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  1. Book ; Online ; E-Book: Therapeutic approaches in cancer treatment

    Qazi, Asma Saleem / Tariq, Kanwal

    (Cancer treatment and research series ; 185)

    2023  

    Author's details Asma Saleem Qazi, Kanwal Tariq editors
    Series title Cancer treatment and research series ; 185
    Collection
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xiv, 310 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030056841
    ISBN 978-3-031-27156-4 ; 9783031271557 ; 3-031-27156-4 ; 3031271556
    DOI 10.1007/978-3-031-27156-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: A Case of Thoracic Perineural (Tarlov) Cyst.

    Tariq, Asma / Majid, Adnan

    American journal of respiratory and critical care medicine

    2020  Volume 201, Issue 11, Page(s) e79

    MeSH term(s) Adult ; Humans ; Male ; Tarlov Cysts/diagnostic imaging ; Thorax ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-01-29
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201908-1574IM
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh II Zs.80: Show issues Location:
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  3. Article ; Online: In-silico analysis of potential anticancer drug for NEK7 and PPP1CA proteins overexpressed in pancreatic ductal adenocarcinoma.

    Adrees, Safa / Imtiaz, Anam / Yaseen, Aiman / Irfan Fareed, Muhammad / Anwar, Waqar / Ashraf, Asma / Shabbir, Rana Muhammad Kamran / Andlib, Shaista / Hussain, Mureed / Tariq, Asma / Mateen, Rana Muhammad / Saqib, Muhammad Arif Nadeem / Parveen, Rukhsana

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–17

    Abstract: NIMA-related kinase 7 (NEK7) and phosphoprotein phosphatase-1 catalytic subunit alpha (PPP1CA) are the most common proteins overexpressed in pancreatic ductal adenocarcinoma, which is the most common type of pancreatic cancer. The goal of the current ... ...

    Abstract NIMA-related kinase 7 (NEK7) and phosphoprotein phosphatase-1 catalytic subunit alpha (PPP1CA) are the most common proteins overexpressed in pancreatic ductal adenocarcinoma, which is the most common type of pancreatic cancer. The goal of the current study was to identify a possible NEK7 and PPP1CA therapeutic inhibitor. For this investigation, 5000 compounds were retrieved from the IMPPAT library of phytochemicals, which were docked with our respective target proteins. Also, a reference compound, gemcitabine, which is a Food and Drug Administration (FDA) approved drug, was docked with the target proteins. The binding energy of the reference compound for both the targeted proteins was -6.5 kcal/mol. The common ligand with the lowest binding energy for both targets is boeravinone B (PubChem ID: 14018348) with -9.2 kcal/mol of NEK7 and -7.6 kcal/mol for PPP1CA. The compound was further investigated through density function theory (DFT) and molecular dynamic simulation analysis. The root mean square deviation (RMSD), root mean square fluctuation (RMSF), radius of gyration (Rg), and hydrogen bonding analysis indicated the stability of the boeravinone B with the target proteins (NEK7 and PPP1CA).Communicated by Ramaswamy H. Sarma.
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2318484
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  4. Article ; Online: Tissue engineered periosteum: Fabrication of a gelatin basedtrilayer composite scaffold with biomimetic properties for enhanced bone healing.

    Tariq, Sana / Shah, Saqlain A / Hameed, Fareeha / Mutahir, Zeeshan / Khalid, Hamad / Tufail, Asma / Akhtar, Hafsah / Chaudhry, Aqif Anwar / Khan, Ather Farooq

    International journal of biological macromolecules

    2024  Volume 263, Issue Pt 2, Page(s) 130371

    Abstract: The periosteum, a vascularized tissue membrane, is essential in bone regeneration following fractures and bone loss due to some other reasons, yet there exist several research gaps concerning its regeneration. These gaps encompass reduced cellular ... ...

