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  1. Article ; Online: What's in a Name? The Time Has Come to Unify Parkinson's Disease and Dementia with Lewy Bodies.

    Weintraub, Daniel

    Movement disorders : official journal of the Movement Disorder Society

    2023  Volume 38, Issue 11, Page(s) 1977–1981

    MeSH term(s) Humans ; Parkinson Disease/diagnosis ; Lewy Body Disease/diagnosis ; Lewy Bodies ; Alzheimer Disease
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.29590
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  2. Article: An addition to the obituary of John Daniel Gilpatrick

    Weintraub, M

    Phytopathology. Jan 1984. v. 74 (1)

    1984  

    Title variant Addition to the obituary of John Daniel Gilpatrick [Plant pathologists, Canada]
    Keywords scientists ; plant pathology ; Canada
    Language English
    Dates of publication 1984-01
    Size p. 45.
    Document type Article
    Note Contains biographical information.
    ZDB-ID 208889-7
    ISSN 1943-7684 ; 0031-949X
    ISSN (online) 1943-7684
    ISSN 0031-949X
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Management of psychiatric disorders in Parkinson's disease : Neurotherapeutics - Movement Disorders Therapeutics.

    Weintraub, Daniel

    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    2020  Volume 17, Issue 4, Page(s) 1511–1524

    Abstract: Affective disorders (depression and anxiety), psychosis, impulse control disorders, and apathy are common and sometimes disabling psychiatric conditions in Parkinson disease (PD). Psychiatric aspects of PD are associated with numerous adverse outcomes, ... ...

    Abstract Affective disorders (depression and anxiety), psychosis, impulse control disorders, and apathy are common and sometimes disabling psychiatric conditions in Parkinson disease (PD). Psychiatric aspects of PD are associated with numerous adverse outcomes, yet in spite of this and their high frequency, there remains incomplete understanding of epidemiology, presentation, risk factors, neural substrate, and management strategies. Psychiatric features are typically co- or multimorbid, and there is great intra- and interindividual variability in presentation [1]. The neuropathophysiological changes that occur in PD, as well as the association between PD treatment and particular psychiatric disorders, suggest a neurobiological contribution to many psychiatric symptoms. There is evidence that psychiatric disorders in PD are still under-recognized and undertreated, and although psychotropic medication use is common, randomized controlled trials demonstrating efficacy and tolerability are largely lacking. Future research on neuropsychiatric complications in PD should be oriented toward determining modifiable correlates or risk factors, and most importantly, establishing efficacious and well-tolerated treatment strategies.
    MeSH term(s) Disease Management ; Disruptive, Impulse Control, and Conduct Disorders/epidemiology ; Disruptive, Impulse Control, and Conduct Disorders/psychology ; Disruptive, Impulse Control, and Conduct Disorders/therapy ; Humans ; Mental Disorders/epidemiology ; Mental Disorders/psychology ; Mental Disorders/therapy ; Parkinson Disease/epidemiology ; Parkinson Disease/psychology ; Parkinson Disease/therapy ; Psychotropic Drugs/therapeutic use
    Chemical Substances Psychotropic Drugs
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2316693-9
    ISSN 1878-7479 ; 1933-7213
    ISSN (online) 1878-7479
    ISSN 1933-7213
    DOI 10.1007/s13311-020-00875-w
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  4. Article ; Online: Impulse control disorders in Parkinson's disease: A 20-year odyssey.

    Weintraub, Daniel

    Movement disorders : official journal of the Movement Disorder Society

    2019  Volume 34, Issue 4, Page(s) 447–452

    MeSH term(s) Disruptive, Impulse Control, and Conduct Disorders/complications ; Disruptive, Impulse Control, and Conduct Disorders/psychology ; Humans ; Parkinson Disease/complications ; Parkinson Disease/psychology
    Language English
    Publishing date 2019-03-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.27668
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  5. Article ; Online: Parkinson's Disease and Dementia with Lewy Bodies: One and the Same.

    Borghammer, Per / Okkels, Niels / Weintraub, Daniel

    Journal of Parkinson's disease

    2024  Volume 14, Issue 3, Page(s) 383–397

    Abstract: The question whether Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are expressions of the same underlying disease has been vigorously debated for decades. The recently proposed biological definitions of Lewy body disease, which ... ...

