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  1. Article: Pathogenesis of focal and segmental glomerulosclerosis: a review.

    Akash, Nabil

    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

    2007  Volume 18, Issue 2, Page(s) 226–230

    MeSH term(s) Activins/genetics ; Animals ; Genetic Predisposition to Disease ; Glomerulosclerosis, Focal Segmental/etiology ; Glomerulosclerosis, Focal Segmental/pathology ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Kidney Glomerulus/ultrastructure ; Membrane Proteins/genetics ; Microscopy, Electron ; Mutation ; Risk Factors
    Chemical Substances Intracellular Signaling Peptides and Proteins ; Membrane Proteins ; NPHS2 protein ; activin A ; Activins (104625-48-1)
    Language English
    Publishing date 2007-06
    Publishing country Saudi Arabia
    Document type Journal Article ; Review
    ZDB-ID 1379955-1
    ISSN 1319-2442
    ISSN 1319-2442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4735: Show issues Location:
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  2. Article ; Online: Targeting GBM with an Oncolytic Picornavirus SVV-001 alone and in combination with fractionated Radiation in a Novel Panel of Orthotopic PDX models

    Huiyuan Zhang / Yuchen Du / Lin Qi / Sophie Xiao / Frank K. Braun / Mari Kogiso / Yulun Huang / Frank Huang / Aalaa Abdallah / Milagros Suarez / Sekar Karthick / Nabil M. Ahmed / Vita S. Salsman / Patricia A. Baxter / Jack M. Su / Daniel J. Brat / Paul L. Hellenbeck / Wan-Yee Teo / Akash J. Patel /
    Xiao-Nan Li

    Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-

    2023  Volume 19

    Abstract: Abstract Background Animal models representing different molecular subtypes of glioblastoma multiforme (GBM) is desired for developing new therapies. SVV-001 is an oncolytic virus selectively targeting cancer cells. It’s capacity of passing through the ... ...

    Abstract Abstract Background Animal models representing different molecular subtypes of glioblastoma multiforme (GBM) is desired for developing new therapies. SVV-001 is an oncolytic virus selectively targeting cancer cells. It’s capacity of passing through the blood brain barrier makes is an attractive novel approach for GBM. Materials and methods 23 patient tumor samples were implanted into the brains of NOD/SCID mice (1 × 105 cells/mouse). Tumor histology, gene expression (RNAseq), and growth rate of the developed patient-derived orthotopic xenograft (PDOX) models were compared with the originating patient tumors during serial subtransplantations. Anti-tumor activities of SVV-001 were examined in vivo; and therapeutic efficacy validated in vivo via single i.v. injection (1 × 1011 viral particle) with or without fractionated (2 Gy/day x 5 days) radiation followed by analysis of animal survival times, viral infection, and DNA damage. Results PDOX formation was confirmed in 17/23 (73.9%) GBMs while maintaining key histopathological features and diffuse invasion of the patient tumors. Using differentially expressed genes, we subclassified PDOX models into proneural, classic and mesenchymal groups. Animal survival times were inversely correlated with the implanted tumor cells. SVV-001 was active in vitro by killing primary monolayer culture (4/13 models), 3D neurospheres (7/13 models) and glioma stem cells. In 2/2 models, SVV-001 infected PDOX cells in vivo without harming normal brain cells and significantly prolonged survival times in 2/2 models. When combined with radiation, SVV-001 enhanced DNA damages and further prolonged animal survival times. Conclusion A panel of 17 clinically relevant and molecularly annotated PDOX modes of GBM is developed, and SVV-001 exhibited strong anti-tumor activities in vitro and in vivo.
    Keywords Patient-derived orthotopic xenograft ; Glioblastoma ; Oncolytic virus ; SVV-001 ; Therapeutic efficacy ; Medicine ; R
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Targeting GBM with an Oncolytic Picornavirus SVV-001 alone and in combination with fractionated Radiation in a Novel Panel of Orthotopic PDX models.

    Zhang, Huiyuan / Du, Yuchen / Qi, Lin / Xiao, Sophie / Braun, Frank K / Kogiso, Mari / Huang, Yulun / Huang, Frank / Abdallah, Aalaa / Suarez, Milagros / Karthick, Sekar / Ahmed, Nabil M / Salsman, Vita S / Baxter, Patricia A / Su, Jack M / Brat, Daniel J / Hellenbeck, Paul L / Teo, Wan-Yee / Patel, Akash J /
    Li, Xiao-Nan

    Journal of translational medicine

    2023  Volume 21, Issue 1, Page(s) 444

    Abstract: Background: Animal models representing different molecular subtypes of glioblastoma multiforme (GBM) is desired for developing new therapies. SVV-001 is an oncolytic virus selectively targeting cancer cells. It's capacity of passing through the blood ... ...

