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  1. Article ; Online: Concern About the Adverse Effects of Thrombocytopenia and Thrombosis After Adenovirus-Vectored COVID-19 Vaccination.

    Haimei, M A

    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

    2021  Volume 27, Page(s) 10760296211040110

    Abstract: Since the outbreak of Covid-19 in December, 2019, scientists worldwide have been committed to developing COVID-19 vaccines. Only when most people have immunity to SARS-CoV-2, COVID-19 can reduce even wholly overcome. So far, nine kinds of COVID-19 ... ...

    Abstract Since the outbreak of Covid-19 in December, 2019, scientists worldwide have been committed to developing COVID-19 vaccines. Only when most people have immunity to SARS-CoV-2, COVID-19 can reduce even wholly overcome. So far, nine kinds of COVID-19 vaccines have passed the phase III clinical trials and have approved for use. At the same time, adverse reactions after COVID-19 vaccination have also reported. This paper focuses on the adverse effects of thrombosis and thrombocytopenia caused by the COVID-19 vaccine, especially the adenovirus-vector vaccine from AstraZeneca and Pfizer, and discusses its mechanism and possible countermeasures.
    MeSH term(s) Adenoviridae/genetics ; Antibodies/blood ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/genetics ; COVID-19 Vaccines/immunology ; ChAdOx1 nCoV-19 ; Genetic Vectors ; Humans ; Platelet Factor 4/immunology ; Risk Assessment ; Risk Factors ; Thrombocytopenia/blood ; Thrombocytopenia/chemically induced ; Thrombocytopenia/immunology ; Thrombosis/blood ; Thrombosis/chemically induced ; Thrombosis/immunology ; Vaccination/adverse effects
    Chemical Substances Antibodies ; COVID-19 Vaccines ; PF4 protein, human ; Platelet Factor 4 (37270-94-3) ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
    Language English
    Publishing date 2021-09-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1237357-6
    ISSN 1938-2723 ; 1076-0296
    ISSN (online) 1938-2723
    ISSN 1076-0296
    DOI 10.1177/10760296211040110
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    Zs.A 4370: Show issues Location:
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  2. Article ; Online: Pathogenesis and Treatment Strategies of COVID-19-Related Hypercoagulant and Thrombotic Complications.

    Haimei, M A

    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

    2020  Volume 26, Page(s) 1076029620944497

    Abstract: The new type of pneumonia caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is endemic worldwide, and many countries cannot be spared, becoming a global health concern. The disease was named COVID-19 by the World Health ... ...

    Abstract The new type of pneumonia caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is endemic worldwide, and many countries cannot be spared, becoming a global health concern. The disease was named COVID-19 by the World Health Organization (WHO) on January 30, 2020, when the WHO declared the Chinese outbreak of COVID-19 to be a public health emergency of international concern. The clinical features of COVID-19 include dry cough, fever, diarrhea, vomiting, and myalgia. Similar to SARS-CoV and MERS-CoV, nearly 20% of patients experienced various fatal complications, including acute kidney injury and acute respiratory distress syndrome caused by cytokine storm. Furthermore, systemic cytokine storm induced vascular endothelial injury, which extensively mediates hypercoagulability in blood vessels and disseminated intravascular coagulation. The autopsy pathology of COVID-19 confirmed the above. This article briefly summarizes the mechanism of hypercoagulability and thrombotic complications of severe COVID-19 and proposes that blood hypercoagulability and intravascular microthrombosis are the development nodes of severe COVID-19. Therefore, anticoagulation and anti-inflammatory therapy can be used as important treatment strategies for severe COVID-19.
    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; Anticoagulants/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Cytokines/metabolism ; Disseminated Intravascular Coagulation/etiology ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Thrombophilia/drug therapy ; Thrombophilia/etiology ; Thrombophilia/virology ; Thrombosis/drug therapy ; Thrombosis/etiology ; Thrombosis/virology
    Chemical Substances Anti-Inflammatory Agents ; Anticoagulants ; Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-09-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1237357-6
    ISSN 1938-2723 ; 1076-0296
    ISSN (online) 1938-2723
    ISSN 1076-0296
    DOI 10.1177/1076029620944497
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  3. Article: Pathogenesis and Treatment Strategies of COVID-19-Related Hypercoagulant and Thrombotic Complications

    Haimei, M A

    Clin Appl Thromb Hemost

    Abstract: The new type of pneumonia caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is endemic worldwide, and many countries cannot be spared, becoming a global health concern. The disease was named COVID-19 by the World Health ... ...

