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  1. Article ; Online: Predictability of rotational tooth movement with orthodontic aligners comparing software-based and achieved data: A systematic review and meta-analysis of observational studies.

    Koletsi, Despina / Iliadi, Anna / Eliades, Theodore

    Journal of orthodontics

    2021  Volume 48, Issue 3, Page(s) 277–287

    Abstract: Objective: To evaluate all available evidence on the prediction of rotational tooth movements with aligners.: Data sources: Seven databases of published and unpublished literature were searched up to 4 August 2020 for eligible studies.: Data ... ...

    Abstract Objective: To evaluate all available evidence on the prediction of rotational tooth movements with aligners.
    Data sources: Seven databases of published and unpublished literature were searched up to 4 August 2020 for eligible studies.
    Data selection: Studies were deemed eligible if they included evaluation of rotational tooth movement with any type of aligner, through the comparison of software-based and actually achieved data after patient treatment.
    Data extraction and data synthesis: Data extraction was done independently and in duplicate and risk of bias assessment was performed with the use of the QUADAS-2 tool. Random effects meta-analyses with effect sizes and their 95% confidence intervals (CIs) were performed and the quality of the evidence was assessed through GRADE.
    Results: Seven articles were included in the qualitative synthesis, of which three contributed to meta-analyses. Overall results revealed a non-accurate prediction of the outcome for the software-based data, irrespective of the use of attachments or interproximal enamel reduction (IPR). Maxillary canines demonstrated the lowest percentage accuracy for rotational tooth movement (three studies: effect size = 47.9%; 95% CI = 27.2-69.5;
    Conclusion: Allowing for all identified caveats, prediction of rotational tooth movements with aligner treatment does not appear accurate, especially for canines. Careful selection of patients and malocclusions for aligner treatment decisions remain challenging.
    MeSH term(s) Cuspid ; Humans ; Incisor ; Malocclusion ; Observational Studies as Topic ; Software ; Tooth Movement Techniques
    Language English
    Publishing date 2021-06-27
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2011954-9
    ISSN 1465-3133 ; 0301-228X ; 1465-3125
    ISSN (online) 1465-3133
    ISSN 0301-228X ; 1465-3125
    DOI 10.1177/14653125211027266
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  2. Article: Particulate Production and Composite Dust during Routine Dental Procedures. A Systematic Review with Meta-Analyses.

    Iliadi, Anna / Koletsi, Despina / Eliades, Theodore / Eliades, George

    Materials (Basel, Switzerland)

    2020  Volume 13, Issue 11

    Abstract: Composite dust generation is most likely a continuous and daily procedure in dental practice settings. The aim of this systematic review was to identify, compile and evaluate existing evidence on interventions and composite material properties related to ...

    Abstract Composite dust generation is most likely a continuous and daily procedure in dental practice settings. The aim of this systematic review was to identify, compile and evaluate existing evidence on interventions and composite material properties related to the production of aerosolized dust during routine dental procedures. Seven electronic databases were searched, with no limits, supplemented by a manual search, on 27 April 2020 for published and unpublished research. Eligibility criteria comprised of studies of any design, describing composite dust production related to the implementation of any procedure in dental practice. Study selection, data extraction and risk of bias (RoB) assessment was undertaken independently either in duplicate, or confirmed by a second reviewer. Random effects meta-analyses of standardized mean differences (SMD) with associated 95% confidence intervals (CIs) were employed where applicable. A total of 375 articles were initially identified, resulting in 13 articles being included in the qualitative synthesis, of which 5 contributed to meta-analyses overall. Risk of bias recordings ranged between low and high, pertaining to unclear/raising some concerns, in most cases. All types of composites, irrespective of the filler particles, released significant amounts of nano-sized particles after being ground, with potentially disruptive respiratory effects. Evidence supported increased % distribution of particles < 100 nm for nanocomposite Filtek Supreme XTE compared to both conventional hybrid Z100MP (SMD: 1.96, 95% CI: 0.85, 3.07; p-value; 0.001) and nano- hybrid Tetric EvoCeram (SMD: 1.62, 95% CI: 0.56, 2.68; p-value: 0.003). For cytotoxicity considerations of generated aerosolized particles, both nanocomposites Filtek Supreme XTE and nanohybrid GradiO revealed negative effects on bronchial epithelial cell viability, as represented by % formazan reduction at 330-400 μg/ml for 24 hours, with no recorded differences between them (SMD: 0.19; 95% CI: -0.17, 0.55; p-value: 0.30). Effective and more rigorous management of dental procedures potentially liable to the generation of considerable amounts of aerosolized composite dust should be prioritized in contemporary dental practice. In essence, protective measures for the clinician and the practices' personnel should also be systematically promoted and additional interventions may be considered in view of the existing evidence.
    Keywords covid19
    Language English
    Publishing date 2020-05-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma13112513
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  3. Article ; Online: Εffect of cleansers on the composition and mechanical properties of orthodontic aligners in vitro.

