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Article ; Online: Substantial immune response in Omicron infected breakthrough and unvaccinated individuals against SARS-CoV-2 variants of concern.

Yadav, Pragya D / Sapkal, Gajanan N / Sahay, Rima R / Potdar, Varsha A / Deshpande, Gururaj R / Patil, Deepak Y / Nyayanit, Dimpal A / Shete, Anita M / Shastri, Jayanthi / Awate, Pradip / Malhotra, Bharti / Abraham, Priya

The Journal of infection

2022 Volume 84, Issue 5, Page(s) e80–e81

MeSH term(s)	Antibodies, Neutralizing ; COVID-19 ; Humans ; Immunity ; SARS-CoV-2
Chemical Substances	Antibodies, Neutralizing
Language	English
Publishing date	2022-02-12
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2022.02.005
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Article ; Online: Past and current perspective on new therapeutic targets for Type-II diabetes.

Patil, Pradip D / Mahajan, Umesh B / Patil, Kalpesh R / Chaudhari, Sandip / Patil, Chandragouda R / Agrawal, Yogeeta O / Ojha, Shreesh / Goyal, Sameer N

Drug design, development and therapy

2017 Volume 11, Page(s) 1567–1583

Abstract: Loss of pancreatic β-cell function is a hallmark of Type-II diabetes mellitus (DM). It is a chronic metabolic disorder that results from defects in both insulin secretion and insulin action. Recently, United Kingdom Prospective Diabetes Study reported ... ...

Abstract	Loss of pancreatic β-cell function is a hallmark of Type-II diabetes mellitus (DM). It is a chronic metabolic disorder that results from defects in both insulin secretion and insulin action. Recently, United Kingdom Prospective Diabetes Study reported that Type-II DM is a progressive disorder. Although, DM can be treated initially by monotherapy with oral agent; eventually, it may require multiple drugs. Additionally, insulin therapy is needed in many patients to achieve glycemic control. Pharmacological approaches are unsatisfactory in improving the consequences of insulin resistance. Single therapeutic approach in the treatment of Type-II DM is unsuccessful and usually a combination therapy is adopted. Increased understanding of biochemical, cellular and pathological alterations in Type-II DM has provided new insight in the management of Type-II DM. Knowledge of underlying mechanisms of Type-II DM development is essential for the exploration of novel therapeutic targets. Present review provides an insight into therapeutic targets of Type-II DM and their role in the development of insulin resistance. An overview of important signaling pathways and mechanisms in Type-II DM is provided for the better understanding of disease pathology. This review includes case studies of drugs that are withdrawn from the market. The experience gathered from previous studies and knowledge of Type-II DM pathways can guide the anti-diabetic drug development toward the discovery of clinically viable drugs that are useful in Type-II DM.
Language	English
Publishing date	2017
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S133453
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Article ; Online: Eplerenone pretreatment protects the myocardium against ischaemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway in diabetic rats.

Mahajan, Umesh B / Patil, Pradip D / Chandrayan, Govind / Patil, Chandragouda R / Agrawal, Yogeeta O / Ojha, Shreesh / Goyal, Sameer N

Molecular and cellular biochemistry

2018 Volume 446, Issue 1-2, Page(s) 91–103

Abstract: We investigated the eplerenone-induced, PI3K/Akt- and GSK-3β-mediated cardioprotection against ischemia/reperfusion (I/R) injury in diabetic rats. The study groups comprising diabetic rats were treated for 14 days with 150 mg/kg/day eplerenone orally and ...

