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  1. Article ; Online: Microbes and the fate of neutrophils.

    Kobayashi, Scott D / DeLeo, Frank R / Quinn, Mark T

    Immunological reviews

    2022  Volume 314, Issue 1, Page(s) 210–228

    Abstract: Neutrophils or polymorphonuclear neutrophils (PMNs) are an important component of innate host defense. These phagocytic leukocytes are recruited to infected tissues and kill invading microbes. There are several general characteristics of neutrophils that ...

    Abstract Neutrophils or polymorphonuclear neutrophils (PMNs) are an important component of innate host defense. These phagocytic leukocytes are recruited to infected tissues and kill invading microbes. There are several general characteristics of neutrophils that make them highly effective as antimicrobial cells. First, there is tremendous daily production and turnover of granulocytes in healthy adults-typically 10
    MeSH term(s) Humans ; Aged ; Neutrophils/physiology ; Phagocytosis ; Apoptosis ; Cell Death ; Anti-Infective Agents
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2022-11-08
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Microbes and the fate of neutrophils

    Kobayashi, Scott D. / DeLeo, Frank R. / Quinn, Mark T.

    Immunological Reviews 2023 Mar. v.314, no.1, p. 210-228

    2023  , Page(s) 210–228

    Abstract: Neutrophils or polymorphonuclear neutrophils (PMNs) are an important component of innate host defense. These phagocytic leukocytes are recruited to infected tissues and kill invading microbes. There are several general characteristics of neutrophils that ...

    Abstract Neutrophils or polymorphonuclear neutrophils (PMNs) are an important component of innate host defense. These phagocytic leukocytes are recruited to infected tissues and kill invading microbes. There are several general characteristics of neutrophils that make them highly effective as antimicrobial cells. First, there is tremendous daily production and turnover of granulocytes in healthy adults—typically 10¹¹ per day. The vast majority (~95%) of these cells are neutrophils. In addition, neutrophils are mobilized rapidly in response to chemotactic factors and are among the first leukocytes recruited to infected tissues. Most notably, neutrophils contain and/or produce an abundance of antimicrobial molecules. Many of these antimicrobial molecules are toxic to host cells and can destroy host tissues. Thus, neutrophil activation and turnover are highly regulated processes. To that end, aged neutrophils undergo apoptosis constitutively, a process that contains antimicrobial function and proinflammatory capacity. Importantly, apoptosis facilitates nonphlogistic turnover of neutrophils and removal by macrophages. This homeostatic process is altered by interaction with microbes and their products, as well as host proinflammatory molecules. Microbial pathogens can delay neutrophil apoptosis, accelerate apoptosis following phagocytosis, or cause neutrophil cytolysis. Here, we review these processes and provide perspective on recent studies that have potential to impact this paradigm.
    Keywords apoptosis ; chemotaxis ; cytolysis ; macrophages ; neutrophils ; phagocytosis ; toxicity
    Language English
    Dates of publication 2023-03
    Size p. 210-228
    Publishing place John Wiley & Sons, Inc
    Document type Article ; Online
    Note Resource is Open Access ; Wiley License Information
    ISSN 0082-5948
    ISSN 0082-5948
    DOI 10.1111/imr.13163
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Endoscopic ultrasound-directed transgastric endoscopic retrograde cholangiopancreatography for patients with Roux-en-Y gastric bypass anatomy: technical overview.

    Honda, Hirokazu / Mosko, Jeffrey D / Kobayashi, Ryosuke / Fecso, Andras / Kim, Bong Sik / Scott, Schoeman / May, Gary R

    Clinical endoscopy

    2022  Volume 55, Issue 6, Page(s) 736–741

    Abstract: Endoscopic retrograde cholangiopancreatography (ERCP) in patients with Roux-en-Y gastric bypass anatomy is a well-documented challenge. Traditionally, this problem has been overcome with adjunctive techniques, such as device-assisted ERCP, including ... ...

    Abstract Endoscopic retrograde cholangiopancreatography (ERCP) in patients with Roux-en-Y gastric bypass anatomy is a well-documented challenge. Traditionally, this problem has been overcome with adjunctive techniques, such as device-assisted ERCP, including double-balloon or single-balloon enteroscopy and laparoscopy-assisted transgastric ERCP. Endoscopic ultrasound-directed transgastric ERCP (EDGE) is a novel technique that enables access to the ampulla using a duodenoscope without surgical intervention and has shown high clinical and technical success rates in recent studies. However, this approach is technically demanding, necessitating a thorough understanding of the gastrointestinal anatomy as well as high operator experience. In this review, we provide a technical overview of EDGE in parallel with our personal experience at our center and propose a simple algorithm to select patients for its appropriate application. In conjunction, the outcomes of EDGE compared with those of device-assisted and laparoscopy-assisted transgastric ERCP will be discussed.
    Language English
    Publishing date 2022-10-05
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2643507-X
    ISSN 2234-2443 ; 2234-2400
    ISSN (online) 2234-2443
    ISSN 2234-2400
    DOI 10.5946/ce.2022.114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Toward Optimization of a Rabbit Model of Staphylococcus aureus (USA300) Skin and Soft Tissue Infection.

