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Article: Prosthetic Joint Infection: Updates on Prevention, Diagnosis and Therapy.

Gallo, Jiri

2020 Volume 9, Issue 12

Abstract: Total joint arthroplasty (TJA) delivers highly valuable outcomes to patients with end-stage joint diseases [ ... ]. ...

Abstract	Total joint arthroplasty (TJA) delivers highly valuable outcomes to patients with end-stage joint diseases [...].
Language	English
Publishing date	2020-11-30
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9123892
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prosthetic Joint Infection

Jiri Gallo

Journal of Clinical Medicine, Vol 9, Iss 3892, p

Updates on Prevention, Diagnosis and Therapy

2020 Volume 3892

Abstract: Total joint arthroplasty (TJA) delivers highly valuable outcomes to patients with end-stage joint diseases [.] ...

Abstract	Total joint arthroplasty (TJA) delivers highly valuable outcomes to patients with end-stage joint diseases [.]
Keywords	n/a ; Medicine ; R
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Combined and intravenous administration of TXA reduces blood loss more than topical administration in primary total knee arthroplasty

Jiri Lostak / Jiri Gallo / Lubos Balaz / Jana Zapletalova

Biomedical Papers, Vol 166, Iss 1, Pp 68-

A randomized clinical trial

2022 Volume 76

Abstract: Aim. To determine the most effective administration of tranexamic acid (TXA) in patients with primary total knee arthroplasty (TKA). Material and Method. We enrolled a total of 400 patients (154 men and 346 women) in this randomized trial (4 groups, each ...

Abstract	Aim. To determine the most effective administration of tranexamic acid (TXA) in patients with primary total knee arthroplasty (TKA). Material and Method. We enrolled a total of 400 patients (154 men and 346 women) in this randomized trial (4 groups, each of 100 patients). The first group (IV1) had a single intravenous dose (15 mg TXA/kg) prior to skin incision. Group 2 (IV2) had TXA in 2 intravenous doses (15 mg TXA/kg): prior to skin incision and 6 hours after the first dose. Group 3 (TOP) had 2 g TXA in 50 mL of saline irrigated topically at the end of the surgery. The fourth group (COMB) combined IV1 and TOP regimens. We monitored the amount of total blood loss (TBL), haemoglobin drop, use of blood transfusions (BTs), and complications in each patient. Results. The amount of TBL was significantly lower in IV1, IV2 and COMB regimens compared to the TOP (P<0.0001). The lowest decrease in haemoglobin within 12 hours after surgery was observed in intravenous regimens (P=0.045). A significant difference in haemoglobin decrease on day 1 after the surgery was demonstrated in the COMB and intravenous regimens (P=0.011). Conclusion. In primary TKA, it is preferable to administer TXA intravenously in two doses or in a combined regimen. Simple topical administration of TXA was not as effective and is indicated only in cases where systemic administration of TXA is contraindicated. No substantial complications occurred in either group of patients.
Keywords	total knee arthroplasty ; tranexamic acid ; topical administration ; intravenous administration ; combined administration ; randomized clinical trial ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Palacký University Olomouc, Faculty of Medicine and Dentistry
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Corrigendum to 'Gender Differences in Contribution of Smoking, Low Physical Activity, and High BMI to Increased Risk of Early Reoperation After TKA' [The Journal of Arthroplasty 35 (2020) 1545-1557].

Gallo, Jiri / Kriegova, Eva / Kudelka, Milos / Lostak, Jiri / Radvansky, Martin

The Journal of arthroplasty

2020 Volume 35, Issue 9, Page(s) 2694

Language	English
Publishing date	2020-06-24
Publishing country	United States
Document type	Published Erratum
ZDB-ID	632770-9
ISSN	1532-8406 ; 0883-5403
ISSN (online)	1532-8406
ISSN	0883-5403
DOI	10.1016/j.arth.2020.06.001
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Article: Combined and intravenous administration of TXA reduces blood loss more than topical administration in primary total knee arthroplasty: A randomized clinical trial.

