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  1. Article ; Online: Melatonin regulates L-arginine transport and NADPH oxidase in young rats with bile duct ligation: role of protein kinase C.

    Tain, You-Lin / Chen, Chih-Cheng / Lee, Chien-Te / Kao, Ying-Hsien / Sheen, Jiunn-Ming / Yu, Hong-Ren / Huang, Li-Tung

    Pediatric research

    2013  Volume 73, Issue 4 Pt 1, Page(s) 395–401

    Abstract: ... We hypothesized that protein kinase C-α (PKC-α) is involved in the increases of L-arginine in melatonin-treated ... We recently found that L-arginine levels were significantly raised by melatonin in young rats with BDL ... Results: Melatonin prevented BDL-induced mortality and kidney injury. Melatonin additionally increased L ...

    Abstract Background: Bile duct ligation (BDL) is a commonly used cholestatic liver disease (CLD) model. We recently found that L-arginine levels were significantly raised by melatonin in young rats with BDL. We hypothesized that protein kinase C-α (PKC-α) is involved in the increases of L-arginine in melatonin-treated BDL rats. In addition, we tested whether melatonin prevents nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-induced reactive oxygen species (ROS) production, in rats with BDL, through PKC.
    Methods: Four groups of young male rats were studied: shams (n = 6), untreated BDL rats (n = 9), melatonin-treated shams (n = 6, M), and melatonin-treated BDL rats (n = 6, BDL + M). Melatonin-treated rats received daily melatonin 1 mg/kg/d via i.p. injection. All surviving rats were killed 14 d after surgery.
    Results: Melatonin prevented BDL-induced mortality and kidney injury. Melatonin additionally increased L-arginine concentrations in BDL liver, which is correlated with decreased PKC-α translocation. Next, melatonin increased L-arginine levels in BDL kidneys, which was correlated with decreased renal levels of arginase II. In the BDL kidney, melatonin decreased PKC-β translocation, reduced p47phox translocation, and diminished NADPH-dependent superoxide production.
    Conclusion: Melatonin inhibits PKC-α to increase cationic amino acid transporter-1 (CAT-1)-mediated L-arginine uptake in BDL liver, whereas it inhibits PKC-β to reduce NADPH-dependent superoxide production.
    MeSH term(s) Animals ; Arginase/metabolism ; Arginine/analogs & derivatives ; Arginine/blood ; Arginine/metabolism ; Biological Transport ; Cationic Amino Acid Transporter 1/metabolism ; Cholestasis, Extrahepatic/blood ; Cholestasis, Extrahepatic/drug therapy ; Cholestasis, Extrahepatic/enzymology ; Cholestasis, Extrahepatic/etiology ; Common Bile Duct/surgery ; Disease Models, Animal ; Female ; Injections, Intraperitoneal ; Kidney/drug effects ; Kidney/enzymology ; Ligation ; Liver/drug effects ; Liver/enzymology ; Male ; Melatonin/administration & dosage ; Melatonin/pharmacology ; NADPH Oxidases/metabolism ; Protein Kinase C/antagonists & inhibitors ; Protein Kinase C/metabolism ; Protein Kinase C beta ; Protein Kinase C-alpha/antagonists & inhibitors ; Protein Kinase C-alpha/metabolism ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/pharmacology ; Protein Transport ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism
    Chemical Substances Cationic Amino Acid Transporter 1 ; Protein Kinase Inhibitors ; Reactive Oxygen Species ; N,N-dimethylarginine (63CV1GEK3Y) ; Arginine (94ZLA3W45F) ; NADPH Oxidases (EC 1.6.3.-) ; neutrophil cytosolic factor 1 (EC 1.6.3.1) ; Protein Kinase C (EC 2.7.11.13) ; Protein Kinase C beta (EC 2.7.11.13) ; Protein Kinase C-alpha (EC 2.7.11.13) ; Arg2 protein, rat (EC 3.5.3.1) ; Arginase (EC 3.5.3.1) ; Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2013-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/pr.2012.203
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    Zs.A 564: Show issues Location:
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  2. Article ; Online: Retrospective analysis of liver lobe torsion in pet rabbits: 40 cases (2016-2021).

