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  1. Article: Off-Label Use of Ceftazidime/Avibactam for the Treatment of Pan-Drug-Resistant

    Mangarov, Iliya / Georgieva, Ralitsa / Petkova, Valentina / Nikolova, Irina

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 8

    Abstract: Background: Klebsiella pneumoniae: Case presentation: This report describes a severely intoxicated 24-day-old, full-term, male neonate transferred to NICU level III from a secondary maternity hospital due to the deterioration of his general condition. ...

    Abstract Background: Klebsiella pneumoniae
    Case presentation: This report describes a severely intoxicated 24-day-old, full-term, male neonate transferred to NICU level III from a secondary maternity hospital due to the deterioration of his general condition. On day four of admission, blood culture revealed the pan-drug-resistant (PDR)
    Conclusions: In healthcare settings, treating resistant
    Language English
    Publishing date 2023-08-09
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12081302
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  2. Article: Off-Label Prescribing in Pediatric Population-Literature Review for 2012-2022.

    Petkova, Valentina / Georgieva, Dilyana / Dimitrov, Milen / Nikolova, Irina

    Pharmaceutics

    2023  Volume 15, Issue 12

    Abstract: Off-label prescribing is widespread among pediatricians, and it is unlikely that this trend will soon be bound by a uniform legal framework. This is necessitated by the fact that there are four variables: the patient's health condition, the physician's ... ...

    Abstract Off-label prescribing is widespread among pediatricians, and it is unlikely that this trend will soon be bound by a uniform legal framework. This is necessitated by the fact that there are four variables: the patient's health condition, the physician's experience and knowledge, the legislative measures (laws, directives, guidelines, and recommendations), and finally, the pharmaceutical industry. There is considerable concern worldwide about the use of off-label medicines in children. We may call it an enormous global problem that is much talked about and written about; however, we should not forget that the goal around which everyone should unite is the patient's life. For healthcare providers, the most important thing will always be the health and preservation of the patient's life, particularly when it comes to children with life-threatening conditions in neonatal and pediatric intensive care units (NICU and PICU). The study aimed to examine the prevalence of off-label drug use in pediatrics. Literature research was conducted, and we included studies from 2012 to 2022 that evaluated off-label drug prevalence in various pediatric patient populations.
    Language English
    Publishing date 2023-11-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15122652
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  3. Article ; Online: Ecology dictates the value of memory for foraging bees.

    Pull, Christopher D / Petkova, Irina / Watrobska, Cecylia / Pasquier, Grégoire / Perez Fernandez, Marta / Leadbeater, Ellouise

    Current biology : CB

    2022  Volume 32, Issue 19, Page(s) 4279–4285.e4

    Abstract: Ecological intelligence" hypotheses posit that animal learning and memory evolve to meet the demands posed by foraging and, together with social intelligence and cognitive buffer hypotheses, provide a key framework for understanding cognitive evolution. ...

    Abstract "Ecological intelligence" hypotheses posit that animal learning and memory evolve to meet the demands posed by foraging and, together with social intelligence and cognitive buffer hypotheses, provide a key framework for understanding cognitive evolution.
    MeSH term(s) Animals ; Bees ; Feeding Behavior ; Learning ; Memory, Short-Term ; Plant Extracts ; Seasons
    Chemical Substances Plant Extracts
    Language English
    Publishing date 2022-08-19
    Publishing country England
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2022.07.062
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    In stock of ZB MED Cologne/Königswinter

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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Bioactivity of Biomass and Crude Exopolysaccharides Obtained by Controlled Submerged Cultivation of Medicinal Mushroom

    Angelova, Galena / Brazkova, Mariya / Mihaylova, Dasha / Slavov, Anton / Petkova, Nadejda / Blazheva, Denica / Deseva, Ivelina / Gotova, Irina / Dimitrov, Zhechko / Krastanov, Albert

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 7

    Abstract: The aim of this study is to characterize the bioactivity of mycelial biomass and crude exopolysaccharides (EPS) produced ... ...

