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Article ; Online: Methodological optimisation of thymocyte isolation and cryopreservation of human thymus samples.

Hagen, Ruth R / Xu, Calvin / Koay, Hui-Fern / Konstantinov, Igor E / Berzins, Stuart P / Kedzierska, Katherine / van de Sandt, Carolien E

Journal of immunological methods

2024 Volume 528, Page(s) 113651

Abstract: Premature lymphocytes develop into non-autoreactive, mature naïve ... ...

Abstract	Premature lymphocytes develop into non-autoreactive, mature naïve CD4
MeSH term(s)	Mice ; Animals ; Humans ; Thymocytes ; CD8-Positive T-Lymphocytes ; Thymus Gland ; Cell Differentiation
Language	English
Publishing date	2024-02-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	120142-6
ISSN	1872-7905 ; 0022-1759
ISSN (online)	1872-7905
ISSN	0022-1759
DOI	10.1016/j.jim.2024.113651
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Article ; Online: Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge.

Pellicci, Daniel G / Koay, Hui-Fern / Berzins, Stuart P

Nature reviews. Immunology

2020 Volume 20, Issue 12, Page(s) 756–770

Abstract: T cell lineages are defined by specialized functions and differential expression of surface antigens, cytokines and transcription factors. Conventional ... ...

Abstract	T cell lineages are defined by specialized functions and differential expression of surface antigens, cytokines and transcription factors. Conventional CD4
MeSH term(s)	Animals ; Humans ; Intestinal Mucosa/immunology ; Liver/immunology ; T-Lymphocyte Subsets/immunology ; Thymus Gland/immunology
Language	English
Publishing date	2020-06-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2062776-2
ISSN	1474-1741 ; 1474-1733
ISSN (online)	1474-1741
ISSN	1474-1733
DOI	10.1038/s41577-020-0345-y
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Zs.A 5565: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: A Role for MAIT Cells in Colorectal Cancer.

Berzins, Stuart P / Wallace, Morgan E / Kannourakis, George / Kelly, Jason

Frontiers in immunology

2020 Volume 11, Page(s) 949

Abstract: MAIT cells are MR1-restricted T cells that are well-known for their anti-microbial properties, but they have recently been associated with different forms of cancer. Several studies have reported activated MAIT cells within the microenvironment of ... ...

Abstract	MAIT cells are MR1-restricted T cells that are well-known for their anti-microbial properties, but they have recently been associated with different forms of cancer. Several studies have reported activated MAIT cells within the microenvironment of colorectal tumors, but there is conjecture about the nature of their response and whether they are contributing to anti-tumor immunity, or to the progression of the disease. We have reviewed the current state of knowledge about the role of MAIT cells in colorectal cancer, including their likely influence when activated and potential sources of stimulation in the tumor microenvironment. The prospects for MAIT cells being used in clinical settings as biomarkers or as targets of new immunotherapies designed to harness their function are discussed.
MeSH term(s)	Animals ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy ; Humans ; Immunotherapy ; Lymphocyte Activation ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Mucosal-Associated Invariant T Cells/immunology ; Mucosal-Associated Invariant T Cells/metabolism ; Phenotype ; Tumor Escape ; Tumor Microenvironment
Language	English
Publishing date	2020-05-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.00949
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Article ; Online: Distinct subpopulations of DN1 thymocytes exhibit preferential γδ T lineage potential.

Oh, Seungyoul / Liu, Xin / Tomei, Sara / Luo, Mengxiao / Skinner, Jarrod P / Berzins, Stuart P / Naik, Shalin H / Gray, Daniel H D / Chong, Mark M W

Frontiers in immunology

2023 Volume 14, Page(s) 1106652

Abstract: The αβ and γδ T cell lineages both differentiate in the thymus from common uncommitted progenitors. The earliest stage of T cell development is known as ... ...

