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Article ; Online: Argonaute 5-mediated antiviral defense and viral counter-defense in Nicotiana benthamiana.

Tu, Chin-Wei / Huang, Ying-Wen / Lee, Chin-Wei / Kuo, Song-Yi / Lin, Na-Sheng / Hsu, Yau-Heiu / Hu, Chung-Chi

2023 Volume 334, Page(s) 199179

Abstract: The argonaute (AGO) family proteins play a crucial role in preventing viral invasions through the plant antiviral RNA silencing pathway, with distinct AGO proteins recruited for specific antiviral mechanisms. Our previous study revealed that Nicotiana ... ...

Abstract	The argonaute (AGO) family proteins play a crucial role in preventing viral invasions through the plant antiviral RNA silencing pathway, with distinct AGO proteins recruited for specific antiviral mechanisms. Our previous study revealed that Nicotiana benthamiana AGO5 (NbAGO5) expression was significantly upregulated in response to bamboo mosaic virus (BaMV) infection. However, the roles of NbAGO5 in antiviral mechanisms remained to be explored. In this research, we examined the antiviral functions of NbAGO5 in the infections of different viruses. It was found that the accumulation of NbAGO5 was induced not only at the RNA but also at the protein level following the infections of BaMV, potato virus X (PVX), tobacco mosaic virus (TMV), and cucumber mosaic virus (CMV) in N. benthamiana. To explore the antiviral mechanism and regulatory function of NbAGO5, we generated NbAGO5 overexpression (OE-NbAGO5) and knockout (nbago5) transgenic N. benthamiana lines. Our findings reveal that NbAGO5 provides defense against BaMV, PVX, TMV, and a mutant CMV deficient in 2b gene, but not against the wild-type CMV and turnip mosaic virus (TuMV). Through affinity purification and small RNA northern blotting, we demonstrated that NbAGO5 exerts its antiviral function by binding to viral small interfering RNAs (vsiRNAs). Moreover, we observed that CMV 2b and TuMV HC-Pro interact with NbAGO5, triggering its degradation via the 26S proteasome and autophagy pathways, thereby allowing these viruses to overcome NbAGO5-mediated defense. In addition, TuMV HC-Pro provides another line of counter-defense by interfering with vsiRNA binding by NbAGO5. Our study provides further insights into the antiviral RNA interference mechanism and the complex interplay between NbAGO5 and plant viruses.
MeSH term(s)	Nicotiana ; Antiviral Agents/metabolism ; RNA Interference ; Cucumovirus/genetics ; RNA/metabolism ; Cytomegalovirus Infections ; Plant Diseases
Chemical Substances	Antiviral Agents ; RNA (63231-63-0)
Language	English
Publishing date	2023-07-26
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605780-9
ISSN	1872-7492 ; 0168-1702
ISSN (online)	1872-7492
ISSN	0168-1702
DOI	10.1016/j.virusres.2023.199179
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Article ; Online: Enantioselective Radical-Type 1,2-Alkoxy-Phosphinoylation to Styrenes Catalyzed by Chiral Vanadyl Complexes.

Chuang, Chin-Wei / Huang, Guan-Ru / Hung, Shiang-Fu / Hsu, Chan-Wei / Liu, Yue-Hua / Hwang, Chiu-Han / Chen, Chien-Tien

Angewandte Chemie (International ed. in English)

2023 Volume 62, Issue 16, Page(s) e202300654

Abstract: A series of vanadyl complexes bearing 3-t-butyl-5-bromo, 3-aryl-5-bromo, 3,5-dihalo-, and benzo-fused N-salicylidene-tert-leucinates was examined as catalysts for 1,2-alkoxy-phosphinoylation of 4-, 3-, 3,4-, and 3,5-substituted styrene derivatives ( ... ...

Abstract	A series of vanadyl complexes bearing 3-t-butyl-5-bromo, 3-aryl-5-bromo, 3,5-dihalo-, and benzo-fused N-salicylidene-tert-leucinates was examined as catalysts for 1,2-alkoxy-phosphinoylation of 4-, 3-, 3,4-, and 3,5-substituted styrene derivatives (including Me/t-Bu, Ph, OR, Cl/Br, OAc, NO
Language	English
Publishing date	2023-03-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202300654
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Article: The efficacy and safety of cuttlebone for lowering serum phosphate in patients with end-stage renal disease: a meta-analysis of randomized controlled trials.