    Abstract The new type of pneumonia caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is endemic worldwide, and many countries cannot be spared, becoming a global health concern. The disease was named COVID-19 by the World Health Organization (WHO) on January 30, 2020, when the WHO declared the Chinese outbreak of COVID-19 to be a public health emergency of international concern. The clinical features of COVID-19 include dry cough, fever, diarrhea, vomiting, and myalgia. Similar to SARS-CoV and MERS-CoV, nearly 20% of patients experienced various fatal complications, including acute kidney injury and acute respiratory distress syndrome caused by cytokine storm. Furthermore, systemic cytokine storm induced vascular endothelial injury, which extensively mediates hypercoagulability in blood vessels and disseminated intravascular coagulation. The autopsy pathology of COVID-19 confirmed the above. This article briefly summarizes the mechanism of hypercoagulability and thrombotic complications of severe COVID-19 and proposes that blood hypercoagulability and intravascular microthrombosis are the development nodes of severe COVID-19. Therefore, anticoagulation and anti-inflammatory therapy can be used as important treatment strategies for severe COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #690548
    Database COVID19

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  4. Article ; Online: Ectopic CD4

    Wang, Keer / Hou, Xiaoxiao / Lu, Haimei / Han, Ning / Xie, Meijuan / Xi, Anran / Xu, Zhenghao

    Journal of autoimmunity

    2024  Volume 145, Page(s) 103199

    Abstract: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a disabling and potentially life-threatening complication of SLE. This study aims to investigate whether ectopic ... ...

    Abstract Neuropsychiatric systemic lupus erythematosus (NPSLE) is a disabling and potentially life-threatening complication of SLE. This study aims to investigate whether ectopic CD4
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 639452-8
    ISSN 1095-9157 ; 0896-8411
    ISSN (online) 1095-9157
    ISSN 0896-8411
    DOI 10.1016/j.jaut.2024.103199
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    Zs.A 2368: Show issues Location:
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  5. Article ; Online: Efficacy and safety of traditional Chinese medicine for the treatment of epilepsy: A updated meta-analysis of randomized controlled trials.

    Lu, Haimei / Luo, Mengxian / Chen, Rongrong / Luo, Yijun / Xi, Anran / Wang, Keer / Xu, Zhenghao

    Epilepsy research

    2023  Volume 189, Page(s) 107075

    Abstract: Objective: To evaluate the efficacy and safety of Traditional Chinese Medicine (TCM) in the treatment of epilepsy.: Methods: A comprehensive search of the database in both Chinese and English was performed. Data from the selected studies were ... ...

    Abstract Objective: To evaluate the efficacy and safety of Traditional Chinese Medicine (TCM) in the treatment of epilepsy.
    Methods: A comprehensive search of the database in both Chinese and English was performed. Data from the selected studies were extracted and analyzed independently by two authors.
    Results: 30 randomized controlled trials (RCTs) were included in the meta-analysis with a total of 2471 patients. Among them, 4 trials (n = 235) focused on TCM monotherapy, while the other 26 trials (n = 2236) assessed the benefit of TCM as an add-on therapy to antiseizure medications (ASMs). For the efficacy, the meta-analysis found (1) The effective rate in TCM monotherapy group was higher than that in control group (OR = 4.92, 95 % CI: 2.29-10.57, Z = 4.08, P 0.0001); (2) The add-on of TCM also increased the effective rate (OR = 3.37, 95 % CI: 2.65-4.30, Z = 9.85, P 0.00001) and seizure freedom rate (OR = 1.93, 95 % CI: 1.53-2.44, Z = 5.58, P 0.00001). In terms of safety, the add-on of TCM reduced the rate of total adverse events (OR = 0.46, 95 % CI: 0.31-0.67, Z = 3.96, P 0.0001) as well as adverse events of the gastrointestinal and nervous system. 26 different TCM prescriptions were used in these included RCTs. Among them, the 5 most frequently used herbs were Acorus tatarinowii (19 out of 26), Glycyrrhiza uralensis (13 out of 26), Gastrodia elata (12 out of 26), Pinellia ternata (11 out of 26) and Poria cocos (11 out of 26).
    Conclusion: This study suggested that TCM may be a relatively efficacious and safe clinical strategy for the treatment of epilepsy. Several limitations still exist, such as the risk of bias in the included studies, the diversified composition of TCM prescriptions, and the relatively low quality of study design.
    MeSH term(s) Humans ; Medicine, Chinese Traditional ; Drugs, Chinese Herbal/adverse effects ; Randomized Controlled Trials as Topic ; Epilepsy/drug therapy ; Phytotherapy
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2023-01-02
    Publishing country Netherlands
    Document type Meta-Analysis ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 632939-1
    ISSN 1872-6844 ; 0920-1211
    ISSN (online) 1872-6844
    ISSN 0920-1211
    DOI 10.1016/j.eplepsyres.2022.107075
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    Zs.A 2193: Show issues Location:
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  6. Article ; Online: Site-specific controlled-release nanoparticles for immune reprogramming via dual metabolic inhibition against triple-negative breast cancer.

