LIVIVO - Search results -

Search results

Result 1 - 10 of total 39

Search options

Article ; Online: A(H1N1)pdm09 Influenza Viruses Replicating in Ferret Upper or Lower Respiratory Tract Differed in Onward Transmission Potential by Air.

Xie, Chenyi / Su, Wen / Sia, Sin Fun / Choy, Ka-Tim / Morrell, Steven / Zhou, Jie / Peiris, Malik / Bloom, Jesse D / Yen, Hui-Ling

The Journal of infectious diseases

2021 Volume 225, Issue 1, Page(s) 65–74

Abstract: Background: A(H1N1)pdm09 influenza viruses replicate efficiently in respiratory epithelia and are transmitted via respiratory droplets and aerosols expelled by infected hosts. The relative onward transmission potential of influenza viruses replicating ... ...

Abstract	Background: A(H1N1)pdm09 influenza viruses replicate efficiently in respiratory epithelia and are transmitted via respiratory droplets and aerosols expelled by infected hosts. The relative onward transmission potential of influenza viruses replicating in the upper and lower respiratory epithelial cells has not been fully defined. Methods: Wild-type and barcoded A(H1N1)pdm09 viruses that differed by 2 synonymous mutations per gene segment were inoculated into ferrets via intranasal and intratracheal routes. Naive recipients were exposed to the exhaled breath of inoculated donors for 8 hours on day 2 postinoculation. Onward transmission potential of wild-type and barcoded genotypes were monitored by next generation sequencing. Results: Transmissible airborne particles were respired from the upper but not the lower respiratory epithelial cells of donor ferrets. There was limited mixing of viral populations replicating in the upper and lower respiratory tissues. Conclusions: The ferret upper respiratory epithelium was mapped as the anatomic site that generated influenza virus-laden particles mediating onward transmission by air. Our results suggest that vaccines and antivirals should aim to reduce viral loads in the upper respiratory tract for prevention of influenza transmission.
MeSH term(s)	Animals ; Ferrets/virology ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H1N1 Subtype/isolation & purification ; Orthomyxoviridae Infections/diagnosis ; Orthomyxoviridae Infections/epidemiology ; Orthomyxoviridae Infections/transmission ; Respiratory Aerosols and Droplets ; Respiratory System ; Viral Tropism ; Virus Replication
Language	English
Publishing date	2021-01-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiab286
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh II Zs.50: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 445: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Cellular tropism of SARS-CoV-2 in the respiratory tract of Syrian hamsters and B6.Cg-Tg(K18-ACE2)2Prlmn/J transgenic mice

Yen, Hui-Ling / Valkenburg, Sophie / Sia, Sin Fun / Choy, Ka Tim / Peiris, J. S. Malik / Wong, Karen H. M. / Crossland, Nicholas / Douam, Florian / Nicholls, John M.

Veterinary pathology. 2022 July, v. 59, no. 4

2022

Abstract: Several animal models have been developed to study the pathophysiology of SARS-CoV-2 infection and to evaluate vaccines and therapeutic agents for this emerging disease. Similar to infection with SARS-CoV-1, infection of Syrian hamsters with SARS-CoV-2 ... ...