    Abstract The aim of this study is to characterize the bioactivity of mycelial biomass and crude exopolysaccharides (EPS) produced by
    Language English
    Publishing date 2022-07-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8070738
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  5. Article: Late Pathomorphological Features of the Endocrine Pancreas in Patients With Type 2 Diabetes Mellitus.

    Tomova, Irina / Stoyanov, George S / Dzhenkov, Deyan L / Petkova, Lilyana

    Cureus

    2020  Volume 12, Issue 6, Page(s) e8777

    Abstract: Introduction Islet amyloid polypeptide (IAPP) amyloidosis is a pathologic alteration of the pancreas, represented by abnormal accumulation of amylin in the interstitial tissue. Amylin is a neuroendocrine hormone, co-secreted with insulin by beta cells ... ...

    Abstract Introduction Islet amyloid polypeptide (IAPP) amyloidosis is a pathologic alteration of the pancreas, represented by abnormal accumulation of amylin in the interstitial tissue. Amylin is a neuroendocrine hormone, co-secreted with insulin by beta cells and participating in downstream regulation of postprandial glycemia. This report aims to examine IAPP amyloidosis as a late consequence of poor control of blood glucose levels in patients with type 2 diabetes mellitus (T2DM) who have been referred for autopsy. Materials and methods A total of 34 consecutive autopsies performed at the St. Marina University Hospital, Varna, Bulgaria, carried out by a single pathologist were included in the study. Samples from the tail of the pancreas were obtained to evaluate the state of the changes and were analyzed together with the specific organ changes associated with T2DM, as well as the medical documentation of the patients. Results Of the 34 autopsies, 10 cases (six females and four males) were included in the study, seven of whom had a medical history of T2D. The average age was 65.7 years (range 50 to 85 years). In all of the cases, morphological features of fibrosis and lipomatosis were present, with one of the patients having signs of pancreatic amyloidosis - Congo red positive deposition of pink, amorphous material in the extracellular matrix. Conclusion The described pathological alterations in all of the cases illustrate the progressing impairment of the structure of the pancreas, especially beta cells dysfunction in late stages of T2D, and highlight IAPP amyloidosis as the cause of irreversible damage of the isles of Langerhans and beta cell death.
    Language English
    Publishing date 2020-06-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.8777
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  6. Article: Parasite infection and host personality:

    Petkova, Irina / Abbey-Lee, Robin N / Løvlie, Hanne

    Behavioral ecology and sociobiology

    2018  Volume 72, Issue 11, Page(s) 173

    Abstract: Abstract: The existence of animal personality is now well-documented, although the causes and consequences of this phenomenon are still largely unclear. Parasite infection can have pervasive effects on hosts, including altering host behaviour, and may ... ...

    Abstract Abstract: The existence of animal personality is now well-documented, although the causes and consequences of this phenomenon are still largely unclear. Parasite infection can have pervasive effects on hosts, including altering host behaviour, and may thus contribute to differences in host personality. We investigated the relationship between the three-spined stickleback and its common parasite
    Significance statement: Parasite infection that alters host behaviour could be a possible avenue of research into the causes of animal personality. We studied the link between infection and personality using the three-spined stickleback and its parasite
    Language English
    Publishing date 2018-10-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 194510-5
    ISSN 1432-0762 ; 0340-5443
    ISSN (online) 1432-0762
    ISSN 0340-5443
    DOI 10.1007/s00265-018-2586-3
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    In stock of ZB MED Bonn / Germany

    Z 78/731: Show issues

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  7. Article: Crystal-Chemical and Thermal Properties of Decorative Cement Composites.

    Petkova, Vilma / Stoyanov, Ventseslav / Kostova, Bilyana / Kostov-Kytin, Vladislav / Kalinkin, Alexander / Zvereva, Irina / Tzvetanova, Yana

    Materials (Basel, Switzerland)

    2021  Volume 14, Issue 17

    Abstract: The advanced tendencies in building materials development are related to the design of cement composites with a reduced amount of Portland cement, contributing to reduced ... ...

