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  1. Article ; Online: Transmembrane H

    Leung, Ho Chi / Leclerc, Catherine / Moreau, Marc / Shipley, Alan M / Miller, Andrew L / Webb, Sarah E

    Zygote (Cambridge, England)

    2021  Volume 30, Issue 2, Page(s) 267–278

    Abstract: ... 11-12.5 hpf). It was proposed that such increases (potentially due to H+ being extruded, sequestered ... an extracellular ion-selective electrode to non-invasively measure H+ fluxes at eight locations ... that at stages 9-11, there was a small H+ efflux recorded from all the measuring positions. At stage 12 there was ...

    Abstract It has previously been reported that in ex vivo planar explants prepared from Xenopus laevis embryos, the intracellular pH (pHi) increases in cells of the dorsal ectoderm from stage 10.5 to 11.5 (i.e. 11-12.5 hpf). It was proposed that such increases (potentially due to H+ being extruded, sequestered, or buffered in some manner), play a role in regulating neural induction. Here, we used an extracellular ion-selective electrode to non-invasively measure H+ fluxes at eight locations around the equatorial circumference of intact X. laevis embryos between stages 9-12 (˜7-13.25 hpf). We showed that at stages 9-11, there was a small H+ efflux recorded from all the measuring positions. At stage 12 there was a small, but significant, increase in the efflux of H+ from most locations, but the efflux from the dorsal side of the embryo was significantly greater than from the other positions. Embryos were also treated from stages 9-12 with bafilomycin A1, to block the activity of the ATP-driven H+ pump. By stage 22 (24 hpf), these embryos displayed retarded development, arresting before the end of gastrulation and therefore did not display the usual anterior and neural structures, which were observed in the solvent-control embryos. In addition, expression of the early neural gene, Zic3, was absent in treated embryos compared with the solvent controls. Together, our new in vivo data corroborated and extended the earlier explant-derived report describing changes in pHi that were suggested to play a role during neural induction in X. laevis embryos.
    MeSH term(s) Animals ; Ectoderm/physiology ; Embryonic Development ; Gene Expression Regulation, Developmental ; Nervous System ; Xenopus laevis/metabolism
    Language English
    Publishing date 2021-09-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1166294-3
    ISSN 1469-8730 ; 0967-1994
    ISSN (online) 1469-8730
    ISSN 0967-1994
    DOI 10.1017/S0967199421000630
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    Zs.A 3816: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Prevalence of H. pylori and gastric intestinal metaplasia in BRCA1 and BRCA2 carriers.

    Niccum, Blake A / Coughlin, Sarah / Clay, Daniel / Heiman, Jordan / Buckley, Kole H / Dungan, Michaela / Daniel, Michael G / Ruiz, Jose / Maxwell, Kara N / Domchek, Susan M / Leung, Galen / Ahmad, Nuzhat A / Ginsberg, Gregory G / Kochman, Michael L / Katona, Bryson W

    Cancer prevention research (Philadelphia, Pa.)

    2024  

    Abstract: ... Helicobacter pylori (H. pylori) infection and gastric intestinal metaplasia (GIM) among BRCA1/2 carriers to gain ... gastric antrum and body biopsies. The study population (70% women; mean age: 60.1) included 66% BRCA2 carriers. H ... no GCs were diagnosed. Among BRCA1/2 carriers, H. pylori prevalence was low and GIM prevalence was ...

    Abstract BRCA1 and BRCA2 carriers may be at increased risk for gastric cancer (GC), however the mechanisms of gastric carcinogenesis remain poorly understood. We sought to determine the prevalence of GC risk factors Helicobacter pylori (H. pylori) infection and gastric intestinal metaplasia (GIM) among BRCA1/2 carriers to gain insight into the pathogenesis of GC in this population. 100 unselected BRCA1/2 carriers undergoing endoscopic ultrasound from 3/2022-3/2023 underwent concomitant upper endoscopy with non-targeted gastric antrum and body biopsies. The study population (70% women; mean age: 60.1) included 66% BRCA2 carriers. H. pylori was detected in one (1%) individual, 7 (7%) had GIM, 2 (2%) had autoimmune atrophic gastritis, and no GCs were diagnosed. Among BRCA1/2 carriers, H. pylori prevalence was low and GIM prevalence was similar to the general population, however identification of H. pylori or GIM may help inform future GC risk management strategies in BRCA1/2 carriers.
    Language English
    Publishing date 2024-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2434717-6
    ISSN 1940-6215 ; 1940-6207
    ISSN (online) 1940-6215
    ISSN 1940-6207
    DOI 10.1158/1940-6207.CAPR-24-0039
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  3. Article ; Online: Observation of Directed Flow of Hypernuclei _{Λ}^{3}H and _{Λ}^{4}H in sqrt[s_{NN}]=3  GeV Au+Au Collisions at RHIC.