Abstract	The αβ and γδ T cell lineages both differentiate in the thymus from common uncommitted progenitors. The earliest stage of T cell development is known as CD4
MeSH term(s)	Mice ; Animals ; Thymocytes ; Interleukin-17/metabolism ; Thymus Gland ; Cell Differentiation ; Transcription Factors/metabolism
Chemical Substances	Interleukin-17 ; Transcription Factors
Language	English
Publishing date	2023-04-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1106652
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Article ; Online: A potentially important role for T cells and regulatory T cells in Langerhans cell histiocytosis.

Mitchell, Jenée M / Berzins, Stuart P / Kannourakis, George

Clinical immunology (Orlando, Fla.)

2018 Volume 194, Page(s) 19–25

Abstract: Langerhans cell histiocytosis is characterized by lesions containing inflammatory immune cells, including myeloid cells and T cells. Patient mortality remains unacceptably high and new treatment options are required. Several LCH studies have identified ... ...

Abstract	Langerhans cell histiocytosis is characterized by lesions containing inflammatory immune cells, including myeloid cells and T cells. Patient mortality remains unacceptably high and new treatment options are required. Several LCH studies have identified aberrant frequencies of T cell subsets with potential immune regulatory properties. High numbers of Foxp3
MeSH term(s)	Forkhead Transcription Factors/immunology ; Histiocytosis, Langerhans-Cell/immunology ; Humans ; Langerhans Cells/immunology ; T-Lymphocyte Subsets/immunology ; T-Lymphocytes, Regulatory/immunology
Chemical Substances	Forkhead Transcription Factors
Language	English
Publishing date	2018-06-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2018.06.004
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Zs.A 880: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article: Plasma Signaling Factors in Patients With Langerhans Cell Histiocytosis (LCH) Correlate With Relative Frequencies of LCH Cells and T Cells Within Lesions.

Mitchell, Jenée / Kvedaraite, Egle / von Bahr Greenwood, Tatiana / Lourda, Magda / Henter, Jan-Inge / Berzins, Stuart P / Kannourakis, George

Frontiers in pediatrics

2022 Volume 10, Page(s) 872859

Abstract: Langerhans cell histiocytosis (LCH) lesions contain an inflammatory infiltrate of immune cells including myeloid-derived LCH cells. Cell-signaling proteins within the lesion environment suggest that LCH cells and T cells contribute majorly to the ... ...

Abstract	Langerhans cell histiocytosis (LCH) lesions contain an inflammatory infiltrate of immune cells including myeloid-derived LCH cells. Cell-signaling proteins within the lesion environment suggest that LCH cells and T cells contribute majorly to the inflammation. Foxp3+ regulatory T cells (Tregs) are enriched in lesions and blood from patients with LCH and are likely involved in LCH pathogenesis. In contrast, mucosal associated invariant T (MAIT) cells are reduced in blood from these patients and the consequence of this is unknown. Serum/plasma levels of cytokines have been associated with LCH disease extent and may play a role in the recruitment of cells to lesions. We investigated whether plasma signaling factors differed between patients with active and non-active LCH. Cell-signaling factors (38 analytes total) were measured in patient plasma and cell populations from matched lesions and/or peripheral blood were enumerated. This study aimed at understanding whether plasma factors corresponded with LCH cells and/or LCH-associated T cell subsets in patients with LCH. We identified several associations between plasma factors and lesional/circulating immune cell populations, thus highlighting new factors as potentially important in LCH pathogenesis. This study highlights plasma cell-signaling factors that are associated with LCH cells, MAIT cells or Tregs in patients, thus they are potentially important in LCH pathogenesis. Further study into these associations is needed to determine whether these factors may become suitable prognostic indicators or therapeutic targets to benefit patients.
Language	English
Publishing date	2022-06-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2022.872859
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Article ; Online: Effect of Hydralazine on Angiotensin II-Induced Abdominal Aortic Aneurysm in Apolipoprotein E-Deficient Mice.