    Sheen, Joanne C / Vella, David / Hung, Lily

    The Veterinary record

    2022  Volume 191, Issue 7, Page(s) e1971

    Abstract: Background: Liver lobe torsion (LLT) in rabbits can be under-recognised and potentially fatal. The clinical features of cases presented to an exotic animal veterinary service in Australia were retrospectively reviewed.: Method: Medical records of ... ...

    Abstract Background: Liver lobe torsion (LLT) in rabbits can be under-recognised and potentially fatal. The clinical features of cases presented to an exotic animal veterinary service in Australia were retrospectively reviewed.
    Method: Medical records of confirmed rabbit LLT cases between 2016 and 2021 were reviewed for signalment, clinical signs and findings, diagnostic imaging results, management strategies and outcomes. Variables of interest were analysed for statistical association with outcome.
    Results: A total of 40 rabbits were included. The mean presenting age was 56.2 months (SD 30.5). Neutered males (23/40, 57.5%) were over-represented. Common clinical signs and findings included reduced appetite (40/40, 100%), lethargy (32/40, 80.0%), reduced faecal production (16/40, 40.0%), a doughy distended stomach (20/40, 50.0%), pale mucous membranes (19/40, 47.5%) and hypothermia (17/40, 42.5%). Anaemia and elevated plasma alanine aminotransferase and blood urea nitrogen were common clinicopathologic findings. Computed tomography (CT) was performed in 34 of 40 rabbits, confirming the presence and position of LLT (34/34, 100%), stenosis of the caudal vena cava or portal system (28/34, 82.4%) and increased free peritoneal fluid (29/34, 85.3%). Fifteen (15/40, 37.5%) rabbits were medically managed, and surgical intervention was performed in 23 of 40 (57.5%) rabbits. Overall, 30 of 40 (75.0%) rabbits survived. Surgical intervention did not confer a significant difference in outcome compared to medical management (odds ratio 0.77, 95% confidence interval 0.15-4.10, p = 0.761).
    Conclusion: CT can be an invaluable diagnostic modality for rabbit LLT. Favourable outcomes can be achieved in selected cases with medical management alone.
    MeSH term(s) Alanine Transaminase ; Animals ; Liver/diagnostic imaging ; Male ; Medical Records ; Rabbits ; Retrospective Studies ; Torsion Abnormality/diagnosis ; Torsion Abnormality/surgery ; Torsion Abnormality/veterinary
    Chemical Substances Alanine Transaminase (EC 2.6.1.2)
    Language English
    Publishing date 2022-07-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 390015-0
    ISSN 2042-7670 ; 0042-4900
    ISSN (online) 2042-7670
    ISSN 0042-4900
    DOI 10.1002/vetr.1971
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  3. Article: Modeling the reduction of Salmonella and Listeria monocytogenes in ground chicken meat high pressure processing and trans-cinnamaldehyde

    Chuang, S. / Sheen, S. / Sommers, C. H. / Sheen, L.-Y.

    LWT - food science and technology

    2021  Volume 139, Issue -, Page(s) 110601

    Language English
    Document type Article
    ZDB-ID 2169058-3
    ISSN 0023-6438
    Database Current Contents Nutrition, Environment, Agriculture

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  4. Article ; Online: The prevalence of probable mental health disorders among hospital healthcare workers during COVID-19: A systematic review and meta-analysis.

    Lee, Brian En Chyi / Ling, Mathew / Boyd, Leanne / Olsson, Craig / Sheen, Jade

    Journal of affective disorders

    2023  Volume 330, Page(s) 329–345

    Abstract: Objectives: The mental health impacts of the COVID-19 pandemic continue to be documented worldwide with systematic reviews playing a pivotal role. Here we present updated findings from our systematic review and meta-analysis on the mental health impacts ...