    Aboona, B E / Adam, J / Adams, J R / Agakishiev, G / Aggarwal, I / Aggarwal, M M / Ahammed, Z / Aitbaev, A / Alekseev, I / Anderson, D M / Aparin, A / Atchison, J / Averichev, G S / Bairathi, V / Baker, W / Ball Cap, J G / Barish, K / Bhagat, P / Bhasin, A /
    Bhatta, S / Bordyuzhin, I G / Brandenburg, J D / Brandin, A V / Cai, X Z / Caines, H / Calderón de la Barca Sánchez, M / Cebra, D / Ceska, J / Chakaberia, I / Chan, B K / Chang, Z / Chen, D / Chen, J / Chen, J H / Chen, Z / Cheng, J / Cheng, Y / Choudhury, S / Christie, W / Chu, X / Crawford, H J / Dale-Gau, G / Das, A / Daugherity, M / Dedovich, T G / Deppner, I M / Derevschikov, A A / Dhamija, A / Di Carlo, L / Didenko, L / Dixit, P / Dong, X / Drachenberg, J L / Duckworth, E / Dunlop, J C / Engelage, J / Eppley, G / Esumi, S / Evdokimov, O / Ewigleben, A / Eyser, O / Fatemi, R / Fazio, S / Feng, C J / Feng, Y / Finch, E / Fisyak, Y / Flor, F A / Fu, C / Geurts, F / Ghimire, N / Gibson, A / Gopal, K / Gou, X / Grosnick, D / Gupta, A / Hamed, A / Han, Y / Harasty, M D / Harris, J W / Harrison, H / He, W / He, X H / He, Y / Hu, C / Hu, Q / Hu, Y / Huang, H / Huang, H Z / Huang, S L / Huang, T / Huang, X / Huang, Y / Humanic, T J / Isenhower, D / Isshiki, M / Jacobs, W W / Jalotra, A / Jena, C / Ji, Y / Jia, J / Jin, C / Ju, X / Judd, E G / Kabana, S / Kabir, M L / Kalinkin, D / Kang, K / Kapukchyan, D / Kauder, K / Ke, H W / Keane, D / Kechechyan, A / Kelsey, M / Kimelman, B / Kiselev, A / Knospe, A G / Ko, H S / Kochenda, L / Korobitsin, A A / Kravtsov, P / Kumar, L / Kumar, S / Kunnawalkam Elayavalli, R / Lacey, R / Landgraf, J M / Lebedev, A / Lednicky, R / Lee, J H / Leung, Y H / Lewis, N / Li, C / Li, W / Li, X / Li, Y / Li, Z / Liang, X / Liang, Y / Lin, T / Liu, C / Liu, F / Liu, H / Liu, L / Liu, T / Liu, X / Liu, Y / Liu, Z / Ljubicic, T / Llope, W J / Lomicky, O / Longacre, R S / Loyd, E / Lu, T / Lukow, N S / Luo, X F / Luong, V B / Ma, L / Ma, R / Ma, Y G / Magdy, N / Mallick, D / Margetis, S / Matis, H S / Mazer, J A / McNamara, G / Mi, K / Minaev, N G / Mohanty, B / Mooney, I / Morozov, D A / Mudrokh, A / Nagy, M I / Nain, A S / Nam, J D / Nasim, Md / Neff, D / Nelson, J M / Nemes, D B / Nie, M / Nigmatkulov, G / Niida, T / Nishitani, R / Nogach, L V / Nonaka, T / Nunes, A S / Odyniec, G / Ogawa, A / Oh, S / Okorokov, V A / Okubo, K / Page, B S / Pak, R / Pan, J / Pandav, A / Pandey, A K / Panebratsev, Y / Pani, T / Parfenov, P / Paul, A / Perkins, C / Pokhrel, B R / Posik, M / Protzman, T / Pruthi, N K / Putschke, J / Qin, Z / Qiu, H / Quintero, A / Racz, C / Radhakrishnan, S K / Raha, N / Ray, R L / Ritter, H G / Robertson, C W / Rogachevsky, O V / Rosales Aguilar, M A / Roy, D / Ruan, L / Sahoo, A K / Sahoo, N R / Sako, H / Salur, S / Samigullin, E / Sato, S / Schmidke, W B / Schmitz, N / Seger, J / Seto, R / Seyboth, P / Shah, N / Shahaliev, E / Shanmuganathan, P V / Shao, M / Shao, T / Sharma, M / Sharma, N / Sharma, R / Sharma, S R / Sheikh, A I / Shen, D Y / Shen, K / Shi, S S / Shi, Y / Shou, Q Y / Si, F / Singh, J / Singha, S / Sinha, P / Skoby, M J / Söhngen, Y / Song, Y / Srivastava, B / Stanislaus, T D S / Stewart, D J / Strikhanov, M / Stringfellow, B / Su, Y / Sun, C / Sun, X / Sun, Y / Surrow, B / Svirida, D N / Sweger, Z W / Tamis, A / Tang, A H / Tang, Z / Taranenko, A / Tarnowsky, T / Thomas, J H / Tlusty, D / Todoroki, T / Tokarev, M V / Tomkiel, C A / Trentalange, S / Tribble, R E / Tribedy, P / Tsai, O D / Tsang, C Y / Tu, Z / Ullrich, T / Underwood, D G / Upsal, I / Van Buren, G / Vasiliev, A N / Verkest, V / Videbæk, F / Vokal, S / Voloshin, S A / Wang, F / Wang, G / Wang, J S / Wang, X / Wang, Y / Wang, Z / Webb, J C / Weidenkaff, P C / Westfall, G D / Wieman, H / Wilks, G / Wissink, S W / Wu, J / Wu, X / Wu, Y / Xi, B / Xiao, Z G / Xie, W / Xu, H / Xu, N / Xu, Q H / Xu, Y / Xu, Z / Yan, G / Yan, Z / Yang, C / Yang, Q / Yang, S / Yang, Y / Ye, Z / Yi, L / Yip, K / Yu, Y / Zha, W / Zhang, C / Zhang, D / Zhang, J / Zhang, S / Zhang, X / Zhang, Y / Zhang, Z J / Zhang, Z / Zhao, F / Zhao, J / Zhao, M / Zhou, C / Zhou, J / Zhou, S / Zhou, Y / Zhu, X / Zurek, M / Zyzak, M