Lostak, Jiri / Gallo, Jiri / Balaz, Lubos / Zapletalova, Jana

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia

2020 Volume 166, Issue 1, Page(s) 68–76

Abstract: Aim: To determine the most effective administration of tranexamic acid (TXA) in patients with primary total knee arthroplasty (TKA).: Material and method: We enrolled a total of 400 patients (154 men and 346 women) in this randomized trial (4 groups, ...

Abstract	Aim: To determine the most effective administration of tranexamic acid (TXA) in patients with primary total knee arthroplasty (TKA). Material and method: We enrolled a total of 400 patients (154 men and 346 women) in this randomized trial (4 groups, each of 100 patients). The first group (IV1) had a single intravenous dose (15 mg TXA/kg) prior to skin incision. Group 2 (IV2) had TXA in 2 intravenous doses (15 mg TXA/kg): prior to skin incision and 6 hours after the first dose. Group 3 (TOP) had 2 g TXA in 50 mL of saline irrigated topically at the end of the surgery. The fourth group (COMB) combined IV1 and TOP regimens. We monitored the amount of total blood loss (TBL), haemoglobin drop, use of blood transfusions (BTs), and complications in each patient. Results: The amount of TBL was significantly lower in IV1, IV2 and COMB regimens compared to the TOP (P<0.0001). The lowest decrease in haemoglobin within 12 hours after surgery was observed in intravenous regimens (P=0.045). A significant difference in haemoglobin decrease on day 1 after the surgery was demonstrated in the COMB and intravenous regimens (P=0.011). Conclusion: In primary TKA, it is preferable to administer TXA intravenously in two doses or in a combined regimen. Simple topical administration of TXA was not as effective and is indicated only in cases where systemic administration of TXA is contraindicated. No substantial complications occurred in either group of patients.
MeSH term(s)	Administration, Intravenous ; Administration, Topical ; Antifibrinolytic Agents ; Arthroplasty, Replacement, Knee ; Blood Loss, Surgical/prevention & control ; Female ; Humans ; Male ; Tranexamic Acid
Chemical Substances	Antifibrinolytic Agents ; Tranexamic Acid (6T84R30KC1)
Language	English
Publishing date	2020-10-15
Publishing country	Czech Republic
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	17196-7
ISSN	1804-7521 ; 1213-8118 ; 0231-5599 ; 0862-481X
ISSN (online)	1804-7521
ISSN	1213-8118 ; 0231-5599 ; 0862-481X
DOI	10.5507/bp.2020.045
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Article: Prevention of Prosthetic Joint Infection: From Traditional Approaches towards Quality Improvement and Data Mining.

Gallo, Jiri / Nieslanikova, Eva

Journal of clinical medicine

2020 Volume 9, Issue 7

Abstract: A projected increased use of total joint arthroplasties will naturally result in a related increase in the number of prosthetic joint infections (PJIs). Suppression of the local peri-implant immune response counters efforts to eradicate bacteria, ... ...

Abstract	A projected increased use of total joint arthroplasties will naturally result in a related increase in the number of prosthetic joint infections (PJIs). Suppression of the local peri-implant immune response counters efforts to eradicate bacteria, allowing the formation of biofilms and compromising preventive measures taken in the operating room. For these reasons, the prevention of PJI should focus concurrently on the following targets: (i) identifying at-risk patients; (ii) reducing "bacterial load" perioperatively; (iii) creating an antibacterial/antibiofilm environment at the site of surgery; and (iv) stimulating the local immune response. Despite considerable recent progress made in experimental and clinical research, a large discrepancy persists between proposed and clinically implemented preventative strategies. The ultimate anti-infective strategy lies in an optimal combination of all preventative approaches into a single "clinical pack", applied rigorously in all settings involving prosthetic joint implantation. In addition, "anti-infective" implants might be a choice in patients who have an increased risk for PJI. However, further progress in the prevention of PJI is not imaginable without a close commitment to using quality improvement tools in combination with continual data mining, reflecting the efficacy of the preventative strategy in a particular clinical setting.
Language	English
Publishing date	2020-07-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9072190
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Article: Nutraceutika v terapii gonartrózy: pohled ortopeda.

