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Article ; Online: Ultrasound-guided transvaginal biopsies of pelvic lesions: diagnostic yield, safety profile, and technical considerations over a 20-year experience.

Wood, Erika J / Pickhardt, Perry J / Elissa, Matthew / Mankowski Gettle, Lori / Lubner, Meghan G

2023 Volume 48, Issue 3, Page(s) 1154–1163

Abstract: Purpose: To evaluate diagnostic yield, safety profile, and specific technical considerations of transvaginal ultrasound (TVUS) guided biopsy/aspiration.: Materials/methods: TVUS guided biopsy (core, FNA) procedures with pre-procedure CT/MRI imaging ... ...

Abstract	Purpose: To evaluate diagnostic yield, safety profile, and specific technical considerations of transvaginal ultrasound (TVUS) guided biopsy/aspiration. Materials/methods: TVUS guided biopsy (core, FNA) procedures with pre-procedure CT/MRI imaging at a single institution between 2001 and 2021 were reviewed. Relevant patient demographic data was extracted via the Electronic Health Record (EMR), technical details of the biopsy procedure were collected, and distance to target via transvaginal and transabdominal biopsy approach was measured on pre-procedure imaging. Surgical pathology was reviewed and assessed for concordance. Complications were assessed. Statistical analysis was performed using SPSS. Results: 96 TVUS procedures (mean age, 58.7 ± 15.2 years; mean BMI, 27.4) were reviewed. TVUS guided approach decreased the distance to target (mean, 1.1 cm vs 8.6 cm transabdominal; p < 0.0001) and created a safe path not otherwise available in two patients. Average lesion size was 4.0 ± 2.1 cm (IQR 2.5, 5.2 cm) and targets at or above the vaginal cuff (0.9 ± 1.5 cm) and up to 0.5 ± 1.0 cm above the acetabular roof were accessible. 75 (78%) cases were core biopsies (18G; median, 2 passes) and 21 were FNA. Conscious sedation was used in 84.4% (n = 81) of cases and local anesthetic was also used in 84.4% (n = 81) of cases. Overall diagnostic yield was 98.9% (n = 94) with 94.7% (n = 89) cases confirmed as concordant diagnoses, including 57.4% (n = 54) malignant. Complications occurred in eight patients (8.3%), all minor. No post-biopsy infections were encountered regardless of administration of pre-procedure antibiotics (n = 14, 14.6%,), documentation of sterile prep (n = 92, 95.8%), or speculum use (n = 19, 19.8%). 50% (n = 48) had a prior hysterectomy, with no association with adequacy or complications (p = 0.9). Conclusion: Transvaginal biopsy of pelvic lesions offers excellent diagnostic yield and favorable safety profile, and can dramatically decrease distance to target. Clinical relevance: Ultrasound-guided transvaginal approach offers a safe and effective way to biopsy pelvic lesions in women.
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Aged ; Image-Guided Biopsy/methods ; Ultrasonography ; Biopsy, Fine-Needle ; Magnetic Resonance Imaging ; Retrospective Studies ; Ultrasonography, Interventional/methods
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2839786-1
ISSN	2366-0058 ; 2366-004X
ISSN (online)	2366-0058
ISSN	2366-004X
DOI	10.1007/s00261-022-03792-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Comparison of Intercropping and Pure Cropping as Determinants of the Stem and Canopy Foliage of Linseed (Linum Usitatissimum L.) and Pea (Pisum Sativum L.) Cultivars Their Productivity

Klimek-Kopyra, A. / Zając, T. / Mańkowski, J. / Oleksy, A.

Journal of natural fibers

2021 Volume 18, Issue 10/12, Page(s) 2364

Language	English
Document type	Article
ZDB-ID	2182715-1
ISSN	1544-0478
Database	Current Contents Nutrition, Environment, Agriculture

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Article: Comparison of Intercropping and Pure Cropping as Determinants of the Stem and Canopy Foliage of Linseed (Linum Usitatissimum L.) and Pea (Pisum Sativum L.) Cultivars and their Productivity

Klimek-Kopyra, A. / Zając, T. / Mańkowski, J. / Oleksy, A.

