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  1. Article ; Online: Recent Advances in Pathology: the 2023 Annual Review Issue of The Journal of Pathology.

    Jones, J Louise / Poulsom, Richard / Coates, Philip J

    The Journal of pathology

    2023  Volume 260, Issue 5, Page(s) 495–497

    Abstract: The 2023 Annual Review Issue of The Journal of Pathology, Recent Advances in Pathology, contains 12 invited reviews on topics of current interest in pathology. This year, our subjects include immuno-oncology and computational pathology approaches for ... ...

    Abstract The 2023 Annual Review Issue of The Journal of Pathology, Recent Advances in Pathology, contains 12 invited reviews on topics of current interest in pathology. This year, our subjects include immuno-oncology and computational pathology approaches for diagnostic and research applications in human disease. Reviews on the tissue microenvironment include the effects of apoptotic cell-derived exosomes, how understanding the tumour microenvironment predicts prognosis, and the growing appreciation of the diverse functions of fibroblast subtypes in health and disease. We also include up-to-date reviews of modern aspects of the molecular basis of malignancies, and our final review covers new knowledge of vascular and lymphatic regeneration in cardiac disease. All of the reviews contained in this issue are written by expert groups of authors selected to discuss the recent progress in their particular fields and all articles are freely available online (https://pathsocjournals.onlinelibrary.wiley.com/journal/10969896). © 2023 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
    MeSH term(s) Humans ; Neoplasms/pathology ; Prognosis ; Tumor Microenvironment ; United Kingdom ; Review Literature as Topic
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 3119-7
    ISSN 1096-9896 ; 0022-3417
    ISSN (online) 1096-9896
    ISSN 0022-3417
    DOI 10.1002/path.6192
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  2. Article ; Online: Recent Advances in Pathology: the 2020 Annual Review Issue of The Journal of Pathology.

    Herrington, C Simon / Poulsom, Richard / Coates, Philip J

    The Journal of pathology

    2020  Volume 250, Issue 5, Page(s) 475–479

    Abstract: This year's Annual Review Issue of The Journal of Pathology contains 18 invited reviews on current research areas in pathology. The subject areas reflect the broad range of topics covered by the journal and this year encompass the development and ... ...

    Abstract This year's Annual Review Issue of The Journal of Pathology contains 18 invited reviews on current research areas in pathology. The subject areas reflect the broad range of topics covered by the journal and this year encompass the development and application of software in digital histopathology, implementation of biomarkers in pathology practice; genetics and epigenetics, and stromal influences in disease. The reviews are authored by experts in their field and provide comprehensive updates in the chosen areas, in which there has been considerable recent progress in our understanding of disease. © 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
    MeSH term(s) Animals ; Biomarkers, Tumor ; Epigenesis, Genetic ; Humans ; Inflammation/pathology ; Neoplasms/genetics ; Neoplasms/pathology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; United Kingdom
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2020-04-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3119-7
    ISSN 1096-9896 ; 0022-3417
    ISSN (online) 1096-9896
    ISSN 0022-3417
    DOI 10.1002/path.5425
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  3. Article ; Online: Experimental models of renal disease.

    Poulsom, Richard

    International journal of experimental pathology

    2011  Volume 92, Issue 3, Page(s) 141–142

    Abstract: This review series consists of seven articles, which focus on the different processes that are involved in the initiation or prevention of renal disease. The articles incorporate a critical analysis of the different experimental models that are used ... ...