    Malachowa, Natalia / McGuinness, Will / Kobayashi, Scott D / Porter, Adeline R / Shaia, Carl / Lovaglio, Jamie / Smith, Brian / Rungelrath, Viktoria / Saturday, Greg / Scott, Dana P / Falugi, Fabiana / Missiakas, Dominique / Schneewind, Olaf / DeLeo, Frank R

    Microbiology spectrum

    2022  Volume 10, Issue 2, Page(s) e0271621

    Abstract: Staphylococcus aureus remains a leading cause of skin and soft tissue infections (SSTIs) globally. In the United States, many of these infections are caused by isolates classified as USA300. Our understanding of the success of USA300 as a human pathogen ... ...

    Abstract Staphylococcus aureus remains a leading cause of skin and soft tissue infections (SSTIs) globally. In the United States, many of these infections are caused by isolates classified as USA300. Our understanding of the success of USA300 as a human pathogen is due in part to data obtained from animal infection models, including rabbit SSTI models. These animal models have been used to study S. aureus virulence and pathogenesis and to gain an enhanced understanding of the host response to infection. Although significant knowledge has been gained, the need to use a relatively high inoculum of USA300 (1 × 10
    MeSH term(s) Animals ; Methicillin-Resistant Staphylococcus aureus/genetics ; Rabbits ; Reinfection ; Soft Tissue Infections ; Staphylococcal Infections/microbiology ; Staphylococcal Skin Infections/microbiology ; Staphylococcus aureus ; United States ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2022-04-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02716-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Klebsiella pneumoniae

    Opoku-Temeng, Clement / Kobayashi, Scott D / DeLeo, Frank R

    Computational and structural biotechnology journal

    2019  Volume 17, Page(s) 1360–1366

    Abstract: Carbapenem-resistant (CR) ...

    Abstract Carbapenem-resistant (CR)
    Language English
    Publishing date 2019-10-25
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2019.09.011
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  6. Article ; Online: Interaction of multidrug-resistant hypervirulent

    DeLeo, Frank R / Porter, Adeline R / Kobayashi, Scott D / Freedman, Brett / Hao, Mingju / Jiang, Jianping / Lin, Yi-Tsung / Kreiswirth, Barry N / Chen, Liang

    mBio

    2023  Volume 14, Issue 5, Page(s) e0194923

    Abstract: Importance: Klebsiella ... ...

    Abstract Importance: Klebsiella pneumoniae
    MeSH term(s) Humans ; Virulence/genetics ; Klebsiella pneumoniae ; Neutrophils ; Genotype ; Klebsiella Infections ; Anti-Bacterial Agents
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.01949-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Towards a Monoclonal Antibody-Based Therapy for Prevention and Treatment of Staphylococcus aureus Infections.

    Kobayashi, Scott D / DeLeo, Frank R

    The Journal of infectious diseases

    2018  Volume 219, Issue 6, Page(s) 848–850

    MeSH term(s) Animals ; Methicillin-Resistant Staphylococcus aureus ; Mice ; Staphylococcal Infections ; Staphylococcus aureus
    Language English
    Publishing date 2018-10-23
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiy667
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  8. Article ; Online: Extended Induction and Prognostic Indicators of Response in Patients Treated with Mirikizumab with Moderately to Severely Active Ulcerative Colitis in the LUCENT Trials.

    D'Haens, Geert / Higgins, Peter D R / Peyrin-Biroulet, Laurent / Sands, Bruce E / Lee, Scott / Moses, Richard E / Redondo, Isabel / Escobar, Rodrigo / Gibble, Theresa Hunter / Keohane, Anthony / Morris, Nathan / Zhang, Xin / Arora, Vipin / Kobayashi, Taku

    Inflammatory bowel diseases

    2024  

    Abstract: Background: Efficacy and safety of mirikizumab, a p19-targeted anti-interleukin-23 monoclonal antibody, for moderately to severely active ulcerative colitis was demonstrated previously. We evaluated clinical response, baseline characteristics, and ... ...