Abstract	We investigated the eplerenone-induced, PI3K/Akt- and GSK-3β-mediated cardioprotection against ischemia/reperfusion (I/R) injury in diabetic rats. The study groups comprising diabetic rats were treated for 14 days with 150 mg/kg/day eplerenone orally and 1 mg/kg wortmannin (PI3K/Akt antagonist) intraperitoneally with eplerenone. On the 15th day, the rats were exposed to I/R injury by 20-min occlusion of the left anterior descending coronary artery followed by 30 min of reperfusion. The hearts were processed for biochemical, molecular, and histological investigations. The I/R injury in diabetic rats inflicted a significant rise in the oxidative stress and apoptosis along with a decrease in the arterial and ventricular function and the expressions of PI3K/Akt and GSK-3β proteins. Eplerenone pretreatment reduced the arterial pressure, cardiac inotropy, and lusitropy. It significantly reduced apoptosis and cardiac injury markers. The histology revealed cardioprotection in eplerenone-treated rats. Eplerenone up-regulated the PI3K/Akt and reduced the GSK-3β expression. The group receiving wortmannin with eplerenone was deprived eplerenone-induced cardioprotection. Our results reveal the eplerenone-induced cardioprotection against I/R injury in diabetic rats and substantiate the involvement of PI3K/Akt and GSK-3β pathways in its efficacy.
MeSH term(s)	Animals ; Cardiotonic Agents/pharmacology ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Male ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/pathology ; Myocardial Reperfusion Injury/prevention & control ; Myocardium/metabolism ; Myocardium/pathology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Wistar ; Signal Transduction/drug effects ; Spironolactone/analogs & derivatives ; Spironolactone/pharmacology
Chemical Substances	Cardiotonic Agents ; Spironolactone (27O7W4T232) ; eplerenone (6995V82D0B) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2018-01-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-018-3276-1
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Zs.A 892: Show issues

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Article ; Online: Preparedness, administrative challenges for establishing obstetric services, and experience of delivering over 400 women at a tertiary care COVID-19 hospital in India.

Mahajan, Niraj N / Pednekar, Rahi / Patil, Sarika R / Subramanyam, Alka A / Rathi, Surbhi / Malik, Sushma / Mohite, Shailesh C / Shinde, Ganesh / Joshi, Mohan / Kumbhar, Padmaja / Tilve, Arundhati / Lokhande, Pradip D / Srivastava, Shayla A

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

2020 Volume 151, Issue 2, Page(s) 188–196

Abstract: Objective: To provide a descriptive account of the challenges and administrative preparedness for establishing and sustaining safe obstetric services during the COVID-19 pandemic at Topiwala National Medical College & BYL Nair Charitable Hospital (NH), ... ...

Abstract	Objective: To provide a descriptive account of the challenges and administrative preparedness for establishing and sustaining safe obstetric services during the COVID-19 pandemic at Topiwala National Medical College & BYL Nair Charitable Hospital (NH), Mumbai, India. Methods: The management of pregnant women with COVID-19 was implemented as per international (WHO, RCOG, ACOG) and national (Indian Council of Medical Research) recommendations and guidelines at an academic, tertiary care, COVID-19 hospital in India. Results: Using a multidisciplinary approach and active engagement of a multispecialty team, obstetric services were provided to over 400 women with laboratory-confirmed COVID-19. A sustainable model is established for providing services to pregnant women with COVID-19 in Mumbai Metropolitan Region, India. Conclusion: With limited resources, it is possible to set up dedicated maternity services, aligned to international guidelines, for safe pregnancy outcomes in COVID-19 settings. This COVID-19 hospital addressed the challenges and implemented several known and novel methods to establish and sustain obstetric services for women with COVID-19. The model established in the present study can be replicated in other low- and middle-income countries.
MeSH term(s)	Adult ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Delivery, Obstetric/methods ; Female ; Humans ; India/epidemiology ; Infection Control/methods ; Infection Control/standards ; Organizational Innovation ; Pandemics ; Perinatal Care/organization & administration ; Perinatal Care/trends ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Practice Guidelines as Topic ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/therapy ; Pregnancy Outcome ; SARS-CoV-2 ; Tertiary Healthcare/methods ; Tertiary Healthcare/organization & administration
Keywords	covid19
Language	English
Publishing date	2020-09-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	80149-5
ISSN	1879-3479 ; 0020-7292
ISSN (online)	1879-3479
ISSN	0020-7292
DOI	10.1002/ijgo.13338
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Zs.A 355: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Preparedness, administrative challenges for establishing obstetric services, and experience of delivering over 400 women at a tertiary care COVID‐19 hospital in India

Mahajan, Niraj N. / Pednekar, Rahi / Patil, Sarika R. / Subramanyam, Alka A. / Rathi, Surbhi / Malik, Sushma / Mohite, Shailesh C. / Shinde, Ganesh / Joshi, Mohan / Kumbhar, Padmaja / Tilve, Arundhati / Lokhande, Pradip D. / Srivastava, Shayla A.