Chen, Hsiao-Tien / Hung, Kuo-Chuan / Hsu, Chin-Wei / Chen, Jui-Yi / Liu, Chien-Cheng / Chen, I-Wen / Sun, Cheuk-Kwan

Frontiers in pharmacology

2023 Volume 14, Page(s) 1206366

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-07-24
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1206366
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Article ; Online: Inhaled corticosteroid for patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials.

Hsu, Chin-Wei / Lee, Mei-Chuan / Hua, Yi-Ming / Lai, Chih-Cheng / Tang, Hung-Jen / Chao, Chien-Ming

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

2023 Volume 56, Issue 5, Page(s) 921–930

Abstract: Background: The efficacy of inhaled corticosteroid (ICS) in the treatment of patients with COVID-19 has been evaluated in randomized controlled trials (RCTs), however, their findings are not consistent.: Methods: PubMed, Embase, Cochrane Library, ... ...

Abstract	Background: The efficacy of inhaled corticosteroid (ICS) in the treatment of patients with COVID-19 has been evaluated in randomized controlled trials (RCTs), however, their findings are not consistent. Methods: PubMed, Embase, Cochrane Library, ClinicalTrials.gov, Scopus, Web of Science and Google Scholar were searched to June 10, 2023. Only RCTs that investigated the clinical efficacy and safety of ICS for patients with COVID-19 were included. Results: Eleven RCTs were included. ICS users had significantly higher rate of symptom alleviation at day 14 than the control group (risk ratio [RR], 1.13; 95% CI, 1.04-1.23; I Conclusions: Additional ICS use, particularly inhaled budesonide may help symptom relief in patients with COVID-19. However, ICS use did not help reduce the risk of urgent care, ED visit, hospitalization, or death.
Language	English
Publishing date	2023-08-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1497590-7
ISSN	1995-9133 ; 1684-1182 ; 0253-2662
ISSN (online)	1995-9133
ISSN	1684-1182 ; 0253-2662
DOI	10.1016/j.jmii.2023.07.008
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Article ; Online: Malignant Perivascular Epithelioid Cell Tumour in a Savannah Monitor (Varanus exanthematicus).

Hsu, Chin-Wei / Lee, An-Hsing / Lien, Chen-Yeh / Chang, Hui-Wen

Journal of comparative pathology

2021 Volume 188, Page(s) 26–31

Abstract: A 9-year-old male captive savannah monitor (Varanus exanthematicus) with a history of general debility was submitted for necropsy. Grossly, there were multiple white masses in the colon, mesorchium and tracheal adventitia. Histologically, the lesions ... ...

Abstract	A 9-year-old male captive savannah monitor (Varanus exanthematicus) with a history of general debility was submitted for necropsy. Grossly, there were multiple white masses in the colon, mesorchium and tracheal adventitia. Histologically, the lesions were composed of epithelioid to spindloid neoplastic cells arranged in sheets to interlacing and interwoven bundles, and separated by abundant myxoid material or extensive stromal hyalinization and fibrosis with occasional chondroid metaplasia. Perivascular infiltration of epithelioid neoplastic cells was occasionally seen. Neoplastic cells were immunopositive for alpha-smooth muscle actin, melan-A and S100. The unique histological features and concurrent myogenic and melanocytic immunophenotypes suggest a malignant perivascular epithelioid cell tumour. To our knowledge, this is the first report of perivascular epithelioid cell tumours in a non-human species.
MeSH term(s)	Animals ; Epithelioid Cells ; Lizards ; MART-1 Antigen ; Male ; Perivascular Epithelioid Cell Neoplasms/veterinary ; Sarcoma/veterinary
Chemical Substances	MART-1 Antigen
Language	English
Publishing date	2021-09-15
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	390920-7
ISSN	1532-3129 ; 0021-9975
ISSN (online)	1532-3129
ISSN	0021-9975
DOI	10.1016/j.jcpa.2021.08.003
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Article ; Online: Clinical efficacy and safety of novel antibiotics for complicated urinary tract infection: A systematic review and meta-analysis of randomized controlled trials

Hung, Kuo-Chuan / Tsai, Wen-Wen / Hsu, Chin-Wei / Lai, Chih-Cheng / Tang, Hung-Jen / Chen, I-Wen

International Journal of Antimicrobial Agents. 2023 July, v. 62, no. 1 p.106830-

2023

Abstract: To assess the clinical efficacy and safety of novel antibiotics for complicated urinary tract infections (cUTIs). Three electronic databases (Medline, Embase and the Cochrane Library) were searched from inception until 20 October 2022 to identify ... ...

