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  1. Article ; Online: Particle sizes of infectious aerosols: implications for infection control.

    Fennelly, Kevin P

    The Lancet. Respiratory medicine

    2020  Volume 8, Issue 9, Page(s) 914–924

    Abstract: The global pandemic of COVID-19 has been associated with infections and deaths among health-care workers. This Viewpoint of infectious aerosols is intended to inform appropriate infection control measures to protect health-care workers. Studies of cough ... ...

    Abstract The global pandemic of COVID-19 has been associated with infections and deaths among health-care workers. This Viewpoint of infectious aerosols is intended to inform appropriate infection control measures to protect health-care workers. Studies of cough aerosols and of exhaled breath from patients with various respiratory infections have shown striking similarities in aerosol size distributions, with a predominance of pathogens in small particles (<5 μm). These are immediately respirable, suggesting the need for personal respiratory protection (respirators) for individuals in close proximity to patients with potentially virulent pathogens. There is no evidence that some pathogens are carried only in large droplets. Surgical masks might offer some respiratory protection from inhalation of infectious aerosols, but not as much as respirators. However, surgical masks worn by patients reduce exposures to infectious aerosols to health-care workers and other individuals. The variability of infectious aerosol production, with some so-called super-emitters producing much higher amounts of infectious aerosol than most, might help to explain the epidemiology of super-spreading. Airborne infection control measures are indicated for potentially lethal respiratory pathogens such as severe acute respiratory syndrome coronavirus 2.
    MeSH term(s) Aerosols ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Health Personnel ; Humans ; Infection Control/methods ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Inhalation Exposure/prevention & control ; Pandemics ; Particle Size ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; SARS-CoV-2
    Chemical Substances Aerosols
    Keywords covid19
    Language English
    Publishing date 2020-07-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(20)30323-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pulmonary Rehabilitation for Post-Tuberculosis Lung Disease.

    Anidi, Ifeanyichukwu U / Kirenga, Bruce / Fennelly, Kevin P

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 11, Page(s) 1246–1247

    MeSH term(s) Humans ; Lung Diseases/rehabilitation ; Tuberculosis
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202309-1571LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Abandon the Acid-Fast Bacilli Smear for Patients With TB on Effective Treatment.

    Cooper, Ryan / Williams, Margaret / Fennelly, Kevin P

    Chest

    2023  Volume 164, Issue 1, Page(s) 21–23

    MeSH term(s) Humans ; Tuberculosis, Pulmonary ; Mycobacterium tuberculosis ; Treatment Outcome ; Sputum
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Intramural
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Aerosol Sampling Outperforms Sputum to Predict Mycobacterium tuberculosis Transmission.

    Acuña-Villaorduña, Carlos / Fennelly, Kevin P / Jones-López, Edward C

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 7, Page(s) 1072

    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Particle sizes of infectious aerosols: implications for infection control

    Fennelly, Kevin P

    Lancet Respir Med

    Abstract: The global pandemic of COVID-19 has been associated with infections and deaths among health-care workers. This Viewpoint of infectious aerosols is intended to inform appropriate infection control measures to protect health-care workers. Studies of cough ... ...

    Abstract The global pandemic of COVID-19 has been associated with infections and deaths among health-care workers. This Viewpoint of infectious aerosols is intended to inform appropriate infection control measures to protect health-care workers. Studies of cough aerosols and of exhaled breath from patients with various respiratory infections have shown striking similarities in aerosol size distributions, with a predominance of pathogens in small particles (<5 µm). These are immediately respirable, suggesting the need for personal respiratory protection (respirators) for individuals in close proximity to patients with potentially virulent pathogens. There is no evidence that some pathogens are carried only in large droplets. Surgical masks might offer some respiratory protection from inhalation of infectious aerosols, but not as much as respirators. However, surgical masks worn by patients reduce exposures to infectious aerosols to health-care workers and other individuals. The variability of infectious aerosol production, with some so-called super-emitters producing much higher amounts of infectious aerosol than most, might help to explain the epidemiology of super-spreading. Airborne infection control measures are indicated for potentially lethal respiratory pathogens such as severe acute respiratory syndrome coronavirus 2.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #670335
    Database COVID19

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  6. Article ; Online: Particle sizes of infectious aerosols

    Fennelly, Kevin P

    reponame:Expeditio Repositorio Institucional UJTL ; instname:Universidad de Bogotá Jorge Tadeo Lozano

    implications for infection control

    2020  

    Abstract: The global pandemic of COVID-19 has been associated with infections and deaths among health-care workers. This Viewpoint of infectious aerosols is intended to inform appropriate infection control measures to protect health-care workers. Studies of cough ... ...

