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Article: Diagnosen und Risikokategorien bei in die Maßregel eingewiesenen zurechnungsfähigen Straftätern - eine Stichtagsuntersuchung aus Österreich

Seiser, Alexander

Forensische Psychiatrie und Psychotherapie

2022 Volume 29, Issue 1, Page(s) 69

Language	German ; English ; French
Document type	Article
ZDB-ID	1203700-X
ISSN	0945-2540
Database	Current Contents Medicine

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Article: Diagnosen und Risikokategorien bei in die Maßregel eingewiesenen zurechnungsfähigen Straftätern - Eine Stichtagsuntersuchung aus Österreich

Seiser, Alexander

Forensische Psychiatrie und Psychotherapie

2022 Volume 29, Issue 1, Page(s) 69–95

Abstract: In der vorliegenden Stichtagsuntersuchung wurden die Daten von n=334 Personen aus sechs österreichischen Justizanstalten im Hinblick auf Straffälligkeit, Diagnosen einweisungsbegründender psychischer Störungen und Risikoparameter ausgewertet, die zum ... ...

Title translation	Diagnoses and risk categories of forensic admissions in Austria
Abstract	In der vorliegenden Stichtagsuntersuchung wurden die Daten von n=334 Personen aus sechs österreichischen Justizanstalten im Hinblick auf Straffälligkeit, Diagnosen einweisungsbegründender psychischer Störungen und Risikoparameter ausgewertet, die zum Erhebungszeitpunkt am 1. Juli 2018 im österreichischen Maßnahmenvollzug nach § 21 Abs. 2 öStGB untergebracht waren. Über 90% der Verurteilungen lagen Sexual- oder Gewaltdelikte zugrunde. Etwa 62 % der Gesamtstichprobe wies neben der Leitdiagnose zumindest eine weitere behandlungsbedürftige psychische Störung auf. Persönlichkeitsstörungen stellten mit einem Anteil von etwa 78 % die größte Störungsgruppe dar. Ausgehend von den Ergebnissen der Psychopathy Checklist Revised (PCL-R) zeigte etwa ein Drittel der Gesamtstichprobe eine hohe bis sehr hohe Ausprägung psychopathischer Persönlichkeitsmerkmale. Auf Grundlage der gebildeten Static-99 Risikokategorien wies jeder zweite untergebrachte männliche Sexualstraftäter ein überdurchschnittliches oder hohes Risiko für neuerliche Sexualstraftaten auf.
Keywords	Criminal Behavior ; Criminal Offenders ; Epidemiologie ; Epidemiology ; Kriminelles Verhalten ; Mental Disorders ; Personality Disorders ; Persönlichkeitsstörungen ; Psychische Störungen ; Psychopathie ; Psychopathy ; Risikofaktoren ; Risk Factors ; Sex Offenses ; Sexualdelikte ; Straffällige
Language	German
Document type	Article
ZDB-ID	1203700-x
ISSN	0945-2540
ISSN	0945-2540
Database	PSYNDEX

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Zs.A 4624: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 656: Show issues

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Article: The prevalence of mental disorders among incarcerated adult men convicted of child sexual exploitation material offences.

Seiser, Alexander / Eher, Reinhard / Turner, Daniel / Rettenberger, Martin

CNS spectrums

2023 Volume 28, Issue 6, Page(s) 719–725

Abstract: Objective: Despite the growing body of research on individuals convicted of child sexual exploitation material (CSEM), relatively little is known about the prevalence of mental disorders in this population. The aim of the present study was to describe ... ...