Abstract	To assess the clinical efficacy and safety of novel antibiotics for complicated urinary tract infections (cUTIs). Three electronic databases (Medline, Embase and the Cochrane Library) were searched from inception until 20 October 2022 to identify randomized controlled trials (RCTs) investigating the efficacy and safety of novel antibiotics (novel β-lactam/β-lactamase inhibitor combinations, aminoglycosides, fluoroquinolones and cefiderocol) against cUTIs. The primary outcome was the clinical cure rate (CCR) at test of cure (TOC), while secondary outcomes included CCR at end of treatment (EOT), microbiological eradication rate, and the risk of adverse events (AEs). Trial sequential analysis (TSA) was used to examine the evidence. In total, 11 RCTs demonstrated a higher CCR [83.6% vs 80.3%, odds ratio (OR) 1.37, 95% confidence interval (CI) 1.08–1.74, P=0.01, I²=35%, 11 RCTs, 3514 participants] and microbiological eradication rate (77.7% vs 67.2%, OR 1.79, 95% CI 1.46–2.20, P<0.00001, 11 RCTs, 4347 participants) at TOC in the intervention group compared with the control group. At EOT, there was no significant difference in CCR (OR 0.96, P=0.81, I²=4%, nine RCTs, 3429 participants) or risk of treatment-emergent AEs (OR 0.95, P=0.57, I²=51%, 11 RCTs, 5790 participants) between the intervention and control groups. TSA showed robust evidence regarding microbiological eradication rate and treatment-emergent AEs, while the CCR at TOC and EOT remained inconclusive. While showing similar safety, the investigated novel antibiotics may be more effective than the conventional antibiotics for patients with cUTIs. However, as the pooled evidence relating to CCR remained inconclusive, further studies are required to address this issue.
Keywords	aminoglycosides ; confidence interval ; fluoroquinolones ; meta-analysis ; odds ratio ; risk ; systematic review ; urinary tract ; urinary tract diseases ; Complicated urinary tract infection ; Ceftazidime/avibactam ; Ceftolozane/tazobactam ; Cefiderocol ; Cefepime/enmetazobactam ; Imipenem/cilastatin plus relebactam ; Meropenem/vaborbactam ; Plazomicin ; Finafloxacin
Language	English
Dates of publication	2023-07
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2023.106830
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Cross-Sectional Analysis of Taiwanese Pharmacy Students' Experiences and Perceptions of Transitioning from In-Hospital Internships to Distance Learning Due to COVID-19.

Huang, Shu-Fen / Hsu, Chin-Wei / Lin, Chia-Li / Ko, Yen-Ling / Su, Hui-Chen

Healthcare (Basel, Switzerland)

2022 Volume 10, Issue 8

Abstract: The introductory pharmacy practice experiences (IPPE) in Taiwan, which are traditionally conducted in physical hospital settings, incorporated up to 30% distance learning from May 2021 due to Coronavirus Disease 2019 (COVID-19). A web-based cross- ... ...

Abstract	The introductory pharmacy practice experiences (IPPE) in Taiwan, which are traditionally conducted in physical hospital settings, incorporated up to 30% distance learning from May 2021 due to Coronavirus Disease 2019 (COVID-19). A web-based cross-sectional survey was adopted to investigate pharmacy students' experiences and perceptions of transitioning from in-hospital internships to distance learning due to COVID-19 in the pharmacy department of a university in Southern Taiwan. We analyzed the results to discover factors that significantly affected students' perceptions of transitioning from in-hospital internships to distance learning. In total, 81 interns from the university's pharmacy department responded to the questionnaire. Approximately half of the participants felt happy when they learned, before the internship began, that the internship would be partially replaced with distance learning. The overall satisfaction rate was 67.9%, and no significant differences was observed in students' satisfaction between hospital size or distance-learning time. However, more students in the medical center felt they had insufficient time to finish assignments compared to those in the regional hospitals, and the students who had 11-15 days of distance learning felt that they interacted more smoothly with their peers compared to those who had other durations. Program designers should make distance internship courses more student-centered, with a focus on increasing interactions between students, teachers, and peers to compensate for the lack of physical presence.
Language	English
Publishing date	2022-07-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare10081369
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Article ; Online: Clinical efficacy and safety of novel antibiotics for complicated urinary tract infection: A systematic review and meta-analysis of randomized controlled trials.

