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Article ; Online: Past, present and future of spike sorting techniques.

Rey, Hernan Gonzalo / Pedreira, Carlos / Quian Quiroga, Rodrigo

2015 Volume 119, Issue Pt B, Page(s) 106–117

Abstract: Spike sorting is a crucial step to extract information from extracellular recordings. With new recording opportunities provided by the development of new electrodes that allow monitoring hundreds of neurons simultaneously, the scenario for the new ... ...

Abstract	Spike sorting is a crucial step to extract information from extracellular recordings. With new recording opportunities provided by the development of new electrodes that allow monitoring hundreds of neurons simultaneously, the scenario for the new generation of algorithms is both exciting and challenging. However, this will require a new approach to the problem and the development of a common reference framework to quickly assess the performance of new algorithms. In this work, we review the basic concepts of spike sorting, including the requirements for different applications, together with the problems faced by presently available algorithms. We conclude by proposing a roadmap stressing the crucial points to be addressed to support the neuroscientific research of the near future.
MeSH term(s)	Action Potentials/physiology ; Algorithms ; Animals ; Computer Simulation ; Electrodes, Implanted ; Humans ; Models, Neurological ; Neuroimaging/instrumentation ; Neuroimaging/methods ; Neurons/physiology
Language	English
Publishing date	2015-04-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	197620-5
ISSN	1873-2747 ; 0361-9230
ISSN (online)	1873-2747
ISSN	0361-9230
DOI	10.1016/j.brainresbull.2015.04.007
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Article ; Online: Single trial analysis of field potentials in perception, learning and memory.

Rey, Hernan Gonzalo / Ahmadi, Maryam / Quian Quiroga, Rodrigo

Current opinion in neurobiology

2014 Volume 31, Page(s) 148–155

Abstract: The analysis of single trial responses of field potentials is an important tool to study brain signals. Single trial analyses can indeed provide additional information that is obscured or simply not available in the average responses. The importance of ... ...

Abstract	The analysis of single trial responses of field potentials is an important tool to study brain signals. Single trial analyses can indeed provide additional information that is obscured or simply not available in the average responses. The importance of studying single trial responses is reinforced by the fact that different brain processes are correlated with trial-by-trial variation of the responses. Here, we review key studies implementing single trial analyses of field potentials-using methods such as single trial latency, amplitude and power changes, spike and LFP relationships, correlations between areas, cross frequency coupling, decoding of the presented stimuli-that bring light into the neural basis of perception, learning and memory.
MeSH term(s)	Brain/physiology ; Electroencephalography ; Evoked Potentials/physiology ; Humans ; Learning/physiology ; Memory/physiology ; Perception/physiology ; Reaction Time/physiology
Language	English
Publishing date	2014-11-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1078046-4
ISSN	1873-6882 ; 0959-4388
ISSN (online)	1873-6882
ISSN	0959-4388
DOI	10.1016/j.conb.2014.10.009
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Article ; Online: Timing of single-neuron and local field potential responses in the human medial temporal lobe.

Rey, Hernan Gonzalo / Fried, Itzhak / Quian Quiroga, Rodrigo

Current biology : CB

2014 Volume 24, Issue 3, Page(s) 299–304

Abstract: The relationship between the firing of single cells and local field potentials (LFPs) has received increasing attention, with studies in animals [1-11] and humans [12-14]. Recordings in the human medial temporal lobe (MTL) have demonstrated the existence ...

Abstract	The relationship between the firing of single cells and local field potentials (LFPs) has received increasing attention, with studies in animals [1-11] and humans [12-14]. Recordings in the human medial temporal lobe (MTL) have demonstrated the existence of neurons with selective and invariant responses [15], with a relatively late but precise response onset around 300 ms after stimulus presentation [16-18] and firing only upon conscious recognition of the stimulus [19]. This represents a much later onset than expected from direct projections from inferotemporal cortex [16, 18]. The neural mechanisms underlying this onset remain unclear. To address this issue, we performed a joint analysis of single-cell and LFP responses during a visual recognition task. Single-neuron responses were preceded by a global LFP deflection in the theta range. In addition, there was a local and stimulus-specific increase in the single-trial gamma power. These LFP responses correlated with conscious recognition. The timing of the neurons' firing was phase locked to these LFP responses. We propose that whereas the gamma phase locking reflects the activation of local networks encoding particular recognized stimuli, the theta phase locking reflects a global activation that provides a temporal window for processing consciously perceived stimuli in the MTL.
MeSH term(s)	Action Potentials/physiology ; Electrodes, Implanted ; Electroencephalography ; Epilepsy/physiopathology ; Humans ; Neurons/physiology ; Signal Processing, Computer-Assisted ; Temporal Lobe/physiology
Language	English
Publishing date	2014-01-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2013.12.004
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Article ; Online: Encoding of long-term associations through neural unitization in the human medial temporal lobe.

