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  1. Book ; Online: Fast Facts

    Drummond, M. Bradley / MacNee, William

    Chronic Obstructive Pulmonary Disease (COPD)

    (Fast facts)

    2016  

    Abstract: A practical and accessible resource that considers current guidelines, investigations, interventions and pharmacological treatments in chronic obstructive pulmonary diease. ...

    Author's details M. Bradley Drummond MD MHS, associate professor, Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA, William MacNee CHB MD FRCP, professor of respiratory and environmental medicine, Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh Medical School, Edinburgh, UK
    Series title Fast facts
    Abstract A practical and accessible resource that considers current guidelines, investigations, interventions and pharmacological treatments in chronic obstructive pulmonary diease.
    Keywords Lungs/Diseases, Obstructive ; Respiratory organs/Diseases ; Lungs/Diseases, Obstructive/Treatment ; Respiratory muscles/Physiology ; Lungs/Diseases, Obstructive/Complications ; Lungs/Diseases, Obstructive/Diagnosis
    Language English
    Dates of publication 2016-2016
    Size 1 online resource (150 pages) :, color illustrations
    Edition 3rd edition
    Publisher Health Press
    Publishing place Abingdon, Oxford
    Document type Book ; Online
    Note Includes index.
    ISBN 1-908541-87-3 ; 9781908541734 ; 978-1-908541-87-1 ; 1908541733
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Beta-Blockers in COPD - A Controversy Resolved?

    MacNee, William

    The New England journal of medicine

    2019  Volume 381, Issue 24, Page(s) 2367–2368

    MeSH term(s) Adrenergic beta-Antagonists ; Humans ; Metoprolol ; Pulmonary Disease, Chronic Obstructive
    Chemical Substances Adrenergic beta-Antagonists ; Metoprolol (GEB06NHM23)
    Language English
    Publishing date 2019-10-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1912664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Conference proceedings: Inflammation and respiratory disease

    MacNee, William

    proceedings of the First ERS Lung Science Conference, Taormina, Sicily, Italy, March 28 - 30, 2003

    (European respiratory journal : Supplement ; 44)

    2003  

    Institution European Respiratory Society
    Event/congress Lung Science Conference (1, 2003, Taormina)
    Author's details ed. by W. MacNee
    Series title European respiratory journal : Supplement ; 44
    The European respiratory journal
    European respiratory journal ; Supplement
    Collection The European respiratory journal
    European respiratory journal ; Supplement
    Language English
    Size 60s S. : Ill., graph. Darst.
    Publisher Maney Publ
    Publishing place Leeds
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT013811066
    Database Catalogue ZB MED Medicine, Health

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    Zs A 2322 -Suppl.44- not available for loan Zeitschriften-Lesesaal

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  4. Book: Chronic obstructive lung disease

    Voelkel, Norbert F. / MacNee, William

    2008  

    Author's details Norbert F. Voelkel ; William MacNee
    Keywords Pulmonary Disease, Chronic Obstructive ; Lungs/Diseases, Obstructive
    Subject code 616.24
    Language English
    Size XVI, 512 S. : zahlr. Ill., graph. Darst.
    Edition 2. ed.
    Publisher Decker
    Publishing place Hamilton
    Publishing country Canada
    Document type Book
    HBZ-ID HT015541047
    ISBN 978-1-55009-390-2 ; 1-55009-390-8
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 363 order for loan Magazin

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  5. Book ; Conference proceedings: Consensus Conference on Management of Chronic Obstructive Pulmonary Disease

    MacNee, William

    papers from a conference held on 27 and 28 March 2001 in the Royal College of Physicians of Edinburgh

    (The journal of the Royal College of Physicians of Edinburgh : Supplement ; 10 ; Publication / Royal College of Physicians of Edinburgh ; 72)