    Abstract The periosteum, a vascularized tissue membrane, is essential in bone regeneration following fractures and bone loss due to some other reasons, yet there exist several research gaps concerning its regeneration. These gaps encompass reduced cellular proliferation and bioactivity, potential toxicity, heightened stiffness of scaffold materials, unfavorable porosity, expensive materials and procedures, and suboptimal survivability or inappropriate degradation rates of the implanted materials. This research used an interdisciplinary approach by forming a new material fabricated through electrospinning for the proposed application as a layer-by-layer tissue-engineered periosteum (TEP). TEP comprises poly(ε-caprolactone) (PCL), PCL/gelatin/magnesium-doped zinc oxide (vascular layer), and gelatin/bioactive glass/COD liver oil (osteoconductive layer). These materials were selected for their diverse properties, when integrated into the scaffold formation, successfully mimic the characteristics of native periosteum. Scanning electron microscopy (SEM) was employed to confirm the trilayer structure of the scaffold and determine the average fiber diameter. In-vitro degradation and swelling studies demonstrated a uniform degradation rate that matches the typical recovery time of periosteum. The scaffold exhibited excellent mechanical properties comparable to natural periosteum. Furthermore, the sustained release kinetics of COD liver oil were observed in the trilayer scaffold. Cell culture results indicated that the three-dimensional topography of the scaffold promoted cell growth, proliferation, and attachment, confirming its non-toxicity, biocompatibility, and bioactivity. This study suggests that the fabricated scaffold holds promise as a potential artificial periosteum for treating periostitis and bone fractures.
    MeSH term(s) Tissue Scaffolds/chemistry ; Gelatin/chemistry ; Periosteum ; Biomimetics ; Cod Liver Oil ; Polyesters/chemistry ; Tissue Engineering/methods
    Chemical Substances Gelatin (9000-70-8) ; Cod Liver Oil (8001-69-2) ; Polyesters
    Language English
    Publishing date 2024-02-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.130371
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    Zs.B 2374: Show issues Location:
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  5. Article ; Online: 3D printed implantable drug delivery devices for women's health: Formulation challenges and regulatory perspective.

    Al-Litani, Karen / Ali, Tariq / Robles Martinez, Pamela / Buanz, Asma

    Advanced drug delivery reviews

    2023  Volume 198, Page(s) 114859

    Abstract: Modern pharmaceutical interventions are shifting from traditional "one-size-fits-all" approaches toward tailored therapies. Following the regulatory approval of Spritam®, the first marketed drug manufactured using three-dimensional printing (3DP) ... ...

    Abstract Modern pharmaceutical interventions are shifting from traditional "one-size-fits-all" approaches toward tailored therapies. Following the regulatory approval of Spritam®, the first marketed drug manufactured using three-dimensional printing (3DP) technologies, there is a precedence set for the use of 3DP in the manufacture of pharmaceutical products. The involvement of 3DP technologies in pharmaceutical research has demonstrated its capabilities in enabling the customisation of characteristics such as drug dosing, release characteristics and product designs on an individualised basis. Nonetheless, research into 3DP implantable drug delivery devices lags behind that for oral devices, cell-based therapies and tissue engineering applications. The recent efforts and initiatives to address the disparity in women's health is overdue but should provide a drive for more research into this area, especially using new and emerging technologies as 3DP. Therefore, the focus of this review has been placed on the unique opportunity of formulating personalised implantable drug delivery systems using 3DP for women's health applications, particularly passive implants. An evaluation of the current landscape and key formulation challenges for achieving this is provided supplemented with critical insight into the current global regulatory status and its outlook.
    MeSH term(s) Female ; Humans ; Drug Delivery Systems/methods ; Printing, Three-Dimensional ; Pharmaceutical Preparations ; Pharmacy ; Precision Medicine/methods ; Technology, Pharmaceutical/methods
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2023-05-05
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639113-8
    ISSN 1872-8294 ; 0169-409X
    ISSN (online) 1872-8294
    ISSN 0169-409X
    DOI 10.1016/j.addr.2023.114859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2241: Show issues Location:
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  6. Article ; Online: Increasing acceptability of forensic DNA analysis in Pakistan

    Rana Muhammad Mateen / Asma Tariq

    Egyptian Journal of Forensic Sciences, Vol 9, Iss 1, Pp 1-

    2019  Volume 2

    Keywords Law in general. Comparative and uniform law. Jurisprudence ; K1-7720 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Crime scene investigation in Pakistan: A perspective.

    Mateen, Rana Muhammad / Tariq, Asma

    Forensic science international. Synergy

    2019  Volume 1, Page(s) 285–287

    Abstract: Crime scene investigation is an important tool in criminal investigation process. Proper processing of crime scene is a prerequisite for successfully solving a criminal case. In Pakistan, local policemen are not properly trained and equipped with the ... ...

    Abstract Crime scene investigation is an important tool in criminal investigation process. Proper processing of crime scene is a prerequisite for successfully solving a criminal case. In Pakistan, local policemen are not properly trained and equipped with the necessary items required for systematic processing of crime scene including proper identification and collection of evidence. Certain capacity building measures and improvements must be needed for proper processing of crime scene in Pakistan. This article focuses the current situation and strategies being practiced in Pakistan followed by suggestions for capacity building measures in this field.
    Language English
    Publishing date 2019-07-19
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 424042-x
    ISSN 2589-871X ; 1872-6283 ; 0379-0738
    ISSN (online) 2589-871X ; 1872-6283
    ISSN 0379-0738
    DOI 10.1016/j.fsisyn.2019.06.046
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    Zs.B 1104: Show issues Location:
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  8. Article ; Online: Incidence and Nature of Respiratory Events in Patients Undergoing Bronchoscopy Under Conscious Sedation.

