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  1. Book ; Online: Low-Income Students, Human Development and Higher Education in South Africa

    Walker, Melanie / McLean, Monica / Mukwando, Patience

    Opportunities, obstacles and outcomes

    2022  

    Keywords Education ; Higher & further education, tertiary education ; Colleges of higher education ; higher education ; human development ; South Africa ; students
    Language English
    Size 1 electronic resource (224 pages)
    Publisher African Minds
    Publishing place Cape Town
    Document type Book ; Online
    Note English
    HBZ-ID HT030375167
    ISBN 9781928502395 ; 1928502393
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Lipstick meningioma: artifactual findings during diagnostic cerebral angiogram.

    Walker, Melanie

    Postgraduate medical journal

    2019  Volume 95, Issue 1125, Page(s) 404

    Language English
    Publishing date 2019-05-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/postgradmedj-2019-136511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.340: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article: In-hospital end-of-life care: an appreciative analysis of bereaved family feedback.

    Walker, Wendy / Jones, Jennifer / Astley, Melanie

    British journal of nursing (Mark Allen Publishing)

    2024  Volume 33, Issue 3, Page(s) 126–131

    Abstract: Experience feedback data is increasingly recognised as being helpful in improving healthcare services, and in meeting patient and family needs. This end-of-life care project, based on the principles of appreciative inquiry, sought to learn from the ... ...

    Abstract Experience feedback data is increasingly recognised as being helpful in improving healthcare services, and in meeting patient and family needs. This end-of-life care project, based on the principles of appreciative inquiry, sought to learn from the experiences of bereaved people whose relative had died in an acute hospital setting. Informal feedback, offered during a routine telephone call, was thematically analysed and interpreted in an appreciative manner. Confirmatory representations of caring practices and behaviours were identified, categorised and disseminated in a way that enabled staff to come to know and understand end-of-life care at its best, rather than as a set of problematised events. The findings served as a benchmark for individuals and teams to assess and progress their practice reflectively. The authors conclude that staff receptiveness to informal bereaved family feedback may be enhanced by focusing on the positive qualities of end-of-life care within existing practices.
    MeSH term(s) Humans ; Feedback ; Family ; Hospitals ; Terminal Care ; Nursing Care
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1119191-0
    ISSN 0966-0461
    ISSN 0966-0461
    DOI 10.12968/bjon.2024.33.3.126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3449: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Production of PfEMP1-Specific Human Monoclonal Antibodies from Naturally Immune Individuals.

    Walker, Melanie R / Barfod, Lea

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2470, Page(s) 407–421

    Abstract: Plasmodium falciparum parasites express variable surface antigens on the infected erythrocyte surface allowing adhesion to human host receptors on the blood and endothelial cells, which can result in immune evasion. One of the most studied and key ... ...

    Abstract Plasmodium falciparum parasites express variable surface antigens on the infected erythrocyte surface allowing adhesion to human host receptors on the blood and endothelial cells, which can result in immune evasion. One of the most studied and key antigens in adhesion is the highly polymorphic PfEMP1. However, despite the vast variation in the PfEMP1 antigens, they are the main targets of naturally acquired immunity and are therefore promising candidates for malaria vaccine development. Generating PfEMP1-specific human monoclonal antibodies from naturally immune individuals will help to determine the best targets of protection from clinical disease. Immortalization of human B cells is one of the oldest and most efficient techniques to generate human monoclonal antibodies. Nevertheless, most protocols require flow cytometry-based cell sorting, which can be a limiting factor for many laboratories. This chapter describes an efficient protocol for the generation of PfEMP1-specific human monoclonal antibodies from malaria immune individuals that can be performed without the use of advanced cell-sorting techniques.
    MeSH term(s) Antibodies, Monoclonal ; Antibodies, Protozoan ; Antigens, Protozoan ; Endothelial Cells ; Erythrocytes/parasitology ; Humans ; Malaria ; Malaria, Falciparum/parasitology ; Plasmodium falciparum ; Protozoan Proteins
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Protozoan ; Antigens, Protozoan ; Protozoan Proteins
    Language English
    Publishing date 2022-07-26
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2189-9_30
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  6. Article ; Online: Parent Anxiety, Depression, Protective Responses, and Parenting Stress in the Context of Parent and Child Chronic Pain: A Daily Diary Study of Parent Variability.

