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Book: Williams textbook of endocrinology

Williams, Robert H. / Kronenberg, Henry M.

2008

Title variant	Textbook of endocrinology ; Endocrinology
Author's details	Henry M. Kronenberg
Keywords	Endocrine Glands ; Endocrine Diseases ; Endokrinologie
Language	English
Size	XIX, 1911 S. : Ill., graph. Darst.
Edition	11. ed., 1. print
Publisher	Saunders Elsevier
Publishing place	Philadelphia, Pa
Publishing country	United States
Document type	Book
HBZ-ID	HT015247500
ISBN	978-1-416-02911-3 ; 1-416-02911-7
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2008 A 961	order for loan	Magazin
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2011 A 3522	order for loan	Magazin
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Article ; Online: Withdrawal of parathyroid hormone after prolonged administration leads to adipogenic differentiation of mesenchymal precursors in vivo.

Balani, Deepak H / Kronenberg, Henry M

Bone

2018 Volume 118, Page(s) 16–19

Abstract: Intermittent PTH-like drugs are the only approved so-called anabolic agent that increases bone mass in both mice and humans. It is well documented that PTH targets mature cells of the osteoblast lineage, with only indirect evidence of its actions on ... ...

Abstract	Intermittent PTH-like drugs are the only approved so-called anabolic agent that increases bone mass in both mice and humans. It is well documented that PTH targets mature cells of the osteoblast lineage, with only indirect evidence of its actions on early cells of the osteoblast lineage. Using a triple transgenic mouse model that allowed labeling of very early cells of the osteoblast lineage, we traced the progeny of these into osteoblast lineage in adult mice. These early cells expressed PTH1R and multiplied when PTH (1-34) was administered daily. We also showed that the early mesenchymal cells showed accelerated differentiation into mature osteocalcin-positive osteoblasts and osteocytes. Rather surprisingly, when teriparatide administration was stopped, these early mesenchymal precursors differentiated into adipocytes. We showed that the adipogenic differentiation is accompanied by a decrease in wnt signaling in osteoblast precursors. In this review, we discuss the possible clinical relevance of this finding and the possible molecular mechanisms that contribute to this phenotype in vivo.
MeSH term(s)	Adipocytes/cytology ; Adipocytes/drug effects ; Adipocytes/metabolism ; Adipogenesis/drug effects ; Animals ; Cell Lineage/drug effects ; Humans ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/drug effects ; Mesenchymal Stem Cells/metabolism ; Parathyroid Hormone/administration & dosage ; Parathyroid Hormone/pharmacology ; Wnt Signaling Pathway/drug effects
Chemical Substances	Parathyroid Hormone
Language	English
Publishing date	2018-05-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	632515-4
ISSN	1873-2763 ; 8756-3282
ISSN (online)	1873-2763
ISSN	8756-3282
DOI	10.1016/j.bone.2018.05.024
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Zs.A 1571: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 332: Show issues

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Book ; Online: Verslag van een bezoek aan de Sengana G.m.b.H. te Hamburg - Volksdorf op 18 juni 1963

Kronenberg, H.G. / Hofman, K. / Wassenaar, L.M.

1964

Keywords	cultivation ; cultural methods ; fragaria ; germany ; strawberries ; aardbeien ; cultuurmethoden ; duitsland ; teelt
Language	Dutch
Publishing country	nl
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sclerostin Antibody Administration Increases the Numbers of Sox9creER+ Skeletal Precursors and Their Progeny.

Balani, Deepak H / Trinh, Sophia / Xu, Mingxin / Kronenberg, Henry M

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

2021 Volume 36, Issue 4, Page(s) 757–767

Abstract: Blocking the Wnt inhibitor, sclerostin, increases the rate of bone formation in rodents and in humans. On a cellular level, the antibody against sclerostin acts by increasing osteoblast numbers partly by activating the quiescent bone-lining cells in vivo. ...