    Abstract This review series consists of seven articles, which focus on the different processes that are involved in the initiation or prevention of renal disease. The articles incorporate a critical analysis of the different experimental models that are used currently in this field of research. They provide an expert overview which is of particular relevance to glomerular diseases, renal fibrosis and obstructive kidney diseases, and all their contributions have significant implications for our understanding of human health and disease.
    MeSH term(s) Animals ; Disease Models, Animal ; Fibrosis ; Glomerulonephritis/pathology ; Glomerulonephritis/physiopathology ; Humans ; Kidney/pathology ; Kidney/physiopathology ; Kidney Diseases/pathology ; Kidney Diseases/physiopathology ; Mice ; Ureteral Obstruction/pathology ; Ureteral Obstruction/physiopathology
    Language English
    Publishing date 2011-05-16
    Publishing country England
    Document type Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1016006-1
    ISSN 1365-2613 ; 0958-4625 ; 0007-1021 ; 0959-9673
    ISSN (online) 1365-2613
    ISSN 0958-4625 ; 0007-1021 ; 0959-9673
    DOI 10.1111/j.1365-2613.2011.00776.x
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  4. Article ; Online: Recent Advances in Pathology: the 2021 Annual Review Issue of The Journal of Pathology.

    Herrington, C Simon / Poulsom, Richard / Koeppen, Hartmut / Coates, Philip J

    The Journal of pathology

    2021  Volume 254, Issue 4, Page(s) 303–306

    Abstract: The 2021 Annual Review Issue of The Journal of Pathology contains 14 invited reviews on current research areas of particular importance in pathology. The subjects included here reflect the broad range of interests covered by the journal, including both ... ...

    Abstract The 2021 Annual Review Issue of The Journal of Pathology contains 14 invited reviews on current research areas of particular importance in pathology. The subjects included here reflect the broad range of interests covered by the journal, including both basic and applied research fields but always with the aim of improving our understanding of human disease. This year, our reviews encompass the huge impact of the COVID-19 pandemic, the development and application of biomarkers for immune checkpoint inhibitors, recent advances in multiplexing antigen/nucleic acid detection in situ, the use of genomics to aid drug discovery, organoid methodologies in research, the microbiome in cancer, the role of macrophage-stroma interactions in fibrosis, and TGF-β as a driver of fibrosis in multiple pathologies. Other reviews revisit the p53 field and its lack of clinical impact to date, dissect the genetics of mitochondrial diseases, summarise the cells of origin and genetics of sarcomagenesis, provide new data on the role of TRIM28 in tumour predisposition, review our current understanding of cancer stem cell niches, and the function and regulation of p63. The reviews are authored by experts in their field from academia and industry, and provide comprehensive updates of the chosen areas, in which there has been considerable recent progress. © 2021 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
    MeSH term(s) COVID-19/genetics ; COVID-19/pathology ; COVID-19/virology ; Genomics/methods ; Humans ; Neoplasms/complications ; Neoplasms/genetics ; Neoplasms/pathology ; Organoids/pathology ; SARS-CoV-2/pathogenicity ; United Kingdom
    Language English
    Publishing date 2021-06-09
    Publishing country England
    Document type Editorial
    ZDB-ID 3119-7
    ISSN 1096-9896 ; 0022-3417
    ISSN (online) 1096-9896
    ISSN 0022-3417
    DOI 10.1002/path.5687
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  5. Article ; Online: Recent Advances in Pathology: the 2022 Annual Review Issue of The Journal of Pathology.

    Herrington, C Simon / Poulsom, Richard / Pillay, Nischalan / Bankhead, Peter / Coates, Philip J

    The Journal of pathology

    2022  Volume 257, Issue 4, Page(s) 379–382

    Abstract: The 2022 Annual Review Issue of The Journal of Pathology, Recent Advances in Pathology, contains 15 invited reviews on research areas of growing importance in pathology. This year, the articles include those that focus on digital pathology, employing ... ...