Gallo, Jiří

Vnitrni lekarstvi

2018 Volume 64, Issue 2, Page(s) 191–196

Abstract: Knee osteoarthritis is one of the most frequent diagnoses of load-carrying joints encountered in orthopaedic surgeons offices. Depending on the clinical stage, the therapy starts with conservative treatment. Corrective osteotomy is indicated in younger ... ...

Title translation	Nutraceuticals in therapy of knee osteoarthritis: orthopaedic view.
Abstract	Knee osteoarthritis is one of the most frequent diagnoses of load-carrying joints encountered in orthopaedic surgeons offices. Depending on the clinical stage, the therapy starts with conservative treatment. Corrective osteotomy is indicated in younger patients without an extensive and serious impairment. Implantation of TKR (total knee replacement) is usually indicated in more advanced stages. One of the pillars of conservative therapy is analgesics and non-steroidal antirheumatic drugs. A specific group consists of perorally administered drugs for suppression of symptoms or even deceleration of knee osteoarthrosis. These products are popular mainly thanks to their good tolerance and minimal side effects. The clinical effect ranges between minimal and medium depending on the degree of osteoarthrosis, type of drug and study. Similar to rheumatologists, orthopaedic surgeons also find it difficult to identify candidates suitable for a particular type of therapy, except indication for TKR. By all means, nutraceuticals are still considered part of clinical practice.Key words: chondroitin sulphate - glucosamine sulphate - knee osteoarthrosis - methylsulfonylmethane - nutraceuticals - pharmaceutical intervention.
MeSH term(s)	Chondroitin Sulfates/therapeutic use ; Dietary Supplements ; Glucosamine/therapeutic use ; Humans ; Osteoarthritis, Knee
Chemical Substances	Chondroitin Sulfates (9007-28-7) ; Glucosamine (N08U5BOQ1K)
Language	Czech
Publishing date	2018-03-28
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	138213-5
ISSN	1801-7592 ; 0042-773X
ISSN (online)	1801-7592
ISSN	0042-773X
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Article ; Online: Macrophage Polarization and the Osteoimmunology of Periprosthetic Osteolysis.

Goodman, Stuart B / Gibon, Emmanuel / Gallo, Jiri / Takagi, Michiaki

Current osteoporosis reports

2022 Volume 20, Issue 1, Page(s) 43–52

Abstract: Purpose of review: Joint replacement has revolutionized the treatment of end-stage arthritis. We highlight the key role of macrophages in the innate immune system in helping to ensure that the prosthesis-host interface remains biologically robust.: ... ...

Abstract	Purpose of review: Joint replacement has revolutionized the treatment of end-stage arthritis. We highlight the key role of macrophages in the innate immune system in helping to ensure that the prosthesis-host interface remains biologically robust. Recent findings: Osteoimmunology is of great interest to researchers investigating the fundamental biological and material aspects of joint replacement. Constant communication between cells of the monocyte/macrophage/osteoclast lineage and the mesenchymal stem cell-osteoblast lineage determines whether a durable prosthesis-implant interface is obtained, or whether implant loosening occurs. Tissue and circulating monocytes/macrophages provide local surveillance of stimuli such as the presence of byproducts of wear and can quickly polarize to pro- and anti-inflammatory phenotypes to re-establish tissue homeostasis. When these mechanisms fail, periprosthetic osteolysis results in progressive bone loss and painful failure of mechanical fixation. Immune modulation of the periprosthetic microenvironment is a potential intervention to facilitate long-term durability of prosthetic interfaces.
MeSH term(s)	Arthroplasty, Replacement ; Humans ; Joint Prosthesis ; Macrophages ; Osteolysis ; Prosthesis Failure
Language	English
Publishing date	2022-02-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2186581-4
ISSN	1544-2241 ; 1544-1873
ISSN (online)	1544-2241
ISSN	1544-1873
DOI	10.1007/s11914-022-00720-3
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Article ; Online: Prevention of Prosthetic Joint Infection