    Abstract Objectives: The mental health impacts of the COVID-19 pandemic continue to be documented worldwide with systematic reviews playing a pivotal role. Here we present updated findings from our systematic review and meta-analysis on the mental health impacts among hospital healthcare workers during COVID-19.
    Methods: We searched MEDLINE, CINAHL, PsycINFO, Embase and Web Of Science Core Collection between 1st January 2000 to 17th February 2022 for studies using validated methods and reporting on the prevalence of diagnosed or probable mental health disorders in hospital healthcare workers during the COVID-19 pandemic. A meta-analysis of proportions and odds ratio was performed using a random effects model. Heterogeneity was investigated using test of subgroup differences and 95 % prediction intervals.
    Results: The meta-analysis included 401 studies, representing 458,754 participants across 58 countries. Pooled prevalence of depression was 28.5 % (95 % CI: 26.3-30.7), anxiety was 28.7 % (95 % CI: 26.5-31.0), PTSD was 25.5 % (95 % CI: 22.5-28.5), alcohol and substance use disorder was 25.3 % (95 % CI: 13.3-39.6) and insomnia was 24.4 % (95 % CI: 19.4-29.9). Prevalence rates were stratified by physicians, nurses, allied health, support staff and healthcare students, which varied considerably. There were significantly higher odds of probable mental health disorders in women, those working in high-risk units and those providing direct care.
    Limitations: Majority of studies used self-report measures which reflected probable mental health disorders rather than actual diagnosis.
    Conclusions: These updated findings have enhanced our understanding of at-risk groups working in hospitals. Targeted support and research towards these differences in mental health risks are recommended to mitigate any long-term consequences.
    MeSH term(s) Female ; Humans ; COVID-19/epidemiology ; Mental Health ; Pandemics ; Prevalence ; Depression/epidemiology ; Health Personnel/psychology ; Hospitals ; Delivery of Health Care
    Language English
    Publishing date 2023-03-16
    Publishing country Netherlands
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2023.03.012
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    Zs.A 1485: Show issues Location:
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  5. Article: Assessing Arsenic Species in Foods Using Regularized Linear Regression of the Arsenic K-edge X-ray Absorption Near Edge Structure.

    Jahrman, Evan P / Yu, Lee L / Krekelberg, William P / Sheen, David A / Allison, Thomas C / Molloy, John L

    Journal of analytical atomic spectrometry

    2022  Volume 37, Issue 6

    Abstract: The toxicity and bioavailability of arsenic is heavily dependent on its speciation. Therefore, robust and accurate methods are needed to determine arsenic speciation profiles for materials related to public health initiatives, such as food safety. Here, ... ...

    Abstract The toxicity and bioavailability of arsenic is heavily dependent on its speciation. Therefore, robust and accurate methods are needed to determine arsenic speciation profiles for materials related to public health initiatives, such as food safety. Here, X-ray spectroscopies are attractive candidates as they provide
    Language English
    Publishing date 2022-10-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1484654-8
    ISSN 1364-5544 ; 0267-9477
    ISSN (online) 1364-5544
    ISSN 0267-9477
    DOI 10.1039/d1ja00445j
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  6. Article ; Online: DNMT3L promotes neural differentiation by enhancing STAT1 and STAT3 phosphorylation independent of DNA methylation.

    Qin, Lin / Qiao, Chong / Sheen, Volney / Wang, Yu / Lu, Jie

    Progress in neurobiology

    2021  Volume 201, Page(s) 102028

    Abstract: Previously, we reported global hypermethylation in DS might be attributed to the overexpression of HSA21 gene DNMT3L, which can enhance DNMT3A and DNMT3B activities in DNA methylation. To test this hypothesis, we compared the DNA methylation and RNA ... ...

