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Article ; Online: Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases

Xi-Dian Tang / Tian-Tian Ji / Jia-Rui Dong / Hao Feng / Feng-Qiang Chen / Xi Chen / Hui-Ying Zhao / De-Kun Chen / Wen-Tao Ma

International Journal of Molecular Sciences, Vol 22, Iss 13009, p

2021 Volume 13009

Abstract: Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that most often occur after an overreactive immune system is activated by an acute systemic infection. A variety of cells participate in cytokine storm induction and ... ...

Abstract	Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that most often occur after an overreactive immune system is activated by an acute systemic infection. A variety of cells participate in cytokine storm induction and progression, with profiles of cytokines released during cytokine storm varying from disease to disease. This review focuses on pathophysiological mechanisms underlying cytokine storm induction and progression induced by pathogenic invasive infectious diseases. Strategies for targeted treatment of various types of infection-induced cytokine storms are described from both host and pathogen perspectives. In summary, current studies indicate that cytokine storm-targeted therapies can effectively alleviate tissue damage while promoting the clearance of invading pathogens. Based on this premise, “multi-omics” immune system profiling should facilitate the development of more effective therapeutic strategies to alleviate cytokine storms caused by various diseases.
Keywords	cytokine storm ; inflammation ; infectious disease ; pathophysiological mechanism ; treatment strategies ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Interleukin-17 mediates lung injury by promoting neutrophil accumulation during the development of contagious caprine pleuropneumonia.

Ma, Wen-Tao / Gu, Kui / Yang, Rui / Tang, Xi-Dian / Qi, Yu-Xu / Liu, Ming-Jie / Chen, De-Kun

Veterinary microbiology

2020 Volume 243, Page(s) 108651

Abstract: Contagious caprine pleuropneumonia (CCPP) is a highly contagious infectious disease of goats caused by Mycoplasma capricolum subspecies capripneumoniae (Mccp). CCPP outbreaks usually result in high morbidity and mortality of the affected goats, making ... ...

Abstract	Contagious caprine pleuropneumonia (CCPP) is a highly contagious infectious disease of goats caused by Mycoplasma capricolum subspecies capripneumoniae (Mccp). CCPP outbreaks usually result in high morbidity and mortality of the affected goats, making this disease a major cause of economic losses to goat producers globally. However, the pathogenesis of CCPP remains unclear. Here, we show that IL-17-driven neutrophil accumulation is involved in the lung damage in CCPP goats. During CCPP development, intense inflammatory infiltrates could be observed in the injured lungs. Specifically, neutrophils were observed to be present within the alveoli. Increased IL-17 release drove the excessive influx of neutrophils into the lung, as IL-17 effectively stimulated the production of neutrophil chemoattractants from lung epithelial cells following Mccp infection. Our data highlight a critical role of IL-17-driven neutrophil accumulation in the pathogenesis of CCPP and suggest that IL-17 may potentially be a useful immunotherapeutic target for the treatment of CCPP.
MeSH term(s)	Animals ; Goat Diseases/immunology ; Goat Diseases/microbiology ; Goats/immunology ; Inflammation ; Interleukin-17/immunology ; Lung/immunology ; Lung/pathology ; Lung Injury/immunology ; Lung Injury/microbiology ; Male ; Mycoplasma capricolum/immunology ; Neutrophil Infiltration ; Neutrophils/immunology ; Pleuropneumonia, Contagious/immunology ; Pleuropneumonia, Contagious/pathology ; Pulmonary Alveoli/immunology
Chemical Substances	Interleukin-17
Language	English
Publishing date	2020-03-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2020.108651
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Article ; Online: Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases.

Tang, Xi-Dian / Ji, Tian-Tian / Dong, Jia-Rui / Feng, Hao / Chen, Feng-Qiang / Chen, Xi / Zhao, Hui-Ying / Chen, De-Kun / Ma, Wen-Tao

