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Book: Stretching und Beweglichkeit

Albrecht, Karin / Meyer, Stephan

das neue Expertenhandbuch

2022

Author's details	Karin Albrecht, Stephan Meyer
Keywords	Dehnübung
Subject	Stretching ; Dehngymnastik ; Dehnungsübung ; Dehnübungen
Language	German
Size	168 Seiten, Illustrationen, 22.5 cm x 15 cm
Edition	4., aktualisierte Auflage
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Publishing country	Germany
Document type	Book
HBZ-ID	HT021201817
ISBN	978-3-13-244261-0 ; 3-13-244261-5 ; 9783132442740 ; 9783132442757 ; 3132442747 ; 3132442755
Database	Catalogue ZB MED Medicine, Health

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2022 A 459	available for loan (reading room)	Lesesaal EG

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Article ; Online: Reducing computational demands of restricted maximum likelihood estimation with genomic relationship matrices.

Meyer, Karin

Genetics, selection, evolution : GSE

2023 Volume 55, Issue 1, Page(s) 7

Abstract: Restricted maximum likelihood estimation of genetic parameters accounting for genomic relationships has been reported to impose computational burdens which typically are many times higher than those of corresponding analyses considering pedigree based ... ...

Abstract	Restricted maximum likelihood estimation of genetic parameters accounting for genomic relationships has been reported to impose computational burdens which typically are many times higher than those of corresponding analyses considering pedigree based relationships only. This can be attributed to the dense nature of genomic relationship matrices and their inverses. We outline a reparameterisation of the multivariate linear mixed model to principal components and its effects on the sparsity pattern of the pertaining coefficient matrix in the mixed model equations. Using two data sets we demonstrate that this can dramatically reduce the computing time per iterate of the widely used 'average information' algorithm for restricted maximum likelihood. This is primarily due to the fact that on the principal component scale, the first derivatives of the coefficient matrix with respect to the parameters modelling genetic covariances between traits are independent of the relationship matrix between individuals, i.e. are not afflicted by a multitude of genomic relationships.
MeSH term(s)	Humans ; Likelihood Functions ; Breeding ; Models, Genetic ; Genomics/methods ; Phenotype ; Algorithms ; Pedigree
Language	English
Publishing date	2023-01-25
Publishing country	France
Document type	Journal Article
ZDB-ID	1005838-2
ISSN	1297-9686 ; 0754-0264 ; 0999-193X
ISSN (online)	1297-9686
ISSN	0754-0264 ; 0999-193X
DOI	10.1186/s12711-023-00781-7
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Article ; Online: Reducing computational demands of restricted maximum likelihood estimation with genomic relationship matrices

Meyer, Karin

Genet Sel Evol. 2023 Dec., v. 55, no. 1 p.7-7

2023

Abstract	Restricted maximum likelihood estimation of genetic parameters accounting for genomic relationships has been reported to impose computational burdens which typically are many times higher than those of corresponding analyses considering pedigree based relationships only. This can be attributed to the dense nature of genomic relationship matrices and their inverses. We outline a reparameterisation of the multivariate linear mixed model to principal components and its effects on the sparsity pattern of the pertaining coefficient matrix in the mixed model equations. Using two data sets we demonstrate that this can dramatically reduce the computing time per iterate of the widely used ‘average information’ algorithm for restricted maximum likelihood. This is primarily due to the fact that on the principal component scale, the first derivatives of the coefficient matrix with respect to the parameters modelling genetic covariances between traits are independent of the relationship matrix between individuals, i.e. are not afflicted by a multitude of genomic relationships.
Keywords	algorithms ; genomics ; pedigree ; statistical analysis ; statistical models
Language	English
Dates of publication	2023-12
Size	p. 7.
Publishing place	BioMed Central
Document type	Article ; Online
ZDB-ID	1005838-2
ISSN	1297-9686 ; 0754-0264 ; 0999-193X
ISSN (online)	1297-9686
ISSN	0754-0264 ; 0999-193X
DOI	10.1186/s12711-023-00781-7
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Book: Extreme stress mobbing. Approaches for coping and prevention in agile organizations

Meyer, Karin

2023

Abstract: In addition to high pressure to meet deadlines and succeed, emotional stress and a poor working atmosphere, bullying is one of the most severe stresses to which employees are exposed in their everyday working lives. Employers usually perceive conflicts ... ...