International Journal of Gynecology & Obstetrics

2020 Volume 151, Issue 2, Page(s) 188–196

Keywords	Obstetrics and Gynaecology ; General Medicine ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ZDB-ID	80149-5
ISSN	1879-3479 ; 0020-7292
ISSN (online)	1879-3479
ISSN	0020-7292
DOI	10.1002/ijgo.13338
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Zs.A 355: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Clinical, immunological and genomic analysis of the post vaccinated SARS-CoV-2 infected cases with Delta derivatives from Maharashtra, India, 2021.

Yadav, Pragya D / Sahay, Rima R / Agrawal, Sachee / Shete, Anita / Adsul, Balkrishna / Tripathy, Srikanth / Nyayanit, Dimpal A / Manrai, Manish / Patil, Deepak Y / Kumar, Sanjay / Marwah, Vikas / Sapkal, Gajanan N / Shastri, Jayanthi / Viswanathan, Rajlakshmi / Pandit, Priyanka / Mishra, Yogendra / Chavan, Smita / Joshi, Yash / Kumar, T Ajai /

The Journal of infection

2022 Volume 85, Issue 1, Page(s) e26–e29

MeSH term(s)	Antibodies, Viral ; COVID-19/prevention & control ; Genomics ; Humans ; India/epidemiology ; SARS-CoV-2/genetics
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2022-04-08
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2022.04.014
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Zs.A 1501: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Addendum: Liquid biopsy and multi-analyte testing guided treatment of

Nagarkar, Rajnish / Patil, Darshana / Limaye, Sewanti / Devhare, Pradip / Ghaisas, Ashwini / Srivastava, Navin / Apurwa, Sachin / Patil, Sanket / John, Jinumary / Raazi, Zarrine / Shreenivas, Aditya / Sambath, Janani / Srinivasan, Ajay / Kumar, Prashant / Akolkar, Dadasaheb / Datar, Rajan

Oncotarget

2022 Volume 13, Page(s) 1215

Language	English
Publishing date	2022-11-02
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.28296
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Article: Preparedness, administrative challenges for establishing obstetric services, and experience of delivering over 400 women at a tertiary care COVID-19 hospital in India

Int J Gynaecol Obstet

Abstract: OBJECTIVE: To provide a descriptive account of the challenges and administrative preparedness for establishing and sustaining safe obstetric services during the COVID-19 pandemic at Topiwala National Medical College & BYL Nair Charitable Hospital (NH), ... ...

Abstract	OBJECTIVE: To provide a descriptive account of the challenges and administrative preparedness for establishing and sustaining safe obstetric services during the COVID-19 pandemic at Topiwala National Medical College & BYL Nair Charitable Hospital (NH), Mumbai, India. METHODS: The management of pregnant women with COVID-19 was implemented as per international (WHO, RCOG, ACOG) and national (Indian Council of Medical Research) recommendations and guidelines at an academic, tertiary care, COVID-19 hospital in India. RESULTS: Using a multidisciplinary approach and active engagement of a multispecialty team, obstetric services were provided to over 400 women with laboratory-confirmed COVID-19. A sustainable model is established for providing services to pregnant women with COVID-19 in Mumbai Metropolitan Region, India. CONCLUSION: With limited resources, it is possible to set up dedicated maternity services, aligned to international guidelines, for safe pregnancy outcomes in COVID-19 settings. This COVID-19 hospital addressed the challenges and implemented several known and novel methods to establish and sustain obstetric services for women with COVID-19. The model established in the present study can be replicated in other low- and middle-income countries.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #696170
Database	COVID19

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Article: Zika a Vector Borne Disease Detected in Newer States of India Amidst the COVID-19 Pandemic.