    Iliadi, Anna / Enzler, Vera / Polychronis, Georgios / Peltomaki, Timo / Zinelis, Spiros / Eliades, Theodore

    Progress in orthodontics

    2022  Volume 23, Issue 1, Page(s) 54

    Abstract: Background: The aim of the study was to investigate the effect of three aligner cleaners on the composition and mechanical properties of two types of orthodontic aligners.: Materials and methods: The cleaners tested were two alkaline peroxide ... ...

    Abstract Background: The aim of the study was to investigate the effect of three aligner cleaners on the composition and mechanical properties of two types of orthodontic aligners.
    Materials and methods: The cleaners tested were two alkaline peroxide solutions (Retainer Brite-RB; Retainer Cleaner-RC) and one peroxide-free (Steraligner-ST) and the aligners Clear Aligner (C, polyester) and Invisalign (I, polyester-urethane). The aligners were immersed in the cleaner solutions as instructed every day (15 min for RB, RC; 5 min for ST) for a two-week period. The acidity of the solutions was tested with a pH meter. The changes in the chemical composition of the aligners were studied by attenuated total-reflection Fourier transform infrared spectrometry (ATR-FTIR), while Instrumented Indentation Testing (IIT) was used for assessment of changes in Martens Hardness (HM), modulus (E
    Results: RB and RC were weakly acidic (pH = 6.3), whereas ST was mildly acidic (pH = 4.8). The ATR-FTIR analysis demonstrated evidence of acidic hydrolysis of C in ST and I in RB. The IIT-derived properties of I were not affected by the cleaners. However, for C a significant change was found in HM (all cleaners), n
    Conclusions: Caution should be exerted in the selection of aligner cleaners. The mild acidic cleanser was more aggressive to the polyester, whereas an alkaline peroxide to the polyester-urethane aligner.
    MeSH term(s) Humans ; Materials Testing ; Hardness ; Orthodontic Appliances, Removable ; Polyesters ; Urethane
    Chemical Substances Polyesters ; Urethane (3IN71E75Z5)
    Language English
    Publishing date 2022-12-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2040711-7
    ISSN 2196-1042 ; 1600-9975 ; 1723-7785 ; 1399-7513
    ISSN (online) 2196-1042 ; 1600-9975
    ISSN 1723-7785 ; 1399-7513
    DOI 10.1186/s40510-022-00449-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5560: Show issues Location:
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  4. Article ; Online: Cytotoxicity and estrogenicity of a novel 3-dimensional printed orthodontic aligner.

    Pratsinis, Harris / Papageorgiou, Spyridon N / Panayi, Nearchos / Iliadi, Anna / Eliades, Theodore / Kletsas, Dimitris

    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics

    2022  Volume 162, Issue 3, Page(s) e116–e122

    Abstract: Introduction: Orthodontic aligners printed with in-office 3-dimensional (3D) procedures have been described, but no data on their biocompatibility exist. This study investigates the cytotoxicity and estrogenicity of a 3D-printed orthodontic aligner by ... ...