    Abstract Background: Animal models representing different molecular subtypes of glioblastoma multiforme (GBM) is desired for developing new therapies. SVV-001 is an oncolytic virus selectively targeting cancer cells. It's capacity of passing through the blood brain barrier makes is an attractive novel approach for GBM.
    Materials and methods: 23 patient tumor samples were implanted into the brains of NOD/SCID mice (1 × 10
    Results: PDOX formation was confirmed in 17/23 (73.9%) GBMs while maintaining key histopathological features and diffuse invasion of the patient tumors. Using differentially expressed genes, we subclassified PDOX models into proneural, classic and mesenchymal groups. Animal survival times were inversely correlated with the implanted tumor cells. SVV-001 was active in vitro by killing primary monolayer culture (4/13 models), 3D neurospheres (7/13 models) and glioma stem cells. In 2/2 models, SVV-001 infected PDOX cells in vivo without harming normal brain cells and significantly prolonged survival times in 2/2 models. When combined with radiation, SVV-001 enhanced DNA damages and further prolonged animal survival times.
    Conclusion: A panel of 17 clinically relevant and molecularly annotated PDOX modes of GBM is developed, and SVV-001 exhibited strong anti-tumor activities in vitro and in vivo.
    MeSH term(s) Humans ; Animals ; Mice ; Oncolytic Viruses ; Glioblastoma/radiotherapy ; Glioblastoma/metabolism ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/metabolism ; Xenograft Model Antitumor Assays ; Mice, Inbred NOD ; Mice, SCID ; Disease Models, Animal ; Cell Line, Tumor ; Oncolytic Virotherapy
    Language English
    Publishing date 2023-07-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-023-04237-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Abnormal Aspects of IgA in IgA Nephropathy

    Akash Nabil / El-Lozi Mohammad

    Saudi Journal of Kidney Diseases and Transplantation, Vol 11, Iss 2, Pp 191-

    2000  Volume 196

    Keywords Medicine ; R
    Language English
    Publishing date 2000-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Identification of diverse astrocyte populations and their malignant analogs.

    John Lin, Chia-Ching / Yu, Kwanha / Hatcher, Asante / Huang, Teng-Wei / Lee, Hyun Kyoung / Carlson, Jeffrey / Weston, Matthew C / Chen, Fengju / Zhang, Yiqun / Zhu, Wenyi / Mohila, Carrie A / Ahmed, Nabil / Patel, Akash J / Arenkiel, Benjamin R / Noebels, Jeffrey L / Creighton, Chad J / Deneen, Benjamin

    Nature neuroscience

    2017  Volume 20, Issue 3, Page(s) 396–405

    Abstract: Astrocytes are the most abundant cell type in the brain, where they perform a wide array of functions, yet the nature of their cellular heterogeneity and how it oversees these diverse roles remains shrouded in mystery. Using an intersectional ... ...

    Abstract Astrocytes are the most abundant cell type in the brain, where they perform a wide array of functions, yet the nature of their cellular heterogeneity and how it oversees these diverse roles remains shrouded in mystery. Using an intersectional fluorescence-activated cell sorting-based strategy, we identified five distinct astrocyte subpopulations present across three brain regions that show extensive molecular diversity. Application of this molecular insight toward function revealed that these populations differentially support synaptogenesis between neurons. We identified correlative populations in mouse and human glioma and found that the emergence of specific subpopulations during tumor progression corresponded with the onset of seizures and tumor invasion. In sum, we have identified subpopulations of astrocytes in the adult brain and their correlates in glioma that are endowed with diverse cellular, molecular and functional properties. These populations selectively contribute to synaptogenesis and tumor pathophysiology, providing a blueprint for understanding diverse astrocyte contributions to neurological disease.
    MeSH term(s) Aldehyde Dehydrogenase/metabolism ; Animals ; Astrocytes/metabolism ; Astrocytes/physiology ; Brain/metabolism ; Coculture Techniques ; Female ; Flow Cytometry ; Glioma/metabolism ; Glioma/physiopathology ; Humans ; Male ; Mice ; Mice, Transgenic ; Neurons/physiology ; Oxidoreductases Acting on CH-NH Group Donors ; Seizures/physiopathology ; Synapses/physiology ; Transcriptome
    Chemical Substances Aldehyde Dehydrogenase (EC 1.2.1.3) ; Oxidoreductases Acting on CH-NH Group Donors (EC 1.5.-) ; formyltetrahydrofolate dehydrogenase (EC 1.5.1.6)
    Language English
    Publishing date 2017-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/nn.4493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4891: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 67: Show issues