Abstract	Several animal models have been developed to study the pathophysiology of SARS-CoV-2 infection and to evaluate vaccines and therapeutic agents for this emerging disease. Similar to infection with SARS-CoV-1, infection of Syrian hamsters with SARS-CoV-2 results in moderate respiratory disease involving the airways and lung parenchyma but does not lead to increased mortality. Using a combination of immunohistochemistry and transmission electron microscopy, we showed that the epithelium of the conducting airways of hamsters was the primary target for viral infection within the first 5 days of infection, with little evidence of productive infection of pneumocytes. At 6 days postinfection, antigen was cleared but parenchymal damage persisted, and the major pathological changes resolved by day 14. These findings are similar to those previously reported for hamsters with SARS-CoV-1 infection. In contrast, infection of K18-hACE2 transgenic mice resulted in pneumocyte damage, with viral particles and replication complexes in both type I and type II pneumocytes together with the presence of convoluted or cubic membranes; however, there was no evidence of virus replication in the conducting airways. The Syrian hamster is a useful model for the study of SARS-CoV-2 transmission and vaccination strategies, whereas infection of the K18-hCE2 transgenic mouse results in lethal disease with fatal neuroinvasion but with sparing of conducting airways.
Keywords	Mesocricetus auratus ; Severe acute respiratory syndrome coronavirus ; Severe acute respiratory syndrome coronavirus 2 ; animal pathology ; antigens ; epithelium ; immunohistochemistry ; mice ; mortality ; parenchyma (animal tissue) ; pathophysiology ; pneumocytes ; respiratory tract diseases ; transmission electron microscopy ; vaccination ; virus replication
Language	English
Dates of publication	2022-07
Size	p. 639-647.
Publishing place	SAGE Publications
Document type	Article
ZDB-ID	188012-3
ISSN	1544-2217 ; 0300-9858
ISSN (online)	1544-2217
ISSN	0300-9858
DOI	10.1177/03009858211043084
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 1959: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Reduced Pathogenicity and Transmission Potential of Omicron BA.1 and BA.2 Sublineages Compared with the Early Severe Acute Respiratory Syndrome Coronavirus 2 D614G Variant in Syrian Hamsters.

Su, Wen / Choy, Ka Tim / Gu, Haogao / Sia, Sin Fun / Cheng, Ka Man / Nizami, Sarea Islam Nuha / Krishnan, Pavithra / Ng, Yuet Mai / Chang, Lydia Dai Jia / Liu, Yingzhi / Cheng, Samuel M S / Peiris, Malik / Poon, Leo L M / Nicholls, John M / Yen, Hui-Ling

The Journal of infectious diseases

2022 Volume 227, Issue 10, Page(s) 1143–1152

Abstract: Background: The epidemiological advantage of Omicron variant is evidenced by its rapid spread and the ability to outcompete prior variants. Among Omicron sublineages, early outbreaks were dominated by BA.1, while BA.2 has gained dominance since February ...

Abstract	Background: The epidemiological advantage of Omicron variant is evidenced by its rapid spread and the ability to outcompete prior variants. Among Omicron sublineages, early outbreaks were dominated by BA.1, while BA.2 has gained dominance since February 2022. The relative pathogenicity and transmissibility of BA.1 and BA.2 have not been fully defined. Methods: We compared viral loads and clinical signs in Syrian hamsters after infection with BA.1, BA.2, or D614G variant. A competitive transmission model and next-generation sequencing were used to compare the relative transmission potential of BA.1 and BA.2. Results: BA.1 and BA.2 caused no apparent clinical signs, while D614G caused more than 10% weight loss. Higher viral loads were detected in nasal wash samples and nasal turbinate and lung tissues from BA.1-inoculated hamsters compared with BA.2-inoculated hamsters. No aerosol transmission was observed for BA.1 or BA.2 under the experimental condition in which D614G transmitted efficiently. BA.1 and BA.2 were able to transmit among hamsters via direct contact; however, BA.1 transmitted more efficiently than BA.2 under the competitive transmission model. No recombination was detected from direct contacts exposed simultaneously to BA.1 and BA.2. Conclusions: Omicron BA.1 and BA.2 demonstrated attenuated pathogenicity and reduced transmission potential in hamsters compared with early SARS-CoV-2 strains.
MeSH term(s)	Animals ; Cricetinae ; Humans ; Mesocricetus ; SARS-CoV-2/genetics ; Virulence ; COVID-19
Language	English
Publishing date	2022-07-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiac276
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh II Zs.50: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 445: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Limited onward transmission potential of reassortment genotypes from chickens co-infected with H9N2 and H7N9 avian influenza viruses.

Su, Wen / Sia, Sin Fun / Choy, Ka-Tim / Ji, Yue / Chen, Dongdong / Lau, Eric Ho Yin / Fu, Guanghua / Huang, Yu / Liu, Jinhua / Peiris, Malik / Pu, Juan / Yen, Hui-Ling

Emerging microbes & infections

2021 Volume 10, Issue 1, Page(s) 2030–2041

Abstract: The segmented genome of influenza A virus has conferred significant evolutionary advantages to this virus through genetic reassortment, a mechanism that facilitates the rapid expansion of viral genetic diversity upon influenza co-infections. Therefore, ... ...

