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  1. Article ; Online: Combining chemotherapy and immunotherapy for advanced anal cancer: are we ready?

    Martinelli, Erika / Ciardiello, Davide

    The Lancet. Oncology

    2024  Volume 25, Issue 4, Page(s) 416–417

    MeSH term(s) Humans ; Anus Neoplasms/drug therapy ; Combined Modality Therapy ; Immunotherapy/adverse effects
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(24)00131-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Angiogenesis inhibition in metastatic colorectal cancer continuum of care.

    Martinelli, Erika / Ciardiello, Fortunato

    Lancet (London, England)

    2023  Volume 402, Issue 10395, Page(s) 4–5

    MeSH term(s) Humans ; Bevacizumab/therapeutic use ; Angiogenesis Inhibitors/therapeutic use ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Continuity of Patient Care ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/pathology
    Chemical Substances Bevacizumab (2S9ZZM9Q9V) ; Angiogenesis Inhibitors
    Language English
    Publishing date 2023-06-15
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)00867-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Endoscopic calcium electroporation for unfit-for-surgery bleeding colorectal cancer: the dawn of a new treatment?

    Pellegrino, Raffaele / Nacca, Valeria / Paragliola, Fernando / Martinelli, Erika / Federico, Alessandro / Gravina, Antonietta G

    Minerva medica

    2024  

    Language English
    Publishing date 2024-04-10
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123586-2
    ISSN 1827-1669 ; 0026-4806
    ISSN (online) 1827-1669
    ISSN 0026-4806
    DOI 10.23736/S0026-4806.24.09270-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Towards the era of precision medicine in metastatic colorectal cancer.

    Napolitano, Stefania / Troiani, Teresa / Martinelli, Erika / Ciardiello, Fortunato

    ESMO open

    2020  Volume 5, Issue 2

    MeSH term(s) Colorectal Neoplasms/epidemiology ; Humans ; Neoplasm Metastasis ; Precision Medicine/methods
    Language English
    Publishing date 2020-03-27
    Publishing country England
    Document type Editorial
    ISSN 2059-7029
    ISSN (online) 2059-7029
    DOI 10.1136/esmoopen-2020-000685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: European expert panel consensus on the clinical management of BRAF

    Martinelli, Erika / Arnold, Dirk / Cervantes, Andres / Stintzing, Sebastian / Van Cutsem, Eric / Tabernero, Josep / Taieb, Julien / Wasan, Harpreet / Ciardiello, Fortunato

    Cancer treatment reviews

    2023  Volume 115, Page(s) 102541

    Abstract: Metastatic colorectal cancer (mCRC) is a heterogenous disease caused by various genetic alterations. The ... ...

    Abstract Metastatic colorectal cancer (mCRC) is a heterogenous disease caused by various genetic alterations. The BRAF
    MeSH term(s) Humans ; Proto-Oncogene Proteins B-raf/genetics ; Colorectal Neoplasms/therapy ; Colorectal Neoplasms/drug therapy ; Colonic Neoplasms ; Rectal Neoplasms ; Mutation
    Chemical Substances Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; BRAF protein, human (EC 2.7.11.1)
    Language English
    Publishing date 2023-03-11
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 125102-8
    ISSN 1532-1967 ; 0305-7372
    ISSN (online) 1532-1967
    ISSN 0305-7372
    DOI 10.1016/j.ctrv.2023.102541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Role of Dual-Energy CT for the Assessment of Liver Metastasis Response to Treatment: Above the RECIST 1.1 Criteria.

    Reginelli, Alfonso / Del Canto, Mariateresa / Clemente, Alfredo / Gragnano, Eduardo / Cioce, Fabrizio / Urraro, Fabrizio / Martinelli, Erika / Cappabianca, Salvatore

    Journal of clinical medicine

    2023  Volume 12, Issue 3

    Abstract: Imaging assessment of liver lesions is fundamental to predict therapeutic response and improve patient survival rates. Dual-Energy Computed Tomography (DECT) is an increasingly used technique in the oncologic field with many emerging applications. The ... ...

    Abstract Imaging assessment of liver lesions is fundamental to predict therapeutic response and improve patient survival rates. Dual-Energy Computed Tomography (DECT) is an increasingly used technique in the oncologic field with many emerging applications. The assessment of iodine concentration within a liver lesion reflects the biological properties of the tumor and provides additional information to radiologists that is normally invisible to the human eye. The possibility to predict tumor aggressiveness and therapeutic response based on quantitative and reproducible parameters obtainable from DECT images could improve clinical decisions and drive oncologists to choose the best therapy according to metastasis biological features. Moreover, in comparison with standard dimensional criteria, DECT provides further data on the cancer microenvironment, especially for patients treated with antiangiogenic-based drugs, in which tumor shrinkage is a late parameter of response. We investigated the predictive role of DECT in the early assessment of liver metastasis response to treatment in comparison with standard dimensional criteria during antiangiogenetic-based therapy.
    Language English
    Publishing date 2023-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12030879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Different fractions from wheat flour provide distinctive phenolic profiles and different bioaccessibility of polyphenols following in vitro digestion.

    Zhang, Leilei / García-Pérez, Pascual / Martinelli, Erika / Giuberti, Gianluca / Trevisan, Marco / Lucini, Luigi

    Food chemistry

    2022  Volume 404, Issue Pt A, Page(s) 134540

    Abstract: Wheat is a prevalent food worldwide, although its production arises several tonnes of industrial by-products that merit valorisation, owing to sustainable demands. In this work, an untargeted metabolomics approach was applied to shed light on the profile ...