    Abstract Introduction: Orthodontic aligners printed with in-office 3-dimensional (3D) procedures have been described, but no data on their biocompatibility exist. This study investigates the cytotoxicity and estrogenicity of a 3D-printed orthodontic aligner by assessing its biological and behavioral effects.
    Methods: Ten sets of 1 type of aligner were immersed in sterile deionized water for 14 days, and the cytotoxicity and estrogenicity of released factors were assessed via MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assays on human gingival fibroblasts and the estrogen-sensitive MCF-7 and the estrogen-insensitive MDA-MB-231 breast cancer cell lines. 17β-Estradiol and bisphenol-A were used as positive controls. The statistical analysis of data was performed with generalized linear models at a 0.05 level of significance.
    Results: No signs of cytotoxicity were seen for the aligner samples for concentrations (v/v) of 20% (P = 0.32), 10% (P = 0.79), or 5% (P = 0.76). The antioxidant activity expressed as the capacity to reduce intracellular levels of reactive oxygen species was not affected in the aligner samples (P = 0.08). No significant estrogenicity was induced by the aligner samples compared with eluents from the negative control for both MCF-7 (P = 0.65) and MDA-MB-231 (P = 0.78). As expected, 17β-Estradiol and bisphenol-A stimulated MCF-7 cell proliferation, whereas no effect was observed on MDA-MB-231 cells.
    Conclusions: In conclusion, if any factors were released during the 14-day aging of 3D-printed aligners in water, these were not found to be cytotoxic for human gingival fibroblasts and did not affect their intracellular reactive oxygen species levels. Moreover, no estrogenic effects of these putative eluates were observed based on an E-screen assay.
    MeSH term(s) Estradiol/pharmacology ; Estrogens/pharmacology ; Humans ; Oxygen ; Printing, Three-Dimensional ; Water
    Chemical Substances Estrogens ; Water (059QF0KO0R) ; Estradiol (4TI98Z838E) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 356699-7
    ISSN 1097-6752 ; 0889-5406 ; 0002-9416
    ISSN (online) 1097-6752
    ISSN 0889-5406 ; 0002-9416
    DOI 10.1016/j.ajodo.2022.06.014
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    Ul III Zs.73: Show issues Location:
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  5. Article: In Vitro Simulation and In Vivo Assessment of Tooth Wear: A Meta-Analysis of In Vitro and Clinical Research.

    Koletsi, Despina / Iliadi, Anna / Eliades, Theodore / Eliades, George

    Materials (Basel, Switzerland)

    2019  Volume 12, Issue 21

    Abstract: Tooth wear may be described as a side-effect of occlusal forces that may be further induced by the common use of contemporary prosthetic materials in practice. The purpose of this systematic review was to appraise existing evidence on enamel wear from ... ...

    Abstract Tooth wear may be described as a side-effect of occlusal forces that may be further induced by the common use of contemporary prosthetic materials in practice. The purpose of this systematic review was to appraise existing evidence on enamel wear from both in vitro and clinical research and explore whether evidence from these study designs lies on the same direction. Five databases of published and unpublished research were searched without limitations in August 2019 and study selection criteria included in vitro and clinical research on enamel tooth wear. Study selection, data extraction, and risk of bias assessment were done independently and in duplicate. Random effects meta-analyses of standardized mean differences (SMDs) or weighted mean differences (WMDs) with 95% confidence intervals (CIs) were conducted while a Monte Carlo permutation test for meta-regression on the exploration of the effect of the study design on the reported outcomes was planned. A total of 27 studies (23 in vitro and 4 clinical) were eligible while 12 contributed to meta-analyses. Overall, some concerns were raised for the quality of the existing evidence and the potential for risk of bias. Enamel wear (mm) of antagonist teeth was more pronounced when opposed to conventional porcelain compared to machinable ceramics (SMD = 2.18; 95%CIs: 1.34, 3.02;
    Language English
    Publishing date 2019-10-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma12213575
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  6. Article ; Online: Forces and moments generated by aligner-type appliances for orthodontic tooth movement: A systematic review and meta-analysis.

    Iliadi, Anna / Koletsi, Despina / Eliades, Theodore

    Orthodontics & craniofacial research

    2019  Volume 22, Issue 4, Page(s) 248–258

    Abstract: The aim of this review was to systematically appraise the evidence on aligner mechanics and forces and moments generated across difference types of aligners. In vitro- laboratory studies for model simulated tooth movement with aligners. Database searches ...