Wang, Yutang / Sargisson, Owen / Nguyen, Dinh Tam / Parker, Ketura / Pyke, Stephan J R / Alramahi, Ahmed / Thihlum, Liam / Fang, Yan / Wallace, Morgan E / Berzins, Stuart P / Oqueli, Ernesto / Magliano, Dianna J / Golledge, Jonathan

International journal of molecular sciences

2023 Volume 24, Issue 21

Abstract: The rupture of an abdominal aortic aneurysm (AAA) causes about 200,000 deaths worldwide each year. However, there are currently no effective drug therapies to prevent AAA formation or, when present, to decrease progression and rupture, highlighting an ... ...

Abstract	The rupture of an abdominal aortic aneurysm (AAA) causes about 200,000 deaths worldwide each year. However, there are currently no effective drug therapies to prevent AAA formation or, when present, to decrease progression and rupture, highlighting an urgent need for more research in this field. Increased vascular inflammation and enhanced apoptosis of vascular smooth muscle cells (VSMCs) are implicated in AAA formation. Here, we investigated whether hydralazine, which has anti-inflammatory and anti-apoptotic properties, inhibited AAA formation and pathological hallmarks. In cultured VSMCs, hydralazine (100 μM) inhibited the increase in inflammatory gene expression and apoptosis induced by acrolein and hydrogen peroxide, two oxidants that may play a role in AAA pathogenesis. The anti-apoptotic effect of hydralazine was associated with a decrease in caspase 8 gene expression. In a mouse model of AAA induced by subcutaneous angiotensin II infusion (1 µg/kg body weight/min) for 28 days in apolipoprotein E-deficient mice, hydralazine treatment (24 mg/kg/day) significantly decreased AAA incidence from 80% to 20% and suprarenal aortic diameter by 32% from 2.26 mm to 1.53 mm. Hydralazine treatment also significantly increased the survival rate from 60% to 100%. In conclusion, hydralazine inhibited AAA formation and rupture in a mouse model, which was associated with its anti-inflammatory and anti-apoptotic properties.
MeSH term(s)	Animals ; Mice ; Angiotensin II/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Aorta, Abdominal/metabolism ; Aortic Aneurysm, Abdominal/chemically induced ; Aortic Aneurysm, Abdominal/drug therapy ; Aortic Aneurysm, Abdominal/metabolism ; Apolipoproteins/pharmacology ; Apolipoproteins E ; Apoptosis ; Disease Models, Animal ; Mice, Inbred C57BL ; Mice, Knockout
Chemical Substances	Angiotensin II (11128-99-7) ; Anti-Inflammatory Agents ; Apolipoproteins ; Apolipoproteins E
Language	English
Publishing date	2023-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242115955
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Article ; Online: Modulation of TCR signalling components occurs prior to positive selection and lineage commitment in iNKT cells.

Dinh, Xuyen T / Stanley, Dragana / Smith, Letitia D / Moreau, Morgane / Berzins, Stuart P / Gemiarto, Adrian / Baxter, Alan G / Jordan, Margaret A

Scientific reports

2021 Volume 11, Issue 1, Page(s) 23650

Abstract: iNKT cells play a critical role in controlling the strength and character of adaptive and innate immune responses. Their unique functional characteristics are induced by a transcriptional program initiated by positive selection mediated by CD1d expressed ...

Abstract	iNKT cells play a critical role in controlling the strength and character of adaptive and innate immune responses. Their unique functional characteristics are induced by a transcriptional program initiated by positive selection mediated by CD1d expressed by CD4
MeSH term(s)	Animals ; Antigens, CD1d/immunology ; Cell Lineage ; Mice ; Mice, Inbred NOD ; Mice, Transgenic ; Natural Killer T-Cells/cytology ; Natural Killer T-Cells/immunology ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction
Chemical Substances	Antigens, CD1d ; CD1D protein, human ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2021-12-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-02885-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Natural killer T cells: drivers or passengers in preventing human disease?