    Abstract The global pandemic of COVID-19 has been associated with infections and deaths among health-care workers. This Viewpoint of infectious aerosols is intended to inform appropriate infection control measures to protect health-care workers. Studies of cough aerosols and of exhaled breath from patients with various respiratory infections have shown striking similarities in aerosol size distributions, with a predominance of pathogens in small particles (<5 µm). These are immediately respirable, suggesting the need for personal respiratory protection (respirators) for individuals in close proximity to patients with potentially virulent pathogens. There is no evidence that some pathogens are carried only in large droplets. Surgical masks might offer some respiratory protection from inhalation of infectious aerosols, but not as much as respirators. However, surgical masks worn by patients reduce exposures to infectious aerosols to health-care workers and other individuals. The variability of infectious aerosol production, with some socalled super-emitters producing much higher amounts of infectious aerosol than most, might help to explain the epidemiology of super-spreading. Airborne infection control measures are indicated for potentially lethal respiratory pathogens such as severe acute respiratory syndrome coronavirus 2.
    Keywords Infectious aerosols ; COVID-19 ; Síndrome respiratorio agudo grave ; SARS-CoV-2 ; Coronavirus ; covid19
    Publisher The Lancet
    Publishing country co
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Tuberculosis: First in Flight.

    Fennelly, Kevin P / Martinez, Leonardo / Mandalakas, Anna Maria

    American journal of respiratory and critical care medicine

    2021  Volume 205, Issue 3, Page(s) 272–274

    MeSH term(s) Aerosols ; Humans ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology
    Chemical Substances Aerosols
    Language English
    Publishing date 2021-12-14
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202111-2513ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Snoring may transmit infectious aerosols from the upper to the lower respiratory tract.

    Bax, Adriaan / Shen, Yang / Kakeshpour, Tayeb / Fennelly, Kevin P

    Medical hypotheses

    2022  Volume 168, Page(s) 110966

    Abstract: Migration to the lungs of an initial upper airway infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or other respiratory pathogens can lead to pneumonia, associated with progression from mild to severe symptoms. Chemical ... ...

    Abstract Migration to the lungs of an initial upper airway infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or other respiratory pathogens can lead to pneumonia, associated with progression from mild to severe symptoms. Chemical pneumonitis or bacterial pneumonia may be caused by the 'macroaspiration' of large volumes of oropharyngeal or gastroesophageal secretions into the lower respiratory tract. 'Microaspiration',
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2022.110966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: What is in a cough?

    Fennelly, Kevin P

    International journal of mycobacteriology

    2016  Volume 5 Suppl 1, Page(s) S51

    Abstract: ... and 30%, respectively, p=0.009). In adjusted multivariate analyses, high cough aerosols were the only ...

    Abstract Objective/background: The aims of this talk are to: (a) provide an overview of our method of collecting, quantifying, and sizing infectious aerosols of Mycobacterium tuberculosis; and (b) to review data indicating that cough aerosol cultures of M. tuberculosis are the best predictors of infection and incident disease among household contacts of persons with active tuberculosis (TB). New infection was defined as tuberculin skin test conversion.
    Methods: We developed a cough aerosol sampling system by placing two Andersen cascade impactor viability samplers inside a cylinder into which patients cough via connector tubing. We recruited sputum acid fast bacilli (AFB) smear-positive patients from the tuberculosis clinic and wards at Mulago Hospital in Kampala, Uganda. Patients were asked to cough as strongly and frequently as they comfortably could for two 5-min sessions of coughing.
    Results: In a cohort of 96 sputum culture positive index TB cases, 43 (45%) produced culture-positive cough aerosols. Household contacts of TB patients who produced high aerosols (⩾10colony forming units (CFU)) were more likely to have a new infection compared with contacts with low aerosol CFU (1-9CFU) and aerosol-negative cases (69%, 25%, and 30%, respectively, p=0.009). In adjusted multivariate analyses, high cough aerosols were the only predictor of new TB infection (odds ratio [OR] 4.81; 1.20-19.23). In a follow-up (median 3.9years) of this cohort, 369 (84%) of the contacts could be traced; eight (2%) had developed TB disease. Incident TB disease was associated with larger bacillary load in sputum measured by days to positive in liquid culture (OR 7.9; 0.7-70.5), exposure to a high-aerosol TB case patient (OR 6.0, 1.4-25.2) and marginally to HIV infection in the contact (OR 7.2; 0.7-70.5). Cough aerosol studies of TB patients in Brazil and South Africa are ongoing and appear to be finding similar proportions of cough aerosol cultures among TB patients (personal communication).
    Conclusion: Cough aerosol cultures of M. tuberculosis are the best predictors of infectiousness and predict incident TB disease among sputum smear-positive patients in Uganda. We propose that cough aerosol cultures are a better surrogate of inhaled dose than sputum smear.
    Language English
    Publishing date 2016-12
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2212-554X
    ISSN (online) 2212-554X
    DOI 10.1016/j.ijmyco.2016.10.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Evaluation of a modified small membrane filtration method.

    Fennelly, Kevin P

    Journal of clinical microbiology

    2014  Volume 52, Issue 12, Page(s) 4447

    MeSH term(s) Bacteriological Techniques/methods ; Female ; Filtration/methods ; Humans ; Male ; Microscopy/methods ; Mycobacterium tuberculosis/isolation & purification ; Specimen Handling/methods ; Sputum/microbiology ; Tuberculosis, Pulmonary/diagnosis
    Language English
    Publishing date 2014-12
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.02567-14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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