    Abstract The question whether Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are expressions of the same underlying disease has been vigorously debated for decades. The recently proposed biological definitions of Lewy body disease, which do not assign any particular importance to the dopamine system over other degenerating neurotransmitter systems, has once more brought the discussion about different types of Lewy body disease to the forefront. Here, we briefly compare PDD and DLB in terms of their symptoms, imaging findings, and neuropathology, ultimately finding them to be indistinguishable. We then present a conceptual framework to demonstrate how one can view different clinical syndromes as manifestations of a shared underlying Lewy body disease. Early Parkinson's disease, isolated RBD, pure autonomic failure and other autonomic symptoms, and perhaps even psychiatric symptoms, represent diverse manifestations of the initial clinical stages of Lewy body disease. They are characterized by heterogeneous and comparatively limited neuronal dysfunction and damage. In contrast, Lewy body dementia, an encompassing term for both PDD and DLB, represents a more uniform and advanced stage of the disease. Patients in this category display extensive and severe Lewy pathology, frequently accompanied by co-existing pathologies, as well as multi-system neuronal dysfunction and degeneration. Thus, we propose that Lewy body disease should be viewed as a single encompassing disease entity. Phenotypic variance is caused by the presence of individual risk factors, disease mechanisms, and co-pathologies. Distinct subtypes of Lewy body disease can therefore be defined by subtype-specific disease mechanisms or biomarkers.
    MeSH term(s) Humans ; Lewy Body Disease/pathology ; Parkinson Disease/complications ; Parkinson Disease/pathology ; Diagnosis, Differential
    Language English
    Publishing date 2024-04-17
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2620609-2
    ISSN 1877-718X ; 1877-7171
    ISSN (online) 1877-718X
    ISSN 1877-7171
    DOI 10.3233/JPD-240002
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    Zs.A 6964: Show issues Location:
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  6. Article ; Online: Diagnosis and Treatment of Cognitive and Neuropsychiatric Symptoms in Parkinson Disease and Dementia With Lewy Bodies.

    Weintraub, Daniel / Irwin, David

    Continuum (Minneapolis, Minn.)

    2022  Volume 28, Issue 5, Page(s) 1314–1332

    Abstract: Purpose of review: This article summarizes the underlying biology and current diagnostic and treatment strategies for the cognitive and neuropsychiatric features of Parkinson disease (PD) and dementia with Lewy bodies (DLB).: Recent findings: ... ...

    Abstract Purpose of review: This article summarizes the underlying biology and current diagnostic and treatment strategies for the cognitive and neuropsychiatric features of Parkinson disease (PD) and dementia with Lewy bodies (DLB).
    Recent findings: Cognitive impairment and neuropsychiatric symptoms have been increasingly recognized in PD and DLB, leading to improved diagnosis and treatment strategies. While PD is most associated with and diagnosed by the presence of motor symptoms, nonmotor symptoms can often be the most debilitating for patients. Neuropsychiatric symptoms are highly prevalent nonmotor features and include cognitive impairment, depression, anxiety, psychosis, impulse control disorders, and apathy. Neuropsychiatric symptoms can be difficult to recognize and diagnose in patients with PD, in part because of comorbidity and symptom overlap with core PD features. Treatment strategies are a combination of pharmacologic and nonpharmacologic interventions used in the general population and those specific to PD. DLB is a clinical dementia syndrome, often with similar cognitive, behavioral, autonomic, and motor features as PD. Moreover, DLB has shared underlying pathophysiology with PD, as both are associated with postmortem findings of α-synuclein neuropathology at autopsy and have shared genetic risk and prodromal symptoms. DLB is clinically differentiated from PD by the presenting features of cognitive impairment in DLB, compared with the variable onset of cognitive impairment occurring 1 year or more after established motor onset in PD. Thus, diagnosis and treatment of cognitive impairment and neuropsychiatric symptoms in DLB are similar to that of PD and have important implications for maintaining patient independence and providing support for caregivers because motor, cognitive, and neuropsychiatric symptoms have an additive effect on patient functional disability.
    Summary: A careful history and physical examination are often needed to accurately diagnose and treat the heterogeneous cognitive and behavioral symptoms of PD and DLB. Accurate diagnosis and treatment of neuropsychiatric symptoms and cognitive impairment in PD and DLB are important, as these are a considerable source of patient disability and caregiver burden.
    MeSH term(s) Cognition ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/therapy ; Humans ; Lewy Body Disease/complications ; Lewy Body Disease/diagnosis ; Lewy Body Disease/therapy ; Parkinson Disease/complications ; Parkinson Disease/diagnosis ; Parkinson Disease/therapy ; alpha-Synuclein/therapeutic use
    Chemical Substances alpha-Synuclein
    Language English
    Publishing date 2022-10-12
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1538-6899
    ISSN (online) 1538-6899
    DOI 10.1212/CON.0000000000001151
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  7. Article ; Online: Progress Regarding Parkinson's Disease Psychosis: It's No Illusion.