Abstract	The segmented genome of influenza A virus has conferred significant evolutionary advantages to this virus through genetic reassortment, a mechanism that facilitates the rapid expansion of viral genetic diversity upon influenza co-infections. Therefore, co-infection of genetically diverse avian influenza viruses in poultry may pose a significant public health risk in generating novel reassortants with increased zoonotic potential. This study investigated the reassortment patterns of a Pearl River Delta-lineage avian influenza A(H7N9) virus and four genetically divergent avian influenza A(H9N2) viruses upon co-infection in embryonated chicken eggs and chickens. To characterize "within-host" and "between-host" genetic diversity, we further monitored the viral genotypes that were subsequently transmitted to contact chickens in serial transmission experiments. We observed that co-infection with A(H7N9) and A(H9N2) viruses may lead to the emergence of novel reassortant viruses
MeSH term(s)	Animals ; Chick Embryo ; Chickens ; Coinfection/transmission ; Coinfection/virology ; Genotype ; Humans ; Influenza A Virus, H7N9 Subtype/genetics ; Influenza A Virus, H7N9 Subtype/physiology ; Influenza A Virus, H9N2 Subtype/genetics ; Influenza A Virus, H9N2 Subtype/physiology ; Influenza in Birds/transmission ; Influenza in Birds/virology ; Influenza, Human/transmission ; Influenza, Human/virology ; Phylogeny ; Poultry Diseases/transmission ; Poultry Diseases/virology ; Reassortant Viruses/genetics ; Reassortant Viruses/physiology ; Recombination, Genetic ; Viral Zoonoses/transmission ; Viral Zoonoses/virology
Language	English
Publishing date	2021-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2681359-2
ISSN	2222-1751 ; 2222-1751
ISSN (online)	2222-1751
ISSN	2222-1751
DOI	10.1080/22221751.2021.1996209
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Cellular tropism of SARS-CoV-2 in the respiratory tract of Syrian hamsters and B6.Cg-Tg(K18-ACE2)2Prlmn/J transgenic mice.

Yen, Hui-Ling / Valkenburg, Sophie / Sia, Sin Fun / Choy, Ka Tim / Peiris, J S Malik / Wong, Karen H M / Crossland, Nicholas / Douam, Florian / Nicholls, John M

Veterinary pathology

2021 Volume 59, Issue 4, Page(s) 639–647

Abstract	Several animal models have been developed to study the pathophysiology of SARS-CoV-2 infection and to evaluate vaccines and therapeutic agents for this emerging disease. Similar to infection with SARS-CoV-1, infection of Syrian hamsters with SARS-CoV-2 results in moderate respiratory disease involving the airways and lung parenchyma but does not lead to increased mortality. Using a combination of immunohistochemistry and transmission electron microscopy, we showed that the epithelium of the conducting airways of hamsters was the primary target for viral infection within the first 5 days of infection, with little evidence of productive infection of pneumocytes. At 6 days postinfection, antigen was cleared but parenchymal damage persisted, and the major pathological changes resolved by day 14. These findings are similar to those previously reported for hamsters with SARS-CoV-1 infection. In contrast, infection of K18-hACE2 transgenic mice resulted in pneumocyte damage, with viral particles and replication complexes in both type I and type II pneumocytes together with the presence of convoluted or cubic membranes; however, there was no evidence of virus replication in the conducting airways. The Syrian hamster is a useful model for the study of SARS-CoV-2 transmission and vaccination strategies, whereas infection of the K18-hCE2 transgenic mouse results in lethal disease with fatal neuroinvasion but with sparing of conducting airways.
MeSH term(s)	Angiotensin-Converting Enzyme 2 ; Animals ; COVID-19/virology ; Cricetinae ; Disease Models, Animal ; Lung/pathology ; Mesocricetus ; Mice ; Mice, Transgenic ; Respiratory System/virology ; SARS-CoV-2/genetics ; Viral Tropism
Chemical Substances	Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-09-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	188012-3
ISSN	1544-2217 ; 0300-9858
ISSN (online)	1544-2217
ISSN	0300-9858
DOI	10.1177/03009858211043084
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 629: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Avian influenza virus directly infects human natural killer cells and inhibits cell activity.

