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  1. Article ; Online: Matthew Potolsky’s The National Security Sublime

    Nolan Higdon

    Secrecy and Society, Vol 2, Iss

    On the Aesthetics of Government Secrecy (review)

    2021  Volume 2

    Abstract: Matthew Potolsky’s brilliantly woven The National Security Sublime: On the Aesthetics of Government ...

    Abstract Matthew Potolsky’s brilliantly woven The National Security Sublime: On the Aesthetics of Government Secrecy offers a powerful and engaging discussion of national security and government secrecy. His findings concerning the influence artists have on citizens’ perception of national security is a major contribution to the field. It highlights Americans false sense of awareness regarding government secrecy, that in itself enables government secrecy. Potolsky has made a massive contribution to the study of government secrecy that is sure to spark future research concerning the intersection of national security and aesthetics.
    Keywords esthetics ; civil liberties ; cultural studies ; film ; government secrecy ; indiana jones ; military industrial complex ; national security ; privacy ; security ; surveillance ; usa patriot act ; x-files ; Law ; K ; Social Sciences ; H
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher SJSU Scholarworks
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Memory consolidation: Building influence over the entorhinal cortex.

    Nolan, Matthew F

    Current biology : CB

    2023  Volume 33, Issue 21, Page(s) R1160–R1162

    Abstract: Memory consolidation involves interactions between the hippocampus and other cortical areas. A new study identifies neurons in the medial entorhinal cortex that over learning increase their coordination with hippocampal replay events, suggesting a route ... ...

    Abstract Memory consolidation involves interactions between the hippocampus and other cortical areas. A new study identifies neurons in the medial entorhinal cortex that over learning increase their coordination with hippocampal replay events, suggesting a route for consolidation of spatial memories.
    MeSH term(s) Entorhinal Cortex/physiology ; Memory Consolidation ; Hippocampus/physiology ; Spatial Memory ; Neurons/physiology
    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.09.072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Task-anchored grid cell firing is selectively associated with successful path integration-dependent behaviour.

    Clark, Harry / Nolan, Matthew F

    eLife

    2024  Volume 12

    Abstract: Grid firing fields have been proposed as a neural substrate for spatial localisation in general or for path integration in particular. To distinguish these possibilities, we investigate firing of grid and non-grid cells in the mouse medial entorhinal ... ...

    Abstract Grid firing fields have been proposed as a neural substrate for spatial localisation in general or for path integration in particular. To distinguish these possibilities, we investigate firing of grid and non-grid cells in the mouse medial entorhinal cortex during a location memory task. We find that grid firing can either be anchored to the task environment, or can encode distance travelled independently of the task reference frame. Anchoring varied between and within sessions, while spatial firing of non-grid cells was either coherent with the grid population, or was stably anchored to the task environment. We took advantage of the variability in task-anchoring to evaluate whether and when encoding of location by grid cells might contribute to behaviour. We find that when reward location is indicated by a visual cue, performance is similar regardless of whether grid cells are task-anchored or not, arguing against a role for grid representations when location cues are available. By contrast, in the absence of the visual cue, performance was enhanced when grid cells were anchored to the task environment. Our results suggest that anchoring of grid cells to task reference frames selectively enhances performance when path integration is required.
    MeSH term(s) Mice ; Animals ; Entorhinal Cortex ; Cues ; Action Potentials ; Space Perception ; Models, Neurological
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.89356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Barriers and facilitators to using an objective risk communication tool during primary care dental consultations: A Theoretical Domains Framework (TDF) informed qualitative study.

    Musson, Danielle / Buchanan, Heather / Nolan, Matthew / Asimakopoulou, Koula

    Journal of dentistry

    2024  Volume 142, Page(s) 104853

    Abstract: Objectives: Objective risk communication tools can supplement clinical judgement and support the understanding of potential health risks. This study used the Theoretical Domains Framework (TDF) to identify barriers and facilitators to implementing a ... ...

    Abstract Objectives: Objective risk communication tools can supplement clinical judgement and support the understanding of potential health risks. This study used the Theoretical Domains Framework (TDF) to identify barriers and facilitators to implementing a risk communication aid within primary care dental consultations.
    Methods: Dentists (N = 13), recruited via a dental practice database and through professional contacts were interviewed using a TDF-informed semi-structured interview schedule. Data were analysed inductively and deductively coding the themes using the TDF.
    Results: Eight theoretical domains (environmental context and resources; beliefs about consequences; goals; memory, attention, and decision processes; optimism; reinforcement; social influences and behavioural regulation) and thirteen sub-themes were identified. Insufficient resources and patient factors were commonly encountered barriers and led to increasing pressure to prioritise other tasks. Whilst dentists had a favourable view towards a risk communication aid and acknowledged its benefits, some were sceptical about its ability to facilitate behaviour change. Self-monitoring strategies and colleague support facilitated tool usage.
    Conclusions: This study identified six barriers and seven facilitators to implementing a risk communication tool within primary care dental settings. Dentists appreciated the value of using a risk communication tool during dental consultations, although some required further support to integrate the tool into practice.
    Clinical significance: Our findings provide a sound theoretical base for interventions aimed at facilitating patient behaviour change through the use of risk communication in dentistry. Further research should apply behavioural science to support the implementation of the tool in clinical practice.
    MeSH term(s) Humans ; Communication ; Qualitative Research ; Referral and Consultation ; Primary Health Care
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 186068-9
    ISSN 1879-176X ; 0300-5712
    ISSN (online) 1879-176X
    ISSN 0300-5712
    DOI 10.1016/j.jdent.2024.104853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mortality Rates by Age Group and Intubation Status in Hospitalized Adult Patients From 21 United States Hospital Systems During Three Surges of the COVID-19 Pandemic.