    She, Wenyan / Li, Haimei / Wang, Zichen / Liu, Tingting / Zhao, Dongli / Guo, Zhibin / Liu, Yujiao / Liu, Yi

    Journal of controlled release : official journal of the Controlled Release Society

    2024  Volume 366, Page(s) 204–220

    Abstract: ... sequentially-releasing nanoparticle (AMANC@M) for tumor-targeted delivery of anticancer agents and CRISPR/Cas9 ... has been developed. AMANC@M can reverse the TIME through dual metabolic inhibition, thereby enhancing ... TNBC therapy. AMANC@M demonstrates excellent biosafety and targets tumors precisely through biomimetic ...

    Abstract Metabolic heterogeneity and the tumor immunosuppressive microenvironment (TIME) of triple-negative breast cancer (TNBC) hinder therapeutic effectiveness. Although emerging metabolic therapy and immunotherapy show promise, they are limited by off-target effects and immune escape. Here, a redox-activatable, sequentially-releasing nanoparticle (AMANC@M) for tumor-targeted delivery of anticancer agents and CRISPR/Cas9 has been developed. AMANC@M can reverse the TIME through dual metabolic inhibition, thereby enhancing TNBC therapy. AMANC@M demonstrates excellent biosafety and targets tumors precisely through biomimetic hybrid membrane-mediated homologous homing and the enhanced permeability and retention (EPR) effect. Once internalized into tumor cells, the CRISPR/Cas9 system ("energy nanolock") is released through glutathione (GSH) cleavage and effectively knocks down the expression of lactate dehydrogenase A (LDHA) to suppress glycolysis. After peeling off of the gene editing shell, a newly synthesized targeted drug, CPI-Z2 ("nutrihijacker" and "energy nanolock"), is released in a controlled manner to block the mitochondrial tricarboxylic acid (TCA) cycle. Nitric oxide (NO) produced from loaded L-arginine enhances the efficiency of CPI-Z2 and reduces drug resistance. Combined with NO therapy, both blockades of nutrients and energy production transform the hypoxia and acidic TIME into an immunocompetent tumor microenvironment (TME) for tumor elimination. Furthermore, AMANC@M offers capabilities for photothermal (PT) therapy and provides clear imaging through PT, photoacoustic (PA), or computed tomography (CT) signals in tumor tissue. Thus, this study provides a new and promising sequentially stimuli-responsive targeting strategy for nanoparticle development, making it a potential treatment candidate for TNBC and other tumors.
    MeSH term(s) Humans ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/metabolism ; Delayed-Action Preparations/therapeutic use ; Cell Line, Tumor ; Antineoplastic Agents ; Nanoparticles ; Tumor Microenvironment
    Chemical Substances Delayed-Action Preparations ; Antineoplastic Agents
    Language English
    Publishing date 2024-01-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2023.12.022
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    Zs.A 2055: Show issues Location:
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  7. Article ; Online: One-year follow-up of the effectiveness and mediators of cognitive behavioural therapy among adults with attention-deficit/hyperactivity disorder: secondary outcomes of a randomised controlled trial.

    Pan, Mei-Rong / Dong, Min / Zhang, Shi-Yu / Liu, Lu / Li, Hai-Mei / Wang, Yu-Feng / Qian, Qiu-Jin

    BMC psychiatry

    2024  Volume 24, Issue 1, Page(s) 207

    Abstract: ... symptoms who were randomly allocated to the CBT combined with medication (CBT + M) group or the medication ... M)-only group. Outcomes included ADHD-core symptoms (ADHD Rating Scale), depression symptoms (Self ... of CBT on psychological QoL.: Results: ADHD patients in the CBT + M group outperformed the M-only ...