Abstract	Objective: Despite the growing body of research on individuals convicted of child sexual exploitation material (CSEM), relatively little is known about the prevalence of mental disorders in this population. The aim of the present study was to describe the prevalence of mental disorders among individuals convicted of CSEM offenses. Methods: This cross-sectional study examined data from 66 individuals serving a sentence for CSEM offenses in the Austrian prison system who underwent a clinical assessment between 2002 and 2020. Diagnoses were based on the German version of the Structured Clinical Interview for Axis I and Axis II disorders. Results: In the total sample, n = 53 individuals (80.3%) were diagnosed with a mental disorder. Twenty-seven individuals (40.9%) had an Axis I disorder and n = 47 (71.2%) had an Axis II disorder. More than two-thirds of the sample, n = 47 (71.2%), had a personality disorder diagnosis, with cluster B personality disorders being the most frequent mental disorders. More than half of the sample, n = 43 (65.2%), had a diagnosis of pedophilic disorder, of which n = 9 (13.6%) were of the exclusive type. Twenty-eight persons (42.4%) showed evidence of a hypersexual disorder. Conclusions: In line with previous research, the present sample of convicted CSEM offenders showed a comparatively high prevalence of personality disorders and paraphilic disorders, particularly pedophilic disorders. Additionally, the rate of hypersexual disorder symptoms was considerably high. These findings should be considered for the development of successful risk management strategies for this population.
MeSH term(s)	Adult ; Male ; Child ; Humans ; Female ; Prevalence ; Cross-Sectional Studies ; Mental Disorders/epidemiology ; Mental Disorders/diagnosis ; Sex Offenses ; Prisoners
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2008418-3
ISSN	2165-6509 ; 1092-8529
ISSN (online)	2165-6509
ISSN	1092-8529
DOI	10.1017/S1092852923002262
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Zs.A 5171: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 340: Show issues

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Article ; Online: Downstaging after preoperative chemoradiation for locally advanced rectal cancer is associated with better survival than pathologic stage 0-1 disease treated with upfront surgery.

Kasheri, Eli / Artinyan, Avo / Oka, Kimberly / Zhu, Ruoyan / Seiser, Natalie / Shirinian, Mihran / Barnajian, Moshe / Cohen, Jason / Ellenhorn, Joshua / Nasseri, Yosef

International journal of colorectal disease

2024 Volume 39, Issue 1, Page(s) 16

Abstract: Background and objectives: It is unknown how patients with locally advanced rectal cancer with significant response to preoperative radiotherapy/chemoradiotherapy fare relative to patients with true pathologic 0-1 disease undergoing upfront surgery. We ... ...

Abstract	Background and objectives: It is unknown how patients with locally advanced rectal cancer with significant response to preoperative radiotherapy/chemoradiotherapy fare relative to patients with true pathologic 0-1 disease undergoing upfront surgery. We aimed to determine whether survival is improved in locally advanced rectal cancer downstaged to pathologic stage 0-1 disease compared to true pathologic stage 0-1 tumors. Methods: A retrospective review of the National Cancer Database between 2004 and 2016 was conducted. Three groups were identified: (1) clinical stage 2-3 disease downstaged to pathologic stage 0-1 disease after radiotherapy, (2) clinical stage 2-3 disease not downstaged after radiotherapy, and (3) true pathologic 0-1 tumors undergoing upfront surgery. The primary endpoint was overall survival and was compared using Kaplan-Meier and multivariate Cox regression analyses. Results: The study population consisted of 59,884 patients. Of the 40,130 patients with locally advanced rectal cancer treated with preoperative radiation, 12,670 (31.5%) had significant downstaging (group 1), while 27,460 (68.4%) had no significant downstaging (group 2). A total of 19,754 had pathologic 0-1 disease treated with upfront resection (group 3). On Kaplan-Meier analysis, downstaged patients had significantly better overall survival compared to both non-downstaged and true pathologic stage 0-1 patients (median 156 vs. 99 and 136 months, respectively, p < 0.001). On multivariate analysis, downstaged patients had significantly better survival (HR 0.88, p < 0.001) compared to true pathologic 0-1 patients. Conclusions: Locally advanced rectal cancer downstaged after preoperative radiotherapy has significantly better survival compared to true pathologic stage 0-1 disease treated with upfront surgery. Response to chemoradiotherapy likely identifies a subset of patients with a particularly good prognosis.
MeSH term(s)	Humans ; Neoplasms, Second Primary ; Chemoradiotherapy ; Databases, Factual ; Kaplan-Meier Estimate ; Rectal Neoplasms/therapy
Language	English
Publishing date	2024-01-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	84975-3
ISSN	1432-1262 ; 0179-1958
ISSN (online)	1432-1262
ISSN	0179-1958
DOI	10.1007/s00384-023-04589-1
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Article ; Online: Surfactants for stabilization of dermal emulsions and their skin compatibility under UVA irradiation: Diacyl phospholipids and polysorbate 80 result in high viability rates of primary human skin cells.