    Abstract The advanced tendencies in building materials development are related to the design of cement composites with a reduced amount of Portland cement, contributing to reduced CO
    Language English
    Publishing date 2021-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma14174793
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  8. Article: Parasite infection and host personality: Glugea-infected three-spined sticklebacks are more social

    Petkova, Irina / Abbey-Lee, Robin N / Løvlie, Hanne

    Behavioral ecology and sociobiology. 2018 Nov., v. 72, no. 11

    2018  

    Abstract: The existence of animal personality is now well-documented, although the causes and consequences of this phenomenon are still largely unclear. Parasite infection can have pervasive effects on hosts, including altering host behaviour, and may thus ... ...

    Abstract The existence of animal personality is now well-documented, although the causes and consequences of this phenomenon are still largely unclear. Parasite infection can have pervasive effects on hosts, including altering host behaviour, and may thus contribute to differences in host personality. We investigated the relationship between the three-spined stickleback and its common parasite Glugea anomala, with focus on differences in host personality. Naturally infected and uninfected individuals were assayed for the five personality traits activity, exploration, boldness, sociability, and aggression. If infected fish behaved differently from uninfected, to benefit this parasite with horizontal transmission, we predicted behaviour increasing interactions with other sticklebacks to increase. Infection status explained differences in host personality. Specifically, Glugea-infected individuals were more social than uninfected fish. This confirms a link between parasite infection and host behaviour, and a relationship which may improve the horizontal transmission of Glugea. However, future studies need to establish the consequences of this for the parasite, and the causality of the parasite-host personality relationship. SIGNIFICANCE STATEMENT: Parasite infection that alters host behaviour could be a possible avenue of research into the causes of animal personality. We studied the link between infection and personality using the three-spined stickleback and its parasite Glugea anomala. We predicted that infected individuals would be more prone to interact with other sticklebacks, since this would improve transmission of this parasite. The personality of uninfected and naturally infected fish was measured and we observed that Glugea-infected sticklebacks were more social. Our results confirm a link between parasitism and variation in host personality.
    Keywords Gasterosteus aculeatus ; Glugea ; aggression ; animal behavior ; fish ; host-parasite relationships ; hosts ; microsporidiosis ; parasites ; parasitism ; social behavior
    Language English
    Dates of publication 2018-11
    Size p. 173.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 194510-5
    ISSN 1432-0762 ; 0340-5443
    ISSN (online) 1432-0762
    ISSN 0340-5443
    DOI 10.1007/s00265-018-2586-3
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    In stock of ZB MED Bonn / Germany

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  9. Article ; Online: Effects of monoamine manipulations on the personality and gene expression of three-spined sticklebacks.

    Abbey-Lee, Robin N / Kreshchenko, Anastasia / Fernandez Sala, Xavier / Petkova, Irina / Løvlie, Hanne

    The Journal of experimental biology

    2019  Volume 222, Issue Pt 20

    Abstract: Among-individual behavioral differences (i.e. animal personality) are commonly observed across taxa, although the underlying, causal mechanisms of such differences are poorly understood. Animal personality has been correlated with physiological functions ...