    Physical review letters

    2023  Volume 130, Issue 21, Page(s) 212301

    Abstract: We report here the first observation of directed flow (v_{1}) of the hypernuclei _{Λ}^{3}H and _{Λ ... 4}H in mid-central Au+Au collisions at sqrt[s_{NN}]=3  GeV at RHIC. These data are taken as part ... centrality, about 8400 _{Λ}^{3}H and 5200 _{Λ}^{4}H candidates are reconstructed through two- and three-body ...

    Abstract We report here the first observation of directed flow (v_{1}) of the hypernuclei _{Λ}^{3}H and _{Λ}^{4}H in mid-central Au+Au collisions at sqrt[s_{NN}]=3  GeV at RHIC. These data are taken as part of the beam energy scan program carried out by the STAR experiment. From 165×10^{6} events in 5%-40% centrality, about 8400 _{Λ}^{3}H and 5200 _{Λ}^{4}H candidates are reconstructed through two- and three-body decay channels. We observe that these hypernuclei exhibit significant directed flow. Comparing to that of light nuclei, it is found that the midrapidity v_{1} slopes of _{Λ}^{3}H and _{Λ}^{4}H follow baryon number scaling, implying that the coalescence is the dominant mechanism for these hypernuclei production in the 3 GeV Au+Au collisions.
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.130.212301
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  4. Article ; Online: Confined Ru Sites in a 13X Zeolite for Ultrahigh H

    Leung, Kwan Chee / Hong, Sungil / Li, Guangchao / Xing, Youdong / Ng, Bryan Kit Yue / Ho, Ping-Luen / Ye, Dongpei / Zhao, Pu / Tan, Ephraem / Safonova, Olga / Wu, Tai-Sing / Li, Molly Meng-Jung / Mpourmpakis, Giannis / Tsang, Shik Chi Edman

    Journal of the American Chemical Society

    2023  Volume 145, Issue 26, Page(s) 14548–14561

    Abstract: Catalytic ... ...

    Abstract Catalytic NH
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c05092
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  5. Article ; Online: Measurements of _{Λ}^{3}H and _{Λ}^{4}H Lifetimes and Yields in Au+Au Collisions in the High Baryon Density Region.