    Abstract Background: The long-term effectiveness of cognitive behavioural therapy (CBT) in medicated attention-deficit/hyperactivity disorder (ADHD) adults with residual symptoms needs to be verified across multiple dimensions, especially with respect to maladaptive cognitions and psychological quality of life (QoL). An exploration of the mechanisms underlying the additive benefits of CBT on QoL in clinical samples may be helpful for a better understanding of the CBT conceptual model and how CBT works in medicated ADHD.
    Methods: We conducted a secondary analysis of a randomised controlled trial including 98 medicated ADHD adults with residual symptoms who were randomly allocated to the CBT combined with medication (CBT + M) group or the medication (M)-only group. Outcomes included ADHD-core symptoms (ADHD Rating Scale), depression symptoms (Self-rating Depression Scale), maladaptive cognitions (Automatic Thoughts Questionnaire and Dysfunctional Attitude Scale), and psychological QoL (World Health Organization Quality of Life-Brief Version-psychological domain). Mixed linear models (MLMs) were used to analyse the long-term effectiveness at one-year follow-up, and structural equation modeling (SEM) was performed to explore the potential mechanisms of CBT on psychological QoL.
    Results: ADHD patients in the CBT + M group outperformed the M-only group in reduction of ADHD core symptoms (d = 0.491), depression symptoms (d = 0.570), a trend of reduction of maladaptive cognitions (d = 0.387 and 0.395, respectively), and improvement of psychological QoL (d = - 0.433). The changes in above dimensions correlated with each other (r = 0.201 ~ 0.636). The influence of CBT on QoL was mediated through the following four pathways: 1) changes in ADHD core symptoms; 2) changes in depressive symptoms; 3) changes in depressive symptoms and then maladaptive cognitions; and 4) changes firstly in depressive symptoms, maladaptive cognitions, and then ADHD core symptoms.
    Conclusions: The long-term effectiveness of CBT in medicated ADHD adults with residual symptoms was further confirmed. The CBT conceptual model was verified in clinical samples, which would be helpful for a deeper understanding of how CBT works for a better psychological QoL outcome.
    Trial registration: ChiCTR1900021705 (2019-03-05).
    MeSH term(s) Adult ; Humans ; Attention Deficit Disorder with Hyperactivity/complications ; Attention Deficit Disorder with Hyperactivity/therapy ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Quality of Life ; Follow-Up Studies ; Treatment Outcome ; Cognitive Behavioral Therapy/methods
    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2050438-X
    ISSN 1471-244X ; 1471-244X
    ISSN (online) 1471-244X
    ISSN 1471-244X
    DOI 10.1186/s12888-024-05673-8
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  8. Article ; Online: The risk factors of gestational hypertension in patients with polycystic ovary syndrome: a retrospective analysis.

    Zhou, Shu / Ji, Yiping / Wang, Haimei

    BMC pregnancy and childbirth

    2021  Volume 21, Issue 1, Page(s) 336

    Abstract: ... 048, 95 %CI1.121 ~ 3.208), BMI ≥ 24 kg/m: Conclusions: The incidence of HDCP in PCOS patients is ...

    Abstract Background: The hypertensive disorders complicating pregnancy (HDCP) is common in patients with polycystic ovary syndrome (PCOS), yet the potential influencing factors remained unclear. We aimed to assess the independent risk factors of HDCP in patients with PCOS, to provide clinical evidences for the management of PCOS.
    Methods: Pregnant PCOS patients treated in our hospital from June 1, 2018 to November 30, 2020 were approached. The personal and clinical characteristics of patients with and without gestational hypertension were evaluated. Logistic regressions were conducted to identify the independent risk factors of HDCP, Receiver operating characteristics (ROC)curve analysis was conducted to evaluate the predicting value.
    Results: A total of 188 PCOS patients were included, the incidence of HDCP in patients with PCOS was 27.66 %. There were significant differences in the age, BMI, family history of hypertension, the history of adverse pregnancy, history of contraceptive pills use and family history of HDCP between HDCP group and no-HDCP group (all p < 0.05), and there were no significant differences in the family history of diabetes, multiple pregnancy and long-term smoking history between HDCP group and no-HDCP group (all p > 0.05). Age ≥ 27y(OR2.048, 95 %CI1.121 ~ 3.208), BMI ≥ 24 kg/m
    Conclusions: The incidence of HDCP in PCOS patients is relatively high. In clinical practice, medical workers should carry out early prevention and intervention measures for these risk factors to reduce the incidence of HDCP.
    MeSH term(s) Adolescent ; Adult ; Diabetes, Gestational/epidemiology ; Female ; Humans ; Hypertension, Pregnancy-Induced/epidemiology ; Hypertension, Pregnancy-Induced/etiology ; Logistic Models ; Polycystic Ovary Syndrome/complications ; Pregnancy ; ROC Curve ; Retrospective Studies ; Risk Factors ; Young Adult
    Language English
    Publishing date 2021-04-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059869-5
    ISSN 1471-2393 ; 1471-2393
    ISSN (online) 1471-2393
    ISSN 1471-2393
    DOI 10.1186/s12884-021-03808-3
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  9. Article ; Online: Comprehensive Evaluation of Dust Retention and Metal Accumulation by the Leaves of Roadside Plants in Hangzhou among Seasons