    Abstract The aim of this review was to systematically appraise the evidence on aligner mechanics and forces and moments generated across difference types of aligners. In vitro- laboratory studies for model simulated tooth movement with aligners. Database searches within Medline via Pubmed, Cochrane Central Register of Controlled Trials (CENTRAL), LILACS via BIREME Virtual Health Library. Unpublished literature was also searched in Open Grey, ClinicalTrials.gov (www.clinicaltrials.gov), the National Research Register (www.controlled-trials.com) and Center for Open Science (Open Science Framework), using the terms "aligner" AND "orthodontic". Risk of bias assessment was based on the Cochrane Risk of Bias tool. Random effects meta-analyses were conducted. A total of 447 studies were identified through electronic search and after careful consideration of pre- defined eligibility criteria, 13 deemed eligible for inclusion, while 2 were included in the quantitative synthesis. When palatal tipping of the upper central incisor through PET-G aligners was considered, aligner thickness of 0.5, 0.625 or 0.75 mm was not associated with a significantly different moment to force (M/F) ratio, given a common gingival edge width of 3-4 mm. Aligner thickness does not appear to possess a significant role in forces and moments generated by clear aligners under specific settings, while the most commonly examined tooth movements are tipping and rotation. The findings of this review may be applicable to certain conditions in laboratory settings.
    MeSH term(s) Incisor ; Orthodontic Appliance Design ; Palate ; Rotation ; Tooth Movement Techniques
    Language English
    Publishing date 2019-07-09
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2076514-9
    ISSN 1601-6343 ; 1601-6335
    ISSN (online) 1601-6343
    ISSN 1601-6335
    DOI 10.1111/ocr.12333
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    Zs.A 5412: Show issues Location:
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  7. Article: Safety Considerations for Thermoplastic-Type Appliances Used as Orthodontic Aligners or Retainers. A Systematic Review and Meta-Analysis of Clinical and In-Vitro Research.

    Iliadi, Anna / Koletsi, Despina / Papageorgiou, Spyridon N / Eliades, Theodore

    Materials (Basel, Switzerland)

    2020  Volume 13, Issue 8

    Abstract: Use of thermoplastic material in orthodontics, either as aligner or as retainer appliances, is common practice and is likely to increase in the years to come. However, no systematic assessment on safety considerations of these adjuncts has been ... ...

    Abstract Use of thermoplastic material in orthodontics, either as aligner or as retainer appliances, is common practice and is likely to increase in the years to come. However, no systematic assessment on safety considerations of these adjuncts has been implemented up to date. The aim of this systematic review was to collectively appraise the existing evidence from both clinical and laboratory studies, on whether these appliances are associated with any estrogenic/cytotoxic effects or bisphenol-A (BPA) and monomer leaching. Eight electronic databases were searched with no limits in December 22, 2019, for published and unpublished research. Eligibility criteria comprised of studies of any design, describing use of any type of thermoplastic aligner. Study selection, data extraction and risk of bias (RoB) assessment was done independently, either in duplicate or confirmed by a second reviewer. Random effects meta-analyses of weighted mean differences (WMD) with associated 95% Confidence Intervals (CIs) were planned. Quality of the evidence was evaluated with Grading of Recommendations Assessment, Development and Evaluation (GRADE). A total of 58 articles were initially identified, while 5 were included in qualitative synthesis and 2 of those contributed to the quantitative syntheses. Four studies were in-vitro, while one was a randomized controlled trial; all assessed some type of orthodontic aligner or retainer, either as-received or retrieved. Risk of bias recordings ranged between unclear and high for all studies. Proliferation induction capacity of thermoplastic appliances' eluents on MCF-7 cells failed to be confirmed compared to beta-estradiol (2 studies: 5%
    Language English
    Publishing date 2020-04-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma13081843
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  8. Article ; Online: Cardiovascular Disease and Chronic Endodontic Infection. Is There an Association? A Systematic Review and Meta-Analysis.