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  6. Article ; Online: Temporary Vascular Access for Hemodialysis Patients

    Haddad Ayman / Akash Nabil / Ghnaimat Mohammad / El-Lozi Mohammad

    Saudi Journal of Kidney Diseases and Transplantation, Vol 11, Iss 1, Pp 74-

    2000  Volume 75

    Keywords Medicine ; R
    Language English
    Publishing date 2000-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Kidney Biopsy in Jordan

    Ghnaimat Mohamad / Akash Nabil / El-Lozi Mohamad

    Saudi Journal of Kidney Diseases and Transplantation, Vol 10, Iss 2, Pp 152-

    Complications and Histopathological Findings

    1999  Volume 156

    Abstract: In this retrospective study, we reviewed the medical records, and histopathology findings of 191 patients who underwent renal biopsies at King Hussein Medical Center (KHMC) during a four-year period (1993-97). All were performed using Tru-Cut needles ... ...

    Abstract In this retrospective study, we reviewed the medical records, and histopathology findings of 191 patients who underwent renal biopsies at King Hussein Medical Center (KHMC) during a four-year period (1993-97). All were performed using Tru-Cut needles under ultrasound guidance. There were 119 males (62.3%) and 72 females (37.7%); the mean age was 29.1 years (range 5-76 years). Side effects of the renal biopsies included pain at the site of he biopsy in 17 (8.9%), gross hematuria in six (3.1%) and hematuria requiring blood transfusion in one (0.5%) patient. Nephrotic syndrome was the most common indication for biopsy followed by acute renal failure of unknown etiology. Among the nephritic patients, minimal change disease and post-infectious glomerulonephritis (GN) were the commonest findings in children below the age of 15 years, membrano-proliferative GN ranked first in adults whole membranous GN and amyloidosis were more common in the elderly. WE conclude that renal biopsy was associated with a n acceptably low rate of complications in our practice, and that the patterns of renal histology vary slightly from those reported from other countries.
    Keywords Medicine ; R
    Subject code 616
    Language English
    Publishing date 1999-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Functional Status of Patients on Maintenance Hemodialysis

    Akash Nabil / Ghnaimat Mohamad / Haddad Ayham / El-Lozi Mohamad

    Saudi Journal of Kidney Diseases and Transplantation, Vol 10, Iss 4, Pp 481-

    1999  Volume 486

    Abstract: Factors associated with physical well being were examined in adults with end-stage renal disease (ESRD) in two large hemodialysis units of the Royal Medical Services in Jordan. Utilizing the Karnofski scale we measured the functional status of 200 ... ...

    Abstract Factors associated with physical well being were examined in adults with end-stage renal disease (ESRD) in two large hemodialysis units of the Royal Medical Services in Jordan. Utilizing the Karnofski scale we measured the functional status of 200 Patients who had been on maintenance hemodialysis for at least 12 months. A Marnofski scale of less than 70 incidents frank disability (Inability to perform routine living activities without assistance), in addition current vocational status was assessed as well as any existing comorbid conditions. The mean age of the study group was 45.2 years (range 16 to 70) and included 108 (54%) males and 92 (46%) females, there were 39 (19.5%) diabetic patients and 27 (13.5%) patients were receiving erythropoietin (EPO). The mean hematocrit of the entire group was 27.8%. As measured by Karnofski scale, 64 (32%) of the patients were unable to perform routine living activity without assistance; dependence on wheelchair was reported by 9 (4.5%) patients. The mean comorbidity index of patients who scored less than 70 on the Karnofski scale was 1.5 compared to 0.7 for those who scored at least 70 on the same scale (p< 0.001). Analysis of factors showed that age and diabetes mellitus affected functional status. Of the laboratory variables measured, only serum albumin concentration correlated significant with Karnofski scale. Fourteen (21.8%) of the patients who scored below 70, had serum albumin concentration above 40g/L compared to 66 (48.5%) of the patients who scored at least 70 on the Karnofski scale (p< 0.001). We conclude that a significant proportion of patients on maintenance hemodialysis is functionally disabled. The elderly, diabetics, patients with high co-morbidity index and those with low serum albumin are most likely to have poor functional status.
    Keywords Hemodialysis ; Functional ; Rehabilitation ; Albumin ; Comorbidity. ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 1999-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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