Journal of natural fibers

2021 Volume 18, Issue 10/12, Page(s) 2364

Language	English
Document type	Article
ZDB-ID	2182715-1
ISSN	1544-0478
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Quantitative Viral Outgrowth Assay to Measure the Functional SIV Reservoir in Myeloid Cells.

Abreu, C M / Veenhuis, R T / Shirk, E N / Queen, S E / Bullock, B T / Mankowski, J L / Gama, L / Clements, J E

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2407, Page(s) 333–356

Abstract: The role of CD4+ T cells in HIV infection and the latent reservoir, that is, latently infected cells that harbor replication competent virus, has been rigorously assessed. We have previously reported a quantitative viral outgrowth assay (QVOA) for SIV ... ...

Abstract	The role of CD4+ T cells in HIV infection and the latent reservoir, that is, latently infected cells that harbor replication competent virus, has been rigorously assessed. We have previously reported a quantitative viral outgrowth assay (QVOA) for SIV that demonstrated the frequency of latently infected CD4+ T cells is approximately 1 in a million cells, similar to that of HIV infected individuals on ART. However, the frequency of productively infected monocytes in blood and macrophages in tissues has not been similarly studied. Myeloid cells are infected during acute HIV and SIV infection; however, unlike lymphocytes, they are resistant to the cytopathic effects of the virus. Moreover, tissue-resident macrophages have the ability to self-renew and persist in the body for months to years. Thus, tissue macrophages, once infected, have the characteristics of a stable viral reservoir. A better understanding of the number of productively infected macrophages is critical to understanding the role of infected myeloid cells as a viral reservoir. In order to assess the functional latent reservoir. we have developed specific QVOAs for monocytes in blood, and macrophages in spleen, BAL and brain, which are described in detail in this chapter.
MeSH term(s)	Animals ; CD4-Positive T-Lymphocytes ; HIV Infections ; Humans ; Macaca mulatta ; Myeloid Cells ; Simian Acquired Immunodeficiency Syndrome ; Simian Immunodeficiency Virus ; Viral Load ; Virus Latency ; Virus Replication
Language	English
Publishing date	2022-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1871-4_22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Breast density quantitative measures and breast cancer risk among screened Black women.

Mahmoud, Mattia A / Ehsan, Sarah / Pantalone, Lauren / Mankowski, Walter / Conant, Emily F / Kontos, Despina / Chen, Jinbo / McCarthy, Anne Marie

JNCI cancer spectrum

2023 Volume 7, Issue 4

Abstract: Mammographic density is a strong predictor of breast cancer but only slightly increased the discriminatory ability of existing risk prediction models in previous studies with limited racial diversity. We assessed discrimination and calibration of models ... ...

Abstract	Mammographic density is a strong predictor of breast cancer but only slightly increased the discriminatory ability of existing risk prediction models in previous studies with limited racial diversity. We assessed discrimination and calibration of models consisting of the Breast Cancer Risk Assessment Tool (BCRAT), Breast Imaging-Reporting and Data System density and quantitative density measures. Patients were followed up from the date of first screening mammogram until invasive breast cancer diagnosis or 5-year follow-up. Areas under the curve for White women stayed consistently around 0.59 for all models, whereas the area under the curve increased slightly from 0.60 to 0.62 when adding dense area and area percent density to the BCRAT model for Black women. All women saw underprediction in all models, with Black women having less underprediction. Adding quantitative density to the BCRAT did not statistically significantly improve prediction for White or Black women. Future studies should evaluate whether volumetric breast density improves risk prediction.
MeSH term(s)	Female ; Humans ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/epidemiology ; Breast Density ; Risk Factors ; Risk Assessment ; Breast/diagnostic imaging
Language	English
Publishing date	2023-06-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2515-5091
ISSN (online)	2515-5091
DOI	10.1093/jncics/pkad041
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Successful liver transplantation from deceased donors with active COVID-19 infections with undetectable SARS-CoV-2 in donor liver and aorta.

Weeks, Sharon R / Federova, Ekateria / Lee, Kyungho / Nyberg, Lyle / Mulka, Kathleen / Rabb, Hamid / Pekosz, Andrew / Philosophe, Benjamin / Mankowski, Joseph

Clinical transplantation

2023 Volume 37, Issue 9, Page(s) e15081

Abstract: Background: The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had unprecedented effects on society and modern healthcare. In liver transplantation, uncertainty regarding the safety of performing transplants during the early stage of the ... ...

