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  1. Article ; Online: Response to Bistrian BR. Parenteral Fish-Oil Emulsions in Critically Ill COVID-19 Emulsions.

    Torrinhas, Raquel S / Calder, Philip C / Waitzberg, Dan L

    JPEN. Journal of parenteral and enteral nutrition

    2020  Volume 44, Issue 7, Page(s) 1169–1170

    Abstract: In this letter we discuss the proposition of Bristian BR (2020) to use the intravenous administration of fish-oil emulsions in critically ill patients with Coronavirus Disease 2019 (COVID-19). We consider that immune-modulatory properties of ... ...

    Abstract In this letter we discuss the proposition of Bristian BR (2020) to use the intravenous administration of fish-oil emulsions in critically ill patients with Coronavirus Disease 2019 (COVID-19). We consider that immune-modulatory properties of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, rapidly provided in high amounts by fish-oil emulsions, may be important to change the course of COVID-19's death pathway. Prescriptions should be based on body weight (eg, 0.2-g pure fish-oil lipid emulsion/kg body weight/d) and also should consider combining the parenteral administration of fish-oil emulsions with low oral aspirin intake to trigger resolvin synthesis from EPA and DHA.
    MeSH term(s) Animals ; COVID-19 ; Critical Illness ; Docosahexaenoic Acids ; Eicosapentaenoic Acid ; Emulsions ; Fat Emulsions, Intravenous ; Fish Oils ; Humans ; SARS-CoV-2
    Chemical Substances Emulsions ; Fat Emulsions, Intravenous ; Fish Oils ; Docosahexaenoic Acids (25167-62-8) ; Eicosapentaenoic Acid (AAN7QOV9EA)
    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 800861-9
    ISSN 1941-2444 ; 0148-6071
    ISSN (online) 1941-2444
    ISSN 0148-6071
    DOI 10.1002/jpen.1933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1524: Show issues Location:
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  2. Article ; Online: A Double-blinded Randomized Placebo-controlled Clinical Trial of Omega-3 Fatty Acids for the Treatment of Diabetic Patients With Nonalcoholic Steatohepatitis.

    Torrinhas, Raquel S / Waitzberg, Dan L

    Journal of clinical gastroenterology

    2016  Volume 50, Issue 2, Page(s) 180

    MeSH term(s) Diabetes Mellitus/drug therapy ; Docosahexaenoic Acids/therapeutic use ; Eicosapentaenoic Acid/therapeutic use ; Female ; Humans ; Male ; Non-alcoholic Fatty Liver Disease/drug therapy
    Chemical Substances Docosahexaenoic Acids (25167-62-8) ; Eicosapentaenoic Acid (AAN7QOV9EA)
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 448460-5
    ISSN 1539-2031 ; 0192-0790
    ISSN (online) 1539-2031
    ISSN 0192-0790
    DOI 10.1097/MCG.0000000000000412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1523: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Parenteral fish oil: An adjuvant pharmacotherapy for coronavirus disease 2019?

    Torrinhas, Raquel S / Calder, Philip C / Lemos, Gabriela O / Waitzberg, Dan L

    Nutrition. 2021 Jan., v. 81

    2021  

    Abstract: The new coronavirus associated with severe acute respiratory syndrome (SARS-CoV-2), surprisingly, does not affect only the lungs. The severe response to SARS-CoV-2 appears to include a “cytokine storm,” which indicates a state of hyperinflammation and ... ...

    Abstract The new coronavirus associated with severe acute respiratory syndrome (SARS-CoV-2), surprisingly, does not affect only the lungs. The severe response to SARS-CoV-2 appears to include a “cytokine storm,” which indicates a state of hyperinflammation and subsequent dysfunction of multiple organs and tissues in the most severe cases. This could be the reason why populations at the highest risk for death from the SARS-CoV-2 infection–induced disease (coronavirus disease 2019 [COVID-19]) are those suffering from chronic low-grade inflammation, but prone to hyperinflammation. This includes individuals of advanced age and those with obesity, type 2 diabetes, hypertension, and metabolic syndrome. Inflammation resolution is strongly dependent on lipid mediators, the specialized pro-resolution mediators (SPMs). ω-3 polyunsaturated fatty acids (ω-3 PUFAs) are precursors of very potent SPMs, including resolvins, protectins, and maresins. Additionally, they are associated with a less aggressive inflammatory initiation, after competing with ω-6 fatty acids for eicosanoid synthesis. Therefore, it makes sense to consider the use of ω-3 PUFAs for clinical management of COVID-19 patients. ω-3 PUFAs may be given by oral, enteral, or parenteral routes; however, the parenteral route favors faster incorporation into plasma phospholipids, blood cells, and tissues. Here, we discuss these aspects to propose the parenteral infusion of ω-3 PUFAs as adjuvant immunopharmacotherapy for hospitalized patients with COVID-19.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; adjuvants ; cytokines ; death ; drug therapy ; elderly ; fish oils ; hypertension ; inflammation ; metabolic syndrome ; noninsulin-dependent diabetes mellitus ; nutrition ; obesity ; phospholipids ; risk
    Language English
    Dates of publication 2021-01
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2020.110900
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4802: Show issues

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  4. Article ; Online: Parenteral fish oil: An adjuvant pharmacotherapy for coronavirus disease 2019?