    Weintraub, Daniel

    Movement disorders clinical practice

    2016  Volume 3, Issue 5, Page(s) 431–434

    Language English
    Publishing date 2016-08-11
    Publishing country United States
    Document type Editorial
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.12377
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  8. Article ; Online: Social Control and Health Behaviors Among Individuals Living with Parkinson's Disease: A Pilot Study.

    Mavandadi, Shahrzad / Interian, Alejandro / Sayers, Steven / Dobkin, Roseanne / Weintraub, Daniel

    International journal of behavioral medicine

    2023  

    Abstract: Background: Positive health behaviors (e.g., exercise, healthy eating habits, good sleep hygiene, treatment adherence) are important in ensuring optimal symptom management and health outcomes among individuals living with Parkinson's disease (PD). While ...

    Abstract Background: Positive health behaviors (e.g., exercise, healthy eating habits, good sleep hygiene, treatment adherence) are important in ensuring optimal symptom management and health outcomes among individuals living with Parkinson's disease (PD). While multiple factors may influence engagement in health behaviors, little is known about the occurrence of social control, or relationship partners' attempts to influence and regulate another's behavior, and its potential role in the adoption of health behaviors among individuals with PD.
    Methods: To better understand the types of social control attempts employed and begin to explore the association between social control attempts and behavioral responses (e.g., engage in the targeted health behavior, hide the behavior) to those attempts, survey data were drawn from a cross-sectional, pilot study of married/partnered Veterans diagnosed with idiopathic PD (n = 25). Participants completed self-reported measures of sociodemographics, physical and mental well-being, relationship functioning, and both the frequency of and behavioral responses to positive and negative social control attempts.
    Results: Although the majority of individuals reported their partners engaged in positive social control attempts, half also reported negative attempts. Bivariate analyses revealed more frequent positive social control attempts from one's partner were related to both positive and negative behavioral responses, and negative social control attempts were related to negative behavioral responses. However, when adjusting for covariates, positive social control attempts were related to positive behavioral responses, while negative social exchanges with one's partner (e.g., general conflict), rather than exposure to negative social control attempts, were related to negative behavioral responses.
    Conclusions: Findings lend preliminary evidence of the relationship between social control and exchanges and health behavior that may inform future, adequately powered observational and intervention studies that target interpersonal processes and health behaviors among individuals living with PD and their relationship partners.
    Language English
    Publishing date 2023-10-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1187972-5
    ISSN 1532-7558 ; 1070-5503
    ISSN (online) 1532-7558
    ISSN 1070-5503
    DOI 10.1007/s12529-023-10219-5
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    Zs.A 5090: Show issues Location:
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  9. Article ; Online: Hallucinations, Antipsychotic Use, and Mortality in Older Adults with Dementia: Retrospective Cohort Study of Two Medicare-Linked National Health Surveys.

    Hamedani, Ali G / Weintraub, Daniel / Willis, Allison W

    Drugs & aging

    2022  Volume 39, Issue 12, Page(s) 967–974

    Abstract: Background: Hallucinations are associated with earlier death in older adults with dementia, but antipsychotic medications are also associated with mortality, and comparisons of their relative harms are lacking.: Objective: To determine the individual ...