International journal of molecular sciences

2021 Volume 22, Issue 23

Abstract	Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that most often occur after an overreactive immune system is activated by an acute systemic infection. A variety of cells participate in cytokine storm induction and progression, with profiles of cytokines released during cytokine storm varying from disease to disease. This review focuses on pathophysiological mechanisms underlying cytokine storm induction and progression induced by pathogenic invasive infectious diseases. Strategies for targeted treatment of various types of infection-induced cytokine storms are described from both host and pathogen perspectives. In summary, current studies indicate that cytokine storm-targeted therapies can effectively alleviate tissue damage while promoting the clearance of invading pathogens. Based on this premise, "multi-omics" immune system profiling should facilitate the development of more effective therapeutic strategies to alleviate cytokine storms caused by various diseases.
MeSH term(s)	Anti-Inflammatory Agents/therapeutic use ; Bacteria/immunology ; Bacterial Infections/pathology ; COVID-19/pathology ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/pathology ; Cytokines/blood ; Cytokines/metabolism ; Humans ; Inflammation/pathology ; Macrophages/immunology ; SARS-CoV-2/immunology ; Sepsis/microbiology ; Sepsis/pathology
Chemical Substances	Anti-Inflammatory Agents ; Cytokines
Language	English
Publishing date	2021-11-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222313009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Methods for Enhancing Clustered Regularly Interspaced Short Palindromic Repeats/Cas9-Mediated Homology-Directed Repair Efficiency.

Tang, Xi-Dian / Gao, Fei / Liu, Ming-Jie / Fan, Qin-Lei / Chen, De-Kun / Ma, Wen-Tao

Frontiers in genetics

2019 Volume 10, Page(s) 551

Abstract: The evolution of organisms has provided a variety of mechanisms to maintain the integrity of its genome, but as damage occurs, DNA damage repair pathways are necessary to resolve errors. Among them, the DNA double-strand break repair pathway is highly ... ...

Abstract	The evolution of organisms has provided a variety of mechanisms to maintain the integrity of its genome, but as damage occurs, DNA damage repair pathways are necessary to resolve errors. Among them, the DNA double-strand break repair pathway is highly conserved in eukaryotes, including mammals. Nonhomologous DNA end joining and homologous directed repair are two major DNA repair pathways that are synergistic or antagonistic. Clustered regularly interspaced short palindromic repeats genome editing techniques based on the nonhomologous DNA end joining repair pathway have been used to generate highly efficient insertions or deletions of variable-sized genes but are error-prone and inaccurate. By combining the homology-directed repair pathway with clustered regularly interspaced short palindromic repeats cleavage, more precise genome editing
Language	English
Publishing date	2019-06-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2019.00551
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Article ; Online: Neutrophils

Si-Lu NI / Fei GAO / Chen-Xiang ZUO / Xi-Dian TANG / Ming-Jie LIU / Jian-Jun CHANG / Yong WANG / De-Kun CHEN / Wen-Tao MA

Kafkas Universitesi Veteriner Fakultesi Dergisi, Vol 26, Iss 5, Pp 719-

A Critical Participator in Common Diseases of Ruminants

2020 Volume 727

Abstract: Neutrophils, pivotal effector cells involved in innate immunity, play a central role in various infectious and inflammatory diseases. Using a powerful phagocytic killing mechanism, these cells protect the host by destroying the invading pathogens. ... ...

Abstract	Neutrophils, pivotal effector cells involved in innate immunity, play a central role in various infectious and inflammatory diseases. Using a powerful phagocytic killing mechanism, these cells protect the host by destroying the invading pathogens. However, these cells can also cause varying degrees of tissue damage if their activation is not finely controlled. In recent years, the involvement of neutrophils in human diseases has been extensively studied, while their roles in ruminant diseases have rarely been investigated. In the present review, we mainly summarize current knowledge regarding the characteristics and functions of neutrophils in ruminants such as goats and cattle. We emphasize the involvement of these cells in several common diseases such as mastitis, Brucellosis, Mycoplasma bovis infection and parasitic infections, among others. We also focus on discussing the relevant mechanisms and signaling pathways underlying these observations. In addition, we compare the phenotypes and functions of neutrophils of different ruminant species. The studies about ruminant neutrophils should help elucidate the pathogenesis of many ruminant diseases and ultimately shed light on the development of novel therapeutics for these diseases.
Keywords	neutrophil ; protective immunity ; tissue damage ; ruminant disease ; immunotherapy ; Veterinary medicine ; SF600-1100
Subject code	610
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	University of Kafkas
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pathogenicity of blood orf virus isolates in the development of dairy goat contagious pustular dermatitis.

Cheng, Hong-Yu / Li, Wei-Juan / Li, Xing-Ming / Fan, Qin-Lei / Tang, Xi-Dian / Liu, Ming-Jie / Ma, Wen-Tao / Chen, De-Kun

Veterinary microbiology

2018 Volume 219, Page(s) 178–182

Abstract: Contagious pustular dermatitis is an exanthematous zoonotic disease caused by the orf virus. Pandemic outbreaks of this disease cause great economic losses, while the pathogenesis of this disease still remains obscure. In this study, blood samples were ... ...

