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  1. Article ; Online: Economic Potential for Distributed Manufacturing of Adaptive Aids for Arthritis Patients in the U.S.

    Gallup, Nicole / Bow, Jennifer K / Pearce, Joshua M

    Geriatrics (Basel, Switzerland)

    2018  Volume 3, Issue 4

    Abstract: By 2040, more than a quarter of the U.S. population will have diagnosed arthritic conditions. Adults with arthritis and other rheumatic conditions earn less than average yet have medical care expenditures that are over 12% of average household income. ... ...

    Abstract By 2040, more than a quarter of the U.S. population will have diagnosed arthritic conditions. Adults with arthritis and other rheumatic conditions earn less than average yet have medical care expenditures that are over 12% of average household income. Adaptive aids can help arthritis patients continue to maintain independence and quality of life; however, their high costs limit accessibility for older people and the poor. One method used for consumer price reduction is distributed manufacturing with 3-D printers. In order to assess if such a method would be financially beneficial, this study evaluates the techno-economic viability of distributed manufacturing of adaptive aids for arthritis patients. Twenty freely accessible designs for 3-D printable adaptive aids were successfully fabricated on low-cost desktop 3-D printers and performed their functions adequately. The financial savings averaged >94% compared to commercially-available products. Overall, twenty adaptive aids were printed for US$20 of plastic; while on average, each adaptive aid would save over US$20. As printing a tiny subset of the adaptive aids needed by a single patient would recover the full capital and operational costs of a low-cost 3-D printer, it can be concluded that there is considerable potential for distributed manufacturing to assist arthritis patients.
    Language English
    Publishing date 2018-12-06
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2308-3417
    ISSN (online) 2308-3417
    DOI 10.3390/geriatrics3040089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Parametric nasopharyngeal swab for sampling COVID-19 and other respiratory viruses: Open source design, SLA 3-D printing and UV curing system.

    Gallup, Nicole / Pringle, Adam M / Oberloier, Shane / Tanikella, Nagendra G / Pearce, Joshua M

    HardwareX

    2020  Volume 8, Page(s) e00135

    Abstract: Access to nasopharyngeal swabs for sampling remain a bottleneck in some regions for COVID-19 testing. This study develops a distributed manufacturing solution using only an open source manufacturing tool chain consisting of two types of open source 3-D ... ...

    Abstract Access to nasopharyngeal swabs for sampling remain a bottleneck in some regions for COVID-19 testing. This study develops a distributed manufacturing solution using only an open source manufacturing tool chain consisting of two types of open source 3-D printing and batch UV curing, and provides a parametric fully free design of a nasopharyngeal swab. The swab was designed using parametric OpenSCAD in two components (a head with engineered break point and various handles), which has several advantages: i) minimizing print time on relatively slow SLA printers, ii) enabling the use of smaller print volume open source SLA printers, iii) reducing the amount of relatively expensive UV resin, and iv) enabling production of handle on more accessible material extrusion 3-D printers. A modular open source UV LED box was designed, fabricated for $45 and tested for batch curing. Swabs can be fabricated for $0.06-$0.12/swab. The results of the mechanical validation tests showed that the swabs could withstand greater forces than would be expected in normal clinical use. The swabs were also able to absorb a significant amounts of synthetic mucus materials and passed abrasion and handling tests. The results show the open source swab are promising candidates for clinical trials.
    Keywords covid19
    Language English
    Publishing date 2020-08-29
    Publishing country England
    Document type Journal Article
    ISSN 2468-0672
    ISSN 2468-0672
    DOI 10.1016/j.ohx.2020.e00135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Parametric nasopharyngeal swab for sampling COVID-19 and other respiratory viruses

    Nicole Gallup / Adam M. Pringle / Shane Oberloier / Nagendra G. Tanikella / Joshua M. Pearce

    HardwareX, Vol 8, Iss , Pp e00135- (2020)

    Open source design, SLA 3-D printing and UV curing system

    2020  

    Abstract: Access to nasopharyngeal swabs for sampling remain a bottleneck in some regions for COVID-19 testing. This study develops a distributed manufacturing solution using only an open source manufacturing tool chain consisting of two types of open source 3-D ... ...

