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  1. Article ; Online: Response to J.W. Pike by C.M. Girgis, N. Mokbel, K.M. Cha, P.J. Houweling, M. Abboud, D.R. Fraser, R.S. Mason, R.J. Clifton-Bligh, and J.E. Gunton.

    Girgis, C M / Mokbel, N / Cha, K M / Houweling, P J / Abboud, M / Fraser, D R / Mason, R S / Clifton-Bligh, R J / Gunton, J E

    Endocrinology

    2014  Volume 155, Issue 9, Page(s) 3217

    MeSH term(s) Animals ; Humans ; Male ; Muscle, Skeletal/metabolism ; Myofibrils/metabolism ; Receptors, Calcitriol/metabolism ; Vitamin D/analogs & derivatives ; Vitamin D/metabolism ; Vitamin D Deficiency/metabolism
    Chemical Substances Receptors, Calcitriol ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2014-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
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    In stock of ZB MED Cologne/Königswinter

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  2. Book ; Online ; E-Book: Symptomatic

    Francomano, Clair A. / Hakim, Alan J. / Henderson, Lansdale G. S. / Henderson Sr., Fraser C.

    the symptom-based handbook for Ehlers-Danlos syndromes and hypermobility spectrum disorders

    2023  

    Title variant Symptom-based handbook for Ehlers-Danlos syndromes and hypermobility spectrum disorders
    Author's details edited by Clair A. Francomano [and more]
    MeSH term(s) Ehlers-Danlos Syndrome ; Joint Instability
    Keywords Ehlers-Danlos syndrome ; Joints/Hypermobility
    Subject code 616.77
    Language English
    Size 1 online resource (662 pages)
    Edition 1st ed.
    Publisher Elsevier
    Publishing place San Diego
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-95083-3 ; 9780323950824 ; 978-0-323-95083-1 ; 0323950825
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro.

    Fraser, Christopher S / Lee, Jennifer Y / Mayeur, Greg L / Bushell, Martin / Doudna, Jennifer A / Hershey, John W B

    The Journal of biological chemistry

    2003  Volume 279, Issue 10, Page(s) 8946–8956

    Abstract: ... in binding of initiator methionyl-tRNA and mRNA to the 40 S ribosomal subunit to form the 40 S initiation ... the subunit interactions seen in the yeast eIF3 core complex. In addition, we have used an in vitro 40 S ... subcomplexes to the 40 S ribosomal subunit. eIF3j alone binds to the 40 S ribosomal subunit, and its presence ...

    Abstract Eukaryotic initiation factor 3 (eIF3) is a 12-subunit protein complex that plays a central role in binding of initiator methionyl-tRNA and mRNA to the 40 S ribosomal subunit to form the 40 S initiation complex. The molecular mechanisms by which eIF3 exerts these functions are poorly understood. To learn more about the structure and function of eIF3 we have expressed and purified individual human eIF3 subunits or complexes of eIF3 subunits using baculovirus-infected Sf9 cells. The results indicate that the subunits of human eIF3 that have homologs in Saccharomyces cerevisiae form subcomplexes that reflect the subunit interactions seen in the yeast eIF3 core complex. In addition, we have used an in vitro 40 S ribosomal subunit binding assay to investigate subunit requirements for efficient association of the eIF3 subcomplexes to the 40 S ribosomal subunit. eIF3j alone binds to the 40 S ribosomal subunit, and its presence is required for stable 40 S binding of an eIF3bgi subcomplex. Furthermore, purified eIF3 lacking eIF3j binds 40 S ribosomal subunits weakly, but binds tightly when eIF3j is added. Cleavage of a 16-residue C-terminal peptide from eIF3j by caspase-3 significantly reduces the affinity of eIF3j for the 40 S ribosomal subunit, and the cleaved form provides substantially less stabilization of purified eIF3-40S complexes. These results indicate that eIF3j, and especially its C terminus, play an important role in the recruitment of eIF3 to the 40 S ribosomal subunit.
    MeSH term(s) Animals ; Binding Sites ; Cell Line ; Eukaryotic Initiation Factor-3/analysis ; Eukaryotic Initiation Factor-3/metabolism ; Humans ; Protein Binding ; Protein Subunits ; Ribosomes/metabolism
    Chemical Substances Eukaryotic Initiation Factor-3 ; Protein Subunits
    Language English
    Publishing date 2003-12-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M312745200
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  4. Article ; Online: Artificial intelligence and dental panoramic radiographs: where are we now?

    Webster, Scott / Fraser, Jacqueline

    Evidence-based dentistry

    2024  Volume 25, Issue 1, Page(s) 43–44

    Abstract: Data sources: Bielefeld Academic Search Engine (BASE), Google Scholar Association for Computing Machinery: Guide to Computing Literature (ACM) and National Library of Medicine: PubMed databases were searched for systematic reviews.: Study selection: ... ...