Abstract	Background: The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had unprecedented effects on society and modern healthcare. In liver transplantation, uncertainty regarding the safety of performing transplants during the early stage of the pandemic resulted in increased waitlist mortality. Additionally, concerns about disease transmission led to avoidance of deceased donors with COVID-19 infections. Several successful case reports describing incidental transplant of organs from donors with COVID-19 infections or intentional transplant of such donors into recipients with current or prior COVID-19 infections prompted the transplant community to re-evaluate that position. While excellent short-term results have been published, little is known about use of donors with active infections and the extent of COVID-19 organ involvement, which may affect long term outcomes. Methods: We report the successful transplantation of three livers from deceased donors with active COVID-19 infections. Donor liver and aortic tissues were evaluated by sensitive molecular testing for SARS-CoV-2 RNA via in situ hybridization and real-time quantitative reverse transcription PCR. Results: Postoperatively, all patients had excellent allograft function, without clinical or molecular evidence of SARS-CoV-2 transmission in donor tissues. Conclusion: This evidence supports the use of liver donors with active COVID-19 infections.
MeSH term(s)	Humans ; COVID-19/epidemiology ; SARS-CoV-2 ; Liver Transplantation/methods ; Pandemics ; RNA, Viral/genetics ; Tissue and Organ Procurement ; Living Donors ; Tissue Donors ; Liver ; Aorta
Chemical Substances	RNA, Viral
Language	English
Publishing date	2023-07-27
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.15081
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Anorectal pitfalls in computed tomography colonography.

Mankowski Gettle, Lori / Kim, David H / Pickhardt, Perry J

Abdominal radiology (New York)

2019 Volume 44, Issue 11, Page(s) 3606–3624

Abstract: There is a wide array of pathological lesions seen in the anorectal region with CT colonography (CTC), much of which is unique to this location. Many relatively common findings in the anorectal region are typically benign, but can be misinterpreted as ... ...

Abstract	There is a wide array of pathological lesions seen in the anorectal region with CT colonography (CTC), much of which is unique to this location. Many relatively common findings in the anorectal region are typically benign, but can be misinterpreted as malignant. There are also technique-related pitfalls that can impede accurate diagnosis of anorectal findings at CTC. Understanding common and uncommon lesions in the anorectal region as well as recognizing technical pitfalls will optimize interpretation of CTC and decrease the number of missed cancers and false positives. This review will systematically cover that they key pitfalls confronting the radiologist at CTC interpretation of the anorectal region, primarily dividing them into those related to underlying anatomy and those related to technique. Tips for how to effectively handle these potential pitfalls will also be discussed.
MeSH term(s)	Colonography, Computed Tomographic/methods ; Colorectal Neoplasms/diagnostic imaging ; Diagnosis, Differential ; Diagnostic Errors ; Humans
Language	English
Publishing date	2019-05-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2839786-1
ISSN	2366-0058 ; 2366-004X
ISSN (online)	2366-0058
ISSN	2366-004X
DOI	10.1007/s00261-019-02186-x
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Article ; Online: Feasibility of home administration of nebulised interferon ß-1a (SNG001) for COVID-19: a remote study.

Francis, Nick A / Monk, Phillip D / Nuttall, Jacqueline / Oliver, Thomas / Simpson, Catherine / Brookes, Jody L / Tear, Victoria J / Thompson, Angela G / Batten, Toby N / Mankowski, Marcin / Wilkinson, Thomas Ma

BJGP open

2023 Volume 7, Issue 4

Abstract: Background: Effective therapeutics given early to high-risk ambulatory patients with coronavirus disease 2019 (COVID-19) could improve outcomes and reduce overall healthcare burden. However, conducting site visits in non-hospitalised patients, who ... ...

