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Article ; Online: Intraocular Intrusion of a Scleral Buckle.

Gimeno-Carrero, Monica / Insausti-García, Alfredo / Suarez-Baraza, Jorge

2020 Volume 127, Issue 11, Page(s) 1461

MeSH term(s)	Aged ; Humans ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Retinal Detachment/diagnosis ; Retinal Detachment/surgery ; Scleral Buckling/adverse effects ; Visual Acuity
Language	English
Publishing date	2020-10-23
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	392083-5
ISSN	1549-4713 ; 0161-6420
ISSN (online)	1549-4713
ISSN	0161-6420
DOI	10.1016/j.ophtha.2020.06.061
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Ul II Zs.83: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Post COVID-19 Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis.

Rojas-Correa, Daniela Ximena / Reche-Sainz, José Alberto / Insausti-García, Alfredo / Calleja-García, Cristina / Ferro-Osuna, Manuel

Neuro-ophthalmology (Aeolus Press)

2021 Volume 46, Issue 2, Page(s) 115–121

Abstract: Neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are relatively common. Although some may be consequences of direct cellular viral invasion (neurotropism), many represent post-infectious inflammation mediated by ...

Abstract	Neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are relatively common. Although some may be consequences of direct cellular viral invasion (neurotropism), many represent post-infectious inflammation mediated by autoimmune mechanisms. We herein report the case of a 69-year-old diabetic male who presented with bilateral sub-acute, progressive loss of vision 45 days after suffering a presumed SARS-CoV-2 related pneumonia. He had bilateral optic disc oedema. Magnetic resonance imaging showed uniform contrast enhancement of both optic nerves without spinal cord involvement. He tested positive for SARS-CoV-2 IgG and myelin oligodendrocyte glycoprotein (MOG) IgG antibodies. He was treated with intravenous methylprednisolone for 5 days. The optic disc oedema resolved within 6 weeks with improvement in visual acuity, although optic atrophy developed by week 16. The MOG-IgG antibody test turned negative after 24 weeks.
Language	English
Publishing date	2021-05-24
Publishing country	England
Document type	Case Reports
ZDB-ID	604820-1
ISSN	1744-506X ; 0165-8107
ISSN (online)	1744-506X
ISSN	0165-8107
DOI	10.1080/01658107.2021.1916044
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Article ; Online: Papillophlebitis in a COVID-19 patient: Inflammation and hypercoagulable state.

Insausti-García, Alfredo / Reche-Sainz, José Alberto / Ruiz-Arranz, Celia / López Vázquez, Ángel / Ferro-Osuna, Manuel

European journal of ophthalmology

2020 Volume 32, Issue 1, Page(s) NP168–NP172

Abstract: Introduction: Papillophlebitis is a rare condition characterized by venous congestion and optic disc edema, which has been suggested to occur as a consequence of inflammation of the retinal veins or, possibly, the capillaries of the optic disc, leading ... ...

Abstract	Introduction: Papillophlebitis is a rare condition characterized by venous congestion and optic disc edema, which has been suggested to occur as a consequence of inflammation of the retinal veins or, possibly, the capillaries of the optic disc, leading to venous insufficiency and compression of the central retina vein. The disease affects healthy young adults and commonly has a benign course, however, if complications such as macular edema or ischemia appears, treatment should be instituted immediately to avoid poor prognosis. Case report: A 40-year old white male patient consulted for a slight decrease in the sensitivity of the visual field in his left eye (OS). Visual acuities (VA) were 20/20 in both eyes. OS fundus examination showed dilated and tortuous retinal vessels, disc edema, and retinal hemorrhages. The patient was diagnosed with papillophlebitis. OS VA decreased to 20/200 due to macular edema, and he was treated with a intravitreal dexamethasone implant. An exhaustive and interdisciplinary exploration process was performed, identifying a recent disease and recovery of Covid-19 as the only factor of inflammation and coagulation alteration. Other systemic diseases were excluded. We also describe a rapid decrease in disc and macular edema after intravitreal dexametasone injection, which could support the inflammatory hypothesis. Conclusion: The importance of this case lies in the possible association of papillophlebitis with the new Covid-19 disease. We believe that the inflammatory reaction and the coagulation alteration present in our patient due to Sars-Cov2 coronavirus may have acted as risk factors for the development of papillophlebitis.
MeSH term(s)	Adult ; COVID-19 ; Humans ; Inflammation ; Macular Edema ; Male ; RNA, Viral ; Retinal Vein Occlusion ; SARS-CoV-2
Chemical Substances	RNA, Viral
Keywords	covid19
Language	English
Publishing date	2020-07-30
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/1120672120947591
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Article: Papillophlebitis in a COVID-19 patient: Inflammation and hypercoagulable state