Title translation	Mobbing unter extremem Stress. Ansätze zur Bewältigung und Prävention in agilen Organisationen (DeepL)
Abstract	In addition to high pressure to meet deadlines and succeed, emotional stress and a poor working atmosphere, bullying is one of the most severe stresses to which employees are exposed in their everyday working lives. Employers usually perceive conflicts between employees as a disruptive factor. At the same time, it is often difficult for those affected to grasp the situation completely and in good time. Therefore, in addition to possible behaviors of mobbers, triggers for this form of aggressive behavior as well as working and general conditions conducive to mobbing, such as agile organizations, are examined - as well as approaches to coping and prevention. (c) The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH - Contents: https://d-nb.info/128933403X/04
Keywords	Aggressionsverhalten ; Aggressive Behavior ; Beruflicher Stress ; Bewältigungsverhalten ; Bullying ; Coping Behavior ; Mobbing ; Occupational Stress ; Organisationsverhalten ; Organizational Behavior ; Prevention ; Prävention
Language	English
Size	49 pp.
Publisher	Springer
Publishing place	Berlin, Heidelberg
Document type	Book
Note	This book is a translation of the original German edition "Extrem-Stress Mobbing" by Meyer, Karin, published by Springer Berlin in 2023. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com) with a subsequent human revision in terms of content
ISBN	978-3-662-67589-2 ; 3-662-67589-7
DOI	10.1007/978-3-662-67590-8
Database	PSYNDEX

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Book: Extrem-Stress Mobbing. Ansätze für Bewältigung und Prävention in agilen Organisationen

Meyer, Karin

2023

Abstract: Neben einem hohen Termin- und Erfolgsdruck, emotionalem Stress sowie einem schlechten Arbeitsklima gehört Mobbing zu den stärksten Stress-Belastungen, denen Arbeitnehmer*innen im Arbeitsalltag ausgesetzt sind. Arbeitgeberseitig werden Konflikte zwischen ... ...

Title translation	Extreme stress bullying. Approaches for coping and prevention in agile organizations (DeepL)
Abstract	Neben einem hohen Termin- und Erfolgsdruck, emotionalem Stress sowie einem schlechten Arbeitsklima gehört Mobbing zu den stärksten Stress-Belastungen, denen Arbeitnehmerinnen im Arbeitsalltag ausgesetzt sind. Arbeitgeberseitig werden Konflikte zwischen Mitarbeiterinnen meist als Störfaktor empfunden. Gleichzeitig besteht für Betroffene oftmals das Problem, die Situation rechtzeitig und vollständig zu erfassen. Beleuchtet werden daher neben möglichen Verhaltensweisen von Mobbern auch Auslöser für diese Form aggressiven Verhaltens sowie mobbingfördernde Arbeits- und Rahmenbedingungen, beispielsweise agiler Organisationen - ebenso Ansätze zur Bewältigung und Prävention. (c) Der/die Herausgeber bzw. der/die Autor(en), exklusiv lizenziert an Springer-Verlag GmbH - Inhalt: https://d-nb.info/1275857000/04
Keywords	Aggressionsverhalten ; Aggressive Behavior ; Beruflicher Stress ; Bewältigungsverhalten ; Bullying ; Coping Behavior ; Mobbing ; Occupational Stress ; Organisationsverhalten ; Organizational Behavior ; Prevention ; Prävention
Language	German
Size	49 S.
Publisher	Springer
Publishing place	Berlin, Heidelberg
Document type	Book
ISBN	978-3-662-66808-5 ; 3-662-66808-4
Database	PSYNDEX

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Article ; Online: Trajectories of Long-term Care after Stroke in Sweden: Nationwide Study Exploring Patterns and Determinants.

