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  1. Book ; Online ; E-Book: Stem cells and COVID-19

    Agrawal, Devendra K. / Thankam, Finosh G. / Sharma, Chandra P.

    2022  

    Author's details Chandra P. Sharma, Devendra K. Agrawal and Finosh G. Thankam, editors
    Keywords COVID-19 (Disease)/Prevention ; COVID-19 (Disease)/Treatment ; Stem cells/Therapeutic use.
    Subject code 616.02774
    Language English
    Size 1 online resource (250 pages)
    Publisher Academic Press
    Publishing place London
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-88623-X ; 9780323899727 ; 978-0-323-88623-9 ; 0323899722
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Commentary: Unraveling the mystery of transient innate capacity for neonatal heart regeneration following injury.

    Agrawal, Devendra K

    The Journal of thoracic and cardiovascular surgery

    2021  Volume 164, Issue 6, Page(s) e407–e408

    MeSH term(s) Humans ; Infant, Newborn ; Animals ; Heart ; Regeneration ; Myocytes, Cardiac ; Animals, Newborn ; Cell Proliferation
    Language English
    Publishing date 2021-09-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2021.08.069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.104: Show issues Location:
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  3. Article ; Online: Immunotherapeutic Strategies in the Management of Osteosarcoma.

    Supra, Rajiv / Agrawal, Devendra K

    Journal of orthopaedics and sports medicine

    2023  Volume 5, Issue 1, Page(s) 32–40

    Abstract: Osteosarcoma (OS) is the most common primary malignant bone cancer with a high tendency for metastasis. Although treatment strategies involving surgery and chemotherapy have improved outcomes for patients with OS, the prognosis of recurrent OS is quite ... ...

    Abstract Osteosarcoma (OS) is the most common primary malignant bone cancer with a high tendency for metastasis. Although treatment strategies involving surgery and chemotherapy have improved outcomes for patients with OS, the prognosis of recurrent OS is quite unsatisfactory. Primary reasons leading to mortality in OS patients are resistance to currently used therapies and the subsequent lung metastasis. Immunotherapy, however, has been shown to be a promising therapeutic strategy against OS. As research progresses, immunotherapy is gradually becoming irreplaceable. This article provides a critical evaluation of several therapeutic strategies for OS including immunomodulation, vaccine therapy, and immunologic checkpoint blockade.
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Journal Article
    ISSN 2688-5115
    ISSN (online) 2688-5115
    DOI 10.26502/josm.511500076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Peripheral Nerve Regeneration: Opportunities and Challenges.

    Supra, Rajiv / Agrawal, Devendra K

    Journal of spine research and surgery

    2023  Volume 5, Issue 1, Page(s) 10–18

    Abstract: Peripheral nerve injury has detrimental effects on the quality of life for patients and is a worldwide issue with high rates of morbidity. Research on the molecular mechanisms of nerve injury, microsurgical techniques, and advances in stem cell research ... ...

    Abstract Peripheral nerve injury has detrimental effects on the quality of life for patients and is a worldwide issue with high rates of morbidity. Research on the molecular mechanisms of nerve injury, microsurgical techniques, and advances in stem cell research have led to substantial progress in the field of translational neurophysiology. Current research on peripheral nerve regeneration aims to accelerate peripheral nerve development through pluripotent stem cells and potential use of smart exosomes, pharmacological agents, and bioengineering of nerve conduits. In this article critically reviewed and summarized various methods used for peripheral nerve regeneration and highlight the opportunities and challenges that come along with these strategies.
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article
    ISSN 2687-8046
    ISSN (online) 2687-8046
    DOI 10.26502/fjsrs0052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mechanobiology of MicroRNAs in Intervertebral Disk Degeneration.

    Supra, Rajiv / Agrawal, Devendra K

    Journal of spine research and surgery

    2023  Volume 5, Issue 1, Page(s) 1–9

    Abstract: Intervertebral disk degeneration (IDD) is an intricate pathological process contributing to one of the major causes of low back pain. The degradation of the extracellular matrix (ECM), inflammation, and apoptosis have all been investigated as critical ... ...