Abstract	Blocking the Wnt inhibitor, sclerostin, increases the rate of bone formation in rodents and in humans. On a cellular level, the antibody against sclerostin acts by increasing osteoblast numbers partly by activating the quiescent bone-lining cells in vivo. No evidence currently exists, to determine whether blocking sclerostin affects early cells of the osteoblast lineage. Here we use a lineage-tracing strategy that uses a tamoxifen-dependent cre recombinase, driven by the Sox9 promoter to mark early cells of the osteoblast lineage. We show that, when adult mice are treated with the rat-13C7, an antibody that blocks sclerostin action in rodents, it increases the numbers of osteoblast precursors and their differentiation into mature osteoblasts in vivo. We also show that rat-13C7 administration suppresses adipogenesis by suppressing the differentiation of Sox9creER+ skeletal precursors into bone marrow adipocytes in vivo. Using floxed alleles of the CTNNB1 gene encoding β-catenin, we show that these precursor cells express the canonical Wnt signaling mediator, β-catenin, and that the actions of the rat-13C7 antibody to increase the number of early precursors is dependent on direct stimulation of Wnt signaling. The increase in osteoblast precursors and their progeny after the administration of the antibody leads to a robust suppression of apoptosis without affecting the rate of their proliferation. Thus, neutralizing the Wnt-inhibitor sclerostin increases the numbers of early cells of the osteoblast lineage osteoblasts and suppresses their differentiation into adipocytes in vivo. © 2021 American Society for Bone and Mineral Research (ASBMR).
MeSH term(s)	Adipogenesis ; Animals ; Mice ; Osteoblasts/metabolism ; Osteocytes/metabolism ; Osteogenesis ; Rats ; Wnt Signaling Pathway ; beta Catenin/metabolism
Chemical Substances	beta Catenin
Language	English
Publishing date	2021-01-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	632783-7
ISSN	1523-4681 ; 0884-0431
ISSN (online)	1523-4681
ISSN	0884-0431
DOI	10.1002/jbmr.4238
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Zs.A 2142: Show issues

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Article ; Online: Oral prolonged-release ketamine in treatment-resistant depression - A double-blind randomized placebo-controlled multicentre trial of KET01, a novel ketamine formulation - Clinical and safety results.

Colla, M / Offenhammer, B / Scheerer, H / Kronenberg, G / Vetter, S / Mutschler, J / Mikoteit, T / Bankwitz, A / Adank, A / Schaekel, L / Eicher, C / Brühl, A B / Seifritz, E

Journal of psychiatric research

2024 Volume 173, Page(s) 124–130

Abstract: Introduction: We investigated the antidepressant effects of a novel oral prolonged-release formulation of racemic ketamine (KET01) in patients suffering from treatment-resistant depression (TRD) as add-on therapy.: Material and methods: Patients were ...

Abstract	Introduction: We investigated the antidepressant effects of a novel oral prolonged-release formulation of racemic ketamine (KET01) in patients suffering from treatment-resistant depression (TRD) as add-on therapy. Material and methods: Patients were randomized to an additional 160 mg/day or 240 mg/day KET01 or placebo for 14 days. The primary endpoint was change in Montgomery-Åsberg Depression Rating Scale (MADRS) scores from baseline to day 15. For treatment group comparisons, we used ANOVA with pairwise least squares mean difference tests in a mixed model repeated measures analysis. Results: Twenty-seven patients completed the double-blind protocol before trial premature termination due to poor recruitment during the COVID-19 pandemic. Mean (SD) MADRS scores on day 15 were 23 (10.32) in placebo, 25 (8.28) with 160 mg/day and 17 (10.32) with 240 mg/day KET01. MADRS change was numerically larger but statistically non-significant in the 240 mg/day KET01 group vs placebo on day 7 (-5.67; p = 00.106) and day 15 was (difference: 4.99; p = 00.15). In exploratory analysis, baseline leukocyte count correlated with response to KET01 (p = 00.01). Distribution of adverse event rates were comparable between the treatment arms. Safety analysis did not identify increased risk of suicidality, dissociation, hear rate, systolic and diastolic blood pressure associated with trial treatment. Discussion: Our results suggest that adjunctive oral administration of prolonged-release ketamine at a dose of 240 mg/day shows a positive, although statistically non-significant, trend towards antidepressant efficacy, however, the benefit could not be confirmed due to premature trial termination. Given its ease of use and low side effects, further trials are warranted to investigate this route of ketamine administration as a promising potential treatment of TRD.
MeSH term(s)	Humans ; Ketamine/adverse effects ; Depression ; Pandemics ; Antidepressive Agents/adverse effects ; COVID-19 ; Double-Blind Method ; Depressive Disorder, Treatment-Resistant/drug therapy ; Treatment Outcome
Chemical Substances	Ketamine (690G0D6V8H) ; Antidepressive Agents
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ZDB-ID	3148-3
ISSN	1879-1379 ; 0022-3956
ISSN (online)	1879-1379
ISSN	0022-3956
DOI	10.1016/j.jpsychires.2024.03.002
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Article ; Online: Carbonates and intermediate-depth seismicity: Stable and unstable shear in altered subducting plates and overlying mantle.