Yadav, Pragya D / Kaur, Harmanmeet / Gupta, Nivedita / Sahay, Rima R / Sapkal, Gajanan N / Shete, Anita M / Deshpande, Gururaj R / Mohandas, Sreelekshmy / Majumdar, Triparna / Patil, Savita / Pandit, Priyanka / Kumar, Abhinendra / Nyayanit, Dimpal A / Sreelatha, K H / Manjusree, S / Sami, Hiba / Khan, Haris Mazoor / Malhotra, Anuradha / Dhingra, Kanwardeep /

Frontiers in microbiology

2022 Volume 13, Page(s) 888195

Abstract: Background: During the second wave of the COVID-19 pandemic, outbreaks of Zika were reported from Kerala, Uttar Pradesh, and Maharashtra, India in 2021. The Dengue and Chikungunya negative samples were retrospectively screened to determine the presence ... ...

Abstract	Background: During the second wave of the COVID-19 pandemic, outbreaks of Zika were reported from Kerala, Uttar Pradesh, and Maharashtra, India in 2021. The Dengue and Chikungunya negative samples were retrospectively screened to determine the presence of the Zika virus from different geographical regions of India. Methods: During May to October 2021, the clinical samples of 1475 patients, across 13 states and a union territory of India were screened and re-tested for Dengue, Chikungunya and Zika by CDC Trioplex Real time RT-PCR. The Zika rRTPCR positive samples were further screened with anti-Zika IgM and Plaque Reduction Neutralization Test. Next generation sequencing was used for further molecular characterization. Results: The positivity was observed for Zika (67), Dengue (121), and Chikungunya (10) amongst screened cases. The co-infections of Dengue/Chikungunya, Dengue/Zika, and Dengue/Chikungunya/Zika were also observed. All Zika cases were symptomatic with fever (84%) and rash (78%) as major presenting symptoms. Of them, four patients had respiratory distress, one presented with seizures, and one with suspected microcephaly at birth. The Asian Lineage of Zika and all four serotypes of Dengue were found in circulation. Conclusion: Our study indicates the spread of the Zika virus to several states of India and an urgent need to strengthen its surveillance.
Language	English
Publishing date	2022-06-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.888195
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Article: Guidelines for prevention of hospital acquired infections.

Mehta, Yatin / Gupta, Abhinav / Todi, Subhash / Myatra, Sn / Samaddar, D P / Patil, Vijaya / Bhattacharya, Pradip Kumar / Ramasubban, Suresh

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

2014 Volume 18, Issue 3, Page(s) 149–163

Abstract: These guidelines, written for clinicians, contains evidence-based recommendations for the prevention of hospital acquired infections Hospital acquired infections are a major cause of mortality and morbidity and provide challenge to clinicians. Measures ... ...

Abstract	These guidelines, written for clinicians, contains evidence-based recommendations for the prevention of hospital acquired infections Hospital acquired infections are a major cause of mortality and morbidity and provide challenge to clinicians. Measures of infection control include identifying patients at risk of nosocomial infections, observing hand hygiene, following standard precautions to reduce transmission and strategies to reduce VAP, CR-BSI, CAUTI. Environmental factors and architectural lay out also need to be emphasized upon. Infection prevention in special subsets of patients - burns patients, include identifying sources of organism, identification of organisms, isolation if required, antibiotic prophylaxis to be used selectively, early removal of necrotic tissue, prevention of tetanus, early nutrition and surveillance. Immunodeficient and Transplant recipients are at a higher risk of opportunistic infections. The post tranplant timetable is divided into three time periods for determining risk of infections. Room ventilation, cleaning and decontamination, protective clothing with care regarding food requires special consideration. Monitoring and Surveillance are prioritized depending upon the needs. Designated infection control teams should supervise the process and help in collection and compilation of data. Antibiotic Stewardship Recommendations include constituting a team, close coordination between teams, audit, formulary restriction, de-escalation, optimizing dosing, active use of information technology among other measure. The recommendations in these guidelines are intended to support, and not replace, good clinical judgment. The recommendations are rated by a letter that indicates the strength of the recommendation and a Roman numeral that indicates the quality of evidence supporting the recommendation, so that readers can ascertain how best to apply the recommendations in their practice environments.
Keywords	covid19
Language	English
Publishing date	2014-03-06
Publishing country	India
Document type	Journal Article
ZDB-ID	2121263-6
ISSN	1998-359X ; 0972-5229
ISSN (online)	1998-359X
ISSN	0972-5229
DOI	10.4103/0972-5229.128705
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