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  1. Article ; Online: Role of Viscoelastic and Conventional Coagulation Tests for Management of Blood Product Replacement in the Bleeding Patient.

    Matkovic, Eduard / Lindholm, Paul F

    Seminars in thrombosis and hemostasis

    2022  Volume 48, Issue 7, Page(s) 785–795

    Abstract: An important aim of viscoelastic testing (VET) is to implement transfusion algorithms based on coagulation test results to help reduce transfusion rates and improve patient outcomes. Establishing a rapid diagnosis and providing timely treatment of ... ...

    Abstract An important aim of viscoelastic testing (VET) is to implement transfusion algorithms based on coagulation test results to help reduce transfusion rates and improve patient outcomes. Establishing a rapid diagnosis and providing timely treatment of coagulopathy is the cornerstone of management of severely bleeding patients in trauma, postpartum hemorrhage, and major surgery. As the nature of acute bleeding and trauma leads to an unstable and tenuous physiologic state, conventional coagulation tests (CCTs) are too slow to diagnose, manage, and also course correct any hemostatic abnormalities that accompany an acute critical illness. Viscoelastic point-of-care tests strongly correlate with results from standard laboratory tests but are designed to enable clinicians to make timely, informed bleeding management decisions when time to intervene is critical. These assays provide an individualized and goal-oriented approach to patient blood management and are increasingly becoming involved in transfusion algorithms. The scope of this review aims to evaluate the current literature on VETs and their impact on actionable outputs in clinical decision making and their relationship to CCT.
    MeSH term(s) Female ; Humans ; Blood Coagulation Tests/methods ; Hemorrhage/diagnosis ; Hemorrhage/therapy ; Blood Coagulation Disorders/diagnosis ; Blood Coagulation Disorders/therapy ; Blood Transfusion/methods ; Hemostatics ; Thrombelastography/methods ; Wounds and Injuries
    Chemical Substances Hemostatics
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0042-1756192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1259: Show issues Location:
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  2. Article ; Online: Weak or discrepant RhD phenotypes: Laboratory management strategies for local patient populations.

    Barriteau, Christina M / Lindholm, Paul F / Hartman, Karyn / Pugh, Johnathon / Sumugod, Ricardo D / Ramsey, Glenn

    Transfusion

    2024  Volume 64, Issue 4, Page(s) 765–767

    MeSH term(s) Humans ; Phenotype ; Genotype ; Rh-Hr Blood-Group System/genetics ; Alleles
    Chemical Substances Rh-Hr Blood-Group System
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Letter
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 284: Show issues Location:
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  3. Article ; Online: The Central Role of Fibrinolytic Response in COVID-19-A Hematologist's Perspective.

    Kwaan, Hau C / Lindholm, Paul F

    International journal of molecular sciences

    2021  Volume 22, Issue 3

    Abstract: The novel coronavirus disease (COVID-19) has many characteristics common to those in two other coronavirus acute respiratory diseases, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). They are all highly contagious ... ...

    Abstract The novel coronavirus disease (COVID-19) has many characteristics common to those in two other coronavirus acute respiratory diseases, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). They are all highly contagious and have severe pulmonary complications. Clinically, patients with COVID-19 run a rapidly progressive course of an acute respiratory tract infection with fever, sore throat, cough, headache and fatigue, complicated by severe pneumonia often leading to acute respiratory distress syndrome (ARDS). The infection also involves other organs throughout the body. In all three viral illnesses, the fibrinolytic system plays an active role in each phase of the pathogenesis. During transmission, the renin-aldosterone-angiotensin-system (RAAS) is involved with the spike protein of SARS-CoV-2, attaching to its natural receptor angiotensin-converting enzyme 2 (ACE 2) in host cells. Both tissue plasminogen activator (tPA) and plasminogen activator inhibitor 1 (PAI-1) are closely linked to the RAAS. In lesions in the lung, kidney and other organs, the two plasminogen activators urokinase-type plasminogen activator (uPA) and tissue plasminogen activator (tPA), along with their inhibitor, plasminogen activator 1 (PAI-1), are involved. The altered fibrinolytic balance enables the development of a hypercoagulable state. In this article, evidence for the central role of fibrinolysis is reviewed, and the possible drug targets at multiple sites in the fibrinolytic pathways are discussed.
    MeSH term(s) Animals ; COVID-19/blood ; COVID-19/complications ; Drug Discovery ; Fibrinolysis/drug effects ; Humans ; Molecular Targeted Therapy ; Renin-Angiotensin System/drug effects ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Thrombosis/blood ; Thrombosis/drug therapy ; Thrombosis/etiology ; COVID-19 Drug Treatment
    Language English
    Publishing date 2021-01-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22031283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Role of Viscoelastic and Conventional Coagulation Tests for Management of Blood Product Replacement in the Bleeding Patient

    Matkovic, Eduard / Lindholm, Paul F.