    Nolan, Margaret B / Nolan, Matthew E / Piasecki, Thomas M / Fiore, Michael C

    Chest

    2023  Volume 163, Issue 6, Page(s) 1390–1394

    MeSH term(s) Humans ; Adult ; United States/epidemiology ; COVID-19 ; Pandemics ; Intubation, Intratracheal ; Hospital Mortality ; Retrospective Studies ; Hospitalization
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.01.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Betz cells of the primary motor cortex.

    Nolan, Matthew / Scott, Connor / Hof, Patrick R / Ansorge, Olaf

    The Journal of comparative neurology

    2024  Volume 532, Issue 1, Page(s) e25567

    Abstract: Betz cells, named in honor of Volodymyr Betz (1834-1894), who described them as "giant pyramids" in the primary motor cortex of primates and other mammalian species, are layer V extratelencephalic projection (ETP) neurons that directly innervate α- ... ...

    Abstract Betz cells, named in honor of Volodymyr Betz (1834-1894), who described them as "giant pyramids" in the primary motor cortex of primates and other mammalian species, are layer V extratelencephalic projection (ETP) neurons that directly innervate α-motoneurons of the brainstem and spinal cord. Despite their large volume and circumferential dendritic architecture, to date, no single molecular criterion has been established that unequivocally distinguishes adult Betz cells from other layer V ETP neurons. In primates, transcriptional signatures suggest the presence of at least two ETP neuron clusters that contain mature Betz cells; these are characterized by an abundance of axon guidance and oxidative phosphorylation transcripts. How neurodevelopmental programs drive the distinct positional and morphological features of Betz cells in humans remains unknown. Betz cells display a distinct biphasic firing pattern involving early cessation of firing followed by delayed sustained acceleration in spike frequency and magnitude. Few cell type-specific transcripts and electrophysiological characteristics are conserved between rodent layer V ETP neurons of the motor cortex and primate Betz cells. This has implications for the modeling of disorders that affect the motor cortex in humans, such as amyotrophic lateral sclerosis (ALS). Perhaps vulnerability to ALS is linked to the evolution of neural networks for fine motor control reflected in the distinct morphomolecular architecture of the human motor cortex, including Betz cells. Here, we discuss histological, molecular, and functional data concerning the position of Betz cells in the emerging taxonomy of neurons across diverse species and their role in neurological disorders.
    MeSH term(s) Adult ; Humans ; Animals ; Motor Cortex ; Amyotrophic Lateral Sclerosis ; Pyramidal Cells ; Motor Neurons ; Primates ; Mammals
    Language English
    Publishing date 2024-02-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 3086-7
    ISSN 1096-9861 ; 0021-9967 ; 0092-7317
    ISSN (online) 1096-9861
    ISSN 0021-9967 ; 0092-7317
    DOI 10.1002/cne.25567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Longitudinal Investigation of Lower-Risk Gambling Limits in the Canadian National Study.

    Gooding, Nolan B / Young, Matthew M / Hodgins, David C

    Journal of gambling studies

    2024  

    Abstract: Recent years have seen increased attention given to identifying and describing the levels of gambling participation that confer a risk of harm in order to generate public health advice regarding lower-risk gambling. However, most of the existing ... ...

    Abstract Recent years have seen increased attention given to identifying and describing the levels of gambling participation that confer a risk of harm in order to generate public health advice regarding lower-risk gambling. However, most of the existing literature has failed to explicitly assess these limits in a prospective manner. The purpose of this study is to employ a methodology consistent with prior investigations to evaluate the level of gambling participation associated with an increased risk of future gambling-related harm. Using data from the Alberta Gambling Research Institute's National Project Online Panel Survey, risk ratios and Receiver Operating Characteristic (ROC) analyses were used to determine the relative risk of gambling-related harm associated with participating in a greater number of gambling formats, gambling more days per month, and spending a greater proportion of income gambling. Prospective lower-risk limits were largely consistent with those identified in previous cross-sectional analyses (e.g., no more than two gambling formats, no more than once a week), with the exception that higher limits were found for the percent of household income spent gambling (3.4-6.4% vs. 1%). We advise that future research on lower-risk gambling limits consider the use of more granular assessment instruments and prospective methods to more closely evaluate the association between gambling participation and gambling harm.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016895-0
    ISSN 1573-3602 ; 1050-5350
    ISSN (online) 1573-3602
    ISSN 1050-5350
    DOI 10.1007/s10899-024-10303-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Podcasting as an Innovative Tool for National Physical Therapy Examination Preparation.