    Abstract Intervertebral disk degeneration (IDD) is an intricate pathological process contributing to one of the major causes of low back pain. The degradation of the extracellular matrix (ECM), inflammation, and apoptosis have all been investigated as critical factors involved in the pathology of degenerative disk disease. Additionally, the presence of aberrant microRNAs (miRNAs), conserved molecules that regulate the amount protein post-transcriptionally, may play a crucial role in the pathogenesis of IDD. Research regarding the dysfunction of miRNAs in IDD has been well researched over the past five years. Here, we provide a critical overview of the current knowledge of miRNAs, emphasizing the processes involved in the degenerative disk pathology.
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Journal Article
    ISSN 2687-8046
    ISSN (online) 2687-8046
    DOI 10.26502/fjsrs0051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Discovery of Potential RAGE inhibitors using Receptor-Based Pharmacophore Modeling, High Throughput Virtual Screening and Docking Studies.

    Singh, Harbinder / Agrawal, Devendra K

    Journal of biotechnology and biomedicine

    2023  Volume 6, Issue 4, Page(s) 501–513

    Abstract: Receptor for Advanced Glycation End products (RAGE) is a transmembrane receptor that can bind to various endogenous and exogenous ligands and initiate the inflammatory downstream signaling pathways. So far RAGE has been involved in various disorders ... ...

    Abstract Receptor for Advanced Glycation End products (RAGE) is a transmembrane receptor that can bind to various endogenous and exogenous ligands and initiate the inflammatory downstream signaling pathways. So far RAGE has been involved in various disorders including cardiovascular and neurodegenerative diseases, cancer, and diabetes. Blocking the interactions between RAGE and its ligands is a therapeutic approach to treat these conditions. In this context, we effectively utilized the receptor-based-pharmacophore modeling to discover structurally diverse molecular compounds having potential to effectively bind with RAGE. Two pharmacophore models were developed on V-domain of RAGE using Phase application of Schrodinger suite. The developed pharmacophoric features were used for screening of 1.8 million drug-like molecules downloaded from ChEMBL database. The molecules were scrutinized according to their molecular weight as well as clogP values. Phase screening was performed to find out the molecules that matched the developed pharmacophoric features that were further selected to analyze their binding modes using high-throughput virtual screening, extra precision docking studies and MM-GBSA ΔG binding calculations. These analyses provided ten hit RAGE inhibitory molecules that can bind to two different shallow binding sites on the V-domain of RAGE. Among the obtained compounds two compounds ChEMBL501494 and ChEMBL4081874 were found with best binding free energies that proved their receptor-ligand complex stability within their respective binding cavity on RAGE. Therefore, these molecules could be utilized for further designing and optimizing the future class of potential RAGE inhibitors.
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article
    ISSN 2642-9128
    ISSN (online) 2642-9128
    DOI 10.26502/jbb.2642-91280112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Role of Transcription Factors and MicroRNAs in Regulating Fibroblast Reprogramming in Wound Healing.

    Rai, Vikrant / Agrawal, Devendra K

    Journal of bioinformatics and systems biology : Open access

    2023  Volume 6, Issue 2, Page(s) 110–120

    Abstract: Non-healing diabetic foot ulcer, a chronic inflammatory disease, is a sizable clinical and economic burden to healthcare systems around the world. Chronic inflammation plays a critical role in the nonhealing pattern due to the arrest of the cellular ... ...

    Abstract Non-healing diabetic foot ulcer, a chronic inflammatory disease, is a sizable clinical and economic burden to healthcare systems around the world. Chronic inflammation plays a critical role in the nonhealing pattern due to the arrest of the cellular response during wound healing in the inflammatory phase without progressing to the proliferative and remodeling phase. Fibroblasts play a critical role in all three phases of wound healing. Activation of fibroblasts in the presence of cytokines results in the formation of myofibroblast that contributes to extracellular matrix formation. Additionally, few studies documented the presence of inflammatory, angiogenic, and angiostatic fibroblast subpopulation during wound healing. Various studies have discussed the role of transcription factors and microRNA in regulating the transdifferentiation of fibroblast to myofibroblast, however, what factors regulate the reprogramming of fibroblast to inflammatory, angiogenic, and angiostatic phenotypes have not been clearly addressed in the literature. This critical review article addresses the role of transcription factors and microRNAs in regulating fibroblast to myofibroblast transdifferentiation followed by the prediction of transcription factors and microRNAs, based on the bioinformatics analysis, in regulating transdifferentiation of fibroblasts to inflammatory, angiogenic, and angiostatic subtypes. The results of in-silico networking revealed multiple new transcription factors and microRNAs and their interaction with specific markers on other fibroblasts suggesting their role in the regulation of fibroblast reprogramming.
    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Journal Article
    ISSN 2688-5107
    ISSN (online) 2688-5107
    DOI 10.26502/jbsb.5107054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Thromboembolism in the Complications of Long COVID-19.