    Abdallah, M S / Aboona, B E / Adam, J / Adamczyk, L / Adams, J R / Adkins, J K / Agakishiev, G / Aggarwal, I / Aggarwal, M M / Ahammed, Z / Alekseev, I / Anderson, D M / Aparin, A / Aschenauer, E C / Ashraf, M U / Atetalla, F G / Attri, A / Averichev, G S / Bairathi, V /
    Baker, W / Ball Cap, J G / Barish, K / Behera, A / Bellwied, R / Bhagat, P / Bhasin, A / Bielcik, J / Bielcikova, J / Bordyuzhin, I G / Brandenburg, J D / Brandin, A V / Bunzarov, I / Cai, X Z / Caines, H / Calderón de la Barca Sánchez, M / Cebra, D / Chakaberia, I / Chaloupka, P / Chan, B K / Chang, F-H / Chang, Z / Chankova-Bunzarova, N / Chatterjee, A / Chattopadhyay, S / Chen, D / Chen, J / Chen, J H / Chen, X / Chen, Z / Cheng, J / Chevalier, M / Choudhury, S / Christie, W / Chu, X / Crawford, H J / Csanád, M / Daugherity, M / Dedovich, T G / Deppner, I M / Derevschikov, A A / Dhamija, A / Di Carlo, L / Didenko, L / Dixit, P / Dong, X / Drachenberg, J L / Duckworth, E / Dunlop, J C / Elsey, N / Engelage, J / Eppley, G / Esumi, S / Evdokimov, O / Ewigleben, A / Eyser, O / Fatemi, R / Fawzi, F M / Fazio, S / Federic, P / Fedorisin, J / Feng, C J / Feng, Y / Filip, P / Finch, E / Fisyak, Y / Francisco, A / Fu, C / Fulek, L / Gagliardi, C A / Galatyuk, T / Geurts, F / Ghimire, N / Gibson, A / Gopal, K / Gou, X / Grosnick, D / Gupta, A / Guryn, W / Hamad, A I / Hamed, A / Han, Y / Harabasz, S / Harasty, M D / Harris, J W / Harrison, H / He, S / He, W / He, X H / He, Y / Heppelmann, S / Herrmann, N / Hoffman, E / Holub, L / Hu, Y / Huang, H / Huang, H Z / Huang, S L / Huang, T / Huang, X / Huang, Y / Humanic, T J / Igo, G / Isenhower, D / Jacobs, W W / Jena, C / Jentsch, A / Ji, Y / Jia, J / Jiang, K / Ju, X / Judd, E G / Kabana, S / Kabir, M L / Kagamaster, S / Kalinkin, D / Kang, K / Kapukchyan, D / Kauder, K / Ke, H W / Keane, D / Kechechyan, A / Kelsey, M / Khyzhniak, Y V / Kikoła, D P / Kim, C / Kimelman, B / Kincses, D / Kisel, I / Kiselev, A / Knospe, A G / Ko, H S / Kochenda, L / Kosarzewski, L K / Kramarik, L / Kravtsov, P / Kumar, L / Kumar, S / Kunnawalkam Elayavalli, R / Kwasizur, J H / Lacey, R / Lan, S / Landgraf, J M / Lauret, J / Lebedev, A / Lednicky, R / Lee, J H / Leung, Y H / Lewis, N / Li, C / Li, W / Li, X / Li, Y / Liang, X / Liang, Y / Licenik, R / Lin, T / Lin, Y / Lisa, M A / Liu, F / Liu, H / Liu, P / Liu, T / Liu, X / Liu, Y / Liu, Z / Ljubicic, T / Llope, W J / Longacre, R S / Loyd, E / Lukow, N S / Luo, X F / Ma, L / Ma, R / Ma, Y G / Magdy, N / Mallick, D / Margetis, S / Markert, C / Matis, H S / Mazer, J A / Minaev, N G / Mioduszewski, S / Mohanty, B / Mondal, M M / Mooney, I / Morozov, D A / Mukherjee, A / Nagy, M / Nam, J D / Nasim, Md / Nayak, K / Neff, D / Nelson, J M / Nemes, D B / Nie, M / Nigmatkulov, G / Niida, T / Nishitani, R / Nogach, L V / Nonaka, T / Nunes, A S / Odyniec, G / Ogawa, A / Oh, S / Okorokov, V A / Page, B S / Pak, R / Pan, J / Pandav, A / Pandey, A K / Panebratsev, Y / Parfenov, P / Pawlik, B / Pawlowska, D / Perkins, C / Pinsky, L / Pintér, R L / Pluta, J / Pokhrel, B R / Ponimatkin, G / Porter, J / Posik, M / Prozorova, V / Pruthi, N K / Przybycien, M / Putschke, J / Qiu, H / Quintero, A / Racz, C / Radhakrishnan, S K / Raha, N / Ray, R L / Reed, R / Ritter, H G / Robotkova, M / Rogachevskiy, O V / Romero, J L / Roy, D / Ruan, L / Rusnak, J / Sahoo, A K / Sahoo, N R / Sako, H / Salur, S / Sandweiss, J / Sato, S / Schmidke, W B / Schmitz, N / Schweid, B R / Seck, F / Seger, J / Sergeeva, M / Seto, R / Seyboth, P / Shah, N / Shahaliev, E / Shanmuganathan, P V / Shao, M / Shao, T / Sheikh, A I / Shen, D Y / Shi, S S / Shi, Y / Shou, Q Y / Sichtermann, E P / Sikora, R / Simko, M / Singh, J / Singha, S / Skoby, M J / Smirnov, N / Söhngen, Y / Solyst, W / Sorensen, P / Spinka, H M / Srivastava, B / Stanislaus, T D S / Stefaniak, M / Stewart, D J / Strikhanov, M / Stringfellow, B / Suaide, A A P / Sumbera, M / Summa, B / Sun, X M / Sun, X / Sun, Y / Surrow, B / Svirida, D N / Sweger, Z W / Szymanski, P / Tang, A H / Tang, Z / Taranenko, A / Tarnowsky, T / Thomas, J H / Timmins, A R / Tlusty, D / Todoroki, T / Tokarev, M / Tomkiel, C A / Trentalange, S / Tribble, R E / Tribedy, P / Tripathy, S K / Truhlar, T / Trzeciak, B A / Tsai, O D / Tu, Z / Ullrich, T / Underwood, D G / Upsal, I / Van Buren, G / Vanek, J / Vasiliev, A N / Vassiliev, I / Verkest, V / Videbaek, F / Vokal, S / Voloshin, S A / Wang, F / Wang, G / Wang, J S / Wang, P / Wang, X / Wang, Y / Wang, Z / Webb, J C / Weidenkaff, P C / Wen, L / Westfall, G D / Wieman, H / Wissink, S W / Witt, R / Wu, J / Wu, Y / Xi, B / Xiao, Z G / Xie, G / Xie, W / Xu, H / Xu, N / Xu, Q H / Xu, Y / Xu, Z / Yan, G / Yang, C / Yang, Q / Yang, S / Yang, Y / Ye, Z / Yi, L / Yip, K / Yu, Y / Zbroszczyk, H / Zha, W / Zhang, C / Zhang, D / Zhang, J / Zhang, S / Zhang, X P / Zhang, Y / Zhang, Z J / Zhang, Z / Zhao, J / Zhou, C / Zhou, Y / Zhu, X / Zurek, M / Zyzak, M