Steiner, Katja / Josef Schmolz, Jakob / Hoang, Felisa / Wolf, Hanna / Seiser, Saskia / Elbe-Bürger, Adelheid / Klang, Victoria

International journal of pharmaceutics

2024 Volume 653, Page(s) 123903

Abstract: Phospholipids are versatile formulation compounds with high biocompatibility. However, no data on their effect on skin in combination with UVA radiation exist. Thus, it was the aim of this work to (i) develop o/w nanoemulsions (NEs) differing in ... ...

Abstract	Phospholipids are versatile formulation compounds with high biocompatibility. However, no data on their effect on skin in combination with UVA radiation exist. Thus, it was the aim of this work to (i) develop o/w nanoemulsions (NEs) differing in surfactant type and to investigate their physicochemical stability at different storage temperatures, (ii) establish a standardized protocol for in vitro phototoxicity testing using primary human skin cells and (iii) investigate the phototoxicity of amphoteric phospholipids (S45, S75, E80, S100, LPC80), sodium lauryl ether sulfate (SLES) and polysorbate 80 (PS80). Satisfying systems were developed with all surfactants except S100 due to low zeta potential (-21.4 mV ± 4.69). SLES and PS80-type NEs showed the highest stability after eight weeks; temperature-dependent variations in storage stability were most noticeable for phospholipid surfactants. For phospholipid-based NEs, higher phosphatidylcholine content led to unstable formulations. Phototoxicity assays with primary skin fibroblasts confirmed the lack of UVA-related phototoxicity but revealed cytotoxic effects of LPC80 and SLES, resulting in cell viability as low as 2.7 % ±0.78 and 1.9 % ±1.57 compared to the control. Our findings suggest that surfactants S45, S75 and PS80 are the most promising candidates for skin-friendly emulsifiers in sensitive applications involving exposure to UV light.
MeSH term(s)	Humans ; Surface-Active Agents/chemistry ; Polysorbates/pharmacology ; Ultraviolet Rays ; Phospholipids ; Emulsions/pharmacology ; Skin ; Dermatitis, Phototoxic
Chemical Substances	Surface-Active Agents ; Polysorbates ; Phospholipids ; Emulsions
Language	English
Publishing date	2024-02-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2024.123903
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Article: Erste Validierungsergebnisse der adaptierten deutschen Version des CPORT zur Risikoeinschätzung von Kinderpornografie-Tätern

Seiser, Alexander / Eher, Reinhard

Empirische Forschung in der forensischen Psychiatrie, Psychologie und Psychotherapie

2021 Volume 2019, Issue -, Page(s) 94

Language	German
Document type	Article
ZDB-ID	2688869-5
ISSN	2194-2692
Database	Current Contents Medicine

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Article: Erste Validierungsergebnisse der adaptierten deutschen Version des CPORT zur Risikoeinschätzung von Kinderpornografie-Tätern

Seiser, Alexander / Eher, Reinhard

(In: Müller, Jürgen L.; Briken, Peer; Eher, Reinhard; Jordan, Kirsten (Ed.), EFPPP Jahrbuch 2019. Empirische Forschung in der forensischen Psychiatrie, Psychologie und Psychotherapie (S. 94-102). Berlin: MWV Medizinisch Wissenschaftliche Verlagsgesellschaft)

2021

Abstract: Der CPORT (Child Pornography Offender Risk Tool" ist ein Risikobewertungsinstrument zur Vorhersage neuerlicher Sexualdelikte für Kinderpornografietäter. Die vorliegende Arbeit berichtet über die erste Validierungsstudie des CPORT an einer ... ...