    Abstract Access to nasopharyngeal swabs for sampling remain a bottleneck in some regions for COVID-19 testing. This study develops a distributed manufacturing solution using only an open source manufacturing tool chain consisting of two types of open source 3-D printing and batch UV curing, and provides a parametric fully free design of a nasopharyngeal swab. The swab was designed using parametric OpenSCAD in two components (a head with engineered break point and various handles), which has several advantages: i) minimizing print time on relatively slow SLA printers, ii) enabling the use of smaller print volume open source SLA printers, iii) reducing the amount of relatively expensive UV resin, and iv) enabling production of handle on more accessible material extrusion 3-D printers. A modular open source UV LED box was designed, fabricated for $45 and tested for batch curing. Swabs can be fabricated for $0.06-$0.12/swab. The results of the mechanical validation tests showed that the swabs could withstand greater forces than would be expected in normal clinical use. The swabs were also able to absorb a significant amounts of synthetic mucus materials and passed abrasion and handling tests. The results show the open source swab are promising candidates for clinical trials.
    Keywords Open hardware ; COVID-19 ; Medical hardware ; Nasopharyngeal swab ; Nasal swab ; UV curing ; Science (General) ; Q1-390 ; covid19
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Parametric nasopharyngeal swab for sampling COVID-19 and other respiratory viruses

    Gallup, Nicole / Pringle, Adam M. / Oberloier, Shane / Tanikella, Nagendra G. / Pearce, Joshua M.

    HardwareX

    Open source design, SLA 3-D printing and UV curing system

    2020  Volume 8, Page(s) e00135

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2468-0672
    DOI 10.1016/j.ohx.2020.e00135
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Immunogenicity of BA.5 Bivalent mRNA Vaccine Boosters.

    Collier, Ai-Ris Y / Miller, Jessica / Hachmann, Nicole P / McMahan, Katherine / Liu, Jinyan / Bondzie, Esther A / Gallup, Lydia / Rowe, Marjorie / Schonberg, Eleanor / Thai, Siline / Barrett, Julia / Borducchi, Erica N / Bouffard, Emily / Jacob-Dolan, Catherine / Mazurek, Camille R / Mutoni, Audrey / Powers, Olivia / Sciacca, Michaela / Surve, Nehalee /
    VanWyk, Haley / Wu, Cindy / Barouch, Dan H

    The New England journal of medicine

    2023  Volume 388, Issue 6, Page(s) 565–567

    MeSH term(s) Humans ; Antibodies, Neutralizing ; Antibodies, Viral ; Vaccines, Combined/immunology ; Vaccines, Combined/therapeutic use ; Vaccines, Synthetic/immunology ; Vaccines, Synthetic/therapeutic use ; Immunogenicity, Vaccine/immunology ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/virology ; mRNA Vaccines
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Vaccines, Combined ; Vaccines, Synthetic
    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2213948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Parametric Nasopharyngeal Swab for Sampling COVID-19 and Other Respiratory Viruses: Open Source Design, SLA 3-D Printing and UV Curing System

    Gallup, Nicole / Pringle, Adam M. / Oberloier, Shane / Tanikella, Nagendra G. / Pearce, Joshua M.

    HardwareX

    Abstract: Access to nasopharyngeal swabs for sampling remain a bottleneck in some regions for COVID-19 testing This study develops a distributed manufacturing solution using only an open source manufacturing tool chain consisting of two types of open source 3-D ... ...

    Abstract Access to nasopharyngeal swabs for sampling remain a bottleneck in some regions for COVID-19 testing This study develops a distributed manufacturing solution using only an open source manufacturing tool chain consisting of two types of open source 3-D printing and batch UV curing, and provides a parametric fully free design of a nasopharyngeal swab The swab was designed using parametric OpenSCAD in two components (a head with engineered break point and various handles), which has several advantages: i) minimizing print time on relatively slow SLA printers, ii) enabling the use of smaller print volume open source SLA printers, iii) reducing the amount of relatively expensive UV resin, and iv) enabling production of handle on more accessible material extrusion 3-D printers A modular open source UV LED box was designed, fabricated for $45 and tested for batch curing Swabs can be fabricated for $0 06-$0 12/swab The results of the mechanical validation tests showed that the swabs could withstand greater forces than would be expected in normal clinical use The swabs were also able to absorb a significant amounts of synthetic mucus materials and passed abrasion and handling tests The results show the open source swab are promising candidates for clinical trials
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #733677
    Database COVID19

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  7. Book ; Online: Parametric nasopharyngeal swab for sampling COVID-19 and other respiratory viruses

    Gallup, Nicole / Pringle, Adam / Oberloier, Shane / Tanikella, Nagendra Gautam / Pearce, Joshua M.