Insausti-García, Alfredo / Reche-Sainz, José Alberto / Ruiz-Arranz, Celia / López Vázquez, Ángel / Ferro-Osuna, Manuel

Eur J Ophthalmol

Abstract: INTRODUCTION: Papillophlebitis is a rare condition characterized by venous congestion and optic disc edema, which has been suggested to occur as a consequence of inflammation of the retinal veins or, possibly, the capillaries of the optic disc, leading ... ...

Abstract	INTRODUCTION: Papillophlebitis is a rare condition characterized by venous congestion and optic disc edema, which has been suggested to occur as a consequence of inflammation of the retinal veins or, possibly, the capillaries of the optic disc, leading to venous insufficiency and compression of the central retina vein. The disease affects healthy young adults and commonly has a benign course, however, if complications such as macular edema or ischemia appears, treatment should be instituted immediately to avoid poor prognosis. CASE REPORT: A 40-year old white male patient consulted for a slight decrease in the sensitivity of the visual field in his left eye (OS). Visual acuities (VA) were 20/20 in both eyes. OS fundus examination showed dilated and tortuous retinal vessels, disc edema, and retinal hemorrhages. The patient was diagnosed with papillophlebitis. OS VA decreased to 20/200 due to macular edema, and he was treated with a intravitreal dexamethasone implant. An exhaustive and interdisciplinary exploration process was performed, identifying a recent disease and recovery of Covid-19 as the only factor of inflammation and coagulation alteration. Other systemic diseases were excluded. We also describe a rapid decrease in disc and macular edema after intravitreal dexametasone injection, which could support the inflammatory hypothesis. CONCLUSION: The importance of this case lies in the possible association of papillophlebitis with the new Covid-19 disease. We believe that the inflammatory reaction and the coagulation alteration present in our patient due to Sars-Cov2 coronavirus may have acted as risk factors for the development of papillophlebitis.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #690616
Database	COVID19

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Article ; Online: Papillophlebitis in a COVID-19 patient

Insausti-García, Alfredo / Reche-Sainz, José Alberto / Ruiz-Arranz, Celia / López Vázquez, Ángel / Ferro-Osuna, Manuel