Meyer, Anna C / Ebeling, Marcus / Modig, Karin

Journal of the American Medical Directors Association

2024 Volume 25, Issue 4, Page(s) 599–605.e5

Abstract: Objectives: Stroke is a leading cause of mortality and disability worldwide. Although studies have primarily focused on health and functioning among stroke survivors, there is limited research on longitudinal patterns of long-term care use among older ... ...

Abstract	Objectives: Stroke is a leading cause of mortality and disability worldwide. Although studies have primarily focused on health and functioning among stroke survivors, there is limited research on longitudinal patterns of long-term care use among older adults with stroke. This study explores long-term care trajectories among older men and women with stroke in the Swedish population. Design: Nationwide prospective cohort study. Setting and participants: All individuals aged ≥70 years hospitalized with a first stroke in 2015-2017 followed in the Swedish population registers for 3 years. Methods: Care trajectories among patients with strokes were visualized and compared to trajectories in 2 control groups: (1) same-aged peers randomly drawn from the general population and (2) older adults with health and sociodemographic characteristics similar to patients with strokes but without stroke identified through propensity score matching. Multivariable Cox regression and multistate models were used to identify determinants of mortality and care trajectories among patients with strokes. Results: We identified 31,560 individuals with stroke (mean age 82.9 years). Already before the stroke, these individuals had a higher comorbidity burden and received more long-term care than their same-aged peers. Compared with both control groups, patients with strokes were also more likely to enter long-term care. However, 38% of patients with strokes survived for 3 years without taking up long-term care. Sex, income, cohabitation, and comorbidities were associated with care trajectories. Care status was a more robust predictor of mortality after stroke than the established Charlson comorbidity index. Conclusions and implications: Experiencing a stroke increases both mortality and long-term care utilization, and once formal long-term care is provided, exceedingly few patients with strokes return to living without care. However, a considerable part of care utilization and mortality after stroke is concentrated among those with preexisting care needs. Prestroke care utilization should thus be considered in future studies exploring stroke prognosis.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Aged, 80 and over ; Sweden/epidemiology ; Long-Term Care ; Prospective Studies ; Stroke/epidemiology ; Stroke/therapy ; Prognosis
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171030-2
ISSN	1538-9375 ; 1525-8610
ISSN (online)	1538-9375
ISSN	1525-8610
DOI	10.1016/j.jamda.2023.11.024
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Article ; Online: "Bending" and beyond: Better estimates of quantitative genetic parameters?

Meyer, Karin

Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie

2019 Volume 136, Issue 4, Page(s) 243–251

Abstract: Multivariate estimation of genetic parameters involving more than a handful of traits can be afflicted by problems arising through substantial sampling variation. We present a review of underlying causes and proposals to improve estimates, focusing on ... ...

Abstract	Multivariate estimation of genetic parameters involving more than a handful of traits can be afflicted by problems arising through substantial sampling variation. We present a review of underlying causes and proposals to improve estimates, focusing on linear mixed model-based estimation via restricted maximum likelihood (REML). Both full multivariate analyses and pooling of results from overlapping subsets of traits are considered. It is suggested to impose a penalty on the likelihood designed to reduce sampling variances at the expense of a little additional bias. Simulation results are discussed which demonstrate that this can yield REML estimates that are on average closer to the population values than their unpenalized counterparts. Suitable penalties can be obtained based on assumed prior distributions of selected parameters. Necessary choices of penalty functions and of the stringency of penalization are examined. We argue that scale-free penalty functions lend themselves to a simple scheme imposing a mild, default penalty which can yield "better" estimates without being likely to incur detrimental effects.
MeSH term(s)	Algorithms ; Animals ; Bayes Theorem ; Computational Biology/methods ; Genetic Variation ; Likelihood Functions ; Models, Genetic ; Multivariate Analysis ; Phenotype
Language	English
Publishing date	2019-06-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	631363-2
ISSN	1439-0388 ; 0044-3581 ; 0931-2668 ; 1742-4488
ISSN (online)	1439-0388
ISSN	0044-3581 ; 0931-2668 ; 1742-4488
DOI	10.1111/jbg.12386
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Article ; Online: Variation in End-of-Life Trajectories in Persons Aged 70 Years and Older, Sweden, 2018‒2020.

