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  1. Article ; Online: Pathogenesis, clinical manifestations and complications of coronavirus disease 2019 (COVID-19).

    Kordzadeh-Kermani, Elaheh / Khalili, Hossein / Karimzadeh, Iman

    Future microbiology

    2020  Volume 15, Page(s) 1287–1305

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Betacoronavirus/pathogenicity ; COVID-19 ; Cardiovascular System/pathology ; Cardiovascular System/virology ; Central Nervous System/pathology ; Central Nervous System/virology ; Coronavirus Infections/drug therapy ; Coronavirus Infections/pathology ; Coronavirus Infections/transmission ; Cytokines/blood ; Gastrointestinal Tract/pathology ; Gastrointestinal Tract/virology ; Humans ; Kidney/pathology ; Kidney/virology ; Liver/pathology ; Liver/virology ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/pathology ; Pneumonia, Viral/transmission ; Respiratory System/pathology ; Respiratory System/virology ; SARS-CoV-2
    Chemical Substances Cytokines ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-08-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2254620-0
    ISSN 1746-0921 ; 1746-0913
    ISSN (online) 1746-0921
    ISSN 1746-0913
    DOI 10.2217/fmb-2020-0110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Prevention Strategies to Minimize the Infection Risk Associated with Biologic and Targeted Immunomodulators.

    Kordzadeh-Kermani, Elaheh / Khalili, Hossein / Karimzadeh, Iman / Salehi, Mohammadreza

    Infection and drug resistance

    2020  Volume 13, Page(s) 513–532

    Abstract: The introduction of biologic and targeted immunomodulators is a significant breakthrough in the therapeutic area of various fields of medicine. The occurrence of serious infections, a complication of secondary immunosuppression associated with these ... ...

    Abstract The introduction of biologic and targeted immunomodulators is a significant breakthrough in the therapeutic area of various fields of medicine. The occurrence of serious infections, a complication of secondary immunosuppression associated with these agents, leads to increased morbidity and mortality. Implementing preventive strategies could minimize infection-related complications and improve therapeutic outcomes. The purpose of this review is to focus on current evident approaches regarding screening, monitoring, preventing (immunization and chemoprophylaxis), and management of infections in patients who are candidates for about 70 biologic and targeted immunomodulators. Recommendations are based on relevant guidelines, especially the ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document series published in 2018.
    Language English
    Publishing date 2020-02-18
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S233137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pathogenesis, clinical manifestations and complications of coronavirus disease 2019 (COVID-19)

    Kordzadeh-Kermani, Elaheh / Khalili, Hossein / Karimzadeh, Iman

    Future Microbiol

    Abstract: Aim: Despite the similarities in the pathogenesis of the beta coronaviruses, the precise infective mechanisms of SARS-CoV-2 remain unclear. Objective: In this review, we aim to focus on the proposed theories behind the pathogenesis of SARS-CoV-2 and ... ...

    Abstract Aim: Despite the similarities in the pathogenesis of the beta coronaviruses, the precise infective mechanisms of SARS-CoV-2 remain unclear. Objective: In this review, we aim to focus on the proposed theories behind the pathogenesis of SARS-CoV-2 and highlight the clinical complications related to COVID-19. Methods: We conducted a literature search in Pubmed, Scopus and Google Scholar for the relevant articles regarding clinical complications and pathogenesis of COVID-19. Results: Related articles were included and discussed. Conclusion: Respiratory system and the lungs are the most commonly involved sites of COVID-19 infection. Cardiovascular, liver, kidneys, gastrointestinal and central nervous systems are involved with different frequencies and degrees of severity.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #732937
    Database COVID19

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  4. Article ; Online: Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art Review.