European Journal of Ophthalmology

Inflammation and hypercoagulable state

2020 , Page(s) 112067212094759

Abstract	Introduction: Papillophlebitis is a rare condition characterized by venous congestion and optic disc edema, which has been suggested to occur as a consequence of inflammation of the retinal veins or, possibly, the capillaries of the optic disc, leading to venous insufficiency and compression of the central retina vein. The disease affects healthy young adults and commonly has a benign course, however, if complications such as macular edema or ischemia appears, treatment should be instituted immediately to avoid poor prognosis. Case report: A 40-year old white male patient consulted for a slight decrease in the sensitivity of the visual field in his left eye (OS). Visual acuities (VA) were 20/20 in both eyes. OS fundus examination showed dilated and tortuous retinal vessels, disc edema, and retinal hemorrhages. The patient was diagnosed with papillophlebitis. OS VA decreased to 20/200 due to macular edema, and he was treated with a intravitreal dexamethasone implant. An exhaustive and interdisciplinary exploration process was performed, identifying a recent disease and recovery of Covid-19 as the only factor of inflammation and coagulation alteration. Other systemic diseases were excluded. We also describe a rapid decrease in disc and macular edema after intravitreal dexametasone injection, which could support the inflammatory hypothesis. Conclusion: The importance of this case lies in the possible association of papillophlebitis with the new Covid-19 disease. We believe that the inflammatory reaction and the coagulation alteration present in our patient due to Sars-Cov2 coronavirus may have acted as risk factors for the development of papillophlebitis.
Keywords	Ophthalmology ; General Medicine ; covid19
Language	English
Publisher	SAGE Publications
Publishing country	us
Document type	Article ; Online
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/1120672120947591
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Epithelioid hemangioma of the orbit or angiolymphoid hyperplasia with eosinophilia.

Sánchez-Orgaz, Margarita / Insausti-García, Alfredo / Gregorio, Laura Yébenes / Duralde, Alvaro Arbizu / Romero-Martín, Ricardo

Ophthalmic plastic and reconstructive surgery

2014 Volume 30, Issue 3, Page(s) e70–2

Abstract: A patient was referred to the department for an incidentally discovered right orbital mass on MRI. After surgical excision, histopathologic examination led to the diagnosis of epithelioid hemangioma, a tumor rarely located in the orbit, whose main ... ...

Abstract	A patient was referred to the department for an incidentally discovered right orbital mass on MRI. After surgical excision, histopathologic examination led to the diagnosis of epithelioid hemangioma, a tumor rarely located in the orbit, whose main histopathologic feature is an exuberant proliferation of small vascular channels lined by enlarged endothelial cells. The clinical characteristics and histopathology of epithelioid hemangioma allow differentiation with Kimura disease, angiosarcoma, intravascular papillary endothelial hyperplasia, and other vascular tumors that share the common feature of an abnormal proliferation of endothelial cells. Although epithelioid hemangioma is extremely rare, it should be considered in the differential diagnosis of orbital tumors.
MeSH term(s)	Aged ; Angiolymphoid Hyperplasia with Eosinophilia/diagnosis ; Angiolymphoid Hyperplasia with Eosinophilia/surgery ; Female ; Humans ; Magnetic Resonance Imaging ; Orbital Diseases/diagnosis ; Orbital Diseases/surgery ; Visual Acuity
Language	English
Publishing date	2014-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	632830-1
ISSN	1537-2677 ; 0740-9303
ISSN (online)	1537-2677
ISSN	0740-9303
DOI	10.1097/IOP.0b013e31829c4216
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Zs.A 2159: Show issues

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Article ; Online: CHARACTERIZING COVID-19-RELATED RETINAL VASCULAR OCCLUSIONS: A Case Series and Review of the Literature.

Fonollosa, Alex / Hernández-Rodríguez, José / Cuadros, Carlos / Giralt, Lena / Sacristán, Cristina / Artaraz, Joseba / Pelegrín, Laura / Olate-Pérez, Álvaro / Romero, Rosa / Pastor-Idoate, Salvador / Sobas Bsc, Eva María / Fernández-Fidalgo, Sonia / Abraldes, Maximino J / Oleñik, Andrea / Insausti-García, Alfredo / Torres, Pedro / Porcar, Carmela / Lorca, Daniela Rego / Adan, Alfredo

Retina (Philadelphia, Pa.)

2020 Volume 42, Issue 3, Page(s) 465–475

Abstract: Purpose: To describe clinical and ophthalmologic features and outcomes of patients with coronavirus disease-19 with retinal vascular occlusions.: Methods: Retrospective multicenter case series and PubMed review of cases reported from March 2020 to ... ...