    Torrinhas, Raquel S / Calder, Philip C / Lemos, Gabriela O / Waitzberg, Dan L

    Nutrition (Burbank, Los Angeles County, Calif.)

    2020  Volume 81, Page(s) 110900

    Abstract: The new coronavirus associated with severe acute respiratory syndrome (SARS-CoV-2), surprisingly, does not affect only the lungs. The severe response to SARS-CoV-2 appears to include a "cytokine storm," which indicates a state of hyperinflammation and ... ...

    Abstract The new coronavirus associated with severe acute respiratory syndrome (SARS-CoV-2), surprisingly, does not affect only the lungs. The severe response to SARS-CoV-2 appears to include a "cytokine storm," which indicates a state of hyperinflammation and subsequent dysfunction of multiple organs and tissues in the most severe cases. This could be the reason why populations at the highest risk for death from the SARS-CoV-2 infection-induced disease (coronavirus disease 2019 [COVID-19]) are those suffering from chronic low-grade inflammation, but prone to hyperinflammation. This includes individuals of advanced age and those with obesity, type 2 diabetes, hypertension, and metabolic syndrome. Inflammation resolution is strongly dependent on lipid mediators, the specialized pro-resolution mediators (SPMs). ω-3 polyunsaturated fatty acids (ω-3 PUFAs) are precursors of very potent SPMs, including resolvins, protectins, and maresins. Additionally, they are associated with a less aggressive inflammatory initiation, after competing with ω-6 fatty acids for eicosanoid synthesis. Therefore, it makes sense to consider the use of ω-3 PUFAs for clinical management of COVID-19 patients. ω-3 PUFAs may be given by oral, enteral, or parenteral routes; however, the parenteral route favors faster incorporation into plasma phospholipids, blood cells, and tissues. Here, we discuss these aspects to propose the parenteral infusion of ω-3 PUFAs as adjuvant immunopharmacotherapy for hospitalized patients with COVID-19.
    MeSH term(s) COVID-19/drug therapy ; COVID-19/epidemiology ; COVID-19/immunology ; Chemotherapy, Adjuvant ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/immunology ; Fatty Acids, Omega-3/administration & dosage ; Fish Oils/administration & dosage ; Humans ; Inflammation/diet therapy ; Inflammation/immunology ; Infusions, Parenteral ; Models, Biological ; Nutritional Physiological Phenomena ; Pandemics ; SARS-CoV-2
    Chemical Substances Fatty Acids, Omega-3 ; Fish Oils
    Keywords covid19
    Language English
    Publishing date 2020-06-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2020.110900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2290: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Response to Bistrian BR. Parenteral Fish‐Oil Emulsions in Critically Ill COVID‐19 Emulsions

    Torrinhas, Raquel S. / Calder, Philip C. / Waitzberg, Dan L.

    Journal of Parenteral and Enteral Nutrition

    2020  Volume 44, Issue 7, Page(s) 1169–1170

    Keywords Nutrition and Dietetics ; Medicine (miscellaneous) ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 800861-9
    ISSN 0148-6071
    ISSN 0148-6071
    DOI 10.1002/jpen.1933
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1524: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Response to Bistrian BR. Parenteral Fish-Oil Emulsions in Critically Ill COVID-19 Emulsions

    Torrinhas, Raquel S / Calder, Philip C / Waitzberg, Dan L

    JPEN J. parenter. enteral nutr

    Abstract: In this letter we discuss the proposition of Bristian BR (2020) to use the intravenous administration of fish-oil emulsions in critically ill patients with Coronavirus Disease 2019 (COVID-19). We consider that immune-modulatory properties of ... ...

    Abstract In this letter we discuss the proposition of Bristian BR (2020) to use the intravenous administration of fish-oil emulsions in critically ill patients with Coronavirus Disease 2019 (COVID-19). We consider that immune-modulatory properties of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, rapidly provided in high amounts by fish-oil emulsions, may be important to change the course of COVID-19's death pathway. Prescriptions should be based on body weight (eg, 0.2-g pure fish-oil lipid emulsion/kg body weight/d) and also should consider combining the parenteral administration of fish-oil emulsions with low oral aspirin intake to trigger resolvin synthesis from EPA and DHA.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #613891
    Database COVID19

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  7. Book ; Online: Letter to the Editor in relation to Bistrian BR. Parenteral fish oil emulsions in critically ill COVID-19 emulsions [published online ahead of print, 2020 May 8]. JPEN J Parenter Enteral Nutr. 2020;10.1002/jpen.1871.

    Torrinhas, Raquel S. / Calder, Philip / Waitzberg, Dan L.

    2020  

    Abstract: ... may be important to change the course of COVID‐19’s death pathway. Prescriptions should be based ...