Ebeling, Marcus / Meyer, Anna C / Modig, Karin

American journal of public health

2023 Volume 113, Issue 7, Page(s) 786–794

Abstract: Objectives. ...

Abstract	Objectives.
MeSH term(s)	Humans ; Aged ; Aged, 80 and over ; Sweden ; Aging ; Death
Language	English
Publishing date	2023-04-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121100-6
ISSN	1541-0048 ; 0090-0036 ; 0002-9572
ISSN (online)	1541-0048
ISSN	0090-0036 ; 0002-9572
DOI	10.2105/AJPH.2023.307281
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Article ; Online: Author Response: A Focus on Subtle Signs and Motor Behavior to Unveil Awareness in Unresponsive Brain-Impaired Patients: The Importance of Being Clinical.

Meyer, Ivo A / Jöhr, Jane / Diserens, Karin

Neurology

2023 Volume 101, Issue 3, Page(s) 146–147

MeSH term(s)	Humans ; Brain/diagnostic imaging ; Awareness ; Head
Language	English
Publishing date	2023-07-14
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000207613
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Article: Impact of missing pedigrees in single-step genomic evaluation

Meyer, Karin

Animal production science. 2021, v. 61, no. 18

2021

Abstract: Context A common problem in mixed model-based genetic evaluation schemes for livestock is that cohorts of animals differ systematically in mean genetic merit, for example, due to missing pedigree. This can be modelled by fitting genetic groups. Single- ... ...

Abstract	Context A common problem in mixed model-based genetic evaluation schemes for livestock is that cohorts of animals differ systematically in mean genetic merit, for example, due to missing pedigree. This can be modelled by fitting genetic groups. Single-step genomic evaluation (ssGBLUP) combining information from genotyped and non-genotyped individuals has become routine, but little is known of the effects of unknown parents in this context. Aims To investigate the effects of missing pedigrees on accuracy and bias of predicted breeding values for ssGBLUP analyses. Methods A simulation study was used to examine alternative ways to account for genetic groups in ssGBLUP, for multi-generation data with strong selection and rapidly increasing numbers of genotyped animals in the most recent generations. Key results Results demonstrated that missing pedigrees can markedly impair predicted breeding values. With selection, alignment of genomic and pedigree relationship matrices is essential when fitting unknown parent groups (UPG). Genomic relationships are complete; that is, they ‘automatically’ reference the genomic base, which typically differs from the genetic base for pedigreed animals. This can lead to biased comparisons between genotyped and non-genotyped animals with unknown parents when the two categories of animals are assigned to the same UPG. Allocating genotyped individuals to a separate UPG across all generations for each strain or breed was shown to be a simple and effective way to reduce misalignment bias. In contrast, fitting metafounders modified pedigree-based relationships to account for ancestral genomic relationships and inbreeding rather than the genomic relationship matrix. Thus, no bias due to different types of animals assigned to the same metafounders was apparent. Overall, fitting metafounders yielded slightly higher correlations between true and predicted breeding values than did UPG models, which assume genetic groups to be unrelated. Conclusions Missing pedigrees are more problematic with ssGBLUP than for analyses considering pedigree-based relationships only. UPG models with separation of genotyped and non-genotyped individuals and analyses fitting metafounders yielded comparable predictions of breeding values in terms of accuracy and bias. Implications A previously unidentified incompatibility between alignment of founder populations and assignment of genotyped and non-genotyped animals to the same UPG has been reported. Implementation of the proposed strategy to reduce ‘double counting’ is straightforward and can improve results of ssGBLUP analyses.
Keywords	animal production ; genetic background ; genetic merit ; genomics ; genotyping ; livestock ; pedigree
Language	English
Size	p. 1760-1773.
Publishing place	CSIRO Publishing
Document type	Article
ZDB-ID	2472524-9
ISSN	1836-5787 ; 1836-0939
ISSN (online)	1836-5787
ISSN	1836-0939
DOI	10.1071/AN21045
Database	NAL-Catalogue (AGRICOLA)

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