Abstract	Purpose: To describe clinical and ophthalmologic features and outcomes of patients with coronavirus disease-19 with retinal vascular occlusions. Methods: Retrospective multicenter case series and PubMed review of cases reported from March 2020 to September 2021. Outcome measures are as follows: type of occlusion, treatments, best-corrected visual acuity, and central macular thickness on optical coherence tomography. Results: Thirty-nine patients were identified. Fifteen patients with a median age of 39 (30-67) years were included in the multicenter study. Vascular occlusions included central retinal vein occlusion (12 eyes), branch retinal vein occlusion (4 eyes), and central retinal artery occlusion (2 eyes). Three cases were bilateral. Baseline best-corrected visual acuity was 20/45 (no light perception-20/20). Baseline central macular thickness was 348.64 (±83) μm. Nine eyes received anti-vascular endothelial growth factor agents, dexamethasone intravitreal implant, or both. Final best-corrected visual acuity was 20/25 (no light perception-20/20), and central macular thickness was 273.7 ± 68 μm (follow-up of 19.6 ± 6 weeks). Among the 24 cases from the literature review, retinal vein occlusion was the predominant lesion. Clinical characteristics and outcomes were similar to those found in our series. Conclusion: Coronavirus disease-19-associated retinal vascular occlusions tend to occur in individuals younger than 60 years. Retinal vein occlusion is the most frequent occlusive event, and outcomes are favorable in most cases.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Angiogenesis Inhibitors/therapeutic use ; COVID-19/diagnosis ; COVID-19/virology ; COVID-19 Drug Treatment ; COVID-19 Nucleic Acid Testing ; Dexamethasone/therapeutic use ; Drug Implants ; Eye Infections, Viral/diagnosis ; Eye Infections, Viral/drug therapy ; Eye Infections, Viral/virology ; Fluorescein Angiography ; Glucocorticoids/therapeutic use ; Intravitreal Injections ; Retinal Vein Occlusion/diagnosis ; Retinal Vein Occlusion/drug therapy ; Retinal Vein Occlusion/virology ; Retrospective Studies ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Tomography, Optical Coherence ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Visual Acuity/physiology
Chemical Substances	Angiogenesis Inhibitors ; Dexamethasone (7S5I7G3JQL) ; Drug Implants ; Glucocorticoids ; Vascular Endothelial Growth Factor A ; VEGFA protein, human
Language	English
Publishing date	2020-12-02
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Review
ZDB-ID	603192-4
ISSN	1539-2864 ; 0275-004X
ISSN (online)	1539-2864
ISSN	0275-004X
DOI	10.1097/IAE.0000000000003327
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Article ; Online: Cryopreservation impact on blood progenitor cells: influence of diagnoses, mobilization treatments, and cell concentration.

Majado, Maria J / Salgado-Cecilia, Gema / Blanquer, Miguel / Funes, Consuelo / González-García, Consuelo / Insausti, Carmen L / Parrado, Antonio / Morales, Alfonso / Minguela, Alfredo / Moraleda, José M

Transfusion

2011 Volume 51, Issue 4, Page(s) 799–807

Abstract: Background: The aim of this study was to analyze the impact of cryopreservation in series of peripheral blood progenitor cells stratified by diagnosis, mobilization treatments, and cell concentration, as well as the accuracy of the control aliquots.: ... ...