    Abstract In this letter we discuss the proposition of Bristian BR (2020) to use the intravenous administration of fish oil emulsions in critically ill COVID‐19. We consider that immune modulatory properties of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, rapidly provided in high amounts by fish oil emulsion, may be important to change the course of COVID‐19’s death pathway. Prescriptions should be based on body weight (e.g. 0.2 g pure FOLE/kg body weight/day) and also should consider combining the parenteral administration of fish oil emulsion to low oral aspirin intake, in order to trigger resolvin synthesis from EPA and DHA.
    Keywords covid19
    Language English
    Publishing date 2020-05-19
    Publishing country uk
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  8. Article: Parenteral fish oil: An adjuvant pharmacotherapy for coronavirus disease 2019?

    Torrinhas, Raquel S / Calder, Philip C / Lemos, Gabriela O / Waitzberg, Dan L

    Nutrition

    Abstract: The new coronavirus associated with severe acute respiratory syndrome (SARS-CoV-2), surprisingly, does not affect only the lungs. The severe response to SARS-CoV-2 appears to include a "cytokine storm," which indicates a state of hyperinflammation and ... ...

    Abstract The new coronavirus associated with severe acute respiratory syndrome (SARS-CoV-2), surprisingly, does not affect only the lungs. The severe response to SARS-CoV-2 appears to include a "cytokine storm," which indicates a state of hyperinflammation and subsequent dysfunction of multiple organs and tissues in the most severe cases. This could be the reason why populations at the highest risk for death from the SARS-CoV-2 infection-induced disease (coronavirus disease 2019 [COVID-19]) are those suffering from chronic low-grade inflammation, but prone to hyperinflammation. This includes individuals of advanced age and those with obesity, type 2 diabetes, hypertension, and metabolic syndrome. Inflammation resolution is strongly dependent on lipid mediators, the specialized pro-resolution mediators (SPMs). ω-3 polyunsaturated fatty acids (ω-3 PUFAs) are precursors of very potent SPMs, including resolvins, protectins, and maresins. Additionally, they are associated with a less aggressive inflammatory initiation, after competing with ω-6 fatty acids for eicosanoid synthesis. Therefore, it makes sense to consider the use of ω-3 PUFAs for clinical management of COVID-19 patients. ω-3 PUFAs may be given by oral, enteral, or parenteral routes; however, the parenteral route favors faster incorporation into plasma phospholipids, blood cells, and tissues. Here, we discuss these aspects to propose the parenteral infusion of ω-3 PUFAs as adjuvant immunopharmacotherapy for hospitalized patients with COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #691202
    Database COVID19

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Sarcopenia in liver cirrhosis: the role of computed tomography scan in the assessment of muscle mass compared with dual-energy X-ray absorptiometry and anthropometry.

    Belarmino, Giliane / Torrinhas, Raquel S M / Heymsfield, Steven B / Waitzberg, Dan L

    European journal of gastroenterology & hepatology

    2015  Volume 27, Issue 10, Page(s) 1228

    MeSH term(s) Female ; Humans ; Liver Cirrhosis/complications ; Male ; Muscle, Skeletal/diagnostic imaging ; Radiography ; Sarcopenia/diagnostic imaging ; Sarcopenia/etiology
    Language English
    Publishing date 2015-10
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1034239-4
    ISSN 1473-5687 ; 0954-691X
    ISSN (online) 1473-5687
    ISSN 0954-691X
    DOI 10.1097/MEG.0000000000000411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2932: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: A new anthropometric index for body fat estimation in patients with severe obesity.

    Belarmino, Giliane / Torrinhas, Raquel S / Sala, Priscila / Horie, Lilian M / Damiani, Lucas / Lopes, Natalia C / Heymsfield, Steven B / Waitzberg, Dan L

    BMC obesity

    2018  Volume 5, Page(s) 25

    Abstract: Background: Body mass index (BMI) has been used to assess body adiposity, but it cannot adequately reflect body fat (BF) amount. The body adiposity index (BAI) has been shown a better performance than BMI for this purpose, but it can be inaccurate to ... ...

    Abstract Background: Body mass index (BMI) has been used to assess body adiposity, but it cannot adequately reflect body fat (BF) amount. The body adiposity index (BAI) has been shown a better performance than BMI for this purpose, but it can be inaccurate to estimate BF under extreme amounts of fat. Here, we propose a new anthropometric index, the Belarmino-Waitzberg (BeW) index, for specific estimation of BF in severely obese patients.
    Methods: In 144 adult patients with severe obesity, BF was estimated by air displacement plethysmography (ADP), as the reference method, along with the follow anthropometric measurements: height, abdominal circumference (AC), hip circumference (HC), weight, BMI (weight/ height
    Results: The BF% was 52.05 ± 5.42 for ADP and 59.11 ± 5.95 for the BeW index (all results are expressed as the mean ± standard deviation). A positive Pearson correlation (
    Conclusions: The new BeW index showed a good performance for BF estimation in patients with severe obesity and can be superior to the BAI for this purpose.
    Language English
    Publishing date 2018-10-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2758687-X
    ISSN 2052-9538
    ISSN 2052-9538
    DOI 10.1186/s40608-018-0202-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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