    2002  

    Event/congress Consensus Conference on Management of Chronic Obstructive Pulmonary Disease (2001, Edinburgh)
    Author's details guest ed.: W. MacNee
    Series title The journal of the Royal College of Physicians of Edinburgh : Supplement ; 10
    Publication / Royal College of Physicians of Edinburgh ; 72
    The journal of the Royal College of Physicians of Edinburgh
    The journal of the Royal College of Physicians of Edinburgh ; Supplement
    Collection The journal of the Royal College of Physicians of Edinburgh
    The journal of the Royal College of Physicians of Edinburgh ; Supplement
    Language English
    Size 46 S.
    Publishing place Edinburgh
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT014090381
    Database Catalogue ZB MED Medicine, Health

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    Zs A 3088 -Suppl.10- not available for loan Zeitschriften-Lesesaal

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  6. Book ; Conference proceedings: Chronic obstructive pulmonary disease

    MacNee, William

    workshop reports on COPD in Boston on October 17 - 18, 1996 and in Verona on June 23 - 24, 1997

    (European respiratory review ; 9,67)

    1999  

    Author's details ed. by W. MacNee
    Series title European respiratory review ; 9,67
    Collection
    Language English
    Size S. 159 - 205 : graph. Darst.
    Publisher Munksgaard u.a.
    Publishing place Copenhagen u.a.
    Publishing country Denmark
    Document type Book ; Conference proceedings
    HBZ-ID HT011156193
    Database Catalogue ZB MED Medicine, Health

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  7. Article ; Online: The recognition of lung disease in coal workers: The role of Gough-Wentworth whole lung sections.

    Donaldson, Ken / Wallace, William A / MacNee, William / Henry, Christopher / Seaton, Anthony

    The journal of the Royal College of Physicians of Edinburgh

    2022  Volume 52, Issue 1, Page(s) 65–72

    Abstract: From the identification of a specific lung disease caused by coal dust exposure in miners in 1831 until the demonstration of the association of that exposure to risk of emphysema in 1984, there was continuous argument about the harmfulness of coal dust. ... ...

    Abstract From the identification of a specific lung disease caused by coal dust exposure in miners in 1831 until the demonstration of the association of that exposure to risk of emphysema in 1984, there was continuous argument about the harmfulness of coal dust. Ill health in miners was attributed variously to tuberculosis, quartz exposure or cigarette smoking. An acceptance that coal dust was harmful only started with investigative radiology and pathology in the 1920s, and physiology in the 1950s. Most of the early investigations were in South Wales, the centre of the most important coal field in Great Britain. Among the investigators was Professor Jethro Gough who, with his technician James Wentworth, introduced a technique for making thick sections of whole, inflated lungs on paper backing. Here, we describe this method and its central role in understanding the relationships between coal dust exposure, pneumoconiosis, emphysema and lung dysfunction in miners.
    MeSH term(s) Coal/adverse effects ; Coal Mining ; Dust ; Emphysema/pathology ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Lung Diseases ; Pulmonary Emphysema/pathology ; Quartz
    Chemical Substances Coal ; Dust ; Quartz (14808-60-7)
    Language English
    Publishing date 2022-09-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2866363-9
    ISSN 2042-8189 ; 0953-0932
    ISSN (online) 2042-8189
    ISSN 0953-0932
    DOI 10.1177/14782715221088982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Computed tomography-derived pathological phenotypes in COPD.

    MacNee, William

    The European respiratory journal

    2016  Volume 48, Issue 1, Page(s) 10–13

    MeSH term(s) Humans ; Phenotype ; Pulmonary Disease, Chronic Obstructive ; Pulmonary Emphysema ; Tomography, X-Ray Computed
    Language English
    Publishing date 2016-06-30
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00958-2016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2322: Show issues Location:
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    Zs.MO 292: Show issues

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  9. Article ; Online: Is Chronic Obstructive Pulmonary Disease an Accelerated Aging Disease?

    MacNee, William

    Annals of the American Thoracic Society

    2016  Volume 13 Suppl 5, Page(s) S429–S437

    Abstract: Aging is one of the most important risk factors for most chronic diseases. The worldwide increase in life expectancy has been accompanied by an increase in the prevalence of age-related diseases that result in significant morbidity and mortality and ... ...