Rey, Hernan G / De Falco, Emanuela / Ison, Matias J / Valentin, Antonio / Alarcon, Gonzalo / Selway, Richard / Richardson, Mark P / Quian Quiroga, Rodrigo

Nature communications

2018 Volume 9, Issue 1, Page(s) 4372

Abstract: Besides decades of research showing the role of the medial temporal lobe (MTL) in memory and the encoding of associations, the neural substrates underlying these functions remain unknown. We identified single neurons in the human MTL that responded to ... ...

Abstract	Besides decades of research showing the role of the medial temporal lobe (MTL) in memory and the encoding of associations, the neural substrates underlying these functions remain unknown. We identified single neurons in the human MTL that responded to multiple and, in most cases, associated stimuli. We observed that most of these neurons exhibit no differences in their spike and local field potential (LFP) activity associated with the individual response-eliciting stimuli. In addition, LFP responses in the theta band preceded single neuron responses by ~70 ms, with the single trial phase providing fine tuning of the spike response onset. We postulate that the finding of similar neuronal responses to associated items provides a simple and flexible way of encoding memories in the human MTL, increasing the effective capacity for memory storage and successful retrieval.
MeSH term(s)	Action Potentials/physiology ; Adult ; Electroencephalography ; Female ; Hippocampus/cytology ; Hippocampus/metabolism ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neurons/metabolism ; Temporal Lobe/physiology
Language	English
Publishing date	2018-10-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-018-06870-2
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Article ; Online: Encoding of long-term associations through neural unitization in the human medial temporal lobe

Hernan G. Rey / Emanuela De Falco / Matias J. Ison / Antonio Valentin / Gonzalo Alarcon / Richard Selway / Mark P. Richardson / Rodrigo Quian Quiroga

Nature Communications, Vol 9, Iss 1, Pp 1-

2018 Volume 13

Abstract: In this work, the authors recorded single neurons and field potentials from the human medial temporal lobe (MTL) and show indistinguishable responses to associated stimuli. This coding mechanism provides a simple and flexible way of encoding memories in ... ...

Abstract	In this work, the authors recorded single neurons and field potentials from the human medial temporal lobe (MTL) and show indistinguishable responses to associated stimuli. This coding mechanism provides a simple and flexible way of encoding memories in the human MTL.
Keywords	Science ; Q
Language	English
Publishing date	2018-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Encoding of long-term associations through neural unitization in the human medial temporal lobe

Hernan G. Rey / Emanuela De Falco / Matias J. Ison / Antonio Valentin / Gonzalo Alarcon / Richard Selway / Mark P. Richardson / Rodrigo Quian Quiroga

Nature Communications, Vol 9, Iss 1, Pp 1-

2018 Volume 13

Abstract	In this work, the authors recorded single neurons and field potentials from the human medial temporal lobe (MTL) and show indistinguishable responses to associated stimuli. This coding mechanism provides a simple and flexible way of encoding memories in the human MTL.
Keywords	Science ; Q
Language	English
Publishing date	2018-10-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Single-cell recordings in the human medial temporal lobe.

Rey, Hernan G / Ison, Matias J / Pedreira, Carlos / Valentin, Antonio / Alarcon, Gonzalo / Selway, Richard / Richardson, Mark P / Quian Quiroga, Rodrigo

Journal of anatomy

2014 Volume 227, Issue 4, Page(s) 394–408

Abstract: Recordings from individual neurons in patients who are implanted with depth electrodes for clinical reasons have opened the possibility to narrow down the gap between neurophysiological studies in animals and non-invasive (e.g. functional magnetic ... ...