Title translation	Initial validation results of the adapted German version of the CPORT for risk assessment of child pornography offenders (DeepL)
Series title	In: Müller, Jürgen L.; Briken, Peer; Eher, Reinhard; Jordan, Kirsten (Ed.), EFPPP Jahrbuch 2019. Empirische Forschung in der forensischen Psychiatrie, Psychologie und Psychotherapie (S. 94-102). Berlin: MWV Medizinisch Wissenschaftliche Verlagsgesellschaft
Abstract	Der CPORT (Child Pornography Offender Risk Tool" ist ein Risikobewertungsinstrument zur Vorhersage neuerlicher Sexualdelikte für Kinderpornografietäter. Die vorliegende Arbeit berichtet über die erste Validierungsstudie des CPORT an einer deutschsprachigen Stichprobe. Die Ergebnisse hinsichtlich seiner prädiktiven Validität lassen sich mit denen der Original Version gut vergleichen. Die erhobenen Daten sprechen für eine gute prädiktive Validität des CPORT in der Gruppe der Kinderpornografietäter. Darüber hinaus sprechen sie auch dafür, dass der CPORT bei derjenigen Tätergruppe, die Kinderpornografiedelikte und sexuelle Kontaktdelikte an Kindern aufweist, zu besseren Vorhersageergebnissen führt als der "Static-99".
Keywords	Child Abuse ; Foreign Language Translation ; Forensic Assessment ; Forensische Diagnostik ; Fremdsprachenübersetzung ; Kindesmisshandlung ; Male Criminal Offenders ; Männliche Straffällige ; Predictive Validity ; Prädiktive Validität ; Recidivism ; Risikoerfassung ; Risk Assessment ; Rückfälligkeit (Delinquenz) ; Sexual Abuse ; Sexueller Missbrauch ; Test Validity ; Testvalidität
Language	German
Document type	Article
Database	PSYNDEX

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Article ; Online: Comparative assessment of commercially available wound gels in ex vivo human skin reveals major differences in immune response-modulatory effects.

Seiser, S / Cerbu, D / Gallhofer, A / Matiasek, J / Elbe-Bürger, A

Scientific reports

2022 Volume 12, Issue 1, Page(s) 17481

Abstract: Wound healing is a crucial process for maintaining the function of human skin as a protective barrier to pathogens and other external stress factors. Hydrogels-in combination with antimicrobials-are often used, as moist wound care has been widely ... ...

Abstract	Wound healing is a crucial process for maintaining the function of human skin as a protective barrier to pathogens and other external stress factors. Hydrogels-in combination with antimicrobials-are often used, as moist wound care has been widely accepted as standard therapy. Recently, we reported about immune response-modulatory effects of an octenidine-based hydrogel, however little is known about the mechanism of action of other hydrogels including antiseptic molecules or chlorine-based and chlorine-releasing agents, respectively. The aim of this study was the comparative assessment of commercially available wound gels (octenilin
MeSH term(s)	Humans ; Interleukin-10 ; Caspase 3 ; Eosine Yellowish-(YS) ; Chlorine ; Interleukin-6 ; Interleukin-8 ; Hydrogels/pharmacology ; Hydrogels/chemistry ; Cytokines ; Immunity ; Anti-Infective Agents, Local ; Metalloproteases
Chemical Substances	Interleukin-10 (130068-27-8) ; Caspase 3 (EC 3.4.22.-) ; Eosine Yellowish-(YS) (TDQ283MPCW) ; Chlorine (4R7X1O2820) ; Interleukin-6 ; Interleukin-8 ; Hydrogels ; Cytokines ; Anti-Infective Agents, Local ; Metalloproteases (EC 3.4.-)
Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-20997-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Promoting RAPID Vaccine Science Education at the Onset of the COVID-19 Pandemic.