    Abstract Data sources: Bielefeld Academic Search Engine (BASE), Google Scholar Association for Computing Machinery: Guide to Computing Literature (ACM) and National Library of Medicine: PubMed databases were searched for systematic reviews.
    Study selection: This study addressed a structured PICO question (Population, Intervention, Comparison, Outcome). Population was panoramic radiographs in human subjects. Intervention was use of artificial intelligence (AI) diagnostics, compared to human-only diagnosis. Quantitative or qualitative AI efficiency was the outcome. Systematic reviews were considered if they stated 'systematic review' in their title or abstract, were published in English and were not bound by a certain time frame. No supplemental primary studies were included. Screening and removal of duplicates were performed using the Rayyan tool.
    Data extraction and synthesis: Data were extracted from each systematic review by two authors, with a third author having the deciding vote in cases of inconsistency. Cohen's Kappa co-efficient was used to measure reliability between authors, resulting in almost perfect agreement. The risk of bias was accounted for using the ROBIS method which resulted in one paper being rejected, so only 11 included in results. Data were then grouped into seven domains which were detected by AI: teeth identification and numbering, detection of periapical lesions, periodontal bone loss, osteoporosis, maxillary sinusitis, dental caries, and other tasks. The effectiveness of the AI systems was assessed by various outcome metrics - accuracy, sensitivity, specificity, and precision being the most common variables.
    Results: Results of this overview show a significant increase in accuracy of AI in analysing OPTs between 1988-2023. Latest AI models are most accurate in teeth identification and numbering (93.67%) whilst caries detection and osteoporosis showed 91.5% and 89.29% accuracy, respectively. Accurate results were also observed for the detection of maxillary sinusitis and periodontal bone loss. However, given the heterogeneity of source studies used in these systematic reviews, results should be interpreted with caution.
    Conclusions: With improving AI technology, its use in dental radiology can be increasingly effective in supporting dentists in the detection of different pathologies. This overview has shown that systematic reviews of AI can quickly become outdated and that results of any systematic review should be treated with caution as this field advances. As such, regular updating and ongoing research is required.
    MeSH term(s) United States ; Humans ; Alveolar Bone Loss ; Artificial Intelligence ; Dental Caries ; Maxillary Sinusitis ; Radiography, Panoramic ; Reproducibility of Results ; Systematic Reviews as Topic ; Osteoporosis
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1457588-7
    ISSN 1476-5446 ; 1462-0049
    ISSN (online) 1476-5446
    ISSN 1462-0049
    DOI 10.1038/s41432-024-00978-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4972: Show issues Location:
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  5. Article ; Online: SGLT2 inhibition, glucose transport and peritoneal dialysis: Finding the sweet spot.

    Sridhar, Vikas S / Fraser, Donald J

    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

    2023  Volume 43, Issue 2, Page(s) 115–118

    MeSH term(s) Humans ; Biological Transport ; Dialysis Solutions ; Glucose/metabolism ; Peritoneal Dialysis ; Peritoneum/metabolism ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
    Chemical Substances Dialysis Solutions ; Glucose (IY9XDZ35W2) ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Editorial
    ZDB-ID 645010-6
    ISSN 1718-4304 ; 0896-8608
    ISSN (online) 1718-4304
    ISSN 0896-8608
    DOI 10.1177/08968608231161178
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  6. Article: Insights into Personalised Medicine in Bronchiectasis.

    Fraser, Clementine S / José, Ricardo J

    Journal of personalized medicine

    2023  Volume 13, Issue 1

    Abstract: Bronchiectasis is a heterogenous disease with multiple aetiologies resulting in inflammation and dilatation of the airways with associated mucus production and chronic respiratory infection. The condition is being recognised ever more frequently as the ... ...

    Abstract Bronchiectasis is a heterogenous disease with multiple aetiologies resulting in inflammation and dilatation of the airways with associated mucus production and chronic respiratory infection. The condition is being recognised ever more frequently as the availability of computed tomography increases. It is associated with significant morbidity and healthcare-related costs. With new understanding of the disease process, varying endotypes, identification of underlying causes and treatable traits, the management of bronchiectasis can be increasingly personalised.
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13010133
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  7. Article: Family Member Experiences in Intensive Care Units Care: Insights From a Family Involvement Tool Implementation Trial.

    Alexanian, Janet / Fraser, Ian / Smith, Orla / Kitto, Simon

    Qualitative health research

    2024  , Page(s) 10497323241226678

    Abstract: Family involvement is widely considered an important part of patient care in the intensive care unit. From professional health care organizations, government, and hospital associations, there has been a cultural shift toward family presence as part of a ... ...