    Beveridge, Jaimie K / Walker, Andrew / Orr, Serena L / Wilson, Anna C / Birnie, Kathryn A / Noel, Melanie

    The journal of pain

    2024  

    Abstract: Parents with (vs without) chronic pain report poorer psychosocial functioning (eg, worse mental health, parenting difficulties), which has been linked to poorer child outcomes (eg, child pain). However, emerging research suggests that individuals vary in ...

    Abstract Parents with (vs without) chronic pain report poorer psychosocial functioning (eg, worse mental health, parenting difficulties), which has been linked to poorer child outcomes (eg, child pain). However, emerging research suggests that individuals vary in their functioning from day-to-day, particularly those with chronic pain. This study used daily diaries to compare parents with (versus without) chronic pain on variability in their anxiety, mood, protective responses, and parenting stress. We also examined parent chronic pain status as a moderator of the associations between parent variability and youth daily pain and interference. Participants were 76 youth with chronic pain (M
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2018789-0
    ISSN 1528-8447 ; 1526-5900
    ISSN (online) 1528-8447
    ISSN 1526-5900
    DOI 10.1016/j.jpain.2024.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5237: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Pulmonary immune profiling reveals common inflammatory endotypes of childhood wheeze and suppurative lung disease.

    Neeland, Melanie R / Gubbels, Liam / Wong, Anson Tsz Chun / Walker, Hannah / Ranganathan, Sarath C / Shanthikumar, Shivanthan

    Mucosal immunology

    2024  

    Abstract: Suppurative lung disease and wheezing are common respiratory diseases of childhood, however, due to poor understanding of underlying pathobiology, there are limited treatment options and disease recurrence is common. We aimed to profile the pulmonary and ...

    Abstract Suppurative lung disease and wheezing are common respiratory diseases of childhood, however, due to poor understanding of underlying pathobiology, there are limited treatment options and disease recurrence is common. We aimed to profile the pulmonary and systemic immune response in children with wheeze and chronic suppurative lung disease for identification of endotypes that can inform improved clinical management. We used clinical microbiology data, highly multiplexed flow cytometry and immunoassays to compare pulmonary [bronchoalveolar lavage (BAL)] and systemic immunity in children with lung disease and controls. Unsupervised analytical approaches were applied to BAL immune data to explore biological endotypes. We identified two endotypes that were analogous in both frequency and immune signature across both respiratory diseases. The hyper-inflammatory endotype had a 12-fold increase in neutrophil infiltration and upregulation of 14 soluble signatures associated with type 2 inflammation and cell recruitment to tissue. The non-inflammatory endotype was not significantly different from controls. We showed these endotypes are measurable in a clinical setting and can be defined by measuring only three immune factors in BAL. We identified hyper-inflammatory and non-inflammatory endotypes common across pediatric wheeze and chronic suppurative lung disease that, if validated in future studies, have the potential to inform clinical management.
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2411370-0
    ISSN 1935-3456 ; 1933-0219
    ISSN (online) 1935-3456
    ISSN 1933-0219
    DOI 10.1016/j.mucimm.2024.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6796: Show issues Location:
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  8. Article ; Online: Current bi-national attitudes towards targeted axillary dissection.

    Ofri, Adam / Spillane, Andrew J / Baker, Caroline / Mann, G Bruce / Walker, Melanie / Warrier, Sanjay

    ANZ journal of surgery

    2023  Volume 94, Issue 1-2, Page(s) 11–13

    MeSH term(s) Humans ; Lymph Node Excision ; Lymph Nodes ; Axilla ; Neoplasm Staging ; Sentinel Lymph Node Biopsy
    Language English
    Publishing date 2023-12-27
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.18841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 180: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: "I am the doctor": gender-based bias within the clinical practice of emergency medicine in Canada-a thematic analysis of physician and trainee interview data.

    Jagelaviciute, Gabriele / Bouwsema, Melissa / Walker, Melanie / Steer, Molly / Dagnone, Damon / Brennan, Erin

    CJEM

    2024  Volume 26, Issue 4, Page(s) 249–258

    Abstract: Objectives: While women comprise about half of current Canadian medical students and physicians, only 31% of emergency medicine physicians identify as women and women trainees are less likely to express interest in emergency medicine compared to men. ... ...