Mao, Huawei / Liu, Yinping / Sia, Sin Fun / Peiris, J S Malik / Lau, Yu-Lung / Tu, Wenwei

Virologica Sinica

2017 Volume 32, Issue 2, Page(s) 122–129

Abstract: Natural killer (NK) cell is a key component of innate immunity and plays an important role in host defense against virus infection by directly destroying infected cells. Influenza is a respiratory disease transmitted in the early phase of virus infection. ...

Abstract	Natural killer (NK) cell is a key component of innate immunity and plays an important role in host defense against virus infection by directly destroying infected cells. Influenza is a respiratory disease transmitted in the early phase of virus infection. Evasion of host innate immunity including NK cells is critical for the virus to expand and establish a successful acute infection. Previously, we showed that human influenza H1N1 virus infects NK cells and induces cell apoptosis, as well as inhibits NK cell activity. In this study, we further demonstrated that avian influenza virus also directly targeted NK cells as an immunoevasion strategy. The avian virus infected human NK cells and induced cell apoptosis. In addition, avian influenza virion and HA protein inhibited NK cell cytotoxicity. This novel strategy has obvious advantages for avian influenza virus, allowing the virus sufficient time to expand and subsequent spread before the onset of the specific immune response. Our findings provide an important clue for the immunopathogenesis of avian influenza, and also suggest that direct targeting NK cells may be a common strategy used by both human and avian influenza viruses to evade NK cell immunity.
MeSH term(s)	Apoptosis ; Cells, Cultured ; Host-Pathogen Interactions ; Humans ; Immune Evasion ; Influenza A Virus, H5N1 Subtype/pathogenicity ; Influenza A Virus, H5N1 Subtype/physiology ; Influenza A Virus, H9N2 Subtype/pathogenicity ; Influenza A Virus, H9N2 Subtype/physiology ; Killer Cells, Natural/virology
Language	English
Publishing date	2017-02-23
Publishing country	China
Document type	Journal Article
ZDB-ID	1011219-4
ISSN	1995-820X ; 1000-3223 ; 1003-5125
ISSN (online)	1995-820X
ISSN	1000-3223 ; 1003-5125
DOI	10.1007/s12250-016-3918-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4175: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Pathogenesis and transmission of SARS-CoV-2 in golden hamsters.

Sia, Sin Fun / Yan, Li-Meng / Chin, Alex W H / Fung, Kevin / Choy, Ka-Tim / Wong, Alvina Y L / Kaewpreedee, Prathanporn / Perera, Ranawaka A P M / Poon, Leo L M / Nicholls, John M / Peiris, Malik / Yen, Hui-Ling

Nature

2020 Volume 583, Issue 7818, Page(s) 834–838

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus with high nucleotide identity to SARS-CoV and to SARS-related coronaviruses that have been detected in horseshoe bats, has spread across the world and had a global effect ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus with high nucleotide identity to SARS-CoV and to SARS-related coronaviruses that have been detected in horseshoe bats, has spread across the world and had a global effect on healthcare systems and economies
MeSH term(s)	Aerosols ; Alveolar Epithelial Cells/pathology ; Alveolar Epithelial Cells/virology ; Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Antigens, Viral/immunology ; Antigens, Viral/isolation & purification ; Antigens, Viral/metabolism ; Betacoronavirus/immunology ; Betacoronavirus/isolation & purification ; Betacoronavirus/metabolism ; Betacoronavirus/pathogenicity ; Bronchi/pathology ; Bronchi/virology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Disease Models, Animal ; Duodenum/virology ; Fomites/virology ; Housing, Animal ; Kidney/virology ; Lung/pathology ; Lung/virology ; Male ; Mesocricetus/immunology ; Mesocricetus/virology ; Nasal Mucosa/virology ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; RNA, Viral/analysis ; SARS-CoV-2 ; Viral Load ; Weight Loss
Chemical Substances	Aerosols ; Antibodies, Neutralizing ; Antibodies, Viral ; Antigens, Viral ; RNA, Viral
Keywords	covid19
Language	English
Publishing date	2020-05-14
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-020-2342-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro.