    Abstract Previously, we reported global hypermethylation in DS might be attributed to the overexpression of HSA21 gene DNMT3L, which can enhance DNMT3A and DNMT3B activities in DNA methylation. To test this hypothesis, we compared the DNA methylation and RNA expression profiles of early-differentiated human neuroprogenitors with and without DNMT3L overexpression. We found DNMT3L overexpression only moderately increased the DNA methylation of limited genes, yet significantly altered global RNA expression of genes involved in neural differentiation. We further found that DNMT3L bound STAT1 or STAT3, and increased its phosphorylation and nuclear translocation, which in turn activated the expression of transcription factors including HES3, ASCL1, NEUROD2 and NEUROG2 and CDK inhibitor CDKN1A, which promoted cell cycle exit and neural differentiation. This phenomenon was also confirmed in Dnmt3l conditional knockin mice, which could be rescued by STAT1 and STAT3 phosphorylation inhibitors (Fludarabine and SH-4-54) but not DNA methylation inhibitor (Decitabine). These results suggest that DNMT3L play an important role during neurodevelopment independent of DNA methylation, which may contribute to the abnormal phenotypes observed in Down syndrome cortex.
    MeSH term(s) Animals ; Basic Helix-Loop-Helix Transcription Factors ; Cell Differentiation ; DNA (Cytosine-5-)-Methyltransferases/genetics ; DNA Methylation ; Mice ; Nerve Tissue Proteins ; Phosphorylation ; RNA ; STAT1 Transcription Factor
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; Nerve Tissue Proteins ; Neurog2 protein, mouse ; STAT1 Transcription Factor ; Stat1 protein, mouse ; RNA (63231-63-0) ; Dnmt3l protein, mouse (EC 2.1.1.-) ; DNA (Cytosine-5-)-Methyltransferases (EC 2.1.1.37)
    Language English
    Publishing date 2021-02-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 185535-9
    ISSN 1873-5118 ; 0301-0082
    ISSN (online) 1873-5118
    ISSN 0301-0082
    DOI 10.1016/j.pneurobio.2021.102028
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    In stock of ZB MED Cologne/Königswinter

    Se 205: Show issues Location:
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  7. Article ; Online: The required size of cluster randomized trials of nonpharmaceutical interventions in epidemic settings.

    Sheen, Justin K / Haushofer, Johannes / Metcalf, C Jessica E / Kennedy-Shaffer, Lee

    Statistics in medicine

    2022  Volume 41, Issue 13, Page(s) 2466–2482

    Abstract: To control the SARS-CoV-2 pandemic and future pathogen outbreaks requires an understanding of which nonpharmaceutical interventions are effective at reducing transmission. Observational studies, however, are subject to biases that could erroneously ... ...

    Abstract To control the SARS-CoV-2 pandemic and future pathogen outbreaks requires an understanding of which nonpharmaceutical interventions are effective at reducing transmission. Observational studies, however, are subject to biases that could erroneously suggest an impact on transmission, even when there is no true effect. Cluster randomized trials permit valid hypothesis tests of the effect of interventions on community transmission. While such trials could be completed in a relatively short period of time, they might require large sample sizes to achieve adequate power. However, the sample sizes required for such tests in outbreak settings are largely undeveloped, leaving unanswered the question of whether these designs are practical. We develop approximate sample size formulae and simulation-based sample size methods for cluster randomized trials in infectious disease outbreaks. We highlight key relationships between characteristics of transmission and the enrolled communities and the required sample sizes, describe settings where trials powered to detect a meaningful true effect size may be feasible, and provide recommendations for investigators in planning such trials. The approximate formulae and simulation banks may be used by investigators to quickly assess the feasibility of a trial, followed by more detailed methods to more precisely size the trial. For example, we show that community-scale trials requiring 220 clusters with 100 tested individuals per cluster are powered to identify interventions that reduce transmission by 40% in one generation interval, using parameters identified for SARS-CoV-2 transmission. For more modest treatment effects, or when transmission is extremely overdispersed, however, much larger sample sizes are required.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; Humans ; Pandemics/prevention & control ; Randomized Controlled Trials as Topic ; SARS-CoV-2 ; Sample Size
    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.9365
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    Zs.A 1756: Show issues Location:
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  8. Article ; Online: Women's experiences of maternity care in the United Kingdom during the COVID-19 pandemic: A follow-up systematic review and qualitative evidence synthesis.