    Abstract Objectives: While women comprise about half of current Canadian medical students and physicians, only 31% of emergency medicine physicians identify as women and women trainees are less likely to express interest in emergency medicine compared to men. Gender-based bias continues to negatively impact the career choice, progress, and well-being of women physicians/trainees. Although instances of gender-based bias are well documented within other medical specialties, there remains a gap in the literature addressing the role of gender specific to the Canadian emergency medicine clinical environment.
    Methods: Using a qualitative study with a thematic analytical approach, participants were purposively and snowball sampled from a cross-section of centers across Canada and included emergency medicine attending physicians and trainees. A thematic analysis using an inductive and deductive approach was undertaken. All data were double coded to improve study trustworthiness. Descriptive statistics were used to characterize the study population.
    Results: Thirty-four individuals (17 woman-identifying and 17 man-identifying) from 10 different institutions across 4 provinces in Canada participated in the study. Six themes were identified: (1) women experience gender bias in the form of microaggressions; (2) women experience imposter syndrome and question their role in the clinical setting; (3) more women provide patient care to women patients and vulnerable populations; (4) gender-related challenges with family planning and home responsibilities affect work-life balance; (5) allyship and sponsorship are important for the support and development of women physicians and trainees; and (6) women value discussing shared experiences with other women to debrief situations, find mentorship, and share advice.
    Conclusions: Gender inequity in emergency medicine affects women-identifying providers at all levels of training across Canada. Described experiences support several avenues to implement change against perceived gender bias that is focused on education, policy, and supportive spaces. We encourage institutions to consider these recommendations to achieve gender-equitable conditions in emergency medicine across Canada.
    MeSH term(s) Humans ; Male ; Female ; Canada ; Sexism ; Physicians ; Emergency Medicine ; Physicians, Women
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ISSN 1481-8043
    ISSN (online) 1481-8043
    DOI 10.1007/s43678-024-00672-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Toxicity of Zinc to Aquatic Life in Tropical Freshwaters of Low Hardness.

    Trenfield, Melanie A / Walker, Samantha L / Tanneberger, Claudia / Harford, Andrew J

    Environmental toxicology and chemistry

    2023  Volume 42, Issue 3, Page(s) 679–683

    Abstract: Zinc (Zn) is a metal of potential concern for a uranium mine whose receiving waters are in the World-Heritage listed Kakadu National Park in northern Australia. The chronic toxicity of Zn was assessed using seven tropical species in extremely soft ... ...

    Abstract Zinc (Zn) is a metal of potential concern for a uranium mine whose receiving waters are in the World-Heritage listed Kakadu National Park in northern Australia. The chronic toxicity of Zn was assessed using seven tropical species in extremely soft freshwater from a creek upstream of the mine. Sensitivity to Zn was as follows (most sensitive to least sensitive based on 10% effect concentrations [EC10s]): mussel Velesunio angasi > gastropod Amerianna cumingi > fish Mogurnda mogurnda > cladoceran Moinodaphnia macleayi > green hydra Hydra viridissima > green alga Chlorella sp. > duckweed Lemna aequinoctialis, with EC10s (<0.45 µm filtered fraction) ranging from 21 to 320 µg/L Zn and EC50s ranging from 52 to 1867 µg/L Zn. These data were used to inform the risk assessment for the rehabilitation of the mine-site and contribute to the global Zn dataset. Environ Toxicol Chem 2023;42:679-683. © 2023 Commonwealth of Australia. Environmental Toxicology and Chemistry © 2023 SETAC.
    MeSH term(s) Animals ; Chlorella ; Zinc ; Hardness ; Fresh Water ; Bivalvia ; Water Pollutants, Chemical/toxicity
    Chemical Substances Zinc (J41CSQ7QDS) ; Water Pollutants, Chemical
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 46234-2
    ISSN 1552-8618 ; 0730-7268
    ISSN (online) 1552-8618
    ISSN 0730-7268
    DOI 10.1002/etc.5556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2312: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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