    Koletsi, Despina / Iliadi, Anna / Tzanetakis, Giorgos N / Vavuranakis, Manolis / Eliades, Theodore

    International journal of environmental research and public health

    2021  Volume 18, Issue 17

    Abstract: The aim of the present study was to systematically assess existing evidence on the possible association between chronic endodontic infections and cardiovascular disease (CVD). An electronic database search was implemented until 2 October 2020. The main ... ...

    Abstract The aim of the present study was to systematically assess existing evidence on the possible association between chronic endodontic infections and cardiovascular disease (CVD). An electronic database search was implemented until 2 October 2020. The main outcome was risk of CVD diagnosis. Risk of bias was assessed through the ROBINS-I tool, while random effects meta-analyses were conducted. The quality of the evidence was assessed with the Grading of Recommendations Assessment, Development, and Evaluation. Twenty-one studies were eligible for inclusion, while 10 were included in the quantitative synthesis. Risk for CVD diagnosis in patients with chronic endodontic infection was 1.38 times those without infection (RR = 1.38; 95% CIs: 1.06, 1.80;
    MeSH term(s) Cardiovascular Diseases/epidemiology ; Humans
    Language English
    Publishing date 2021-08-29
    Publishing country Switzerland
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph18179111
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  9. Article ; Online: The Greek Urban Policy Reform through the Local Urban Plans (LUPs) and the Special Urban Plans (SUPs), Funded by Recovery and Resilience Facility (RRF)

    Avgi Vassi / Konstantina Siountri / Kalliopi Papadaki / Alkistis Iliadi / Anna Ypsilanti / Efthimios Bakogiannis

    Land, Vol 11, Iss 8, p

    2022  Volume 1231

    Abstract: The lack of defined land uses in most parts of Greece (80%) has led to multiple environmental problems and phenomena of informal (arbitrary) construction with secondary side effects, such as a lack of basic technical and environmental infrastructure, ... ...

    Abstract The lack of defined land uses in most parts of Greece (80%) has led to multiple environmental problems and phenomena of informal (arbitrary) construction with secondary side effects, such as a lack of basic technical and environmental infrastructure, unfair competition among private investors, the strengthening of climate change (increase in the number of urban diffusion) and the decline of natural and cultural resources. The Greek urban policy, over the last 100 years, has not succeeded in limiting these problems and for that reason the new Law 4759/2020 is expected to promote the development of a more efficient spatial planning system reform implemented through the Local Urban Plans (LUPs) and the Special Urban Plans (SUPs) that are funded by the Recovery and Resilience Facility (RRF). These programs will contribute to the preservation of cultural heritage and to the development of productive activities at both local and national levels, especially on the sectors of renewable energy sources, the circular economy, and the construction of “green” materials, digital applications and products etc. LUPs and SUPs are related to the holistic reform of the national urban policy and the relevant planning system that horizontally affects a wide range of policy areas such as: environmental protection and adaptation to climate change (for natural ecosystems and biodiversity; agriculture; forestry; fisheries; water resources; coastal zones), built environment and development, protection of historic sites and buildings, allocation of the public infrastructure, allocation of investments etc. The General Secretariat of Spatial Planning and Urban Environment Ministry of Environment and Energy has the main responsibility for the implementation procedures of all the proposed actions that will start in 2022 and will end in 2026. This paper focuses on the analysis of the current urban policy reform in Greece and the reasons that this reform is considered an immediate necessity in the current Greek urban legislative framework and ...
    Keywords urban policy reform ; built environment ; digitization ; cultural heritage preservation ; green transition ; RRF ; Agriculture ; S
    Subject code 710
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Comment on: Treatment outcome with orthodontic aligners and fixed appliances: a systematic review with meta-analyses.

    Papageorgiou, Spyridon N / Koletsi, Despina / Iliadi, Anna / Peltomäki, Timo / Eliades, Theodore

    European journal of orthodontics

    2020  Volume 42, Issue 3, Page(s) 344–346

    MeSH term(s) Orthodontic Appliances, Fixed ; Orthodontic Appliances, Removable ; Treatment Outcome
    Language English
    Publishing date 2020-06-12
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 423731-6
    ISSN 1460-2210 ; 0141-5387
    ISSN (online) 1460-2210
    ISSN 0141-5387
    DOI 10.1093/ejo/cjz101
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