    Seminars in Thrombosis and Hemostasis

    (Emerging Use of Viscoelastography in Thrombosis and Hemostasis: A Challenge To Conventional Coagulation Tests?)

    2022  Volume 48, Issue 07, Page(s) 785–795

    Abstract: An important aim of viscoelastic testing (VET) is to implement transfusion algorithms based on coagulation test results to help reduce transfusion rates and improve patient outcomes. Establishing a rapid diagnosis and providing timely treatment of ... ...

    Series title Emerging Use of Viscoelastography in Thrombosis and Hemostasis: A Challenge To Conventional Coagulation Tests?
    Abstract An important aim of viscoelastic testing (VET) is to implement transfusion algorithms based on coagulation test results to help reduce transfusion rates and improve patient outcomes. Establishing a rapid diagnosis and providing timely treatment of coagulopathy is the cornerstone of management of severely bleeding patients in trauma, postpartum hemorrhage, and major surgery. As the nature of acute bleeding and trauma leads to an unstable and tenuous physiologic state, conventional coagulation tests (CCTs) are too slow to diagnose, manage, and also course correct any hemostatic abnormalities that accompany an acute critical illness. Viscoelastic point-of-care tests strongly correlate with results from standard laboratory tests but are designed to enable clinicians to make timely, informed bleeding management decisions when time to intervene is critical. These assays provide an individualized and goal-oriented approach to patient blood management and are increasingly becoming involved in transfusion algorithms. The scope of this review aims to evaluate the current literature on VETs and their impact on actionable outputs in clinical decision making and their relationship to CCT.
    Keywords viscoelastic testing (VET) ; blood transfusions ; coagulopathy ; conventional coagulation tests (CCTs)
    Language English
    Publishing date 2022-09-29
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0042-1756192
    Database Thieme publisher's database

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  5. Article ; Online: Emergent Paradigms of Thrombosis and Cancer (Part II): More on Thrombosis and Cancer.

    Kwaan, Hau C / Lindholm, Paul F

    Seminars in thrombosis and hemostasis

    2019  Volume 45, Issue 6, Page(s) 557–558

    MeSH term(s) Humans ; Neoplasms ; Thrombosis ; Yin-Yang
    Language English
    Publishing date 2019-09-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0039-1694764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Emerging Use of Viscoelastography in Thrombosis and Hemostasis: A Challenge to Conventional Coagulation Tests?-Part II: The Use of Thromboelastography and Thromboelastometry in the Assessment of Clinical Disorders.

    Kwaan, Hau C / Lindholm, Paul F / Othman, Marth / Walsh, Mark

    Seminars in thrombosis and hemostasis

    2022  Volume 49, Issue 2, Page(s) 109–110

    MeSH term(s) Humans ; Thrombelastography ; Blood Coagulation Tests ; Hemostasis ; Thrombosis/diagnosis ; Blood Coagulation Disorders/diagnosis
    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0042-1758061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Emerging Use of Viscoelastography in Thrombosis and Hemostasis: A Challenge to Conventional Coagulation Tests? Part I: The Use of Thromboelastography and Thromboelastometry in the Assessment of Hemostatic Function.

    Kwaan, Hau C / Walsh, Mark / Lindholm, Paul F / Othman, Maha

    Seminars in thrombosis and hemostasis

    2022  Volume 48, Issue 7, Page(s) 767–768

    MeSH term(s) Humans ; Thrombelastography ; Blood Coagulation Tests ; Hemostasis ; Thrombosis/diagnosis ; Hemostatics
    Chemical Substances Hemostatics
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0042-1756700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Emerging Paradigms of Thrombosis and Cancer (Part I): The yin yang Relationship between Thrombosis and Cancer.

    Kwaan, Hau C / Lindholm, Paul F

    Seminars in thrombosis and hemostasis

    2019  Volume 45, Issue 4, Page(s) 319–320

    MeSH term(s) Humans ; Neoplasms/diagnosis ; Neoplasms/pathology ; Thrombosis/diagnosis ; Thrombosis/pathology ; Yin-Yang
    Language English
    Publishing date 2019-06-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0039-1688496
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: P2Y12 inhibitor use predicts hematoma expansion in patients with intracerebral hemorrhage.

