ; Humans ; MicroRNAs/genetics ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Stem Cells/virology ; Tooth/virology
    Chemical Substances MIRN95 microRNA, human ; MicroRNAs
    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Editorial ; Review
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2020.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The body's integrated repair kit: Studying mesenchymal stem cells for better ligament repair.

    Häfner, Sophia Julia

    Biomedical journal

    2020  Volume 42, Issue 6, Page(s) 365–370

    Abstract: In this issue of the Biomedical Journal, we learn that the sport injury-prone knee ligaments might harbour their own repair kit in the form of mesenchymal stem cells, and that TERT transformation helps to keep these cells longer in culture for more ... ...

    Abstract In this issue of the Biomedical Journal, we learn that the sport injury-prone knee ligaments might harbour their own repair kit in the form of mesenchymal stem cells, and that TERT transformation helps to keep these cells longer in culture for more extensive studies. In addition, we get a demonstration that diffusion tensor imaging can reliably show the activity of specific neural circuits, that rheumatoid arthritis patients are more prone to insulin resistance, and that platelet-enriched plasma gels significantly improve wound healing after pilonidal sinus surgery. Furthermore, two procreation-related articles inform us that growth hormone treatment improves endometrial receptivity in older women, and that elevated maternal liver enzymes do not impact on the outcome of laser therapy for twin-twin transfusion syndrome. Finally, our attention is brought to the importance of subjective well-being evaluation for orthodontic correction needs, as well as the possibility that exercise could maybe increase sperm telomere length.
    MeSH term(s) Aged ; Anterior Cruciate Ligament ; Cell Line ; Diffusion Tensor Imaging ; Female ; Humans ; Mesenchymal Stem Cells ; Telomerase ; Wound Healing
    Chemical Substances Telomerase (EC 2.7.7.49)
    Language English
    Publishing date 2020-01-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2019.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Don't sugar coat the COVID (only the vasculature).

    Häfner, Sophia Julia

    Biomedical journal

    2020  Volume 43, Issue 5, Page(s) 393–398

    Abstract: This issue of the Biomedical Journal acquaints us with the compelling hypothesis that the vascular glycocalyx lies at the intersection of severe COVID-19 risk factors and damages, and the ways used by artificial intelligence to predict interactions ... ...

    Abstract This issue of the Biomedical Journal acquaints us with the compelling hypothesis that the vascular glycocalyx lies at the intersection of severe COVID-19 risk factors and damages, and the ways used by artificial intelligence to predict interactions between SARS-CoV-2 and human proteins. Furthermore, we explore the antiviral potential of valinomycin and the long list of COVID-19-related clinical trials, and learn how (not) to fix a broken femoral head. Last but not least, we get to enjoy the tale of the cellular oxygen-sensing system as well as the role of the host complement system during Leptospira infection, and learn that SARS-CoV-2 can sometimes come with a pathogenic plus one.
    MeSH term(s) Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; Artificial Intelligence ; COVID-19/diagnosis ; COVID-19/virology ; Humans ; Risk Factors ; SARS-CoV-2/pathogenicity ; Sugars/pharmacology
    Chemical Substances Antiviral Agents ; Sugars
    Keywords covid19
    Language English
    Publishing date 2020-10-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2020.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Tumour travel tours - Why circulating cancer cells value company.

    Häfner, Sophia Julia

    Biomedical journal

    2020  Volume 43, Issue 1, Page(s) 1–7

    Abstract: Welcome to the New Year and a new issue of the Biomedical Journal, where we learn that travelling with company boosts the metastatic potential of circulating tumour cells, as well as that a worm could be an excellent model to study antidiabetic drugs. In ...

    Abstract Welcome to the New Year and a new issue of the Biomedical Journal, where we learn that travelling with company boosts the metastatic potential of circulating tumour cells, as well as that a worm could be an excellent model to study antidiabetic drugs. In addition, we discover another pair of molecular scissors for genetic engineering, how exactly Leptospira wreaks havoc on its run through the host organism, and that hyperparathyroidism brings its own risks, but does not worsen the outcome of papillary thyroid carcinoma. Furthermore, the importance of taking into account differing beauty ideals for aesthetic surgery surveys is discussed, alongside the question how bad isolated local recurrence is in the case of HR + breast cancer. Finally, we find out that virtual colonoscopy deserves more credit, that the first medical experiment in space was all about the H-reflex, and that it is possible to survive advanced necrotising fasciitis of the face and neck.
    MeSH term(s) Colonoscopy ; Humans ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplastic Cells, Circulating/pathology ; Thyroid Cancer, Papillary/diagnostic imaging ; Thyroid Neoplasms/diagnostic imaging
    Keywords covid19
    Language English
    Publishing date 2020-02-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2020.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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