Abstract	Background: The aim of this study was to analyze the impact of cryopreservation in series of peripheral blood progenitor cells stratified by diagnosis, mobilization treatments, and cell concentration, as well as the accuracy of the control aliquots. Study design and methods: Viability and colony-forming unit-granulocyte-macrophage (CFU-GM), CD34+ cell, lymphocyte, monocyte, and granulocyte counts and recovery were analyzed in 397 leukapheresis procedures before freezing and after thawing. Data from control cryotubes were compared to those from infusing bags. Results: Cell viability decreased after thawing. Viability recovery was lower in cryotubes than in bags in non-Hodgkin's lymphoma (NHL), in cyclophosphamide plus granulocyte-colony-stimulating factor (Cy+G-CSF) mobilization, and in cell concentration of median or greater. Viability recovery in cryotube was higher in NHL (92.1%) than in Hodgkin's disease (HD; 87.3%) and in G-CSF (95.9%) than Cy+G-CSF mobilization (91.3%). The number of CD34+ cells decreased after thawing in total group, Cy+G-CSF mobilization, and cell concentration less than median subgroups. CD34+ cell recovery was higher in cryotubes (111.3%) than in bags (99.6%) in multiple myeloma (MM; p = 0.015). CFU-GM decreased after thawing in all groups. CFU-GM recovery was lower in cryotubes than in bags in MM (26.0% vs. 59.3%) and in Cy+G-CSF mobilization (49.8% vs. 76.3%). CFU-GM recovery in cryotubes was lower in MM compared with NHL (61.5%), HD (45.1%), and breast cancer (84.0%). Lymphocytes, monocytes, and granulocytes showed differences in the subgroups. Conclusion: Cryopreservation negatively impacts in cell viability, CD34+ cell recovery, granulocytes, and CFU-GM, although slight differences between the groups were observed. Cryotubes satisfactorily reflected the quality of the infused cells.
MeSH term(s)	Adolescent ; Adult ; Aged ; Blood Cells/cytology ; Blood Cells/metabolism ; Blood Preservation/adverse effects ; Blood Preservation/methods ; Cell Survival/physiology ; Child ; Child, Preschool ; Cryopreservation/methods ; Female ; Granulocyte-Macrophage Progenitor Cells/cytology ; Granulocyte-Macrophage Progenitor Cells/metabolism ; Granulocytes/cytology ; Granulocytes/metabolism ; Humans ; Leukapheresis ; Lymphocytes/cytology ; Lymphocytes/metabolism ; Male ; Middle Aged ; Stem Cells/cytology ; Stem Cells/metabolism ; Young Adult
Language	English
Publishing date	2011-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/j.1537-2995.2010.02885.x
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Article ; Online: A modified Delphi survey on the signs and symptoms of low back pain: indicators for an interventional management approach.

Pain practice : the official journal of World Institute of Pain

2015 Volume 15, Issue 1, Page(s) 12–21

Abstract: Background: Low back pain (LBP) symptoms and signs are nonspecific. If required, diagnostic blocks may find the source of pain, but indicators of suspect diagnosis must be defined to identify anatomical targets.: Objective: To reach a consensus from ... ...

Abstract	Background: Low back pain (LBP) symptoms and signs are nonspecific. If required, diagnostic blocks may find the source of pain, but indicators of suspect diagnosis must be defined to identify anatomical targets. Objective: To reach a consensus from an expert panel on the indicators for the most common causes of LBP. Material and methods: A 3-round (2 telematic and 1 face-to-face) modified Delphi survey with a questionnaire on 78 evidence-based indicators of 7 LBP etiologies was completed by 23 experts. Results: 98.7% of the questionnaire was consensuated. The most accepted indicators were for zygapophysial joint pain, painful ipsilateral paravertebral palpation, worsening with trunk extension, paravertebral musculature spasm on the affected articulation, and referred pain above the knee, without radicular pattern. For sacroiliac joint pain, unilateral pain when seating, with at least 3 described provoking tests: Approximation; gapping; Patrick's; Gaenslen's; thigh thrust; Fortin finger; and Gillet's tests. For discogenic pain, midline pain that may be provoked by pressure on the spinal processes at the affected level; for quadratus lumborum muscle, painful palpation on both the L1 level paravertebral region, referred to iliac crest, and the iliac crest, referred to greater trochanter. For iliopsoas muscle, pain elicited by thigh flexion, referred to buttock, inguinal region, and anterior thigh. For pyramidal muscle, pain while sitting on the affected side and positive Freiberg's test. For radicular pain, paresthesias and positive Lassègue's test at 60°. Conclusion: Seventy-seven diagnostic suspect indicators of LBP conditions were consensuated. These may facilitate conservative or interventional pain management decision-making.
MeSH term(s)	Arthralgia/complications ; Arthralgia/diagnosis ; Back Muscles ; Delphi Technique ; Humans ; Intervertebral Disc Degeneration/complications ; Intervertebral Disc Degeneration/diagnosis ; Low Back Pain/diagnosis ; Low Back Pain/etiology ; Lumbar Vertebrae ; Myalgia/complications ; Myalgia/diagnosis ; Radiculopathy/complications ; Radiculopathy/diagnosis ; Sacroiliac Joint ; Surveys and Questionnaires ; Symptom Assessment ; Zygapophyseal Joint
Language	English
Publishing date	2015-01
Publishing country	United States
Document type	Consensus Development Conference ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2151272-3
ISSN	1533-2500 ; 1530-7085
ISSN (online)	1533-2500
ISSN	1530-7085
DOI	10.1111/papr.12135
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Article ; Online: Large-volume-apheresis facilitates autologous transplantation of hematopoietic progenitors in poor mobilizer patients.