    Lopes, Leilani A / Agrawal, Devendra K

    Cardiology and cardiovascular medicine

    2023  Volume 7, Issue 2, Page(s) 123–128

    Abstract: SARS-CoV-2 is a +ssRNA helical coronavirus responsible for the global pandemic caused by coronavirus disease 19 (COVID-19). Classical clinical symptoms from primary COVID-19 when symptomatic include cough, fever, pneumonia or even ARDS; however, they are ...

    Abstract SARS-CoV-2 is a +ssRNA helical coronavirus responsible for the global pandemic caused by coronavirus disease 19 (COVID-19). Classical clinical symptoms from primary COVID-19 when symptomatic include cough, fever, pneumonia or even ARDS; however, they are limited primarily to the respiratory system. Long-COVID-19 sequalae is responsible for many pathologies in almost every organ system and may be present in up to 30% of patients who have developed COVID-19. Our review focuses on how long-COVID-19 (3 -24 weeks after primary symptoms) may lead to an increased risk for stroke and thromboembolism. Patients who were found to be primarily at risk for thrombotic events included critically ill and immunocompromised patients. Additional risk factors for thromboembolism and stroke included diabetes, hypertension, respiratory and cardiovascular disease, and obesity. The etiology of how long-COVID-19 leads to a hypercoagulable state are yet to be definitively elucidated. However, anti-phospholipid antibodies and elevated D-dimer are present in many patients who develop thromboembolism. In addition, chronic upregulation and exhaustion of the immune system may lead to a pro-inflammatory and hypercoagulable state, increasing the likelihood for induction of thromboembolism or stroke. This article provides an up-to-date review on the proposed etiologies for thromboembolism and stroke in patients with long-COVID-19 and to assist health care providers in examining patients who may be at a higher risk for developing these pathologies.
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article
    ISSN 2572-9292
    ISSN (online) 2572-9292
    DOI 10.26502/fccm.92920317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pulmonary Fibrosis and Diabetes Mellitus: Two coins with the same face.

    Mari, Yssel Mendoza / Fraix, Marcel P / Agrawal, Devendra K

    Archives of internal medicine research

    2024  Volume 7, Issue 1, Page(s) 53–70

    Abstract: Idiopathic pulmonary fibrosis (IPF) constitutes a long-term disease with a complex pathophysiology composed of multiple molecular actors that lead to the deposition of extracellular matrix, the loss of pulmonary function and ultimately the patient's ... ...

    Abstract Idiopathic pulmonary fibrosis (IPF) constitutes a long-term disease with a complex pathophysiology composed of multiple molecular actors that lead to the deposition of extracellular matrix, the loss of pulmonary function and ultimately the patient's death. Despite the approval of pirfenidone and nintedanib for the treatment of the disease, lung transplant is the only long-term solution to fully recover the respiratory capacity and gain quality of life. One of the risk factors for the development of IPF is the pre-existing condition of diabetes mellitus. Both, IPF and diabetes mellitus, share similar pathological damage mechanisms, including inflammation, endoplasmic reticulum stress, mitochondrial failure, oxidative stress, senescence and signaling from glycated proteins through receptors. In this critical review article, we provide information about this interrelationship, examining molecular mediators that play an essential role in both diseases and identify targets of interest for the development of potential drugs. We review the findings of clinical trials examining the progression of IPF and how novel molecules may be used to stop this process. The results highlight the importance of early detection and addressing multiple therapeutic targets simultaneously to achieve better therapeutic efficacy and potentially reverse lung fibrosis.
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Journal Article
    ISSN 2688-5654
    ISSN (online) 2688-5654
    DOI 10.26502/aimr.0165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Correction: Innate and adaptive immune cells associate with arteriovenous fistula maturation and failure.

    Samra, Gunimat / Rai, Vikrant / Agrawal, Devendra K

    Canadian journal of physiology and pharmacology

    2023  Volume 101, Issue 4, Page(s) 215

    Language English
    Publishing date 2023-02-27
    Publishing country Canada
    Document type Published Erratum
    ZDB-ID 127527-6
    ISSN 1205-7541 ; 0008-4212
    ISSN (online) 1205-7541
    ISSN 0008-4212
    DOI 10.1139/cjpp-2023-0025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (1.OG)
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