Smyth, Davida S / Jordan, Trace / Seiser, Robert / Moran, Meghan / Hasager, Ulla / Sorby, Sheryl / Kahl, Nathan / Shachter, Amy / Oates, Karen

Journal of microbiology & biology education

2023 Volume 24, Issue 2

Abstract: At the onset of the 2019 coronavirus disease (COVID-19) pandemic, it was clear that we needed to support public education on the science of vaccines. This project was born of that need and led to the development of comprehensive educational materials ... ...

Abstract	At the onset of the 2019 coronavirus disease (COVID-19) pandemic, it was clear that we needed to support public education on the science of vaccines. This project was born of that need and led to the development of comprehensive educational materials that addressed the process of science, severe acute respiratory syndrome coronavirus 2 biology, vaccine development, and science communication and outreach. Called the "Online Vaccine Science Resources for COVID-19 Education," the materials generated were designed to be implemented by educators and community groups in various contexts. They took the form of four modules and general audience informational videos available on a YouTube channel. Each module was assembled as a toolkit with instructional videos, assessments, discussion questions, assignments, synthesis activities, and guides for constructing infographics and dual poster (science and general public audience) presentations. The materials were piloted and tested in various educational settings, including 2-year and 4-year colleges. Data gathered from surveys of faculty and student participants suggested that exposure to the materials promoted student trust in vaccination and the scientific process of vaccine development, and increased the likelihood of their getting a freely available vaccine. Assessment data indicated that the materials were successful in helping students achieve the learning objectives for the modules. Our results underscored the continued need for science education strategies that address the critical problem of vaccine hesitancy as we continue to emerge from the COVID-19 pandemic.
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article
ISSN	1935-7877
ISSN	1935-7877
DOI	10.1128/jmbe.00051-23
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Article ; Online: Native human and mouse skin infection models to study Candida auris-host interactions.

Seiser, Saskia / Arzani, Hossein / Ayub, Tanya / Phan-Canh, Trinh / Staud, Clement / Worda, Christof / Kuchler, Karl / Elbe-Bürger, Adelheid

Microbes and infection

2023 Volume 26, Issue 1-2, Page(s) 105234

Abstract: The World Health Organization (WHO) declared certain fungal pathogens as global health threats for the next decade. Candida auris (C. auris) is a newly emerging skin-tropic multidrug-resistant fungal pathogen that can cause life-threatening infections of ...

Abstract	The World Health Organization (WHO) declared certain fungal pathogens as global health threats for the next decade. Candida auris (C. auris) is a newly emerging skin-tropic multidrug-resistant fungal pathogen that can cause life-threatening infections of high mortality in hospitals and healthcare settings. Here, we address an unmet need and present novel native ex vivo skin models, thus extending previous C. auris-host interaction studies. We exploit histology and immunofluorescence analysis of ex vivo skin biopsies of human adult and fetal, as well as mouse origin infected with C. auris via distinct routes. We demonstrate that an intact skin barrier efficiently protects from C. auris penetration and invasion. Although C. auris readily grows on native human skin, it can reach deeper layers only upon physical disruption of the barrier by needling or through otherwise damaged skin. By contrast, a barrier disruption is not necessary for C. auris penetration of native mouse skin. Importantly, we show that C. auris undergoes morphogenetic changes upon skin penetration, as it acquires pseudohyphal growth phenotypes in deeper human and mouse dermis. Taken together, this new human and mouse skin model toolset yields new insights into C. auris colonization, adhesion, growth and invasion properties of native versus damaged human skin. The results form a crucial basis for future studies on skin immune defense to colonizing pathogens, and offer new options for testing the action and efficacy of topical antimicrobial compound formulations.
MeSH term(s)	Animals ; Humans ; Mice ; Candida auris ; Candidiasis/microbiology ; Disease Models, Animal
Language	English
Publishing date	2023-10-07
Publishing country	France
Document type	Journal Article
ZDB-ID	1465093-9
ISSN	1769-714X ; 1286-4579
ISSN (online)	1769-714X
ISSN	1286-4579
DOI	10.1016/j.micinf.2023.105234
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