Abstract	Recordings from individual neurons in patients who are implanted with depth electrodes for clinical reasons have opened the possibility to narrow down the gap between neurophysiological studies in animals and non-invasive (e.g. functional magnetic resonance imaging, electroencephalogram, magnetoencephalography) investigations in humans. Here we provide a description of the main procedures for electrode implantation and recordings, the experimental paradigms used and the main steps for processing the data. We also present key characteristics of the so-called 'concept cells', neurons in the human medial temporal lobe with selective and invariant responses that represent the meaning of the stimulus, and discuss their proposed role in declarative memory. Finally, we present novel results dealing with the stability of the representation given by these neurons, by studying the effect of stimulus repetition in the strength of the responses. In particular, we show that, after an initial decay, the response strength reaches an asymptotic value after approximately 15 presentations that remains above baseline for the whole duration of the experiment.
MeSH term(s)	Animals ; Electrodes, Implanted ; Humans ; Magnetic Resonance Imaging/methods ; Memory/physiology ; Neurons/physiology ; Patch-Clamp Techniques/methods ; Temporal Lobe/anatomy & histology ; Temporal Lobe/physiology
Language	English
Publishing date	2014-08-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2955-5
ISSN	1469-7580 ; 0021-8782
ISSN (online)	1469-7580
ISSN	0021-8782
DOI	10.1111/joa.12228
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Article: A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe.

Borobia, Alberto M / Carcas, Antonio J / Arnalich, Francisco / Álvarez-Sala, Rodolfo / Monserrat-Villatoro, Jaime / Quintana, Manuel / Figueira, Juan Carlos / Torres Santos-Olmo, Rosario M / García-Rodríguez, Julio / Martín-Vega, Alberto / Buño, Antonio / Ramírez, Elena / Martínez-Alés, Gonzalo / García-Arenzana, Nicolás / Núñez, M Concepción / Martí-de-Gracia, Milagros / Moreno Ramos, Francisco / Reinoso-Barbero, Francisco / Martin-Quiros, Alejandro /

Rivera Núñez, Angélica / Mingorance, Jesús / Carpio Segura, Carlos J / Prieto Arribas, Daniel / Rey Cuevas, Esther / Prados Sánchez, Concepción / Rios, Juan J / Hernán, Miguel A / Frías, Jesús / Arribas, José R / On Behalf Of The Covid Hulp Working Group

Journal of clinical medicine

2020 Volume 9, Issue 6

Abstract: Background: Since the confirmation of the first patient infected with SARS-CoV-2 in Spain in January 2020, the epidemic has grown rapidly, with the greatest impact on the region of Madrid. This article describes the first 2226 adult patients with COVID- ... ...

Abstract	Background: Since the confirmation of the first patient infected with SARS-CoV-2 in Spain in January 2020, the epidemic has grown rapidly, with the greatest impact on the region of Madrid. This article describes the first 2226 adult patients with COVID-19, consecutively admitted to La Paz University Hospital in Madrid. Methods: Our cohort included all patients consecutively hospitalized who had a final outcome (death or discharge) in a 1286-bed hospital of Madrid (Spain) from 25 February (first case admitted) to 19 April 2020. The data were manually entered into an electronic case report form, which was monitored prior to the analysis. Results: We consecutively included 2226 adult patients admitted to the hospital who either died (460) or were discharged (1766). The patients' median age was 61 years, and 51.8% were women. The most common comorbidity was arterial hypertension (41.3%), and the most common symptom on admission was fever (71.2%). The median time from disease onset to hospital admission was 6 days. The overall mortality was 20.7% and was higher in men (26.6% vs. 15.1%). Seventy-five patients with a final outcome were transferred to the intensive care unit (ICU) (3.4%). Most patients admitted to the ICU were men, and the median age was 64 years. Baseline laboratory values on admission were consistent with an impaired immune-inflammatory profile. Conclusions: We provide a description of the first large cohort of hospitalized patients with COVID-19 in Europe. Advanced age, male sex, the presence of comorbidities and abnormal laboratory values were more common among the patients with fatal outcomes.
Keywords	covid19
Language	English
Publishing date	2020-06-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9061733
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Article ; Online: A cohort of patients with COVID-19 in a major teaching hospital in Europe

Borobia, Alberto M / Carcas, Antonio J / Arnalich, Francisco / Alvarez-Sala, Rodolfo / Montserrat, Jaime / Quintana, Manuel / Figueira, Juan C / Torres Santos-Olmo, Rosario M / Garcia-Rodriguez, Julio / Martin-Vega, Alberto / Ramirez, Elena / Buno, Antonio / Martinez-Ales, Gonzalo / Garcia-Arenzana, Nicolas / Marti de Gracia, Milagros / Moreno, Francisco / Reinoso-Barbero, Francisco / Martin-Quiros, Alejandro / Rivera, Angelica /

Mingorance, Jesus / Carpio, Carlos C / Prieto Arribas, Daniel / Rey Cuevas, Esther / Prados, Maria C / Rios, Juan J / Hernan, Miguel / Frias, Jesus / Arribas, Jose R / COVID@HULP working team

medRxiv

Abstract: BACKGROUND Since the confirmation of the first patient infected with SARS-CoV-2 in Spain in January 2020, the epidemic has grown rapidly, with the greatest impact on the Madrid region. This article describes the first 2226 consecutive adult patients with ...