    Michigan Tech Publications

    Open source design, SLA 3-D printing and UV curing system

    2020  

    Abstract: Access to nasopharyngeal swabs for sampling remain a bottleneck in some regions for COVID19 testing. This study develops a distributed manufacturing solution using only an open source manufacturing tool chain consisting of two types of open source 3-D ... ...

    Abstract Access to nasopharyngeal swabs for sampling remain a bottleneck in some regions for COVID19 testing. This study develops a distributed manufacturing solution using only an open source manufacturing tool chain consisting of two types of open source 3-D printing and batch UV curing, and provides a parametric fully free design of a nasopharyngeal swab. The swab was designed using parametric OpenSCAD in two components (a head with engineered break point and various handles), which has several advantages: i) minimizing print time on relatively slow SLA printers, ii) enabling the use of smaller print volume open source SLA printers, iii) reducing the amount of relatively expensive UV resin, and iv) enabling production of handle on more accessible material extrusion 3-D printers. A modular open source UV LED box was designed, fabricated for $45 and tested for batch curing. Swabs can be fabricated for $0.06-$0.12/swab. The results of the mechanical validation tests showed that the swabs could withstand greater forces than would be expected in normal clinical use. The swabs were also able to absorb a significant amounts of synthetic mucus materials and passed abrasion and handling tests. The results show the open source swab are promising candidates for clinical trials.
    Keywords open hardware ; COVID-19 ; medical hardware ; nasopharyngeal swab ; nasal swab ; UV curing ; SLA ; RepRap ; 3-D printing ; additive manufacturing ; Department of Biomedical Engineering ; Department of Materials Science and Engineering ; Department of Electrical and Computer Engineering ; Biomedical Engineering and Bioengineering ; Electrical and Computer Engineering ; Materials Science and Engineering ; Mechanical Engineering ; covid19
    Subject code 670
    Publishing date 2020-05-19T07:00:00Z
    Publisher Digital Commons @ Michigan Tech
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Online: Parametric nasopharyngeal swab for sampling COVID-19 and other respiratory viruses

    Gallup, Nicole / Pringle, Adam M. / Oberloier, Shane / Tanikella, Nagendra G. / Pearce, Joshua M.

    Michigan Tech Publications

    Open source design, SLA 3-D printing and UV curing system

    2020  

    Abstract: Access to nasopharyngeal swabs for sampling remain a bottleneck in some regions for COVID-19 testing. This study develops a distributed manufacturing solution using only an open source manufacturing tool chain consisting of two types of open source 3-D ... ...

    Abstract Access to nasopharyngeal swabs for sampling remain a bottleneck in some regions for COVID-19 testing. This study develops a distributed manufacturing solution using only an open source manufacturing tool chain consisting of two types of open source 3-D printing and batch UV curing, and provides a parametric fully free design of a nasopharyngeal swab. The swab was designed using parametric OpenSCAD in two components (a head with engineered break point and various handles), which has several advantages: i) minimizing print time on relatively slow SLA printers, ii) enabling the use of smaller print volume open source SLA printers, iii) reducing the amount of relatively expensive UV resin, and iv) enabling production of handle on more accessible material extrusion 3-D printers. A modular open source UV LED box was designed, fabricated for $45 and tested for batch curing. Swabs can be fabricated for $0.06-$0.12/swab. The results of the mechanical validation tests showed that the swabs could withstand greater forces than would be expected in normal clinical use. The swabs were also able to absorb a significant amounts of synthetic mucus materials and passed abrasion and handling tests. The results show the open source swab are promising candidates for clinical trials.
    Keywords 3-D printing ; Additive manufacturing ; COVID-19 ; Medical hardware ; Nasal swab ; Nasopharyngeal swab ; Open hardware ; RepRap ; SLA ; UV curing ; Department of Biomedical Engineering ; Department of Materials Science and Engineering ; Department of Electrical and Computer Engineering ; Biomedical Engineering and Bioengineering ; Electrical and Computer Engineering ; Materials Science and Engineering ; covid19
    Subject code 670
    Publishing date 2020-10-01T07:00:00Z
    Publisher Digital Commons @ Michigan Tech
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Parametric nasopharyngeal swab for sampling COVID-19 and other respiratory viruses