    Abstract Among-individual behavioral differences (i.e. animal personality) are commonly observed across taxa, although the underlying, causal mechanisms of such differences are poorly understood. Animal personality has been correlated with physiological functions as well as fitness-related traits. Variation in many aspects of monoamine systems, such as metabolite levels and gene polymorphisms, has been linked to behavioral variation. Therefore, here we experimentally investigated the potential role of monoamines in explaining individual variation in personality, using two common pharmaceuticals that respectively alter the levels of serotonin and dopamine in the brain: fluoxetine and ropinirole. We exposed three-spined sticklebacks, a species that shows animal personality, to either chemical alone or to a combination of the two chemicals, for 18 days. During the experiment, fish were assayed at four time points for the following personality traits: exploration, boldness, aggression and sociability. To quantify brain gene expression on short- and longer-term scales, fish were sampled at two time points. Our results show that monoamine manipulations influence fish behavior. Specifically, fish exposed to either fluoxetine or ropinirole were significantly bolder, and fish exposed to the two chemicals together tended to be bolder than control fish. Our monoamine manipulations did not alter the gene expression of monoamine or stress-associated neurotransmitter genes, but control, untreated fish showed covariation between gene expression and behavior. Specifically, exploration and boldness were predicted by genes in the dopaminergic, serotonergic and stress pathways, and sociability was predicted by genes in the dopaminergic and stress pathways. These results add further support to the links between monoaminergic systems and personality, and show that exposure to monoamines can causally alter animal personality.
    MeSH term(s) Animals ; Behavior, Animal ; Biogenic Monoamines/pharmacology ; Gene Expression Regulation/drug effects ; Personality ; Receptors, Dopamine/genetics ; Receptors, Dopamine/metabolism ; Receptors, Serotonin/genetics ; Receptors, Serotonin/metabolism ; Smegmamorpha/genetics ; Smegmamorpha/physiology
    Chemical Substances Biogenic Monoamines ; Receptors, Dopamine ; Receptors, Serotonin
    Language English
    Publishing date 2019-10-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218085-6
    ISSN 1477-9145 ; 0022-0949
    ISSN (online) 1477-9145
    ISSN 0022-0949
    DOI 10.1242/jeb.211888
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2629: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Optical Properties and Antioxidant Activity of Water-Ethanolic Extracts from Sempervivum tectorum L. from Bulgaria

    Gentscheva, Galia / Karadjova, Irina / Minkova, Stefka / Nikolova, Krastena / Andonova, Velichka / Petkova, Nadezhda / Milkova-Tomova, Iliana

    Horticulturae. 2021 Nov. 25, v. 7, no. 12

    2021  

    Abstract: Sempervivum tectorum L. is an evergreen plant belonging to a large family of the Crassulaceae. The fresh juice of the plant is used as a folk remedy almost exclusively for external purposes. The combination of several instrumental methods—transmission ... ...

    Abstract Sempervivum tectorum L. is an evergreen plant belonging to a large family of the Crassulaceae. The fresh juice of the plant is used as a folk remedy almost exclusively for external purposes. The combination of several instrumental methods—transmission and fluorescence spectroscopy, ICP-MS spectrometry, and assays for the assessment of antioxidant activities were used for the characterization of water-ethanolic extracts from the leaves of Sempervivum tectorum L. with different polarities (ethanol content in the extracts varied between 10% and 95%). The highest total phenolic content was found in the 50% ethanol extract—0.84 ± 0.08 mg GAE/mL. Furthermore, this extract also possessed the highest antioxidant potential evaluated by DPPH and FRAP assays—7.02 ± 0.71 mM TE/mL and 6.15 ± 0.25 mM TE/mL, respectively. High correlation coefficients were found between the total phenolic contents and the antioxidant activities of water-ethanolic extracts from Sempervivum tectorum L. The same is true for the strong relationship between the phenolic contents and the concentrations of Na and K. Most likely, the bioavailable species of elements such as Fe, Zn, Ca, and Mg are mostly aqueous soluble. For all the studied extracts, the toxic element (As, Cd, Pb, Tl, Hg) contents are very much below the permissible limits for pharmaceutical products. On the contrary, the concentrations of compounds such as β-carotene and chlorophyll increase with the increase in ethanol in the extract. Results from this study may be used for the preliminary prognosis of pharmaceutical applications of extracts from Sempervivum tectorum L.
    Keywords Sempervivum tectorum ; antioxidant activity ; antioxidants ; bioavailability ; chlorophyll ; ethanol ; fluorescence emission spectroscopy ; juices ; prognosis ; toxicity ; traditional medicine ; Bulgaria
    Language English
    Dates of publication 2021-1125
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2813983-5
    ISSN 2311-7524
    ISSN 2311-7524
    DOI 10.3390/horticulturae7120520
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