    Abstract Background: Efficacy and safety of mirikizumab, a p19-targeted anti-interleukin-23 monoclonal antibody, for moderately to severely active ulcerative colitis was demonstrated previously. We evaluated clinical response, baseline characteristics, and clinical status in patients not responding by 12 weeks (W) of induction who then received extended induction treatment.
    Method: Patients unresponsive to 300 mg of intravenous (IV) mirikizumab every 4 weeks by W12 received 3 additional 300 mg IV doses every 4 weeks. Week-4 responders received 200 mg mirikizumab every 4 weeks subcutaneously until W52. Patients responding by W12 but subsequently losing response received rescue therapy with 300 mg IV for 3 doses every 4 weeks. Logistic regression modelling was performed for patients not achieving W12 clinical response to assess baseline characteristics and W12 efficacy parameters and potential prognostic factors of clinical response at W24.
    Results: Of patients not achieving clinical response during induction, 53.7% achieved response following extended induction. After 52W, 72.2%, 43.1%, and 36.1% of patients achieved clinical response, endoscopic, and clinical remission, respectively. Of induction responders who subsequently lost response, 63.2% and 36.8% achieved symptomatic response and remission, respectively, after receiving rescue therapy No prior biologic or tofacitinib treatment, no immunomodulators at baseline, age older than 40 years, and W12 modified Mayo Score improvement were positively associated with a response to extended induction. The safety profile was similar to initial induction, with 38.3% treatment emergent adverse events, mostly mild.
    Conclusion: With "extended induction," total of 80.3% mirikizumab-treated patients achieved clinical response by W24. Potential prognostic factors determining response include disease severity, disease phenotype, C-reactive protein, and previous biologic therapy.
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1093/ibd/izae004
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  9. Article ; Online: Bacteriophage Treatment Rescues Mice Infected with Multidrug-Resistant Klebsiella pneumoniae ST258.

    Hesse, Shayla / Malachowa, Natalia / Porter, Adeline R / Freedman, Brett / Kobayashi, Scott D / Gardner, Donald J / Scott, Dana P / Adhya, Sankar / DeLeo, Frank R

    mBio

    2021  Volume 12, Issue 1

    Abstract: Severe infections caused by multidrug- ... ...

    Abstract Severe infections caused by multidrug-resistant
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/therapy ; Bacteriophages/physiology ; Drug Resistance, Multiple, Bacterial ; Female ; Klebsiella Infections/blood ; Klebsiella Infections/therapy ; Klebsiella pneumoniae/drug effects ; Mice ; Mice, Inbred C57BL ; Phage Therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.00034-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Neutrophils in innate immunity and systems biology-level approaches.

    Rungelrath, Viktoria / Kobayashi, Scott D / DeLeo, Frank R

    Wiley interdisciplinary reviews. Systems biology and medicine

    2019  Volume 12, Issue 1, Page(s) e1458

    Abstract: The innate immune system is the first line of host defense against invading microorganisms. Polymorphonuclear leukocytes (PMNs or neutrophils) are the most abundant leukocyte in humans and essential to the innate immune response against invading ... ...

    Abstract The innate immune system is the first line of host defense against invading microorganisms. Polymorphonuclear leukocytes (PMNs or neutrophils) are the most abundant leukocyte in humans and essential to the innate immune response against invading pathogens. Compared to the acquired immune response, which requires time to develop and is dependent on previous interaction with specific microbes, the ability of neutrophils to kill microorganisms is immediate, nonspecific, and not dependent on previous exposure to microorganisms. Historically, studies of PMN-pathogen interaction focused on the events leading to killing of microorganisms, such as recruitment/chemotaxis, transmigration, phagocytosis, and activation, whereas postphagocytosis sequelae were infrequently considered. In addition, it was widely accepted that human neutrophils possessed limited capacity for new gene transcription and thus, relatively little biosynthetic capacity. This notion has changed dramatically within the past 20 years. Further, there is now more effort directed to understand the events occurring in PMNs after killing of microbes. Herein, we give an updated review of the systems biology-level approaches that have been used to gain an enhanced view of the role of neutrophils during host-pathogen interaction and neutrophil-mediated diseases. We anticipate that these and future systems-level studies will continue to provide information important for understanding, treatment, and control of diseases caused by pathogenic microorganisms. This article is categorized under: Physiology > Organismal Responses to Environment Physiology > Mammalian Physiology in Health and Disease Biological Mechanisms > Cell Fates.
    Language English
    Publishing date 2019-06-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2503323-2
    ISSN 1939-005X ; 1939-5094
    ISSN (online) 1939-005X
    ISSN 1939-5094
    DOI 10.1002/wsbm.1458
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