    Condo, Matthew / McKay, Jimmy / Dassinger, Juliette / Nolan, Bridget

    Medical science educator

    2023  Volume 33, Issue 3, Page(s) 631–633

    Abstract: The National Physical Therapy Examination (NPTE) is the gold standard for aspiring physical therapists. The NPTE Studycast is an innovative way for physical therapy students to prepare for the NPTE. The NPTE Studycast combines recorded information and ... ...

    Abstract The National Physical Therapy Examination (NPTE) is the gold standard for aspiring physical therapists. The NPTE Studycast is an innovative way for physical therapy students to prepare for the NPTE. The NPTE Studycast combines recorded information and content questions in a quiz format. To date, the podcast is widely downloaded.
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article
    ISSN 2156-8650
    ISSN (online) 2156-8650
    DOI 10.1007/s40670-023-01792-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Relative leg-to-arm skeletal strength proportions in orangutans by species and sex.

    Kralick, Alexandra E / Zemel, Babette S / Nolan, Clara / Lin, Phillip / Tocheri, Matthew W

    Journal of human evolution

    2024  Volume 188, Page(s) 103496

    Abstract: Among extant great apes, orangutans climb most frequently. However, Bornean orangutans (Pongo pygmaeus) exhibit higher frequencies of terrestrial locomotion than do Sumatran orangutans (Pongo abelii). Variation in long bone cross-sectional geometry is ... ...

    Abstract Among extant great apes, orangutans climb most frequently. However, Bornean orangutans (Pongo pygmaeus) exhibit higher frequencies of terrestrial locomotion than do Sumatran orangutans (Pongo abelii). Variation in long bone cross-sectional geometry is known to reflect differential loading of the limbs. Thus, Bornean orangutans should show greater relative leg-to-arm strength than their Sumatran counterparts. Using skeletal specimens from museum collections, we measured two cross-sectional geometric measures of bone strength: the polar section modulus (Zpol) and the ratio of maximum to minimum area moments of inertia (Imax/Imin), at the midshaft of long bones in Bornean (n = 19) and Sumatran adult orangutans (n = 12) using medical CT and peripheral quantitative CT scans, and compared results to published data of other great apes. Relative leg-to-arm strength was quantified using ratios of femur and tibia over humerus, radius, and ulna, respectively. Differences between orangutan species and between sexes in median ratios were assessed using Wilcoxon rank sum tests. The tibia of Bornean orangutans was stronger relative to the humerus and the ulna than in Sumatran orangutans (p = 0.008 and 0.025, respectively), consistent with behavioral studies that indicate higher frequencies of terrestrial locomotion in the former. In three Zpol ratios, adult female orangutans showed greater leg-to-arm bone strength compared to flanged males, which may relate to females using their legs more during arboreal locomotion than in adult flanged males. A greater amount of habitat discontinuity on Borneo compared to Sumatra has been posited as a possible explanation for observed interspecific differences in locomotor behaviors, but recent camera trap studies has called this into question. Alternatively, greater frequencies of terrestriality in Pongo pygmaeus may be due to the absence of tigers on Borneo. The results of this study are consistent with the latter explanation given that habitat continuity was greater a century ago when our study sample was collected.
    MeSH term(s) Female ; Male ; Animals ; Pongo pygmaeus ; Pongo abelii ; Hominidae ; Ecosystem ; Behavior, Animal ; Indonesia
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 120141-4
    ISSN 1095-8606 ; 0047-2484
    ISSN (online) 1095-8606
    ISSN 0047-2484
    DOI 10.1016/j.jhevol.2024.103496
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Enhancing the Discovery of Functional Post-Translational Modification Sites with Machine Learning Models - Development, Validation, and Interpretation.

    English, Nolan / Torres, Matthew

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2499, Page(s) 221–260

    Abstract: Protein posttranslational modifications (PTMs) are a rapidly expanding feature class of significant importance in cell biology. Due to a high burden of experimental proof, the number of functionals PTMs in the eukaryotic proteome is currently ... ...

    Abstract Protein posttranslational modifications (PTMs) are a rapidly expanding feature class of significant importance in cell biology. Due to a high burden of experimental proof, the number of functionals PTMs in the eukaryotic proteome is currently underestimated. Furthermore, not all PTMs are functionally equivalent. Computational approaches that can confidently recommend PTMs of probable function can improve the heuristics of PTM investigation and alleviate these problems. To address this need, we developed SAPH-ire: a multifeature heuristic neural network model that takes community wisdom into account by recommending experimental PTMs similar to those which have previously been established as having regulatory impact. Here, we describe the principle behind the SAPH-ire model, how it is developed, how we evaluate its performance, and important caveats to consider when building and interpreting such models. Finally, we discus current limitations of functional PTM prediction models and highlight potential mechanisms for their improvement.
    MeSH term(s) Machine Learning ; Neural Networks, Computer ; Protein Processing, Post-Translational ; Proteome
    Chemical Substances Proteome
    Language English
    Publishing date 2022-06-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2317-6_12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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