    Abstract The 2022 Annual Review Issue of The Journal of Pathology, Recent Advances in Pathology, contains 15 invited reviews on research areas of growing importance in pathology. This year, the articles include those that focus on digital pathology, employing modern imaging techniques and software to enable improved diagnostic and research applications to study human diseases. This subject area includes the ability to identify specific genetic alterations through the morphological changes they induce, as well as integrating digital and computational pathology with 'omics technologies. Other reviews in this issue include an updated evaluation of mutational patterns (mutation signatures) in cancer, the applications of lineage tracing in human tissues, and single cell sequencing technologies to uncover tumour evolution and tumour heterogeneity. The tissue microenvironment is covered in reviews specifically dealing with proteolytic control of epidermal differentiation, cancer-associated fibroblasts, field cancerisation, and host factors that determine tumour immunity. All of the reviews contained in this issue are the work of invited experts selected to discuss the considerable recent progress in their respective fields and are freely available online (https://onlinelibrary.wiley.com/journal/10969896). © 2022 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
    MeSH term(s) Humans ; Mutation ; Neoplasms/genetics ; Neoplasms/pathology ; Software ; Tumor Microenvironment/genetics ; United Kingdom
    Language English
    Publishing date 2022-05-30
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 3119-7
    ISSN 1096-9896 ; 0022-3417
    ISSN (online) 1096-9896
    ISSN 0022-3417
    DOI 10.1002/path.5972
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  6. Article ; Online: Recent Advances in Pathology: the 2019 Annual Review Issue of The Journal of Pathology.

    Herrington, C Simon / Poulsom, Richard / Coates, Philip J

    The Journal of pathology

    2019  Volume 247, Issue 5, Page(s) 535–538

    Abstract: In this Annual Review Issue of The Journal of Pathology, we present 15 invited reviews on topical aspects of pathology, ranging from the impacts of the microbiome in human disease through mechanisms of cell death and autophagy to recent advances in ... ...

    Abstract In this Annual Review Issue of The Journal of Pathology, we present 15 invited reviews on topical aspects of pathology, ranging from the impacts of the microbiome in human disease through mechanisms of cell death and autophagy to recent advances in immunity and the uses of genomics for understanding, classifying and treating human cancers. Each of the reviews is authored by experts in their fields and our intention is to provide comprehensive updates in specific areas of pathology in which there has been considerable recent progress. Copyright © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
    Language English
    Publishing date 2019-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 3119-7
    ISSN 1096-9896 ; 0022-3417
    ISSN (online) 1096-9896
    ISSN 0022-3417
    DOI 10.1002/path.5255
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  7. Article ; Online: Does bone marrow contain renal precursor cells?

    Poulsom, Richard

    Nephron. Experimental nephrology

    2003  Volume 93, Issue 2, Page(s) e53

    Abstract: In the past few years stem cells normally present within the bone marrow have been shown to have considerable plasticity in the repertoire of the cells that they produce. They are capable of producing specific lineages of cells not only of the blood, but ...

    Abstract In the past few years stem cells normally present within the bone marrow have been shown to have considerable plasticity in the repertoire of the cells that they produce. They are capable of producing specific lineages of cells not only of the blood, but also contribute usefully to lineages of other organs. In the kidney, studies in humans and rodents provide evidence for the presence of bone marrow-derived 're-programmed' cells, but it remains possible that the cells that arrive and re-differentiate are no longer stem cells (quiescent cells, not actively proliferating). Nevertheless, the fact that appropriately differentiated cells are delivered deep within the kidney simply by injection of bone marrow cells should make us think differently about the way these organs regenerate and repair. Migratory pathways for multipotential stem cells could be exploited to effect repair using an individual's own stem cells, perhaps after gene therapy. It is clear also that a transplanted organ would in time become affected by the genetic susceptibilities of the recipient, because of phenotypes that are expressed when trafficking cells engraft and differentiate.
    MeSH term(s) Animals ; Bone Marrow Cells/physiology ; Humans ; Kidney/cytology ; Kidney/physiology ; Multipotent Stem Cells/physiology
    Language English
    Publishing date 2003
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 207121-6
    ISSN 1660-2129 ; 1423-0186 ; 2235-3186 ; 1660-8151 ; 0028-2766
    ISSN (online) 1660-2129 ; 1423-0186 ; 2235-3186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000068515
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  8. Article ; Online: Omnis cellula e cellula revisited: cell biology as the foundation of pathology.