    Abstract Family involvement is widely considered an important part of patient care in the intensive care unit. From professional health care organizations, government, and hospital associations, there has been a cultural shift toward family presence as part of a wider commitment to patient-centered care. At the same time, the meaning and impact of family involvement in the intensive care unit setting remain opaque and under-studied. This study employed an ethnographic approach to better understand family involvement in practice and from the perspective of health care professionals and family members by studying an implementation trial of a family involvement tool in two intensive care units over 2 years. The findings revealed that an expanded and self-defined role for family members as carers in the intensive care unit challenged the current configuration of the nurse patient/family relationship and that family members were aware of these dynamics. While the intensive care unit implementation teams were both motivated to implement a novel way of facilitating family involvement, the processual, organizational, and contextual factors in the intensive care units largely determined the possibilities of its application. This suggests that interventions should address the specific context in which they are employed.
    Language English
    Publishing date 2024-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1275716-0
    ISSN 1552-7557 ; 1049-7323
    ISSN (online) 1552-7557
    ISSN 1049-7323
    DOI 10.1177/10497323241226678
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  8. Article: A Diagnostic Dilemma of Prevertebral Abscess Versus Food Bolus on Lateral Neck X-Ray: A Case Report.

    Mitropoulos, Alexander / Pianko, Stephen / Ptasznik, Ronnie / Fraser, Jacqueline

    Cureus

    2024  Volume 16, Issue 4, Page(s) e57999

    Abstract: In this case, a 76-year-old female presenting with globus sensation post-oral intake demonstrated radiographical evidence of mottled radiolucency and prevertebral widening on a lateral neck X-ray at the inferior C4/cricoid cartilage, leading to concern ... ...

    Abstract In this case, a 76-year-old female presenting with globus sensation post-oral intake demonstrated radiographical evidence of mottled radiolucency and prevertebral widening on a lateral neck X-ray at the inferior C4/cricoid cartilage, leading to concern for a prevertebral abscess. A decision was made to proceed with an urgent gastrointestinal endoscopy, and a food bolus was identified and removed, leading to a full remission of the patients' symptoms. In this case, an appropriate diagnosis was achieved by combining multiple investigations, which highlights to clinicians that taking investigations in isolation, with the aforementioned lateral neck X-ray being the primary example, could lead to potential misdiagnosis and mismanagement of patients.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.57999
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  9. Article ; Online: Inequalities in emergency care use across transition from paediatric to adult care: a retrospective cohort study of young people with chronic kidney disease in England.

    Abbott, Jasmin / Fraser, Lorna K / Jarvis, Stuart

    European journal of pediatrics

    2024  

    Abstract: Transition of young people with chronic kidney disease (CKD) from paediatric to adult healthcare has been associated with poor outcomes, but few population-level studies examine trends in subgroups. We aimed to assess sociodemographic inequalities in ... ...

    Abstract Transition of young people with chronic kidney disease (CKD) from paediatric to adult healthcare has been associated with poor outcomes, but few population-level studies examine trends in subgroups. We aimed to assess sociodemographic inequalities in changes in unplanned secondary care utilisation occurring across transfer to adult care for people with CKD in England. A cohort was constructed from routine healthcare administrative data in England of young people with childhood-diagnosed CKD who transitioned to adult care. The primary outcome was the number of emergency inpatient admissions and accident and emergency department (A&E) attendances per person year, compared before and after transfer. Injury-related and maternity admissions were excluded. Outcomes were compared via sociodemographic data using negative binomial regression with random effects. The cohort included 4505 individuals. Controlling for age, birth year, age at transfer, region and sociodemographic factors, transfer was associated with a significant decrease in emergency admissions (IRR 0.75, 95% CI 0.64-0.88) and no significant change in A&E attendances (IRR 1.10, 95% CI 0.95-1.27). Female sex was associated with static admissions and increased A&E attendances with transfer, with higher admissions and A&E attendances compared to males pre-transfer. Non-white ethnicities and higher deprivation were associated with higher unplanned secondary care use.
    Conclusion:  Sociodemographic inequalities in emergency secondary care usage were evident in this cohort across the transition period, independent of age, with some variation between admissions and A&E use, and evidence of effect modification by transfer. Such inequalities likely have multifactorial origin, but importantly, could represent differential meetings of care needs.
    What is known: • In chronic kidney disease (CKD), transfer from paediatric to adult healthcare is associated with declining health outcomes. • Known differences in CKD outcomes by sociodemographic factors have limited prior exploration in the context of transfer.
    What is new: • Population-level data was used to examine the impacts of transfer and sociodemographic factors on unplanned secondary care utilisation in CKD. • Healthcare utilisation trends may not reflect known CKD pathophysiology and there may be unexplored sociodemographic inequalities in the experiences of young people across transfer.
    Language English
    Publishing date 2024-04-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-024-05561-z
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  10. Article: Labyrinth Suppuration.

    Fraser, J S

    Transactions. Medico-Chirurgical Society of Edinburgh

    2018  Volume 33, Page(s) 171–184

    Language English
    Publishing date 2018-03-19
    Publishing country Scotland
    Document type Journal Article
    ISSN 0267-2790
    ISSN 0267-2790
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