Prakash, Abhishek / Holyoke, Caleb W / Kelemen, Peter B / Kirby, Stephen H / Kronenberg, Andreas K / Lamb, William M

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 21, Page(s) e2219076120

Abstract: A model for intermediate-depth earthquakes of subduction zones is evaluated based on shear localization, shear heating, and runaway creep within thin carbonate layers in an altered downgoing oceanic plate and the overlying mantle wedge. Thermal shear ... ...

Abstract	A model for intermediate-depth earthquakes of subduction zones is evaluated based on shear localization, shear heating, and runaway creep within thin carbonate layers in an altered downgoing oceanic plate and the overlying mantle wedge. Thermal shear instabilities in carbonate lenses add to potential mechanisms for intermediate-depth seismicity, which are based on serpentine dehydration and embrittlement of altered slabs or viscous shear instabilities in narrow fine-grained olivine shear zones. Peridotites in subducting plates and the overlying mantle wedge may be altered by reactions with CO
Language	English
Publishing date	2023-05-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2219076120
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Zs.A 1148: Show issues

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Article ; Online: Stem and progenitor cells in skeletal development.

Ono, Noriaki / Balani, Deepak H / Kronenberg, Henry M

Current topics in developmental biology

2019 Volume 133, Page(s) 1–24

Abstract: Accumulating evidence supports the idea that stem and progenitor cells play important roles in skeletal development. Over the last decade, the definition of skeletal stem and progenitor cells has evolved from cells simply defined by their in vitro ... ...

Abstract	Accumulating evidence supports the idea that stem and progenitor cells play important roles in skeletal development. Over the last decade, the definition of skeletal stem and progenitor cells has evolved from cells simply defined by their in vitro behaviors to cells fully defined by a combination of sophisticated approaches, including serial transplantation assays and in vivo lineage-tracing experiments. These approaches have led to better identification of the characteristics of skeletal stem cells residing in multiple sites, including the perichondrium of the fetal bone, the resting zone of the postnatal growth plate, the bone marrow space and the periosteum in adulthood. These diverse groups of skeletal stem cells appear to closely collaborate and achieve a number of important biological functions of bones, including not only bone development and growth, but also bone maintenance and repair. Although these are important findings, we are only beginning to understand the diversity and the nature of skeletal stem and progenitor cells, and how they actually behave in vivo.
MeSH term(s)	Animals ; Bone Development ; Cell Lineage ; Colony-Forming Units Assay ; Growth Plate/embryology ; Humans ; Osteogenesis ; Stem Cells/cytology ; Stem Cells/metabolism
Language	English
Publishing date	2019-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ISSN	1557-8933 ; 0070-2153
ISSN (online)	1557-8933
ISSN	0070-2153
DOI	10.1016/bs.ctdb.2019.01.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Childhood subacute cutaneous lupus erythematosus associated with transaminitis.