    Dasgupta, Tisha / Horgan, Gillian / Peterson, Lili / Mistry, Hiten D / Balls, Emily / Wilson, Milly / Smith, Valerie / Boulding, Harriet / Sheen, Kayleigh S / Van Citters, Aricca / Nelson, Eugene C / Duncan, Emma L / Dadelszen, Peter von / Rayment-Jones, Hannah / Silverio, Sergio A / Magee, Laura A

    Women and birth : journal of the Australian College of Midwives

    2024  Volume 37, Issue 3, Page(s) 101588

    Abstract: Background: Maternity care services in the United Kingdom have undergone drastic changes due to pandemic-related restrictions. Prior research has shown maternity care during the pandemic was negatively experienced by women and led to poor physical and ... ...

    Abstract Background: Maternity care services in the United Kingdom have undergone drastic changes due to pandemic-related restrictions. Prior research has shown maternity care during the pandemic was negatively experienced by women and led to poor physical and mental health outcomes in pregnancy. A synthesis is required of published research on women's experiences of maternity care during the latter half of the COVID-19 pandemic.
    Aim: To update a previous systematic review of maternity care experiences during the pandemic to June 2021, exploring experiences of maternity care specifically within the United Kingdom and how they may have changed, in order to inform future maternity services.
    Methods: A systematic review of qualitative literature was conducted using comprehensive searches of five electronic databases and the Cochrane COVID Study Register, published between 1 June 2021 and 13 October 2022, and further updated to 30 September 2023. Thematic Synthesis was utilised for data synthesis.
    Findings: Of 21,860 records identified, 27 studies were identified for inclusion. Findings included 14 descriptive themes across the five core concepts: (1)Care-seeking and experience; (2)Virtual care; (3)Self-monitoring; (4)COVID-19 vaccination; (5)Ethical future of maternity care.
    Discussion: Our findings in the UK are consistent with those globally, and extend those of the previous systematic review, particularly about women's perceptions of the COVID-19 vaccine during pregnancy.
    Conclusion: Our findings suggest the following are important to women for future maternity care: personalisation and inclusiveness; clear and evidence-based communication to facilitate informed decision-making; and achieving balance between social commitments and time spent settling into motherhood.
    MeSH term(s) Female ; Pregnancy ; Humans ; COVID-19 Vaccines ; Pandemics/prevention & control ; Follow-Up Studies ; Qualitative Research ; COVID-19/epidemiology ; Maternal Health Services ; United Kingdom/epidemiology
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2024-03-01
    Publishing country Netherlands
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2235085-8
    ISSN 1878-1799 ; 1871-5192
    ISSN (online) 1878-1799
    ISSN 1871-5192
    DOI 10.1016/j.wombi.2024.02.004
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    Zs.A 4015: Show issues Location:
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  9. Article ; Online: Multiantigen print immunoassay (MAPIA) for the diagnosis of neurocysticercosis: a single-center diagnostic optimization and accuracy study in Lima, Peru.

    Toribio, L / Guzman, C / Noazin, S / Zimic-Sheen, A / Zimic, M / Gonzales, I / Saavedra, H / Pretell, E J / Bustos, J A / Handali, S / García, H H

    Journal of clinical microbiology

    2023  Volume 61, Issue 12, Page(s) e0076023

    Abstract: Neurocysticercosis (NCC) is the most common helminthic infection of the human central nervous system. The antibody detection assay of choice is the enzyme-linked immunoelectrotransfer blot assay using lentil-lectin purified parasite antigens (LLGP-EITB, ... ...