    Abstract Wheat is a prevalent food worldwide, although its production arises several tonnes of industrial by-products that merit valorisation, owing to sustainable demands. In this work, an untargeted metabolomics approach was applied to shed light on the profile of free and bound phenolic compounds in white and wholegrain flours, as well as the major wheat by-products, namely wheat bran, wheat shorts and wheat middlings. By-products and wholegrain flours were found to be rich sources of ferulic acid derivatives, lignans, and alkylresorcinols, mostly bound to wheat fibre components, whereas different flavonoids were found in their free forms. Afterwards, the in vitro gastrointestinal digestion of these matrices showed that flour phenolics, in particular lignans, were more bioaccessible than those from wheat by-products. These results support the carrier effect attributed to dietary fibre and open a wide perspective on the use of underexploited wheat by-products to formulate novel functional foods.
    MeSH term(s) Flour/analysis ; Polyphenols/analysis ; Triticum/metabolism ; Phenols/analysis ; Dietary Fiber/analysis ; Digestion ; Lignans
    Chemical Substances Polyphenols ; Phenols ; Dietary Fiber ; Lignans
    Language English
    Publishing date 2022-10-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2022.134540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Different fractions from wheat flour provide distinctive phenolic profiles and different bioaccessibility of polyphenols following in vitro digestion

    Zhang, Leilei / García-Pérez, Pascual / Martinelli, Erika / Giuberti, Gianluca / Trevisan, Marco / Lucini, Luigi

    Food Chemistry. 2023 Mar., v. 404 p.134540-

    2023  

    Abstract: Wheat is a prevalent food worldwide, although its production arises several tonnes of industrial by-products that merit valorisation, owing to sustainable demands. In this work, an untargeted metabolomics approach was applied to shed light on the profile ...

    Abstract Wheat is a prevalent food worldwide, although its production arises several tonnes of industrial by-products that merit valorisation, owing to sustainable demands. In this work, an untargeted metabolomics approach was applied to shed light on the profile of free and bound phenolic compounds in white and wholegrain flours, as well as the major wheat by-products, namely wheat bran, wheat shorts and wheat middlings. By-products and wholegrain flours were found to be rich sources of ferulic acid derivatives, lignans, and alkylresorcinols, mostly bound to wheat fibre components, whereas different flavonoids were found in their free forms. Afterwards, the in vitro gastrointestinal digestion of these matrices showed that flour phenolics, in particular lignans, were more bioaccessible than those from wheat by-products. These results support the carrier effect attributed to dietary fibre and open a wide perspective on the use of underexploited wheat by-products to formulate novel functional foods.
    Keywords alkylresorcinols ; bioavailability ; dietary fiber ; digestion ; ferulic acid ; flavonoids ; food chemistry ; gastrointestinal system ; lignans ; metabolomics ; polyphenols ; wheat ; wheat bran ; wheat flour ; Triticum aestivum ; Wheat fibre ; Bran ; Wholegrain flour ; Phenolic compounds ; Functional foods ; ADF ; ADL ; DM ; FWGF ; NDF ; RWGF ; WS ; WB ; WF ; WM
    Language English
    Dates of publication 2023-03
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2022.134540
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Retraction notice to "Antitumor activity of bortezomib in human cancer cells with acquired resistance to anti-epidermal growth factor receptor tyrosine kinase inhibitors" [Lung Cancer 71 (2011) 283-290].

    Morgillo, Floriana / D'Aiuto, Elena / Troiani, Teresa / Martinelli, Erika / Cascone, Tina / De Palma, Raffaele / Orditura, Michele / De Vita, Ferdinando / Ciardiello, Fortunato

    Lung cancer (Amsterdam, Netherlands)

    2023  Volume 181, Page(s) 107226

    Language English
    Publishing date 2023-05-09
    Publishing country Ireland
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 632771-0
    ISSN 1872-8332 ; 0169-5002
    ISSN (online) 1872-8332
    ISSN 0169-5002
    DOI 10.1016/j.lungcan.2023.107226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Acrylamide determination during an industrial roasting process of coffee and the influence of asparagine and low molecular weight sugars.

    Bertuzzi, Terenzio / Martinelli, Erika / Mulazzi, Annalisa / Rastelli, Silvia

    Food chemistry

    2019  Volume 303, Page(s) 125372

    Abstract: The formation and partial degradation of acrylamide (AA), asparagine and low molecular weight sugars were evaluated during an industrial coffee roasting process, in which the temperature increased from 90° to about 215 °C. Arabica and Robusta varieties ... ...

    Abstract The formation and partial degradation of acrylamide (AA), asparagine and low molecular weight sugars were evaluated during an industrial coffee roasting process, in which the temperature increased from 90° to about 215 °C. Arabica and Robusta varieties were roasted individually. AA content reached the maximum value at 10 min, corresponding to a temperature of 175-177 °C (1045 ± 28 and 795 ± 25 µg kg
    MeSH term(s) Acrylamide/analysis ; Asparagine/chemistry ; Coffee/chemistry ; Food Handling ; Hot Temperature ; Sucrose ; Sugars/chemistry
    Chemical Substances Coffee ; Sugars ; Acrylamide (20R035KLCI) ; Sucrose (57-50-1) ; Asparagine (7006-34-0)
    Language English
    Publishing date 2019-08-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2019.125372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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