    Ning Dang / Handan Zhang / Haimei Li / Mir Md Abdus Salam / Guangcai Chen

    Forests, Vol 13, Iss 8, p

    2022  Volume 1290

    Abstract: ... varied among seasons, with the highest retention in winter (12.19 g·m −2 ) and the lowest retention in spring (6.89 g·m ...

    Abstract The auto exhaust and dust derived from increased traffic volumes have led to an increasing level of atmospheric particulates in urban areas, which have become a primary pollutant of ambient air in urban zones. Roadside plants can effectively retain atmospheric particulates and clean the urban air via foliar capture of road dust. Five common roadside plants in Hangzhou were selected to evaluate their capacity for the retention of particulate matter (PM) and the accumulation of metals. The results showed that the PM retention capacity of the different plants varied greatly, as was the case with Loropetalum chinense var. rubrum Yieh, Osmanthus fragrans (Thunb.) Loureiro, Pittosporum tobira (Thunb.) Ait, Photinia × fraseri Dress and Cinnamomum camphora (L.) Presl. In addition, the amounts of particles retained by the plants varied among seasons, with the highest retention in winter (12.19 g·m −2 ) and the lowest retention in spring (6.89 g·m −2 ). The solids on the leaf surface were mainly irregular particles, such as mineral fragments, soot aggregates, and fly ash particles. Meanwhile, these plant species can effectively accumulate heavy metals that attached to the particles. The leaves of the five tree species had the highest amounts of copper (Cu) and the lowest amounts of cadmium (Cd). Among species, L. chinense and P. tobira had the strongest comprehensive capacity to adsorb particulate matter and heavy metals. The results shed light on the rational selection of road plants, both as ornaments and to purify air via dust suppression in subtropical zones.
    Keywords atmospheric particulate ; heavy metals ; urban vegetation ; air pollution ; ecosystem services ; Plant ecology ; QK900-989
    Subject code 580
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Volatile organic compounds emission in the rubber products manufacturing processes

    Huang, Haimei / Wang, Zhangwei / Dai, Chunhao / Guo, Jia / Zhang, Xiaoshan

    Environmental research. 2022 Sept., v. 212

    2022  

    Abstract: ... by naphthalene, m/p-xylene, o-xylene and carbon disulfide. VOCs emission from mixing process had the highest CR ...

    Abstract Volatile organic compounds (VOCs) emission from rubber products manufacture processes, mixing, shaping and vulcanization were investigated in four rubber products factories in China. The source emission air was passively sampled by pre-vacuumized stainless steel canister and analyzed by gas chromatography-mass spectrometry-flame ionization detection (GC/MS-FID). The species profile of 107 VOCs in the emission processes were obtained. We calculated the photochemical ozone formation potential (OFP) and carcinogenic risk (CR) of the VOCs for each manufacture process. The results showed that mixing process mainly released dichloromethane (14.53%), carbon disulfide (CS₂) (6.88%), styrene (5.72%), 4-methyl-2-pentanone (5.22%) and naphthalene (3.69%) for solvents used and raw rubber degradation in the process. The C6–C8 alkanes, especially heptane and isomers of heptane (44.71%), were dominated in shaping process. The major species released from vulcanization process were carbon disulfide (29.72%), naphthalene (8.17%), acetone (7.73%) and dichloromethane (4.26%). VOCs emitted from vulcanization process had the highest OFP, which contributed by naphthalene, m/p-xylene, o-xylene and carbon disulfide. VOCs emission from mixing process had the highest CR, and 1,2-dibromoethane, 1,2-dichlorethane and 1,3-butadiene were the main contributors to CR. We also estimated the total VOCs emissions into the atmosphere from tires manufacturing in China, which were 7.58 × 10⁵ t in 2018 and contributed about 9% of total industry processes VOCs emissions.
    Keywords acetone ; air ; carbon disulfide ; carcinogenicity ; heptane ; ionization ; manufacturing ; methylene chloride ; naphthalene ; ozone ; photochemistry ; research ; risk ; rubber ; stainless steel ; styrene ; xylene
    Language English
    Dates of publication 2022-09
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2022.113485
    Database NAL-Catalogue (AGRICOLA)

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