    Abstract Aging is one of the most important risk factors for most chronic diseases. The worldwide increase in life expectancy has been accompanied by an increase in the prevalence of age-related diseases that result in significant morbidity and mortality and place an enormous burden on healthcare and resources. Aging is a progressive degeneration of the tissues that has a negative impact on the structure and function of vital organs. The lung ages, resulting in decreased function and reduced capacity to respond to environmental stresses and injury. Many of the changes that occur in the lungs with normal aging, such as decline in lung function, increased gas trapping, loss of lung elastic recoil, and enlargement of the distal air spaces, also are present in chronic obstructive pulmonary disease (COPD). The prevalence of COPD is two to three times higher in people over the age of 60 years than in younger age groups. Indeed, COPD has been considered a condition of accelerated lung aging. Several mechanisms associated with aging are present in the lungs of patients with COPD. Cell senescence is present in emphysematous lungs and is associated with shortened telomeres and decreased antiaging molecules, suggesting accelerated aging in the lungs of patients with COPD. Increasing age leads to elevated basal levels of inflammation and oxidative stress (inflammaging) and to increased immunosenescence associated with changes in both the innate and adaptive immune responses. These changes are similar to those that occur in COPD and may enhance the activity of the disease as well as increase susceptibility to exacerbations in patients with COPD. Understanding the mechanism of age-related changes in COPD may identify novel therapies for this condition.
    MeSH term(s) Adaptive Immunity ; Aging/immunology ; Aging/physiology ; Humans ; Immunity, Innate ; Immunosenescence/immunology ; Immunosenescence/physiology ; Inflammation ; Lung/immunology ; Lung/physiopathology ; Oxidative Stress ; Pulmonary Disease, Chronic Obstructive/immunology ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Telomere Shortening
    Language English
    Publishing date 2016-12-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201602-124AW
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5828: Show issues Location:
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  10. Article ; Online: Right heart function in COPD.

    Macnee, William

    Seminars in respiratory and critical care medicine

    2010  Volume 31, Issue 3, Page(s) 295–312

    Abstract: Pulmonary hypertension is a common complication in patients with severe hypoxic COPD, but the elevation in pulmonary arterial pressure (PAP) is usually relatively mild, although its presence indicates a poor prognosis. A minority of patients have severe ... ...

    Abstract Pulmonary hypertension is a common complication in patients with severe hypoxic COPD, but the elevation in pulmonary arterial pressure (PAP) is usually relatively mild, although its presence indicates a poor prognosis. A minority of patients have severe pulmonary hypertension, whose prognosis is very poor with the development of right heart failure. Pulmonary hypertension in COPD is thought to result from hypoxic pulmonary vasoconstriction leading to structural remodeling of all layers of the pulmonary arterial walls. The simple hypothesis that hypoxemia in patients with chronic lung disease results in pulmonary hypertension, which adversely affects right ventricular function and hence increases morbidity and decreases exercise tolerance, leading to the development of peripheral edema and increased mortality, is still somewhat controversial. Whether therapeutic interventions that directly affect PAP or right ventricular function have a significant effect on long-term survival in patients with pulmonary hypertension secondary to hypoxic lung disease is still a matter of debate. Furthermore, whether such interventions will have an effect on symptoms or exercise tolerance remains unproven. Present therapies are limited to the correction of hypoxemia over the long term, which has been shown to have proven benefits on survival. Further studies are required of more specific pulmonary vasodilators or therapies to improve right ventricular function in these patients.
    MeSH term(s) Exercise Tolerance ; Humans ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/physiopathology ; Hypertension, Pulmonary/therapy ; Hypoxia/physiopathology ; Hypoxia/therapy ; Prognosis ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Severity of Illness Index ; Survival ; Ventricular Dysfunction, Right/etiology ; Ventricular Dysfunction, Right/physiopathology ; Ventricular Dysfunction, Right/therapy
    Language English
    Publishing date 2010-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0030-1254070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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