    Physical review letters

    2022  Volume 128, Issue 20, Page(s) 202301

    Abstract: We report precision measurements of hypernuclei _{Λ}^{3}H and _{Λ}^{4}H lifetimes obtained ... at the Relativistic Heavy Ion Collider, and the first measurement of _{Λ}^{3}H and _{Λ}^{4}H midrapidity yields ... in Au+Au collisions at sqrt[s_{NN}]=3.0  GeV. _{Λ}^{3}H and _{Λ}^{4}H, being the two simplest bound states ...

    Abstract We report precision measurements of hypernuclei _{Λ}^{3}H and _{Λ}^{4}H lifetimes obtained from Au+Au collisions at sqrt[s_{NN}]=3.0  GeV and 7.2 GeV collected by the STAR experiment at the Relativistic Heavy Ion Collider, and the first measurement of _{Λ}^{3}H and _{Λ}^{4}H midrapidity yields in Au+Au collisions at sqrt[s_{NN}]=3.0  GeV. _{Λ}^{3}H and _{Λ}^{4}H, being the two simplest bound states composed of hyperons and nucleons, are cornerstones in the field of hypernuclear physics. Their lifetimes are measured to be 221±15(stat)±19(syst)  ps for _{Λ}^{3}H and 218±6(stat)±13(syst)  ps for _{Λ}^{4}H. The p_{T}-integrated yields of _{Λ}^{3}H and _{Λ}^{4}H are presented in different centrality and rapidity intervals. It is observed that the shape of the rapidity distribution of _{Λ}^{4}H is different for 0%-10% and 10%-50% centrality collisions. Thermal model calculations, using the canonical ensemble for strangeness, describes the _{Λ}^{3}H yield well, while underestimating the _{Λ}^{4}H yield. Transport models, combining baryonic mean-field and coalescence (jam) or utilizing dynamical cluster formation via baryonic interactions (phqmd) for light nuclei and hypernuclei production, approximately describe the measured _{Λ}^{3}H and _{Λ}^{4}H yields. Our measurements provide means to precisely assess our understanding of the fundamental baryonic interactions with strange quarks, which can impact our understanding of more complicated systems involving hyperons, such as the interior of neutron stars or exotic hypernuclei.
    Language English
    Publishing date 2022-06-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.128.202301
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  6. Article ; Online: Liver complications of haemoglobin H disease in adults.