Hung, Kuo-Chuan / Tsai, Wen-Wen / Hsu, Chin-Wei / Lai, Chih-Cheng / Tang, Hung-Jen / Chen, I-Wen

International journal of antimicrobial agents

2023 Volume 62, Issue 1, Page(s) 106830

Abstract: Objective: To assess the clinical efficacy and safety of novel antibiotics for complicated urinary tract infections (cUTIs).: Methods: Three electronic databases (Medline, Embase and the Cochrane Library) were searched from inception until 20 October ...

Abstract	Objective: To assess the clinical efficacy and safety of novel antibiotics for complicated urinary tract infections (cUTIs). Methods: Three electronic databases (Medline, Embase and the Cochrane Library) were searched from inception until 20 October 2022 to identify randomized controlled trials (RCTs) investigating the efficacy and safety of novel antibiotics (novel β-lactam/β-lactamase inhibitor combinations, aminoglycosides, fluoroquinolones and cefiderocol) against cUTIs. The primary outcome was the clinical cure rate (CCR) at test of cure (TOC), while secondary outcomes included CCR at end of treatment (EOT), microbiological eradication rate, and the risk of adverse events (AEs). Trial sequential analysis (TSA) was used to examine the evidence. Results: In total, 11 RCTs demonstrated a higher CCR [83.6% vs 80.3%, odds ratio (OR) 1.37, 95% confidence interval (CI) 1.08-1.74, P=0.01, I Conclusions: While showing similar safety, the investigated novel antibiotics may be more effective than the conventional antibiotics for patients with cUTIs. However, as the pooled evidence relating to CCR remained inconclusive, further studies are required to address this issue.
MeSH term(s)	Humans ; Anti-Bacterial Agents/adverse effects ; Randomized Controlled Trials as Topic ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/microbiology ; beta-Lactamase Inhibitors/therapeutic use ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; beta-Lactamase Inhibitors
Language	English
Publishing date	2023-04-24
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2023.106830
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Article ; Online: First Report of Distinct

Huang, Ying-Wen / Lee, Chin-Wei / Lin, Na-Sheng / Cuong, Ha Viet / Hu, Chung-Chi / Hsu, Yau-Heiu

Viruses

2022 Volume 14, Issue 4

Abstract: New isolates of ... ...

Abstract	New isolates of the
MeSH term(s)	Bambusa/genetics ; Potexvirus/genetics ; RNA, Viral/genetics ; Nicotiana ; Vietnam
Chemical Substances	RNA, Viral
Language	English
Publishing date	2022-03-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14040698
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Article ; Online: The Role of Plant Transcription Factors in the Fight against Plant Viruses.

Viswanath, Kotapati Kasi / Kuo, Song-Yi / Tu, Chin-Wei / Hsu, Yau-Heiu / Huang, Ying-Wen / Hu, Chung-Chi

International journal of molecular sciences

2023 Volume 24, Issue 9

Abstract: Plants are vulnerable to the challenges of unstable environments and pathogen infections due to their immobility. Among various stress conditions, viral infection is a major threat that causes significant crop loss. In response to viral infection, plants ...

Abstract	Plants are vulnerable to the challenges of unstable environments and pathogen infections due to their immobility. Among various stress conditions, viral infection is a major threat that causes significant crop loss. In response to viral infection, plants undergo complex molecular and physiological changes, which trigger defense and morphogenic pathways. Transcription factors (TFs), and their interactions with cofactors and cis-regulatory genomic elements, are essential for plant defense mechanisms. The transcriptional regulation by TFs is crucial in establishing plant defense and associated activities during viral infections. Therefore, identifying and characterizing the critical genes involved in the responses of plants against virus stress is essential for the development of transgenic plants that exhibit enhanced tolerance or resistance. This article reviews the current understanding of the transcriptional control of plant defenses, with a special focus on NAC, MYB, WRKY, bZIP, and AP2/ERF TFs. The review provides an update on the latest advances in understanding how plant TFs regulate defense genes expression during viral infection.
MeSH term(s)	Transcription Factors/metabolism ; Plant Proteins/metabolism ; Gene Expression Regulation, Plant ; Plants, Genetically Modified/genetics ; Plants, Genetically Modified/metabolism ; Plant Viruses/genetics ; Plant Viruses/metabolism ; Stress, Physiological/genetics
Chemical Substances	Transcription Factors ; Plant Proteins
Language	English
Publishing date	2023-05-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24098433
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