    Abstract Background: Hallucinations are associated with earlier death in older adults with dementia, but antipsychotic medications are also associated with mortality, and comparisons of their relative harms are lacking.
    Objective: To determine the individual and combined association between hallucinations, antipsychotic use, and mortality.
    Methods: We performed a retrospective cohort study using Medicare-linked survey data from two nationally representative studies (the National Health and Aging Trends Study and the Health and Retirement Study) containing validated dementia identification algorithms and a screening question for hallucinations. Using Medicare claims, we identified participants with dementia who had no history of antipsychotic use during the year of or prior to entry. We used extended Cox regression with time-varying covariates to analyze the association between hallucinations, antipsychotic use, and mortality adjusting for confounders.
    Results: We identified 1703 eligible subjects who contributed 4,819 person-years of follow-up. 555 (32.6%) had hallucinations at baseline, 705 (41.4%) reported hallucinations at least once during follow-up, and 284 (16.7%) received antipsychotics. Hallucinations were associated with an increased risk of death in unadjusted models (hazard ratio (HR) 1.36; 95% confidence interval (CI): 1.18-1.5), but antipsychotic use was not (HR 1.03; 95% CI 0.85-1.2). After adjusting for age, race, gender, dementia severity, and comorbidities, the HR for hallucinations attenuated and was no longer statistically significant (1.15, 95% CI 0.98-1.34). There was no significant interaction between hallucinations and antipsychotic use.
    Conclusion: Hallucinations are associated with an increased risk of death that is greater than the risk associated with antipsychotic use, though this is partially confounded by dementia severity and comorbidities.
    MeSH term(s) United States/epidemiology ; Aged ; Humans ; Antipsychotic Agents/adverse effects ; Medicare ; Retrospective Studies ; Health Surveys ; Dementia/drug therapy
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2022-12-02
    Publishing country New Zealand
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1075770-3
    ISSN 1179-1969 ; 1170-229X
    ISSN (online) 1179-1969
    ISSN 1170-229X
    DOI 10.1007/s40266-022-00991-6
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    Zs.A 3481: Show issues Location:
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  10. Article ; Online: Validation of the Italian version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) in an Italian Parkinson's disease cohort.

    Maggi, Gianpaolo / Vitale, Carmine / Giacobbe, Chiara / Barone, Angelo / Mastromarino, Clara / Iannotta, Federica / Amboni, Marianna / Weintraub, Daniel / Santangelo, Gabriella

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2024  

    Abstract: Introduction: Impulse control disorders (ICDs) frequently occur in Parkinson's disease (PD), and an early identification is essential to prevent severe psychosocial consequences. The Questionnaire for Impulsive-Compulsive Disorders in Parkinson's ... ...

    Abstract Introduction: Impulse control disorders (ICDs) frequently occur in Parkinson's disease (PD), and an early identification is essential to prevent severe psychosocial consequences. The Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) has been developed to evaluate the severity of ICDs along with a range of impulsive-compulsive behaviors (ICBs) in PD; however, its Italian version has not yet been validated.
    Methods: One hundred consecutive outpatients with PD were administered an Italian version of the QUIP-RS and a brief neuropsychological assessment to evaluate global cognitive status and scales to measure depression, apathy and impulsive disorders. We evaluated the internal consistency, convergent and divergent validity, and factorial structure of QUIP-RS. We also explored the possible association between QUIP-RS scores and clinical factors and dopaminergic medication.
    Results: Subsyndromal ICDs manifestations were observed in 54% of the patients, and one in four (22%) reported two or more ICDs or related behaviors. The QUIP-RS demonstrated good internal consistency (Cronbach's alpha = 0.806) and construct validity, and its factorial structure reflected different ICDs and ICBs domains. No association emerged between QUIP-RS scores and the clinical aspects of PD and dopaminergic medication.
    Conclusion: We provided, for the first time, an Italian translation of the QUIP-RS and demonstrated its feasibility in clinical and research settings. Severity of ICDs was independent of clinical factors and dopaminergic medication, underlining the need to adopt a broader perspective on their etiopathology in PD.
    Language English
    Publishing date 2024-01-17
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-024-07304-2
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