Abstract	Background: Effective therapeutics given early to high-risk ambulatory patients with coronavirus disease 2019 (COVID-19) could improve outcomes and reduce overall healthcare burden. However, conducting site visits in non-hospitalised patients, who should remain isolated, is problematic. Aim: To evaluate the feasibility of a purely remote (virtual) study in non-hospitalised patients with COVID-19; and the efficacy and safety of nebulised recombinant interferon-β1a (SNG001) in this setting. Design & setting: Randomised, double-blind, parallel-group study, which was conducted remotely. Method: Eligible patients aged ≥65 years (or ≥50 years with risk factors) with COVID-19 and not requiring hospital admission were recruited remotely. They were randomised to SNG001 or placebo once-daily via nebuliser for 14 days. The main outcomes were assessments of feasibility and safety, which were all conducted remotely. Results: Of 114 patients treated, 111 (97.4%) completed 28 days of follow-up. Overall compliance to study medication was high, with ≥13 doses taken by 89.7% and 92.9% of treated patients in the placebo and SNG001 groups, respectively. Over the course of the study, only two patients were hospitalised, both in the placebo group; otherwise there were no notable differences between treatments for the efficacy parameters. No patients withdrew owing to an adverse event, and a similar proportion of patients experienced on-treatment adverse events in the two treatment groups (64.3% and 67.2% with SNG001 and placebo, respectively); most were mild or moderate and not treatment-related. Conclusion: This study demonstrated that it is feasible to conduct a purely virtual study in community-based patients with COVID-19, when the study included detailed daily assessments and with medication administered via nebuliser.
Language	English
Publishing date	2023-12-19
Publishing country	England
Document type	Journal Article
ISSN	2398-3795
ISSN (online)	2398-3795
DOI	10.3399/BJGPO.2023.0089
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Comparison of Intercropping and Pure Cropping as Determinants of the Stem and Canopy Foliage of Linseed (Linum Usitatissimum L.) and Pea (Pisum Sativum L.) Cultivars and Their Productivity

Klimek-Kopyra, A. / Zając, T. / Mańkowski, J. / Oleksy, A.

Journal of natural fibers. 2021 Dec. 02, v. 18, no. 12

2021

Abstract: In a two-factor field experiment, the stem and leaf characteristics and productivity of the ‘Flanders’ and ‘Barbara’ linseed cultivars were compared in four developmental stages in relation to the sowing method. The linseed grown in intercropping with ... ...

Abstract	In a two-factor field experiment, the stem and leaf characteristics and productivity of the ‘Flanders’ and ‘Barbara’ linseed cultivars were compared in four developmental stages in relation to the sowing method. The linseed grown in intercropping with pea, irrespective of the cultivar, was characterized by small leaves in the stem extension stage, but the leaf area significantly increased beginning with the budding phase. Comparison of the cultivars showed that the Barbara cultivar had significantly more leaves on the stems, which significantly affected the final protein yield. The choice of linseed cultivar for oilseed–legume intercropping was of great importance for the final yield. Among the mixtures compared, the one composed of ‘Barbara’ linseed and ‘Phönix’ pea was more productive. Cultivation of ‘Flanders’ linseed resulted in high yield in the pure stand and a high-fat yield. Intercropping of linseed with pea resulted in REI values above 1, which demonstrates the agrobiological suitability of the mixture.
Keywords	Barbara ; Linum usitatissimum ; Pisum sativum ; canopy ; cultivars ; field experimentation ; leaf area ; leaves ; linseed ; peas
Language	English
Dates of publication	2021-1202
Size	p. 2364-2378.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2182715-1
ISSN	1544-046X ; 1544-0478
ISSN (online)	1544-046X
ISSN	1544-0478
DOI	10.1080/15440478.2020.1726246
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The persistent inflammation, immunosuppression, and catabolism syndrome 10 years later.

Efron, Philip A / Brakenridge, Scott C / Mohr, Alicia M / Barrios, Evan L / Polcz, Valerie E / Anton, Stephen / Ozrazgat-Baslanti, Tezcan / Bihorac, Azra / Guirgis, Faheem / Loftus, Tyler J / Rosenthal, Martin / Leeuwenburgh, Christian / Mankowski, Robert / Moldawer, Lyle L / Moore, Frederick A

The journal of trauma and acute care surgery

2023 Volume 95, Issue 5, Page(s) 790–799

MeSH term(s)	Humans ; Syndrome ; Immunosuppression Therapy ; Immune Tolerance ; Inflammation ; Critical Illness
Language	English
Publishing date	2023-08-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2651070-4
ISSN	2163-0763 ; 2163-0755
ISSN (online)	2163-0763
ISSN	2163-0755
DOI	10.1097/TA.0000000000004087
Database	MEDical Literature Analysis and Retrieval System OnLINE

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