Choy, Ka-Tim / Wong, Alvina Yin-Lam / Kaewpreedee, Prathanporn / Sia, Sin Fun / Chen, Dongdong / Hui, Kenrie Pui Yan / Chu, Daniel Ka Wing / Chan, Michael Chi Wai / Cheung, Peter Pak-Hang / Huang, Xuhui / Peiris, Malik / Yen, Hui-Ling

Antiviral research

2020 Volume 178, Page(s) 104786

Abstract: An escalating pandemic by the novel SARS-CoV-2 virus is impacting global health and effective therapeutic options are urgently needed. We evaluated the in vitro antiviral effect of compounds that were previously reported to inhibit coronavirus ... ...

Abstract	An escalating pandemic by the novel SARS-CoV-2 virus is impacting global health and effective therapeutic options are urgently needed. We evaluated the in vitro antiviral effect of compounds that were previously reported to inhibit coronavirus replication and compounds that are currently under evaluation in clinical trials for SARS-CoV-2 patients. We report the antiviral effect of remdesivir, lopinavir, homorringtonine, and emetine against SARS-CoV-2 virus in Vero E6 cells with the estimated 50% effective concentration at 23.15 μM, 26.63 μM, 2.55 μM and 0.46 μM, respectively. Ribavirin or favipiravir that are currently evaluated under clinical trials showed no inhibition at 100 μM. Synergy between remdesivir and emetine was observed, and remdesivir at 6.25 μM in combination with emetine at 0.195 μM may achieve 64.9% inhibition in viral yield. Combinational therapy may help to reduce the effective concentration of compounds below the therapeutic plasma concentrations and provide better clinical benefits.
MeSH term(s)	Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; Amides/pharmacology ; Animals ; Antimetabolites/pharmacology ; Antiviral Agents/pharmacology ; Betacoronavirus/drug effects ; Betacoronavirus/physiology ; COVID-19 ; Chlorocebus aethiops ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Drug Combinations ; Emetine/pharmacology ; Epithelial Cells ; Homoharringtonine/pharmacology ; Humans ; Lopinavir/pharmacology ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; Pyrazines/pharmacology ; Ribavirin/pharmacology ; SARS-CoV-2 ; Vero Cells ; Virus Replication/drug effects
Chemical Substances	Amides ; Antimetabolites ; Antiviral Agents ; Drug Combinations ; Pyrazines ; Lopinavir (2494G1JF75) ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Ribavirin (49717AWG6K) ; Homoharringtonine (6FG8041S5B) ; favipiravir (EW5GL2X7E0) ; Alanine (OF5P57N2ZX) ; Emetine (X8D5EPO80M)
Keywords	covid19
Language	English
Publishing date	2020-04-03
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	306628-9
ISSN	1872-9096 ; 0166-3542
ISSN (online)	1872-9096
ISSN	0166-3542
DOI	10.1016/j.antiviral.2020.104786
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1627: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

Antiviral Research

2020 Volume 178, Page(s) 104786

Keywords	Pharmacology ; Virology ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	306628-9
ISSN	1872-9096 ; 0166-3542
ISSN (online)	1872-9096
ISSN	0166-3542
DOI	10.1016/j.antiviral.2020.104786
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Zs.A 1627: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

Sia, Sin Fun / Yan, Li-Meng / Chin, Alex W. H. / Fung, Kevin / Choy, Ka-Tim / Wong, Alvina Y. L. / Kaewpreedee, Prathanporn / Perera, Ranawaka A. P. M. / Poon, Leo L. M. / Nicholls, John M. / Peiris, Malik / Yen, Hui-Ling

Nature

2020 Volume 583, Issue 7818, Page(s) 834–838

Keywords	Multidisciplinary ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-020-2342-5
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito