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  1. Article ; Online: Parkinson's disease is a recognisable and useful diagnostic entity.

    Obeso, Jose A / Calabressi, Paolo

    The Lancet. Neurology

    2024  Volume 23, Issue 2, Page(s) 133–134

    MeSH term(s) Humans ; Parkinson Disease/diagnosis
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(23)00512-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Parkinsons Disease Cell Vulnerability and Disease Progression

    Obeso, Jose A. / Lanciego, Jose L. / Blesa, Javier

    2015  

    Abstract: Parkinsons disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent ... ...

    Abstract Parkinsons disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis of Parkinsons Disease remains unclear. Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinsons Disease and the molecular pathways of cell death important questions remain regarding why are substantia nigra cells especially vulnerable, which mechanisms underlie progressive cell loss or what do Lewy bodies or alpha-synuclein reveal about disease progression. Understanding the different vulnerability of the dopaminergic neurons from midbrain regions and the mechanisms whereby pathology becomes widespread are primary objectives of basic and clinical research in Parkinsons Disease.This e-Book discusses the etiopathogenesis of Parkinsons Disease, presenting a series of papers that provide up-to-date, state-of-the-art information on molecular and cellular mechanisms involved in the neurodegeneration process in the disease, the role of activation of functional anatomical organization of the basal ganglia and in particular habitual vs goal directed systems as a factor of neuronal vulnerability, the possibility that Parkinsons Disease coulb be a prion disease and how genetic factors linked to familial and sporadic forms of PD. We hope that this e-Book will stimulate the continuing efforts to understand the cell and physiological mechanisms underlying the origin of Parkinsons Disease
    Keywords Neurosciences. Biological psychiatry. Neuropsychiatry ; Science (General)
    Size 1 electronic resource (194 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020091116
    ISBN 9782889196760 ; 2889196763
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: The End of a Cycle: A Unique Perspective in the Evolution of Movement Disorders.

    Obeso, Jose A

    Movement disorders : official journal of the Movement Disorder Society

    2020  Volume 34, Issue 12, Page(s) 1755–1757

    MeSH term(s) Humans ; Movement Disorders/therapy ; Periodicals as Topic
    Language English
    Publishing date 2020-01-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.27954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editor's Note: Deep Brain Stimulation and Functional Neurosurgery for Movement Disorders: Is the Current Cycle Waning?

    Obeso, Jose A

    Movement disorders : official journal of the Movement Disorder Society

    2020  Volume 34, Issue 12, Page(s) 1792–1794

    MeSH term(s) Deep Brain Stimulation/history ; Deep Brain Stimulation/trends ; History, 20th Century ; History, 21st Century ; Humans ; Movement Disorders/surgery ; Movement Disorders/therapy ; Neurosurgery/history ; Neurosurgery/trends ; Parkinson Disease/surgery ; Parkinson Disease/therapy ; Subthalamic Nucleus/surgery
    Language English
    Publishing date 2020-01-09
    Publishing country United States
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.27955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Motor Cortex Disinhibition Is Not Associated with Freezing of Gait in Parkinson's Disease.

    Ammann, Claudia / Oliviero, Antonio / Obeso, José A / Foffani, Guglielmo

    Movement disorders : official journal of the Movement Disorder Society

    2024  Volume 39, Issue 3, Page(s) 625–626

    MeSH term(s) Humans ; Parkinson Disease/complications ; Motor Cortex ; Gait Disorders, Neurologic/complications ; Gait/physiology
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Letter
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.29709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Editor's note: Prodromal Parkinson's disease.

    Obeso, José A

    Movement disorders : official journal of the Movement Disorder Society

    2019  Volume 34, Issue 5, Page(s) 664

    MeSH term(s) Humans ; Parkinson Disease ; Prodromal Symptoms
    Language English
    Publishing date 2019-05-15
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.27707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Editor's note: Functional movement disorders: The pendulum keeps moving.

    Obeso, Jose A

    Movement disorders : official journal of the Movement Disorder Society

    2019  Volume 34, Issue 7, Page(s) 970

    MeSH term(s) Brain/physiopathology ; Humans ; Movement Disorders/physiopathology
    Language English
    Publishing date 2019-06-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.27784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Editor's note: The origin of Parkinson's disease: The importance of environment and lifestyle.

    Obeso, Jose A

    Movement disorders : official journal of the Movement Disorder Society

    2019  Volume 34, Issue 6, Page(s) 799–800

    MeSH term(s) Environment ; Humans ; Life Style ; Parkinson Disease/etiology
    Language English
    Publishing date 2019-06-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.27743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Editor's note: This is nature speaking to us in a language we don't understand.

    Obeso, Jose A

    Movement disorders : official journal of the Movement Disorder Society

    2019  Volume 34, Issue 11, Page(s) 1614–1615

    MeSH term(s) Comprehension ; Humans ; Language ; Research ; Speech
    Language English
    Publishing date 2019-11-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.27925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Editor's Note: Pathophysiology of the Basal Ganglia Grows in Understanding and Complexity but Essential Unknown Remains.

    Obeso, Jose A

    Movement disorders : official journal of the Movement Disorder Society

    2019  Volume 34, Issue 8, Page(s) 1128–1129

    MeSH term(s) Basal Ganglia
    Language English
    Publishing date 2019-08-29
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.27829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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