Abstract	Contagious pustular dermatitis is an exanthematous zoonotic disease caused by the orf virus. Pandemic outbreaks of this disease cause great economic losses, while the pathogenesis of this disease still remains obscure. In this study, blood samples were collected from 628 asymptomatic goats across China for PCR-based virus detection. We detected the orf virus in the blood of asymptomatic goats. Moreover, the orf virus obtained from the blood of infected goats was infectious and induced typical symptoms of contagious pustular dermatitis after inoculation of uninfected dairy goats. In summary, our data provide evidence that asymptomatic animals may be carriers of orf virus. Our findings should contribute to elucidating the details underlying the pathogenesis of contagious pustular dermatitis.
MeSH term(s)	Animals ; Asymptomatic Diseases/epidemiology ; China/epidemiology ; Disease Outbreaks/veterinary ; Ecthyma, Contagious/blood ; Ecthyma, Contagious/pathology ; Ecthyma, Contagious/transmission ; Ecthyma, Contagious/virology ; Goat Diseases/epidemiology ; Goat Diseases/virology ; Goats/virology ; Orf virus/genetics ; Orf virus/isolation & purification ; Orf virus/pathogenicity ; Phylogeny ; Polymerase Chain Reaction ; Virulence
Language	English
Publishing date	2018-04-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2018.04.020
Database	MEDical Literature Analysis and Retrieval System OnLINE

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ab Jg. 2022: Lesesaal (EG)

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Article: Pathogenicity of blood orf virus isolates in the development of dairy goat contagious pustular dermatitis

Cheng, Hong-Yu / Chen, De-Kun / Fan, Qin-Lei / Li, Wei-Juan / Li, Xing-Ming / Liu, Ming-Jie / Ma, Wen-Tao / Tang, Xi-Dian

Veterinary microbiology. 2018 June, v. 219

2018

Abstract	Contagious pustular dermatitis is an exanthematous zoonotic disease caused by the orf virus. Pandemic outbreaks of this disease cause great economic losses, while the pathogenesis of this disease still remains obscure. In this study, blood samples were collected from 628 asymptomatic goats across China for PCR-based virus detection. We detected the orf virus in the blood of asymptomatic goats. Moreover, the orf virus obtained from the blood of infected goats was infectious and induced typical symptoms of contagious pustular dermatitis after inoculation of uninfected dairy goats. In summary, our data provide evidence that asymptomatic animals may be carriers of orf virus. Our findings should contribute to elucidating the details underlying the pathogenesis of contagious pustular dermatitis.
Keywords	blood ; blood sampling ; contagious ecthyma ; dairy goats ; Orf virus ; pandemic ; pathogenesis ; pathogenicity ; polymerase chain reaction ; viruses ; zoonoses ; China
Language	English
Dates of publication	2018-06
Size	p. 178-182.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2018.04.020
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 2917: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article: Impact of

Chen, Jing / Kang, Xiao-Yu / Tang, Chuan-Xi / Gao, Dian-Shuai

Neural regeneration research

2017 Volume 12, Issue 8, Page(s) 1347–1351

Abstract: Pitx3 is strongly associated with the phenotype, differentiation, and survival of dopaminergic neurons. The relationship between Pitx3 and glial cell line-derived neurotrophic factor (GDNF) in dopaminergic neurons remains poorly understood. The present ... ...

Abstract	Pitx3 is strongly associated with the phenotype, differentiation, and survival of dopaminergic neurons. The relationship between Pitx3 and glial cell line-derived neurotrophic factor (GDNF) in dopaminergic neurons remains poorly understood. The present investigation sought to construct and screen a lentivirus expression plasmid carrying a rat Pitx3 short hairpin (sh)RNA and to assess the impact of
Language	English
Publishing date	2017-09-15
Publishing country	India
Document type	Journal Article
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.213557
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Recombinant human endostatin injection (Endostar) combined with PF chemotherapy and sequential intensity-modulated radiotherapy is tolerable and improves prognosis of locally advanced nasopharyngeal carcinoma: a randomized, open, multicenter phase II clinical study.

Xu, Lu / Li, Dailong / Ji, Jinxing / Chen, Zhuo / Tang, Xi / Chen, Dian / Li, Xin / Bao, Dan / Yan, Fan / Pang, Yaqi / Liu, Siqi / Zhou, Yunfeng / Xu, Xinhua

American journal of cancer research

2022 Volume 12, Issue 10, Page(s) 4622–4636

Abstract: Nasopharyngeal carcinoma (NPC) is not only a common malignant disease of the head and neck, but also presented as locoregionally advanced NPC at diagnosis with poor prognosis. The efficacy of current chemoradiotherapy is unsatisfactory; therefore, in ... ...