    Wright, Nicholas A / Poulsom, Richard

    The Journal of pathology

    2012  Volume 226, Issue 2, Page(s) 145–147

    Abstract: This 2012 Annual Review Issue of The Journal of Pathology argues strongly that cell biology, in its many disciplines, underpins the foundation of our understanding of the mechanisms of disease-the holy grail of pathology. Our increasing knowledge of the ... ...

    Abstract This 2012 Annual Review Issue of The Journal of Pathology argues strongly that cell biology, in its many disciplines, underpins the foundation of our understanding of the mechanisms of disease-the holy grail of pathology. Our increasing knowledge of the human genome will not be enough to attain this goal without parallel developments in our comprehension of the results, at the cellular level, of these genetic changes. In the end, it is cell biology and cell biologists who will deliver this mission.
    MeSH term(s) Cell Biology ; Cell Communication/physiology ; Cell Nucleus/physiology ; Humans ; Organelles/physiology ; Pathology, Clinical
    Language English
    Publishing date 2012-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 3119-7
    ISSN 1096-9896 ; 0022-3417
    ISSN (online) 1096-9896
    ISSN 0022-3417
    DOI 10.1002/path.3030
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  9. Article ; Online: Identifying the origin and phenotype of cells in tumor xenografts.

    Jeffery, Rosemary / Seedhar, Pooja / Poulsom, Richard

    Methods in molecular biology (Clifton, N.J.)

    2014  Volume 1070, Page(s) 235–245

    Abstract: The growth of human tumor cells transplanted into immunodeficient mice is frequently studied to gain understanding about the way potential drug treatments interfere with growth in vivo. A wide range of methods is available for learning about specific ... ...

    Abstract The growth of human tumor cells transplanted into immunodeficient mice is frequently studied to gain understanding about the way potential drug treatments interfere with growth in vivo. A wide range of methods is available for learning about specific aspects of tumor cell behavior, for example, cells may be administered to follow their ability to grow close to the site of injection which may be at a generic site or one specific to that type of tumor. Some models of metastasis follow the appearance of a tumor mass after intravascular administration of tumor cells; others score remote growth after removal of a primary tumor implanted subcutaneously. Assessing metastatic growth may increasingly rely on serial observation of tumor cell numbers as seen by whole-body imaging, but the sensitivity of these methods is poor in terms of the minimum number of cells detectable, and histological follow-up to establish tumor cell numbers can be confounded by variable expression or even silencing of reporter genes. Here we describe how fluorescence in situ hybridization (FISH) using commercially available probes can very easily be used to detect even single metastatic tumor cells in mouse models, using routinely fixed and processed tissue samples, and without the tumor cell lines needing to express engineered reporter genes. The FISH protocol can be combined with other standard histological protocols to study the behavior of tumor cells and adjacent host cells to improve our understanding of tumor-stroma interactions, and is also useful for simultaneous demonstration of the cell of origin and phenotype of cells used in regenerative medicine-based applications.
    MeSH term(s) Animals ; Humans ; In Situ Hybridization, Fluorescence ; Mice ; Neoplasms/pathology ; Phenotype ; Xenograft Model Antitumor Assays/methods
    Language English
    Publishing date 2014
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4614-8244-4_18
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  10. Article ; Online: Parietal epithelial cells regenerate podocytes.

    Poulsom, Richard / Little, Melissa H

    Journal of the American Society of Nephrology : JASN

    2009  Volume 20, Issue 2, Page(s) 231–233

    MeSH term(s) AC133 Antigen ; Animals ; Antigens, CD/biosynthesis ; Bowman Capsule/metabolism ; CD24 Antigen/biosynthesis ; Epithelial Cells/cytology ; Glycoproteins/biosynthesis ; Humans ; Kidney/cytology ; Kidney Diseases/metabolism ; Kidney Diseases/pathology ; Kidney Glomerulus/cytology ; Nephrons/metabolism ; Peptides ; Podocytes/metabolism ; Regeneration ; Wound Healing
    Chemical Substances AC133 Antigen ; Antigens, CD ; CD24 Antigen ; Glycoproteins ; Peptides
    Language English
    Publishing date 2009-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2008121279
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