    Abstract Neurocysticercosis (NCC) is the most common helminthic infection of the human central nervous system. The antibody detection assay of choice is the enzyme-linked immunoelectrotransfer blot assay using lentil-lectin purified parasite antigens (LLGP-EITB, Western blot), an immunoassay with exceptional performance in clinical samples. However, its use is mainly restricted to a few research laboratories because the assay is labor-intensive and requires sophisticated equipment, expertise, and large amounts of parasite material for preparation of reagents. We report a new immunoprint assay (MAPIA) that overcomes most of these barriers. We initially compared the performance of five different antigen combinations in a subset of defined samples in the MAPIA format. After selecting the best-performing assay format (a combination of rGP50 + rT24H + sTs14 antigens), 148 archived serum samples were tested, including 40 from individuals with parenchymal NCC, 40 with subarachnoid NCC, and 68 healthy controls with no evidence of neurologic disease. MAPIA using three antigens (rGP50 + rT24H + sTs14) was highly sensitive and specific for detecting antibodies in NCC. It detected 39 out of 40 (97.5%) parenchymal NCC cases and 40/40 (100%) subarachnoid cases and was negative in 67 out of 68 (98.53%) negative samples. MAPIA using three recombinant and synthetic antigens is a simple and economical tool with a performance equivalent to the LLGP-EITB assay for the detection of specific antibodies to NCC. The MAPIA overcomes existing barriers to adoption of the EITG LLGP and is a candidate for worldwide use.
    MeSH term(s) Animals ; Humans ; Neurocysticercosis/diagnosis ; Neurocysticercosis/parasitology ; Taenia solium ; Peru ; Antigens, Helminth ; Sensitivity and Specificity ; Immunoassay ; Enzyme-Linked Immunosorbent Assay ; Antibodies, Helminth
    Chemical Substances Antigens, Helminth ; Antibodies, Helminth
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.00760-23
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  10. Article ; Online: Overcoming lung cancer immunotherapy resistance by combining nontoxic variants of IL-12 and IL-2.

    Horton, Brendan L / D'Souza, Alicia D / Zagorulya, Maria / McCreery, Chloe V / Abhiraman, Gita C / Picton, Lora / Sheen, Allison / Agarwal, Yash / Momin, Noor / Wittrup, K Dane / White, Forest M / Garcia, K Christopher / Spranger, Stefani

    JCI insight

    2023  Volume 8, Issue 19

    Abstract: Engineered cytokine-based approaches for immunotherapy of cancer are poised to enter the clinic, with IL-12 being at the forefront. However, little is known about potential mechanisms of resistance to cytokine therapies. We found that orthotopic murine ... ...

    Abstract Engineered cytokine-based approaches for immunotherapy of cancer are poised to enter the clinic, with IL-12 being at the forefront. However, little is known about potential mechanisms of resistance to cytokine therapies. We found that orthotopic murine lung tumors were resistant to systemically delivered IL-12 fused to murine serum albumin (MSA, IL12-MSA) because of low IL-12 receptor (IL-12R) expression on tumor-reactive CD8+ T cells. IL2-MSA increased binding of IL12-MSA by tumor-reactive CD8+ T cells, and combined administration of IL12-MSA and IL2-MSA led to enhanced tumor-reactive CD8+ T cell effector differentiation, decreased numbers of tumor-infiltrating CD4+ regulatory T cells, and increased survival of lung tumor-bearing mice. Predictably, the combination of IL-2 and IL-12 at therapeutic doses led to significant dose-limiting toxicity. Administering IL-12 and IL-2 analogs with preferential binding to cells expressing Il12rb1 and CD25, respectively, led to a significant extension of survival in mice with lung tumors while abrogating dose-limiting toxicity. These findings suggest that IL-12 and IL-2 represent a rational approach to combination cytokine therapy whose dose-limiting toxicity can be overcome with engineered cytokine variants.
    MeSH term(s) Mice ; Animals ; Interleukin-12/genetics ; Interleukin-2/genetics ; Immunotherapy ; Cytokines ; Lung Neoplasms/genetics ; Lung Neoplasms/therapy
    Chemical Substances Interleukin-12 (187348-17-0) ; Interleukin-2 ; Cytokines
    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.172728
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