Majado, Maria Juliana / Minguela, Alfredo / González-García, Consuelo / Salido, Eduardo / Blanquer, Miguel / Funes, Consuelo / Insausti, Carmen Luisa / García-Hernández, Ana María / Moraleda, José María / Morales, Alfonso

Journal of clinical apheresis

2009 Volume 24, Issue 1, Page(s) 12–17

Abstract: Given that pre-apheresis CD34(+) cell count (PA-CD34) predicts the apheresis' yield, a minimum of 5 to 20 PA-CD34/microl is required in many institutions to initiate cell collection. The aim of this study was to clarify whether large-volume-apheresis ( ... ...

Abstract	Given that pre-apheresis CD34(+) cell count (PA-CD34) predicts the apheresis' yield, a minimum of 5 to 20 PA-CD34/microl is required in many institutions to initiate cell collection. The aim of this study was to clarify whether large-volume-apheresis (LVA) could facilitate progenitor cell transplantation in patients with low PA-CD34. Apheresis was initiated in 226 patients, disregarding PA-CD34, at days: +5 in G-CSF, +10 in cyclophosphamide+G-CSF, and +15 to +20 in other chemotherapy+G-CSF mobilization, when leucocytes >2.5 x 10(9)/L. Four times the blood volume was processed. Patients were grouped according to their PA-CD34: >or=10/microl (group-A, n = 143); <10/microl but >or=5/microl (group-B, n = 40) and <5/microl (group-C, n = 43). No differences were found in diagnoses, gender, age, previous treatments or mobilization regimen between groups. Enough CD34(+) cells (>1.9 x 10(6)/kg) were obtained in 31 patients (72%) from group-C, although in this group two mobilizations were needed in 20 patients (46.5%), compared to 5 (3.5%) and 1 (2.5%) in groups A and B, respectively (P < 0.01). Evenly three apheresis or more were required in 28 patients (65.1%) from group-C, compared to 8 (5.6%) and 6 (15.0%) in groups A and B, respectively (P < 0.01). In conclusion LVA can facilitate autologous transplantation in poor-mobilizer-patients, low PA-CD34 should not be an inflexible exclusion factor.
MeSH term(s)	Adolescent ; Adult ; Aged ; Antigens, CD34/analysis ; Blood Component Removal/methods ; Child ; Child, Preschool ; Cyclophosphamide/administration & dosage ; Female ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Hematologic Neoplasms/therapy ; Hematopoietic Stem Cell Mobilization/methods ; Hematopoietic Stem Cell Mobilization/standards ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Leukocyte Count ; Male ; Middle Aged ; Treatment Outcome ; Young Adult
Chemical Substances	Antigens, CD34 ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2009
Publishing country	United States
Document type	Controlled Clinical Trial ; Journal Article
ZDB-ID	604912-6
ISSN	1098-1101 ; 0733-2459
ISSN (online)	1098-1101
ISSN	0733-2459
DOI	10.1002/jca.20191
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