    Gallup, Nicole / Pringle, Adam M. / Oberloier, Shane / Tanikella, Nagendra G. / Pearce, Joshua M.

    Open source design, SLA 3-D printing and UV curing system

    2020  

    Abstract: Access to nasopharyngeal swabs for sampling remain a bottleneck in some regions for COVID-19 testing. This study develops a distributed manufacturing solution using only an open source manufacturing tool chain consisting of two types of open source 3-D ... ...

    Abstract Access to nasopharyngeal swabs for sampling remain a bottleneck in some regions for COVID-19 testing. This study develops a distributed manufacturing solution using only an open source manufacturing tool chain consisting of two types of open source 3-D printing and batch UV curing, and provides a parametric fully free design of a nasopharyngeal swab. The swab was designed using parametric OpenSCAD in two components (a head with engineered break point and various handles), which has several advantages: i) minimizing print time on relatively slow SLA printers, ii) enabling the use of smaller print volume open source SLA printers, iii) reducing the amount of relatively expensive UV resin, and iv) enabling production of handle on more accessible material extrusion 3-D printers. A modular open source UV LED box was designed, fabricated for $45 and tested for batch curing. Swabs can be fabricated for $0.06-$0.12/swab. The results of the mechanical validation tests showed that the swabs could withstand greater forces than would be expected in normal clinical use. The swabs were also able to absorb a significant amounts of synthetic mucus materials and passed abrasion and handling tests. The results show the open source swab are promising candidates for clinical trials.

    Peer reviewed
    Keywords Civil and Structural Engineering ; Biomedical Engineering ; Instrumentation ; Mechanical Engineering ; Industrial and Manufacturing Engineering ; 216 Materials engineering ; 213 Electronic ; automation and communications engineering ; electronics ; 3-D printing ; Additive manufacturing ; COVID-19 ; Medical hardware ; Nasal swab ; Nasopharyngeal swab ; Open hardware ; RepRap ; SLA ; UV curing ; covid19
    Subject code 670
    Language English
    Publisher Elsevier Ltd.
    Publishing country fi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters.

    Collier, Ai-Ris Y / Miller, Jessica / Hachmann, Nicole P / McMahan, Katherine / Liu, Jinyan / Apraku Bondzie, Esther / Gallup, Lydia / Rowe, Marjorie / Schonberg, Eleanor / Thai, Siline / Barrett, Julia / Borducchi, Erica N / Bouffard, Emily / Jacob-Dolan, Catherine / Mazurek, Camille R / Mutoni, Audrey / Powers, Olivia / Sciacca, Michaela / Surve, Nehalee /
    VanWyk, Haley / Wu, Cindy / Barouch, Dan H

    bioRxiv : the preprint server for biology

    2022  

    Abstract: Waning immunity following mRNA vaccination and the emergence of SARS-CoV-2 variants has led to reduced mRNA vaccine efficacy against both symptomatic infection and severe disease. Bivalent mRNA boosters expressing the Omicron BA.5 and ancestral WA1/2020 ... ...

    Abstract Waning immunity following mRNA vaccination and the emergence of SARS-CoV-2 variants has led to reduced mRNA vaccine efficacy against both symptomatic infection and severe disease. Bivalent mRNA boosters expressing the Omicron BA.5 and ancestral WA1/2020 Spike proteins have been developed and approved, because BA.5 is currently the dominant SARS-CoV-2 variant and substantially evades neutralizing antibodies (NAbs). Our data show that BA.5 NAb titers were comparable following monovalent and bivalent mRNA boosters.
    Language English
    Publishing date 2022-10-25
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2022.10.24.513619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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