    Talasaz, Azita H / Sadeghipour, Parham / Kakavand, Hessam / Aghakouchakzadeh, Maryam / Kordzadeh-Kermani, Elaheh / Van Tassell, Benjamin W / Gheymati, Azin / Ariannejad, Hamid / Hosseini, Seyed Hossein / Jamalkhani, Sepehr / Sholzberg, Michelle / Monreal, Manuel / Jimenez, David / Piazza, Gregory / Parikh, Sahil A / Kirtane, Ajay J / Eikelboom, John W / Connors, Jean M / Hunt, Beverley J /
    Konstantinides, Stavros V / Cushman, Mary / Weitz, Jeffrey I / Stone, Gregg W / Krumholz, Harlan M / Lip, Gregory Y H / Goldhaber, Samuel Z / Bikdeli, Behnood

    Journal of the American College of Cardiology

    2021  Volume 77, Issue 15, Page(s) 1903–1921

    Abstract: Endothelial injury and microvascular/macrovascular thrombosis are common pathophysiological features of coronavirus disease-2019 (COVID-19). However, the optimal thromboprophylactic regimens remain unknown across the spectrum of illness severity of COVID- ...

    Abstract Endothelial injury and microvascular/macrovascular thrombosis are common pathophysiological features of coronavirus disease-2019 (COVID-19). However, the optimal thromboprophylactic regimens remain unknown across the spectrum of illness severity of COVID-19. A variety of antithrombotic agents, doses, and durations of therapy are being assessed in ongoing randomized controlled trials (RCTs) that focus on outpatients, hospitalized patients in medical wards, and patients critically ill with COVID-19. This paper provides a perspective of the ongoing or completed RCTs related to antithrombotic strategies used in COVID-19, the opportunities and challenges for the clinical trial enterprise, and areas of existing knowledge, as well as data gaps that may motivate the design of future RCTs.
    MeSH term(s) COVID-19/complications ; COVID-19/drug therapy ; Fibrinolytic Agents/therapeutic use ; Humans ; Randomized Controlled Trials as Topic ; Thromboembolism/prevention & control ; Thromboembolism/virology
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2021-03-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2021.02.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Anti-Leishmania Activity of Osthole.

    Kermani, Elaheh Kordzadeh / Sajjadi, Seyed Ebrahim / Hejazi, Seyed Hossein / Arjmand, Reza / Saberi, Sedigheh / Eskandarian, Abbas Ali

    Pharmacognosy research

    2016  Volume 8, Issue Suppl 1, Page(s) S1–4

    Abstract: Background: Treatment of cutaneous leishmaniasis (CL) is occasionally highly resistant to pentavalent antimonials, the gold standard in pharmacotherapy of CL. Since there is no effective vaccine, the discovery of natural antileishmanial products as ... ...

    Abstract Background: Treatment of cutaneous leishmaniasis (CL) is occasionally highly resistant to pentavalent antimonials, the gold standard in pharmacotherapy of CL. Since there is no effective vaccine, the discovery of natural antileishmanial products as complementary therapeutic agents could be used to improve the current regimens.
    Objective: In this study in vitro and in vivo antileishmanial activities of osthole, a natural coumarin known to possess antibacterial and parasiticidal activities are evaluated.
    Materials and methods: Leishmania major infected J774.A1 macrophages were treated with increasing concentrations of osthole. CL lesions of BALB/c mice were treated topically with 0.2% osthole.
    Results: Osthole exhibited dose-dependent leishmanicidal activity against intracellular amastigotes with IC50 value of 14.95 μg/ml. Treatment of CL lesions in BALB/c mice with osthole significantly declined lesion progression compared to untreated mice (P < 0.05), however did not result in recovery.
    Conclusion: Osthole demonstrated remarkable leishmanicidal activity in vitro. Higher concentrations of osthole may demonstrate the therapeutic property in vivo.
    Summary: In vitro and in vivo antileishmanial activities of osthole, a pernylated coumarin extracted from Prangos asperula Boiss., are studied against Leishmania major.
    Language English
    Publishing date 2016-02-01
    Publishing country India
    Document type Journal Article
    ZDB-ID 2580264-1
    ISSN 0974-8490 ; 0976-4836
    ISSN (online) 0974-8490
    ISSN 0976-4836
    DOI 10.4103/0974-8490.178650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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