Berzins, Stuart P / Ritchie, David S

Nature reviews. Immunology

2014 Volume 14, Issue 9, Page(s) 640–646

Abstract: Natural killer T (NKT) cells are credited with regulatory roles in immunity against cancers, autoimmune diseases, allergies, and bacterial and viral infections. Studies in mice and observational research in patient groups have suggested that NKT cell- ... ...

Abstract	Natural killer T (NKT) cells are credited with regulatory roles in immunity against cancers, autoimmune diseases, allergies, and bacterial and viral infections. Studies in mice and observational research in patient groups have suggested that NKT cell-based therapies could be used to prevent or treat these diseases, yet the translation into clinical settings has been disappointing. We support the view that NKT cells have regulatory characteristics that could be exploited in clinical settings, but there are doubts about the natural roles of NKT cells in vivo and whether NKT cell defects are fundamental drivers of disease in humans. In this Opinion article, we discuss the uncertainties and opportunities regarding NKT cells in humans, and the potential for NKT cells to be manipulated to prevent or treat disease.
MeSH term(s)	Animals ; Antigens, CD1d/immunology ; Asthma/immunology ; Cytokines/metabolism ; Diabetes Mellitus, Type 1/immunology ; Humans ; Lymphocyte Activation/immunology ; Lymphocyte Count ; Mice ; Models, Animal ; Natural Killer T-Cells/immunology ; Neoplasms/immunology ; Receptors, Antigen, T-Cell, alpha-beta/genetics
Chemical Substances	Antigens, CD1d ; Cytokines ; Receptors, Antigen, T-Cell, alpha-beta
Language	English
Publishing date	2014-08-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2062776-2
ISSN	1474-1741 ; 1474-1733
ISSN (online)	1474-1741
ISSN	1474-1733
DOI	10.1038/nri3725
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Zs.A 5565: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 34: Show issues

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Article ; Online: Effect of Hydralazine on Angiotensin II-Induced Abdominal Aortic Aneurysm in Apolipoprotein E-Deficient Mice

Yutang Wang / Owen Sargisson / Dinh Tam Nguyen / Ketura Parker / Stephan J. R. Pyke / Ahmed Alramahi / Liam Thihlum / Yan Fang / Morgan E. Wallace / Stuart P. Berzins / Ernesto Oqueli / Dianna J. Magliano / Jonathan Golledge

International Journal of Molecular Sciences, Vol 24, Iss 21, p

2023 Volume 15955

Abstract	The rupture of an abdominal aortic aneurysm (AAA) causes about 200,000 deaths worldwide each year. However, there are currently no effective drug therapies to prevent AAA formation or, when present, to decrease progression and rupture, highlighting an urgent need for more research in this field. Increased vascular inflammation and enhanced apoptosis of vascular smooth muscle cells (VSMCs) are implicated in AAA formation. Here, we investigated whether hydralazine, which has anti-inflammatory and anti-apoptotic properties, inhibited AAA formation and pathological hallmarks. In cultured VSMCs, hydralazine (100 μM) inhibited the increase in inflammatory gene expression and apoptosis induced by acrolein and hydrogen peroxide, two oxidants that may play a role in AAA pathogenesis. The anti-apoptotic effect of hydralazine was associated with a decrease in caspase 8 gene expression. In a mouse model of AAA induced by subcutaneous angiotensin II infusion (1 µg/kg body weight/min) for 28 days in apolipoprotein E-deficient mice, hydralazine treatment (24 mg/kg/day) significantly decreased AAA incidence from 80% to 20% and suprarenal aortic diameter by 32% from 2.26 mm to 1.53 mm. Hydralazine treatment also significantly increased the survival rate from 60% to 100%. In conclusion, hydralazine inhibited AAA formation and rupture in a mouse model, which was associated with its anti-inflammatory and anti-apoptotic properties.
Keywords	abdominal aortic aneurysm ; hydralazine ; inflammation ; atherosclerosis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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