Abstract	BACKGROUND Since the confirmation of the first patient infected with SARS-CoV-2 in Spain in January 2020, the epidemic has grown rapidly, with the greatest impact on the Madrid region. This article describes the first 2226 consecutive adult patients with COVID-19 admitted to the La Paz University Hospital in Madrid. METHODS Our cohort included all consecutively admitted patients who were hospitalized and who had a final outcome (death or discharge) in a 1286-bed hospital of Madrid (Spain) from February 25th (first case admitted) to April 19th, 2020. Data was entered manually into an electronic case report form, which was monitored prior to the analysis. RESULTS We consecutively included 2226 adult patients admitted to the hospital who either died (460) or were discharged (1766). The patients median age was 61 years; 51.8% were women. The most common comorbidity was arterial hypertension (41.3%). The most common symptoms on admission were fever (71.2%). The median time from disease onset to hospital admission was 6 days. Overall mortality was 20.7% and was higher in men (26.6% vs 15.1%). Seventy-five patients with a final outcome were transferred to the ICU (3.4%). Most patients admitted to the ICU were men, and the median age was 64 years. Baseline laboratory values on admission were consistent with an impaired immune-inflammatory profile. CONCLUSIONS We provide a description of the first large cohort of hospitalized patients with COVID-19 in Europe. Advanced age, male gender, the presence of comorbidities and abnormal laboratory values were more common among the patients with fatal outcomes.
Keywords	covid19
Language	English
Publishing date	2020-05-04
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.04.29.20080853
Database	COVID19

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Article: A cohort of patients with COVID-19 in a major teaching hospital in Europe

Borobia, Alberto M. / Carcas, Antonio J. / Arnalich, Francisco / Álvarez-Sala, Rodolfo / Monserrat-Villatoro, Jaime / Quintana, Manuel / Figueira, Juan Carlos / Torres Santos-Olmo, Rosario M. / García-Rodríguez, Julio / Martín-Vega, Alberto / Buño, Antonio / Ramírez, Elena / Martínez-Alés, Gonzalo / García-Arenzana, Nicolás / Concepción Núñez, M. / Martí-De-Gracia, Milagros / Ramos, Francisco Moreno / Reinoso-Barbero, Francisco / Martin-Quiros, Alejandro /

Núñez, Angélica Rivera / Mingorance, Jesús / Carpio Segura, Carlos J. / Arribas, Daniel Prieto / Cuevas, Esther Rey / Sánchez, Concepción Prados / Rios, Juan J. / Hernán, Miguel A. / Frías, Jesús / Arribas, José R.

J. Clin. Med.

Abstract	Background: Since the confirmation of the first patient infected with SARS-CoV-2 in Spain in January 2020, the epidemic has grown rapidly, with the greatest impact on the region of Madrid. This article describes the first 2226 adult patients with COVID-19, consecutively admitted to La Paz University Hospital in Madrid. Methods: Our cohort included all patients consecutively hospitalized who had a final outcome (death or discharge) in a 1286-bed hospital of Madrid (Spain) from 25 February (first case admitted) to 19 April 2020. The data were manually entered into an electronic case report form, which was monitored prior to the analysis. Results: We consecutively included 2226 adult patients admitted to the hospital who either died (460) or were discharged (1766). The patients’ median age was 61 years, and 51.8% were women. The most common comorbidity was arterial hypertension (41.3%), and the most common symptom on admission was fever (71.2%). The median time from disease onset to hospital admission was 6 days. The overall mortality was 20.7% and was higher in men (26.6% vs. 15.1%). Seventy-five patients with a final outcome were transferred to the intensive care unit (ICU) (3.4%). Most patients admitted to the ICU were men, and the median age was 64 years. Baseline laboratory values on admission were consistent with an impaired immune-inflammatory profile. Conclusions: We provide a description of the first large cohort of hospitalized patients with COVID-19 in Europe. Advanced age, male sex, the presence of comorbidities and abnormal laboratory values were more common among the patients with fatal outcomes.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #593078
Database	COVID19

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