    Tariq, Asma / Hill, Nicholas S / Price, Lori Lyn / Ismail, Khalid

    Journal of bronchology & interventional pulmonology

    2022  Volume 29, Issue 4, Page(s) 283–289

    Abstract: Background: During diagnostic bronchoscopies, conscious sedation improves patient tolerance, but it can contribute to hypercapnia and hypoxia by various mechanisms including depression of ventilatory drive. This prospective study was undertaken to ... ...

    Abstract Background: During diagnostic bronchoscopies, conscious sedation improves patient tolerance, but it can contribute to hypercapnia and hypoxia by various mechanisms including depression of ventilatory drive. This prospective study was undertaken to determine the frequency of respiratory events and associated oxygen desaturations during bronchoscopy with conscious sedation.
    Patients and methods: The Nox-T3 monitoring system was placed before starting the bronchoscopy and remained in place for 30 minutes following the procedure. The primary endpoint was the occurrence of obstructive and central apneic events during bronchoscopy under conscious sedation.
    Results: Obstructive events (apnea and hypopnea) occurred in 100% of patients (n=31), and central apneas occurred in 58% of patients (n=18) during the procedure with a median of 9 and 2 events per patient, respectively. During recovery, a significant proportion of patients had detectable obstructive (86%) and central (36%) events. Higher body mass index was associated with oxygen desaturation to <90% and with the need for escalation of care. Furthermore, a conscious sedation regimen that included propofol was significantly associated with central apneic events.
    Conclusion: Respiratory events are common during and immediately postprocedure after conscious sedation for bronchoscopy. Most events are obstructive, and the use of propofol predisposes to central apneas during the procedure. Both types of events are associated with a higher body mass index. Oxygen desaturation to <90% triggers escalation of care. A further prospective study will be required to determine the clinical significance of these apneic events and whether alleviating these events will improve the safety and outcomes of bronchoscopic procedures performed under conscious sedation.
    MeSH term(s) Bronchoscopy/adverse effects ; Bronchoscopy/methods ; Conscious Sedation/adverse effects ; Conscious Sedation/methods ; Humans ; Incidence ; Oxygen ; Propofol/adverse effects ; Prospective Studies ; Sleep Apnea, Central/chemically induced
    Chemical Substances Oxygen (S88TT14065) ; Propofol (YI7VU623SF)
    Language English
    Publishing date 2022-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2478320-1
    ISSN 1948-8270 ; 1944-6586
    ISSN (online) 1948-8270
    ISSN 1944-6586
    DOI 10.1097/LBR.0000000000000837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4027: Show issues Location:
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  9. Article ; Online: Isolation, molecular characterization and preliminary screening for probiotic properties of lactobacillus fermentum from indigenous dahi

    Farid Wajiha / Masud Tariq / Sohail Asma

    E3S Web of Conferences, Vol 332, p

    2021  Volume 06004

    Abstract: Indigenous dahi is an analogue to fermented milk product of Pakistan produce by uncharacterized strains of LAB. It hides lots of health beneficial properties and unexplored micro-flora. On microbial examination of indigenous dahi, it was found that L. ... ...

    Abstract Indigenous dahi is an analogue to fermented milk product of Pakistan produce by uncharacterized strains of LAB. It hides lots of health beneficial properties and unexplored micro-flora. On microbial examination of indigenous dahi, it was found that L. fermentum was most dominant spp. (22 isolates) of LAB in it. Upon safety assessment eleven showed negative hemolytic and gelatinase activity. All these eleven strains were molecularly characterized through PCR by using universal primers (9F and 1510R). Obtained sequences were submitted to Gene data base of NCBI under accession numbers KX944639-42, KX957930-33 and KY069971-73. Furthermore these strains were screened on the basis of acid and bile tolerance and antimicrobial activity. KX957931, KX957932 and KY069973 were selected for further studies of functional attributes.
    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: A PRECEDE-PROCEED model-based educational intervention to promote healthy eating habits in middle school girls.

    Arshad, Asma / Shaheen, Fouzia / Safdar, Waseem / Tariq, Muhammad R / Navid, Muhammad T / Qazi, Asma S / Awan, Mohammad A / Sajid, Muhammad W / Garti, Humphrey K

    Food science & nutrition

    2022  Volume 11, Issue 3, Page(s) 1318–1327

    Abstract: The present study was designed to develop Nutrition Education Program (NEP) based on PRECEDE-PROCEED model (PPM) to address healthy eating behavior among middle school girls aged between 4 and 12 years. For this, middle school girls from grade 1 to 8 ( ...

    Abstract The present study was designed to develop Nutrition Education Program (NEP) based on PRECEDE-PROCEED model (PPM) to address healthy eating behavior among middle school girls aged between 4 and 12 years. For this, middle school girls from grade 1 to 8 (
    Language English
    Publishing date 2022-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703010-6
    ISSN 2048-7177
    ISSN 2048-7177
    DOI 10.1002/fsn3.3167
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