Abstract	Nasopharyngeal carcinoma (NPC) is not only a common malignant disease of the head and neck, but also presented as locoregionally advanced NPC at diagnosis with poor prognosis. The efficacy of current chemoradiotherapy is unsatisfactory; therefore, in this study, we evaluated the safety and efficacy of treating locally advanced NPC using recombinant human endostatin injection (Endostar), combined with a cisplatin plus 5-fluorouracil (PF) regimen and sequential intensity-modulated radiotherapy (IMRT), and compared it with PF plus IMRT regimen. This phase II study included 83 eligible patients with stages III-IVa NPC (8th AJCC/UICC) who were randomized 1:1 into control (n = 42) and experimental (n = 41) groups. The control group received PF chemotherapy and IMRT for locally advanced NPC; One cycle of induction chemotherapy (IC) was administered before IMRT, and three cycles of adjuvant chemotherapy (AC) were administered four weeks post-radiotherapy. The experimental group received additional Endostar therapy. All patients were followed up for at least 5 years. The primary endpoints were progression-free survival (PFS) and the objective response rate. The secondary endpoints included overall survival and treatment-related toxicities. The short-term efficacy was evaluated at the end of the fourth chemotherapy cycle. Our results showed that the complete response rate of nasopharyngeal lesions was not significantly different between the experimental and control groups (80.5 vs. 71.4%,
Language	English
Publishing date	2022-10-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2589522-9
ISSN	2156-6976
ISSN	2156-6976
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Regulation of the Golgi apparatus via GOLPH3-mediated new selective autophagy.

Lu, Li-Qun / Tang, Ming-Zhu / Qi, Zhi-Hao / Huang, Shi-Fang / He, Yong-Qi / Li, Dian-Ke / Li, Lan-Fang / Chen, Lin-Xi

Life sciences

2020 Volume 253, Page(s) 117700

Abstract: Aims: Although previous studies elaborated that selective autophagy was involved in quality control of some organelles, including nucleus, mitochondria, the endoplasmic reticulum and peroxisomes, it remained unclear whether the selective autophagy of ... ...

Abstract	Aims: Although previous studies elaborated that selective autophagy was involved in quality control of some organelles, including nucleus, mitochondria, the endoplasmic reticulum and peroxisomes, it remained unclear whether the selective autophagy of the Golgi apparatus (Golgiphagy) existed or not. Main methods: In this study, H9c2 cells, HUVECs, HA-VSMCs and HEK293T cells were treated with autophagy inducers, Golgi stress inducers and cardiomyocytes hypertrophy stimulators. The Golgiphagy was evaluated by analysing the co-localization of Golgi markers and LC3B. Furthermore, the transmission electron microscope was used to observe the occurrence of Golgiphagy. The co-immunoprecipitation assay was used to evaluate the interaction of GOLPH3 and LC3B. Key findings: Results showed that starvation promoted the co-localization of both GM130-positive and TGN46-positive Golgi fragments with LC3B-positive autophagosomes in H9c2 cells, HUVECs, HA-VSMCs and HEK293T cells. Transmission electron microscopy images showed that Golgi apparatus was sequestered into the autophagosomes in the starvation group. Moreover, Golgi stress inducers also facilitated the co-localization of Golgi markers and LC3B in H9c2 cells, HUVECs, HA-VSMCs and HEK293T cells. Furthermore, cardiomyocyte hypertrophy stimulators also triggered the appearance of Golgiphagy in H9c2 cells. Importantly, the co-immunoprecipitation assay indicated endogenous GOLPH3 interacted with LC3B in H9c2 cells, HUVECs, HA-VSMCs. However, knocking down GOLPH3 inhibited the Golgiphagy. Significance: This study unveiled a new selective autophagy of the Golgi apparatus (Golgiphagy). In addition, GOLPH3 might act as a novel cargo receptor to regulate Golgiphagy. Maintaining homeostasis of the Golgi apparatus via GOLPH3-mediated autophagy was indispensable for cell survival.
MeSH term(s)	Animals ; Autophagy/physiology ; Cell Line ; Cell Survival/physiology ; Gene Knockdown Techniques ; Golgi Apparatus/metabolism ; HEK293 Cells ; Human Umbilical Vein Endothelial Cells ; Humans ; Immunoprecipitation ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Microscopy, Electron, Transmission ; Microtubule-Associated Proteins/metabolism ; Myocytes, Cardiac/metabolism ; Rats
Chemical Substances	GOLPH3 protein, human ; MAP1LC3B protein, human ; Membrane Proteins ; Microtubule-Associated Proteins
Language	English
Publishing date	2020-04-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2020.117700
Database	MEDical Literature Analysis and Retrieval System OnLINE

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