    Chan, Luke K L / Mak, Vivien W M / Chan, Stanley C H / Yu, Ellen L M / Chan, Nelson C N / Leung, Kate F S / Ng, Carmen K M / Ng, Margaret H L / Chan, Joyce C W / Lee, Harold K K

    British journal of haematology

    2020  Volume 192, Issue 1, Page(s) 171–178

    Abstract: Haemoglobin H (HbH) disease is a type of non-transfusion-dependent thalassaemia ...

    Abstract Haemoglobin H (HbH) disease is a type of non-transfusion-dependent thalassaemia. This cross-sectional study aimed at determining the prevalence and severity of liver iron overload and liver fibrosis in patients with HbH disease. Risk factors for advanced liver fibrosis were also identified. A total of 80 patients were evaluated [median (range) age 53 (24-79) years, male 34%, non-deletional HbH disease 24%]. Patients underwent 'observed' T2-weighted magnetic resonance imaging examination for liver iron concentration (LIC) quantification, and transient elastography for liver stiffness measurement (LSM) and fibrosis staging. In all, 25 patients (31%) had moderate-to-severe liver iron overload (LIC ≥7 mg/g dry weight). The median LIC was higher in non-deletional than in deletional HbH disease (7·8 vs. 2.9 mg/g dry weight, P = 0·002). In all, 16 patients (20%) had advanced liver fibrosis (LSM >7.9 kPa) and seven (9%) out of them had probable cirrhosis (LSM >11.9 kPa). LSM positively correlated with age (R = 0·24, P = 0·03), serum ferritin (R = 0·36, P = 0·001) and LIC (R = 0·28, P = 0·01). In multivariable regression, age ≥65 years [odds ratio (OR) 4·97, 95% confidence interval (CI) 1·52-17·50; P = 0·047] and moderate-to-severe liver iron overload (OR 3·47, 95% CI 1·01-12·14; P = 0·01) were independently associated with advanced liver fibrosis. The findings suggest that regular screening for liver complications should be considered in the management of HbH disease.
    MeSH term(s) Adult ; Aged ; Cross-Sectional Studies ; Female ; Humans ; Iron/analysis ; Iron Overload/etiology ; Iron Overload/pathology ; Liver Cirrhosis/etiology ; Liver Cirrhosis/pathology ; Liver Diseases/etiology ; Liver Diseases/pathology ; Male ; Middle Aged ; Young Adult ; alpha-Thalassemia/complications ; alpha-Thalassemia/pathology
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2020-10-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17115
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  7. Article ; Online: Rh(III)-catalyzed redox-neutral C-H alkenylation of benzamides with

    Cui, Xueli / Qu, Jing / Yi, Jianfeng / Sun, Weiqiang / Hu, Jinhui / Guo, Suqin / Jin, Jing-Wei / Chen, Wen-Hua / Wong, Wing-Leung / Wu, Jia-Qiang

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 25, Page(s) 3747–3750

    Abstract: ... β-H elimination feasible, which suppresses both the β-F elimination and dialkenylation of benzamides ...

    Abstract Fluorinated molecules are widely used in pharmaceutical and agrochemical industries. Herein we report the synthesis of 2-(3,3-difluoro-4-(silyloxy)but-1-en-1-yl)benzamides from the unprecedented rhodium(III)-catalyzed alkenylation of various benzamides with difluorohomoallylic silyl ethers. The practicability of this protocol is demonstrated by its broad substrate compatibility, good functional group tolerance, ready scalability and high regioselectivity. The oxygen in difluorohomoallylic silyl ethers makes β-H elimination feasible, which suppresses both the β-F elimination and dialkenylation of benzamides. This redox-neutral reaction proceeds efficiently
    Language English
    Publishing date 2023-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc00529a
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  8. Article: Photoelectrocatalytic H

    Leung, Jane J / Warnan, Julien / Nam, Dong Heon / Zhang, Jenny Z / Willkomm, Janina / Reisner, Erwin

    Chemical science

    2017  Volume 8, Issue 7, Page(s) 5172–5180

    Abstract: The development of photoelectrodes capable of light-driven hydrogen evolution from water is an important approach for the storage of solar energy in the form of a chemical energy carrier. However, molecular catalyst-based photocathodes remain scarcely ... ...