Gambichler, T / Kronenberg, C / Segert, M H / Susok, L

Clinical and experimental dermatology

2020 Volume 45, Issue 5, Page(s) 593–595

MeSH term(s)	Child, Preschool ; Humans ; Lupus Erythematosus, Cutaneous/blood ; Lupus Erythematosus, Cutaneous/pathology ; Male ; Transaminases/blood
Chemical Substances	Transaminases (EC 2.6.1.-)
Language	English
Publishing date	2020-01-13
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1111/ced.14160
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1278: Show issues

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Article: Novel Insights Into the Neurobiology of the Antidepressant Response From Ketamine Research: A Mini Review.

Colla, Michael / Scheerer, Hanne / Weidt, Steffi / Seifritz, Erich / Kronenberg, Golo

Frontiers in behavioral neuroscience

2021 Volume 15, Page(s) 759466

Abstract: The serendipitous discovery of ketamine's antidepressant effects represents one of the major landmarks in neuropsychopharmacological research of the last 50 years. Ketamine provides an exciting challenge to traditional concepts of antidepressant drug ... ...

Abstract	The serendipitous discovery of ketamine's antidepressant effects represents one of the major landmarks in neuropsychopharmacological research of the last 50 years. Ketamine provides an exciting challenge to traditional concepts of antidepressant drug therapy, producing rapid antidepressant effects seemingly without targeting monoaminergic pathways in the conventional way. In consequence, the advent of ketamine has spawned a plethora of neurobiological research into its putative mechanisms. Here, we provide a brief overview of current theories of antidepressant drug action including monoaminergic signaling, disinhibition of glutamatergic neurotransmission, neurotrophic and neuroplastic effects, and how these might relate to ketamine. Given that research into ketamine has not yet yielded new therapies beyond ketamine itself, current knowledge gaps and limitations of available studies are also discussed.
Language	English
Publishing date	2021-12-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2452960-6
ISSN	1662-5153
ISSN	1662-5153
DOI	10.3389/fnbeh.2021.759466
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Systemic Evidence for Mitochondrial Dysfunction in Age-Related Macular Degeneration as Revealed by mtDNA Copy Number Measurements in Peripheral Blood.

Koller, Adriana / Lamina, Claudia / Brandl, Caroline / Zimmermann, Martina E / Stark, Klaus J / Weissensteiner, Hansi / Würzner, Reinhard / Heid, Iris M / Kronenberg, Florian

International journal of molecular sciences

2023 Volume 24, Issue 22

Abstract: Mitochondrial dysfunction is a common occurrence in the aging process and is observed in diseases such as age-related macular degeneration (AMD). Increased levels of reactive oxygen species lead to damaged mitochondrial DNA (mtDNA), resulting in ... ...

Abstract	Mitochondrial dysfunction is a common occurrence in the aging process and is observed in diseases such as age-related macular degeneration (AMD). Increased levels of reactive oxygen species lead to damaged mitochondrial DNA (mtDNA), resulting in dysfunctional mitochondria, and, consequently, mtDNA causes further harm in the retinal tissue. However, it is unclear whether the effects are locally restricted to the high-energy-demanding retinal pigment epithelium or are also systematically present. Therefore, we measured mtDNA copy number (mtDNA-CN) in peripheral blood using a qPCR approach with plasmid normalization in elderly participants with and without AMD from the AugUR study (n = 2262). We found significantly lower mtDNA-CN in the blood of participants with early (n = 453) and late (n = 170) AMD compared to AMD-free participants (n = 1630). In regression analyses, we found lower mtDNA-CN to be associated with late AMD when compared with AMD-free participants. Each reduction of mtDNA-CN by one standard deviation increased the risk for late AMD by 24%. This association was most pronounced in geographic atrophy (OR = 1.76, 95% CI 1.19-2.60,
MeSH term(s)	Humans ; Aged ; DNA, Mitochondrial/genetics ; DNA Copy Number Variations ; Mitochondria/genetics ; Macular Degeneration/genetics ; Retina
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2023-11-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242216406
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