    Houskamp, Ethan J / Liu, Yuzhe / Silva Pinheiro do Nascimento, Juliana / Jahromi, Babak S / Lindholm, Paul F / Kwaan, Hau C / Naidech, Andrew M

    Annals of clinical and translational neurology

    2024  

    Abstract: Objective: Hematoma expansion (HE) predicts disability and death after acute intracerebral hemorrhage (ICH). Aspirin and anticoagulants have been associated with HE. We tested the hypothesis that P2Y12 inhibitors predict subsequent HE in patients. We ... ...

    Abstract Objective: Hematoma expansion (HE) predicts disability and death after acute intracerebral hemorrhage (ICH). Aspirin and anticoagulants have been associated with HE. We tested the hypothesis that P2Y12 inhibitors predict subsequent HE in patients. We explored laboratory measures of P2Y12 inhibition and dual antiplatelet therapy with aspirin (DAPT).
    Methods: We prospectively identified patients with ICH. Platelet activity was measured with the VerifyNow-P2Y12 assay. Hematoma volumes for initial and follow-up CTs were calculated using a validated semi-automated technique. HE was defined as the difference between hematoma volumes on the initial and follow-up CT scans. Nonparametric statistics were performed with Kruskal-Wallis H, and correction for multiple comparisons performed with Dunn's test.
    Results: In 194 patients, 15 (7.7%) were known to take a P2Y12 inhibitor (clopidogrel in all but one). Patients taking a P2Y12 inhibitor had more HE compared to patients not taking a P2Y12 inhibitor (3.5 [1.2-11.9] vs. 0.1 [-0.8-1.4] mL, p = 0.004). Patients taking DAPT experienced the most HE (7.2 [2.6-13.8] vs. 0.0 [-1.0-1.1] mL, p = 0.04). The use of P2Y12 inhibitors was associated with less P2Y12 activity (178 [149-203] vs. 288 [246-319] P2Y12 reaction units, p = 0.005).
    Interpretation: Patients taking a P2Y12 inhibitor had more HE and less P2Y12 activity. The effect was most pronounced in patients on DAPT, suggesting a synergistic effect of P2Y12 inhibitors and aspirin with respect to HE. Acute reversal of P2Y12 inhibitors in acute ICH requires further study.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2740696-9
    ISSN 2328-9503 ; 2328-9503
    ISSN (online) 2328-9503
    ISSN 2328-9503
    DOI 10.1002/acn3.52070
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  10. Article ; Online: Preanalytic Competency Assessment: A Q-Probes Study Involving 46 Health Care Institutions, 447 Blood Collectors/Phlebotomists, and 2212 Individual Assessments.

    Stankovic, Ana K / Blond, Barbara J / Coulter, Suzanne N / Long, Thomas / Lindholm, Paul F

    Archives of pathology & laboratory medicine

    2023  Volume 147, Issue 3, Page(s) 304–312

    Abstract: Context.—: Health care organizations face a challenge of assessing preanalytic competency of blood collectors/phlebotomists (BC/Ps).: Objective.—: To pilot a novel methodology for BC/P preanalytic competency assessment and identify potential areas ... ...

    Abstract Context.—: Health care organizations face a challenge of assessing preanalytic competency of blood collectors/phlebotomists (BC/Ps).
    Objective.—: To pilot a novel methodology for BC/P preanalytic competency assessment and identify potential areas for improvement.
    Design.—: Study participants identified preanalytic errors present in 5 blood collection video vignettes. Submitted error descriptions were categorized and then consolidated into a list of standardized required errors for evaluation.
    Results.—: The correct identification of required error rates across all videos viewed by 447 BC/Ps from 46 institutions ranged from 0.7% to 91.9%. The median phlebotomist score across all 5 videos was 55.9% for 440 eligible blood collectors and ranged between 38.2% (10th percentile) and 70.6% (90th percentile). The median institutional score from 42 eligible institutions was 55.9% (range, 43.3%-65.3% for the 10th to 90th percentiles). There were no significant associations between any laboratory practice characteristics and the institutional average overall phlebotomist scores. The following phlebotomist characteristics were significantly associated with overall phlebotomist scores: level of education (P = .01), having phlebotomy technician (American Society for Clinical Pathology) certification compared with no or other certifications (P = .002), years of experience in collecting blood specimens (P = .01), and higher average number of venipuncture specimens collected per shift (P = .001).
    Conclusions.—: Improvement of the awareness and knowledge of correct blood collection practices is needed, because the best performers (90th percentile) did not recognize approximately one-third of the errors. Using hypothetical blood collection scenarios that incorporate performance errors may be a way to assess preanalytic competency of BC/Ps and create opportunities for continuous improvement.
    MeSH term(s) Humans ; United States ; Phlebotomy/methods ; Pathology, Clinical ; Laboratories
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2021-0436-CP
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