    Abstract The development of photoelectrodes capable of light-driven hydrogen evolution from water is an important approach for the storage of solar energy in the form of a chemical energy carrier. However, molecular catalyst-based photocathodes remain scarcely reported and typically suffer from low efficiencies and/or stabilities due to inadequate strategies for interfacing the molecular component with the light-harvesting material. In this study, we report the straightforward preparation of a p-silicon|mesoporous titania|molecular catalyst photocathode assembly that is active towards proton reduction in aqueous media with an onset potential of +0.4 V
    Language English
    Publishing date 2017-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/c7sc01277b
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  9. Article ; Online: H. pylori-induced NF-κB-PIEZO1-YAP1-CTGF axis drives gastric cancer progression and cancer-associated fibroblast-mediated tumour microenvironment remodelling.

    Chen, Bonan / Liu, Xiaoli / Yu, Peiyao / Xie, Fuda / Kwan, Johnny S H / Chan, Wai Nok / Fang, Canbin / Zhang, Jinglin / Cheung, Alvin H K / Chow, Chit / Leung, Gloria W M / Leung, Kam Tong / Shi, Shihua / Zhang, Bin / Wang, Shouyu / Xu, Dazhi / Fu, Kaili / Wong, Chi Chun / Wu, William K K /
    Chan, Michael W Y / Tang, Patrick M K / Tsang, Chi Man / Lo, Kwok Wai / Tse, Gary M K / Yu, Jun / To, Ka Fai / Kang, Wei

    Clinical and translational medicine

    2023  Volume 13, Issue 11, Page(s) e1481

    Abstract: ... associated with Helicobacter pylori infection. H. pylori utilizes virulence factors, CagA and VacA, to up ... correlated with H. pylori infection. PIEZO1, a mechanosensor, was confirmed as a direct downstream of NF-κB ... to GC. H. pylori-NF-κB activates the PIEZO1-YAP1-CTGF axis to remodel the GC microenvironment ...

    Abstract Background: Gastric cancer (GC) is one of the most common tumours in East Asia countries and is associated with Helicobacter pylori infection. H. pylori utilizes virulence factors, CagA and VacA, to up-regulate pro-inflammatory cytokines and activate NF-κB signaling. Meanwhile, the PIEZO1 upregulation and cancer-associated fibroblast (CAF) enrichment were found in GC progression. However, the mechanisms of PIEZO1 upregulation and its involvement in GC progression have not been fully elucidated.
    Methods: The CAF enrichment and clinical significance were investigated in animal models and primary samples. The expression of NF-κB and PIEZO1 in GC was confirmed by immunohistochemistry staining, and expression correlation was analysed in multiple GC datasets. GSEA and Western blot analysis revealed the YAP1-CTGF axis regulation by PIEZO1. The stimulatory effects of CTGF on CAFs were validated by the co-culture system and animal studies. Patient-derived organoid and peritoneal dissemination models were employed to confirm the role of the PIEZO1-YAP1-CTGF cascade in GC.
    Results: Both CAF signature and PIEZO1 were positively correlated with H. pylori infection. PIEZO1, a mechanosensor, was confirmed as a direct downstream of NF-κB to promote the transformation from intestinal metaplasia to GC. Mechanistic studies revealed that PIEZO1 transduced the oncogenic signal from NF-κB into YAP1 signaling, a well-documented oncogenic pathway in GC progression. PIEZO1 expression was positively correlated with the YAP1 signature (CTGF, CYR61, and c-Myc, etc.) in primary samples. The secreted CTGF by cancer cells stimulated the CAF infiltration to form a stiffened collagen-enrichment microenvironment, thus activating PIEZO1 to form a positive feedback loop. Both PIEZO1 depletion by shRNA and CTGF inhibition by Procyanidin C1 enhanced the efficacy of 5-FU in suppressing the GC cell peritoneal metastasis.
    Conclusion: This study elucidates a novel driving PIEZO1-YAP1-CTGF force, which opens a novel therapeutic avenue to block the transformation from precancerous lesions to GC. H. pylori-NF-κB activates the PIEZO1-YAP1-CTGF axis to remodel the GC microenvironment by promoting CAF infiltration. Targeting PIEZO1-YAP1-CTGF plus chemotherapy might serve as a potential therapeutic option to block GC progression and peritoneal metastasis.
    MeSH term(s) Animals ; Humans ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Stomach Neoplasms/pathology ; Helicobacter pylori/metabolism ; Cancer-Associated Fibroblasts/metabolism ; Helicobacter Infections/complications ; Helicobacter Infections/genetics ; Helicobacter Infections/metabolism ; Peritoneal Neoplasms ; Tumor Microenvironment/genetics ; Ion Channels
    Chemical Substances NF-kappa B ; PIEZO1 protein, human ; Ion Channels
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1481
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  10. Article ; Online: Safety of high-carbohydrate fluid diet 2 h versus overnight fasting before non-emergency endoscopic retrograde cholangiopancreatography: A single-blind, multicenter, randomized controlled trial.