Jiri Gallo / Eva Nieslanikova

Journal of Clinical Medicine, Vol 9, Iss 2190, p

From Traditional Approaches towards Quality Improvement and Data Mining

2020 Volume 2190

Abstract	A projected increased use of total joint arthroplasties will naturally result in a related increase in the number of prosthetic joint infections (PJIs). Suppression of the local peri-implant immune response counters efforts to eradicate bacteria, allowing the formation of biofilms and compromising preventive measures taken in the operating room. For these reasons, the prevention of PJI should focus concurrently on the following targets: (i) identifying at-risk patients; (ii) reducing “bacterial load” perioperatively; (iii) creating an antibacterial/antibiofilm environment at the site of surgery; and (iv) stimulating the local immune response. Despite considerable recent progress made in experimental and clinical research, a large discrepancy persists between proposed and clinically implemented preventative strategies. The ultimate anti-infective strategy lies in an optimal combination of all preventative approaches into a single “clinical pack”, applied rigorously in all settings involving prosthetic joint implantation. In addition, “anti-infective” implants might be a choice in patients who have an increased risk for PJI. However, further progress in the prevention of PJI is not imaginable without a close commitment to using quality improvement tools in combination with continual data mining, reflecting the efficacy of the preventative strategy in a particular clinical setting.
Keywords	biomaterial-associated infection ; prosthetic joint infection ; preventative measures ; at-risk patient ; bacterial contamination ; anti-adhesive ; Medicine ; R
Subject code	610
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Friend or foe? Inflammation and the foreign body response to orthopedic biomaterials.

Gibon, Emmanuel / Takakubo, Yuya / Zwingenberger, Stefan / Gallo, Jiri / Takagi, Michiaki / Goodman, Stuart B

Journal of biomedical materials research. Part A

2023

Abstract: The use of biomaterials and implants for joint replacement, fracture fixation, spinal stabilization and other orthopedic indications has revolutionized patient care by reliably decreasing pain and improving function. These surgical procedures always ... ...

Abstract	The use of biomaterials and implants for joint replacement, fracture fixation, spinal stabilization and other orthopedic indications has revolutionized patient care by reliably decreasing pain and improving function. These surgical procedures always invoke an acute inflammatory reaction initially, that in most cases, readily subsides. Occasionally, chronic inflammation around the implant develops and persists; this results in unremitting pain and compromises function. The etiology of chronic inflammation may be specific, such as with infection, or be unknown. The histological hallmarks of chronic inflammation include activated macrophages, fibroblasts, T cell subsets, and other cells of the innate immune system. The presence of cells of the adaptive immune system usually indicates allergic reactions to metallic haptens. A foreign body reaction is composed of activated macrophages, giant cells, fibroblasts, and other cells often distributed in a characteristic histological arrangement; this reaction is usually due to particulate debris and other byproducts from the biomaterials used in the implant. Both chronic inflammation and the foreign body response have adverse biological effects on the integration of the implant with the surrounding tissues. Strategies to mitigate chronic inflammation and the foreign body response will enhance the initial incorporation and longevity of the implant, and thereby, improve long-term pain relief and overall function for the patient. The seminal research performed in the laboratory of Dr. James Anderson and co-workers has provided an inspirational and driving force for our laboratory's work on the interactions and crosstalk among cells of the mesenchymal, immune, and vascular lineages, and orthopedic biomaterials. Dr. Anderson's delineation of the fundamental biologic processes and mechanisms underlying acute and chronic inflammation, the foreign body response, resolution, and eventual functional integration of implants in different organ systems has provided researchers with a strategic approach to the use of biomaterials to improve health in numerous clinical scenarios.
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2099989-6
ISSN	1552-4965 ; 1549-3296 ; 0021-9304
ISSN (online)	1552-4965
ISSN	1549-3296 ; 0021-9304
DOI	10.1002/jbm.a.37599
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