Article ; Online: Primary huge gastric leiomyosarcoma with multiple metastases in a 60-year-old female: a case report.
The Pan African medical journal
2022 Volume 42, Page(s) 223
Abstract: The incidence of leiomyosarcomas (LMS) has declined drastically. In fact, the introduction of immunohistochemistry (IHC) helped to differentiate LMS from other gastrointestinal stromal tumors (GIST) by receptor tyrosine kinase (KIT)-mutation detection ... ...
Abstract | The incidence of leiomyosarcomas (LMS) has declined drastically. In fact, the introduction of immunohistochemistry (IHC) helped to differentiate LMS from other gastrointestinal stromal tumors (GIST) by receptor tyrosine kinase (KIT)-mutation detection making gastric LMS a sporadic tumor recently. We report a 60-year-old female who presented with a three-week history of abdominal pain. An abdominal computed tomography scan showed a large exophytic mass (22 ×19 ×15 cm) arising from the greater curvature of the stomach with multiple metastases. A biopsy was taken, and the initial histopathological examination was suggestive of GIST. However, further histopathological examination confirmed a high-grade gastric LMS. The patient refused any surgical intervention. Therefore, the patient had only received chemotherapy. On 9-month follow-up, the patient is still alive without disease progression. In conclusion, gastric LMS is a rare tumor. Due to the possibility of being misdiagnosed with other GIST, extensive pathological evaluation through specialized experts and IHC analysis is recommended. |
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MeSH term(s) | Female ; Humans ; Middle Aged ; Gastrointestinal Stromal Tumors/pathology ; Leiomyosarcoma/pathology ; Stomach Neoplasms/diagnosis ; Biopsy |
Language | English |
Publishing date | 2022-07-21 |
Publishing country | Uganda |
Document type | Case Reports |
ZDB-ID | 2514347-5 |
ISSN | 1937-8688 ; 1937-8688 |
ISSN (online) | 1937-8688 |
ISSN | 1937-8688 |
DOI | 10.11604/pamj.2022.42.223.35513 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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