    Meng, Wenbo / Leung, Joseph W / Wang, Zhenyu / Li, Qiyong / Zhang, Leida / Zhang, Kai / Wang, Xuefeng / Wang, Meng / Wang, Qi / Shao, Yingmei / Zhang, Jijun / Yue, Ping / Zhang, Lei / Zhu, Kexiang / Zhu, Xiaoliang / Zhang, Hui / Hou, Senlin / Cai, Kailin / Sun, Hao /
    Xue, Ping / Liu, Wei / Wang, Haiping / Zhang, Li / Ding, Songming / Yang, Zhiqing / Zhang, Ming / Weng, Hao / Wu, Qingyuan / Chen, Bendong / Jiang, Tiemin / Wang, Yingkai / Zhang, Lichao / Wu, Ke / Yang, Xue / Wen, Zilong / Liu, Chun / Miao, Long / Wang, Zhengfeng / Li, Jiajia / Yan, Xiaowen / Wang, Fangzhao / Zhang, Lingen / Bai, Mingzhen / Mi, Ningning / Zhang, Xianzhuo / Zhou, Wence / Yuan, Jinqiu / Suzuki, Azumi / Tanaka, Kiyohito / Liu, Jiankang / Nur, Ula / Weiderpass, Elisabete / Li, Xun

    Chinese medical journal

    2023  

    Abstract: ... to endoscopic retrograde cholangiopancreatography (ERCP), the benefits and safety of high-carbohydrate fluid diet (CFD) intake 2 h before ERCP ... remain unclear. This study aimed to analyze whether high-CFD intake 2 h before ERCP can be safe and ... fasting group (n = 665). The CFD group received 400 mL of maltodextrin orally 2 h before ERCP ...

    Abstract Background: Although overnight fasting is recommended prior to endoscopic retrograde cholangiopancreatography (ERCP), the benefits and safety of high-carbohydrate fluid diet (CFD) intake 2 h before ERCP remain unclear. This study aimed to analyze whether high-CFD intake 2 h before ERCP can be safe and accelerate patients' recovery.
    Methods: This prospective, multicenter, randomized controlled trial involved 15 tertiary ERCP centers. A total of 1330 patients were randomized into CFD group (n = 665) and fasting group (n = 665). The CFD group received 400 mL of maltodextrin orally 2 h before ERCP, while the control group abstained from food/water overnight (>6 h) before ERCP. All ERCP procedures were performed using deep sedation with intravenous propofol. The investigators were blinded but not the patients. The primary outcomes included postoperative fatigue and abdominal pain score, and the secondary outcomes included complications and changes in metabolic indicators. The outcomes were analyzed according to a modified intention-to-treat principle.
    Results: The post-ERCP fatigue scores were significantly lower at 4 h (4.1 ± 2.6 vs. 4.8 ± 2.8, t = 4.23, P <0.001) and 20 h (2.4 ± 2.1 vs. 3.4 ± 2.4, t = 7.94, P <0.001) in the CFD group, with least-squares mean differences of 0.48 (95% confidence interval [CI]: 0.26-0.71, P <0.001) and 0.76 (95% CI: 0.57-0.95, P <0.001), respectively. The 4-h pain scores (2.1 ± 1.7 vs. 2.2 ± 1.7, t = 2.60, P = 0.009, with a least-squares mean difference of 0.21 [95% CI: 0.05-0.37]) and positive urine ketone levels (7.7% [39/509] vs. 15.4% [82/533], χ2 = 15.13, P <0.001) were lower in the CFD group. The CFD group had significantly less cholangitis (2.1% [13/634] vs. 4.0% [26/658], χ2 = 3.99, P = 0.046) but not pancreatitis (5.5% [35/634] vs. 6.5% [43/658], χ2 = 0.59, P = 0.444). Subgroup analysis revealed that CFD reduced the incidence of complications in patients with native papilla (odds ratio [OR]: 0.61, 95% CI: 0.39-0.95, P = 0.028) in the multivariable models.
    Conclusion: Ingesting 400 mL of CFD 2 h before ERCP is safe, with a reduction in post-ERCP fatigue, abdominal pain, and cholangitis during recovery.
    Trail registration: ClinicalTrials.gov, No. NCT03075280.
    Language English
    Publishing date 2023-08-24
    Publishing country China
    Document type Journal Article
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000002820
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